Marcin J. Suskiewicz
@msuskiewicz.eurosky.social
Structural biologist and biochemist. CNRS researcher at CBM Orléans @cbm-upr4301.bsky.social. Interested in protein modifications & interactions. Also husband, dad of 3, friend, ☧. Personal website: msuskiewicz.github.io
Pinned
New photo of our research team has just dropped (with Sophia, our CNRS concours candidate, and Ambre, a visitor researcher, as guests). Not all members are there but most are, including some short-term interns. Very honoured to (try to) be a leader of this team.
Just read this paper about cooperative binding of the DBD of FLI1 to GGAA-repeat DNA. It includes crystal structures with 2x, 3x, & 4xGGAA + EMSAs & fluorescence polarisation, showing that, on repetitive DNA, each FLI1 copy contacts the next & next+1, giving rise to cooperativity &increased affinity
Structure and cooperative formation of a FLI1 filament on contiguous GGAA DNA sites
Abstract. Ewing sarcoma, a pediatric cancer of bone and soft tissue, is driven in most cases by an abnormal oncogenic fusion of the N-terminal region of EW
academic.oup.com
October 12, 2026 at 4:41 PM
Just read this paper about cooperative binding of the DBD of FLI1 to GGAA-repeat DNA. It includes crystal structures with 2x, 3x, & 4xGGAA + EMSAs & fluorescence polarisation, showing that, on repetitive DNA, each FLI1 copy contacts the next & next+1, giving rise to cooperativity &increased affinity
Reposted by Marcin J. Suskiewicz
I’m very excited to share my postdoc work in the @plaschkalab.bsky.social, where we investigated the very final act of splicing – spliceosome termination, revealing the stepwise dismantling of the spent spliceosome www.nature.com/articles/s41... (1/11)
Mechanism of spliceosome termination - Nature
A coordinated sequence of RNA helicases and associated factors dismantles normal and defective spliceosome complexes to enable intron degradation and ensure accurate gene expression.
www.nature.com
October 8, 2026 at 10:11 AM
I’m very excited to share my postdoc work in the @plaschkalab.bsky.social, where we investigated the very final act of splicing – spliceosome termination, revealing the stepwise dismantling of the spent spliceosome www.nature.com/articles/s41... (1/11)
Reposted by Marcin J. Suskiewicz
Excited to share our new paper thanks to Tom Dix, @davidmcquarrie.bsky.social @yuantian23.bsky.social and the others @mcf-uom.bsky.social @fbmh-uom.bsky.social @manchester.ac.uk about multimerization of prototype RRM ELAV/Hu family RNA binding proteins.
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Multimerization of ELAV in Drosophila is essential for directing neuronal alternative splicing and polyadenylation programs
By Dix et al. and Matthias Soller
➡️ https://ow.ly/jspT50ZPTe1
Matthias Soller David McQuarrie
The University of Manchester
#Drosophila
RESEARCH PAPER: Multimerization of ELAV in Drosophila is essential for directing neuronal alternative splicing and polyadenylation programs
By Dix et al. and Matthias Soller
➡️ https://ow.ly/jspT50ZPTe1
Matthias Soller David McQuarrie
The University of Manchester
#Drosophila
October 1, 2026 at 4:36 PM
Excited to share our new paper thanks to Tom Dix, @davidmcquarrie.bsky.social @yuantian23.bsky.social and the others @mcf-uom.bsky.social @fbmh-uom.bsky.social @manchester.ac.uk about multimerization of prototype RRM ELAV/Hu family RNA binding proteins.
Reposted by Marcin J. Suskiewicz
Hydrophylic loop of PIN2 undergoes homotypic interaction via a conserved β-sheet motif to directly modulate clustering and dynamics
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
A conserved β-sheet motif mediates PIN2 hydrophilic loop–loop interactions to regulate PIN2 dynamics | PNAS
PIN-FORMED (PIN) auxin transporters are essential for plant development, relying on
asymmetric localization at the plasma membrane. While the centr...
www.pnas.org
October 1, 2026 at 5:33 AM
Hydrophylic loop of PIN2 undergoes homotypic interaction via a conserved β-sheet motif to directly modulate clustering and dynamics
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Marcin J. Suskiewicz
I'll save you the click-through:
A lab at University of Copenhagen had been feeding draft manuscripts & data into "Claude Science" & then Anthropic announces a discovery that this lab made a year ago but hasn't published yet.
