📢A new review in U&A proposes VMP1 — a master regulator of autophagy, markedly overexpressed in PDAC downstream of KRAS — as an attractive candidate for #TargetedProteinDegradation.
Read more 👇https://www.sciltp.com/journals/ua/articles/2610005459
#Autophagy #Ubiquitylation #PancreaticCancer #VMP1
Read more 👇https://www.sciltp.com/journals/ua/articles/2610005459
#Autophagy #Ubiquitylation #PancreaticCancer #VMP1
November 4, 2026 at 6:32 AM
📢A new review in U&A proposes VMP1 — a master regulator of autophagy, markedly overexpressed in PDAC downstream of KRAS — as an attractive candidate for #TargetedProteinDegradation.
Read more 👇https://www.sciltp.com/journals/ua/articles/2610005459
#Autophagy #Ubiquitylation #PancreaticCancer #VMP1
Read more 👇https://www.sciltp.com/journals/ua/articles/2610005459
#Autophagy #Ubiquitylation #PancreaticCancer #VMP1
Global Data Fitting Enables Kinetic Dissection of Cullin-RING Ligase-Catalyzed Ubiquitylation: From Substrate Priming to Poly-ubiquitin Chain Formation https://www.biorxiv.org/content/10.64898/2026.11.04.764329v1
November 6, 2026 at 12:45 PM
Global Data Fitting Enables Kinetic Dissection of Cullin-RING Ligase-Catalyzed Ubiquitylation: From Substrate Priming to Poly-ubiquitin Chain Formation https://www.biorxiv.org/content/10.64898/2026.11.04.764329v1
Global Data Fitting Enables Kinetic Dissection of Cullin-RING Ligase-Catalyzed Ubiquitylation: From Substrate Priming to Poly-ubiquitin Chain Formation https://www.biorxiv.org/content/10.64898/2026.11.04.764329v1
November 6, 2026 at 12:45 PM
Global Data Fitting Enables Kinetic Dissection of Cullin-RING Ligase-Catalyzed Ubiquitylation: From Substrate Priming to Poly-ubiquitin Chain Formation https://www.biorxiv.org/content/10.64898/2026.11.04.764329v1
A CK2-β-TrCP kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating tryptophan 2,3-dioxygenase stability
A CK2-β-TrCP kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating tryptophan 2,3-dioxygenase stability
How metabolic enzyme levels are regulated is poorly understood. Studying the tryptophan (Trp)-metabolizing enzyme TDO2, Thielen et al. discover a CK2 kinase-β-TrCP E3 ligase pathway that regulates stability in response to substrate availability. Trp occupation of an exosite restricts degron accessibility, whereas low Trp releases the degron for phosphorylation-ubiquitylation-mediated degradation.
dlvr.it
November 5, 2026 at 11:58 PM
A CK2-β-TrCP kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating tryptophan 2,3-dioxygenase stability
We also provide further evidence related to the nature of the attached #ubiquitin chains and report the ubiquitylation of the glycogenin protein covalently attached to unbranched glycogen, ubiquitylation of which occurs on two C-terminal GYG1 lysine residues.
October 25, 2026 at 4:52 PM
We also provide further evidence related to the nature of the attached #ubiquitin chains and report the ubiquitylation of the glycogenin protein covalently attached to unbranched glycogen, ubiquitylation of which occurs on two C-terminal GYG1 lysine residues.
