Chen, Zhong et al. show that cGAS−STING activation upon chemotherapy treatment leads to TNF expression. Paracrine TNF signalling leads to IKKβ-dependent phosphorylation of ATG9A and autophagy, promoti...

Autophagosome biogenesis depends on the coordinated action of proteins and lipids. However, how LC3B organizes at high density and contributes to autophagy-associated functions remains unclear. Using ...

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Hannah Lloyd, a postdoctoral associate in Cornell’s Weill Institute for Cell and Molecular Biology, has received the 2026 Sam and Nancy Fleming Research Fellowship

Read the full paper: Local autophagy impairment triggers brain-wide presynaptic remodeling and resilience

Leishmaniasis is classified as a neglected tropical disease that the available anti-leishmanial medications are limited, often accompanied by side effects, high costs, and the necessity for prolonged treatment. Factors such as the diversity of species, drug resistance of the parasites, and the presence of coexisting diseases significantly influence treatment efficacy. Autophagy is an immune mechanism to eliminates intracellular pathogens, however, many of them impairs autophagy in phagocytes....

Read the full paper: A human Staufen1 BAC transgenic mouse exhibits abnormal autophagy and neurodegeneration across the central nervous system

Researchers found that reducing autophagy in alveolar macrophages (AMs) enhanced host resistance against both Staphylococcus aureus and influenza A virus (IAV) in preclinical models...

Sereda and colleagues show that chaperone-mediated autophagy declines with aging, which leads to enhanced senescent cell burden that is driven, in part, by failed macrophage-mediated immunosurveillanc...