Join the GBM Lunch on Oct. 28 (12.30 pm)
Speaker: Orsolya Leidecker @unicologne.bsky.social
Title: ADP-ribosyl-linked ubiquitylation on PARP11 revealed by dissecting its interaction architecture
Chair: Florestan Bilsing (Biochemistry Center Heidelberg)
Organization: GBM Postdocs
#GBMLunch
Speaker: Orsolya Leidecker @unicologne.bsky.social
Title: ADP-ribosyl-linked ubiquitylation on PARP11 revealed by dissecting its interaction architecture
Chair: Florestan Bilsing (Biochemistry Center Heidelberg)
Organization: GBM Postdocs
#GBMLunch
October 26, 2026 at 8:15 AM
Join the GBM Lunch on Oct. 28 (12.30 pm)
Speaker: Orsolya Leidecker @unicologne.bsky.social
Title: ADP-ribosyl-linked ubiquitylation on PARP11 revealed by dissecting its interaction architecture
Chair: Florestan Bilsing (Biochemistry Center Heidelberg)
Organization: GBM Postdocs
#GBMLunch
Speaker: Orsolya Leidecker @unicologne.bsky.social
Title: ADP-ribosyl-linked ubiquitylation on PARP11 revealed by dissecting its interaction architecture
Chair: Florestan Bilsing (Biochemistry Center Heidelberg)
Organization: GBM Postdocs
#GBMLunch
Ubiquitin ligase RNF126 exerts functions in lysosomal damage response and lysosomal homeostasis maintenance www.biorxiv.org/content/10.6...
Ubiquitin ligase RNF126 exerts functions in lysosomal damage response and lysosomal homeostasis maintenance
The response to lysosomal membrane permeabilization involves extensive ubiquitylation at the lysosome; however, the ubiquitin ligases identified so far cannot account for the complexity of the respons...
www.biorxiv.org
October 20, 2026 at 2:57 PM
Ubiquitin ligase RNF126 exerts functions in lysosomal damage response and lysosomal homeostasis maintenance www.biorxiv.org/content/10.6...
Targeting the HIF-1α–FTH/FTMT axis via inulin, butyrate, or alternative approaches may represent a promising therapeutic strategy for alleviating DCM and other diabetes complications.
Read here ➡️ doi.org/10.2337/db26-0063
Read here ➡️ doi.org/10.2337/db26-0063
October 17, 2026 at 11:45 PM
Targeting the HIF-1α–FTH/FTMT axis via inulin, butyrate, or alternative approaches may represent a promising therapeutic strategy for alleviating DCM and other diabetes complications.
Read here ➡️ doi.org/10.2337/db26-0063
Read here ➡️ doi.org/10.2337/db26-0063
Online Now: A CK2-β-TrCP kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating tryptophan 2,3-dioxygenase stability Online now:
A CK2-β-TrCP kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating tryptophan 2,3-dioxygenase stability
How metabolic enzyme levels are regulated is poorly understood. Studying the tryptophan (Trp)-metabolizing enzyme TDO2, Thielen et al. discover a CK2 kinase-β-TrCP E3 ligase pathway that regulates stability in response to substrate availability. Trp occupation of an exosite restricts degron accessibility, whereas low Trp releases the degron for phosphorylation-ubiquitylation-mediated degradation.
dlvr.it
October 12, 2026 at 7:14 PM
Online Now: A CK2-β-TrCP kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating tryptophan 2,3-dioxygenase stability Online now:
Dundee researchers launch targeted Parkinson’s trial
DUNDEE researchers are taking part in an international trial testing a targeted treatment for Parkinson’s disease....
DUNDEE researchers are taking part in an international trial testing a targeted treatment for Parkinson’s disease....
Dundee researchers launch targeted Parkinson’s trial
DUNDEE researchers are taking part in an international trial testing a targeted treatment for Parkinson’s disease. The NEULARK trial is exploring whether a precision medicine approach could slow the progression of the condition in people with LRRK2-driven Parkinson’s. Researchers at the University of Dundee’s Medical Research Council Protein Phosphorylation and Ubiquitylation Unit are among a select group of research centres involved in the Phase 2 clinical trial.
www.deadlinenews.co.uk
October 5, 2026 at 11:45 AM
Dundee researchers launch targeted Parkinson’s trial
DUNDEE researchers are taking part in an international trial testing a targeted treatment for Parkinson’s disease....
DUNDEE researchers are taking part in an international trial testing a targeted treatment for Parkinson’s disease....
Now online! Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties
Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties
(Cell 187, 2875–2892.e1–e10; May 23, 2024)
dlvr.it
September 30, 2026 at 12:41 PM
Now online! Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties
Holy shit that looks amazing. Reminds me a bit of seeing talks from a scientist who talked about Incan knotting as a way to explain protein modifications.
(I was almost afraid to look him up...no one would ever say his last name, which wasn't US English in origin.)
mcb.berkeley.edu/labs/rape/
(I was almost afraid to look him up...no one would ever say his last name, which wasn't US English in origin.)
mcb.berkeley.edu/labs/rape/
Rape Lab | UC Berkeley
The Rape lab research group at UC Berkeley uses biochemical and cell biological methods to understand ubiquitylation and its role in development and disease.
mcb.berkeley.edu
September 30, 2026 at 7:47 PM
Holy shit that looks amazing. Reminds me a bit of seeing talks from a scientist who talked about Incan knotting as a way to explain protein modifications.
(I was almost afraid to look him up...no one would ever say his last name, which wasn't US English in origin.)
mcb.berkeley.edu/labs/rape/
(I was almost afraid to look him up...no one would ever say his last name, which wasn't US English in origin.)
mcb.berkeley.edu/labs/rape/
Msp1-dependent extraction promotes ubiquitylation of translocation-stalled mitochondrial precursor proteins https://www.biorxiv.org/content/10.64898/2026.09.28.754956v1
September 29, 2026 at 10:17 AM
Msp1-dependent extraction promotes ubiquitylation of translocation-stalled mitochondrial precursor proteins https://www.biorxiv.org/content/10.64898/2026.09.28.754956v1
Msp1-dependent extraction promotes ubiquitylation of translocation-stalled mitochondrial precursor proteins https://www.biorxiv.org/content/10.64898/2026.09.28.754956v1
September 29, 2026 at 10:17 AM
Msp1-dependent extraction promotes ubiquitylation of translocation-stalled mitochondrial precursor proteins https://www.biorxiv.org/content/10.64898/2026.09.28.754956v1
Esther Sammler receives the 2026 Tom Isaacs Award www.ppu.mrc.ac.uk/news/esther-...
Esther Sammler receives the 2026 Tom Isaacs Award | MRC PPU
Dr Esther Sammler, Group Leader in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) at the University of Dundee and Honorary Consultant Neurologist at NHS Tayside, has received the pr...
www.ppu.mrc.ac.uk
September 28, 2026 at 8:27 AM
Esther Sammler receives the 2026 Tom Isaacs Award www.ppu.mrc.ac.uk/news/esther-...
New study identifies MARCH7 as a key E3 ligase that suppresses ferroptosis by regulating Fe²⁺ levels via K48-linked ubiquitylation of NCOA4, offering potential for ferroptosis-targeted therapies. PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #RNA 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0
No description available
www.cell.com
September 26, 2026 at 5:00 AM
New study identifies MARCH7 as a key E3 ligase that suppresses ferroptosis by regulating Fe²⁺ levels via K48-linked ubiquitylation of NCOA4, offering potential for ferroptosis-targeted therapies. PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #RNA 🧪
It's always a treat to actually sit down and read a paper. This one's really nice. Unlike some plant hormones such as auxins that act through ubiquitylation + protein degradation, salicylic acid (SA) activates gene expression via its receptor/transcription factor NPR1. The paper elucidates
Transcriptional activation of plant immunity by salicylic acid - Nature
A mechanistic basis for how the hormone salicylic acid promotes transcriptional activation during plant immune responses is described.
www.nature.com
September 22, 2026 at 9:26 PM
It's always a treat to actually sit down and read a paper. This one's really nice. Unlike some plant hormones such as auxins that act through ubiquitylation + protein degradation, salicylic acid (SA) activates gene expression via its receptor/transcription factor NPR1. The paper elucidates
New research identifies MARCH7 as a key E3 ubiquitin ligase that stabilizes iron homeostasis, reducing ferroptosis via K48-linked ubiquitylation of NCOA4. PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0
No description available
www.cell.com
September 21, 2026 at 8:00 PM
Quality control of glycogen through direct ubiquitylation by RNF213 pubmed.ncbi.nlm.nih.gov/42744304/ #cryoem
September 16, 2026 at 10:27 AM
Quality control of glycogen through direct ubiquitylation by RNF213 pubmed.ncbi.nlm.nih.gov/42744304/ #cryoem
More evidence of glycogen ubiquitination:
Quality control of glycogen through direct ubiquitylation by RNF213
www.nature.com/articles/s41...
Quality control of glycogen through direct ubiquitylation by RNF213
www.nature.com/articles/s41...
Quality control of glycogen through direct ubiquitylation by RNF213 - Nature
Nature - Quality control of glycogen through direct ubiquitylation by RNF213
www.nature.com
September 15, 2026 at 11:23 PM
More evidence of glycogen ubiquitination:
Quality control of glycogen through direct ubiquitylation by RNF213
www.nature.com/articles/s41...
Quality control of glycogen through direct ubiquitylation by RNF213
www.nature.com/articles/s41...
MARCH7 identified as a key E3 ubiquitin ligase that safeguards against ferroptosis by regulating intracellular Fe homeostasis via NCOA4 ubiquitylation. PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0
No description available
www.cell.com
September 16, 2026 at 12:00 PM
Quality control of glycogen through direct ubiquitylation by RNF213
Nature, Published online: 15 September 2026; doi:10.1038/s41586-026-11139-6Quality control of glycogen through direct ubiquitylation by RNF213
Nature, Published online: 15 September 2026; doi:10.1038/s41586-026-11139-6Quality control of glycogen through direct ubiquitylation by RNF213
Quality control of glycogen through direct ubiquitylation by RNF213
Nature, Published online: 15 September 2026; doi:10.1038/s41586-026-11139-6Quality control of glycogen through direct ubiquitylation by RNF213
drwebdomain.blog
September 15, 2026 at 4:57 PM
Quality control of glycogen through direct ubiquitylation by RNF213
Nature, Published online: 15 September 2026; doi:10.1038/s41586-026-11139-6Quality control of glycogen through direct ubiquitylation by RNF213
Nature, Published online: 15 September 2026; doi:10.1038/s41586-026-11139-6Quality control of glycogen through direct ubiquitylation by RNF213
MARCH7 identified as a key E3 ubiquitin ligase regulating ferroptosis by targeting NCOA4 for K48-linked ubiquitylation, promoting iron homeostasis. Essential for cell death control! PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0
No description available
www.cell.com
September 6, 2026 at 6:00 AM
MARCH7 identified as a key E3 ubiquitin ligase regulating ferroptosis by targeting NCOA4 for K48-linked ubiquitylation, promoting iron homeostasis. Essential for cell death control! PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA 🧪
📢 Big milestone for Ubiquitylation & Atg8ylation (U&A)— we’ve officially got our ISSN 3083-1105! 🚀
🎉Great thanks to @vderetic.bsky.social, and all authors, reviewers, and readers who have supported us along the way!
🎉Great thanks to @vderetic.bsky.social, and all authors, reviewers, and readers who have supported us along the way!
September 2, 2026 at 8:21 AM
📢 Big milestone for Ubiquitylation & Atg8ylation (U&A)— we’ve officially got our ISSN 3083-1105! 🚀
🎉Great thanks to @vderetic.bsky.social, and all authors, reviewers, and readers who have supported us along the way!
🎉Great thanks to @vderetic.bsky.social, and all authors, reviewers, and readers who have supported us along the way!