It's plausible that Claude found the same signatures independently...
A lab at University of Copenhagen had been feeding draft manuscripts & data into "Claude Science" & then Anthropic announces a discovery that this lab made a year ago but hasn't published yet.
It's plausible that Claude found the same signatures independently...
Four days ago, a scientist was surprised by the news that Anthropic discovered new virus genes for making DNA. He says he’s been studying them for years—and feeding his data to Anthropic’s AI as part of his own research. Coincidence? Here’s my story. nyti.ms/3VSWayc
Did Anthropic’s A.I. Really Make a Scientific Discovery on Its Own? (Gift Article)
An expert at the University of Copenhagen said his team had been sharing its research with the company’s A.I. model, Claude, and that its new finding matched their work.
nyti.ms
September 27, 2026 at 10:25 PM
I'll save you the click-through:
A lab at University of Copenhagen had been feeding draft manuscripts & data into "Claude Science" & then Anthropic announces a discovery that this lab made a year ago but hasn't published yet.
It's plausible that Claude found the same signatures independently...
A lab at University of Copenhagen had been feeding draft manuscripts & data into "Claude Science" & then Anthropic announces a discovery that this lab made a year ago but hasn't published yet.
It's plausible that Claude found the same signatures independently...
Reposted by Marcin J. Suskiewicz
Reposted by Marcin J. Suskiewicz
This is it. This is what everyone is enabling by humoring genAI: you spend months writing something that took you years to get at, for an opaque algorithm that a few control to spit a number and cut you off right there and then. This is what we're up against 🧪
Had a UKRI funded grant proposal rejected at the "AI triage stage". "This AI-based triage was used only to identify approximately 50% of the strongest proposals to take forward to full human review." 🧪 #academicsky
September 25, 2026 at 6:56 AM
This is it. This is what everyone is enabling by humoring genAI: you spend months writing something that took you years to get at, for an opaque algorithm that a few control to spit a number and cut you off right there and then. This is what we're up against 🧪
Reposted by Marcin J. Suskiewicz
Pretty cool
Using expandable DNA-origami rings with site-specifically tethered FG-Nups as mechanically responsive NPC mimics
Using expandable DNA-origami rings with site-specifically tethered FG-Nups as mechanically responsive NPC mimics
September 24, 2026 at 12:28 PM
Pretty cool
Using expandable DNA-origami rings with site-specifically tethered FG-Nups as mechanically responsive NPC mimics
Using expandable DNA-origami rings with site-specifically tethered FG-Nups as mechanically responsive NPC mimics
Reposted by Marcin J. Suskiewicz
RNF213 M1-ubiquitinates damaged mitochondria to activate pro-inflammatory NF-κB signaling https://www.biorxiv.org/content/10.64898/2026.09.21.752888v1
September 23, 2026 at 1:30 AM
RNF213 M1-ubiquitinates damaged mitochondria to activate pro-inflammatory NF-κB signaling https://www.biorxiv.org/content/10.64898/2026.09.21.752888v1
Reposted by Marcin J. Suskiewicz
Use reward-guided search in a generative model's latent space to design high-affinity protein binders to proteins and carbohydrates.
@karstenkreis.bsky.social @pierceogden.bsky.social
www.biorxiv.org/content/10.6...
@karstenkreis.bsky.social @pierceogden.bsky.social
www.biorxiv.org/content/10.6...
September 22, 2026 at 2:57 PM
Use reward-guided search in a generative model's latent space to design high-affinity protein binders to proteins and carbohydrates.
@karstenkreis.bsky.social @pierceogden.bsky.social
www.biorxiv.org/content/10.6...
@karstenkreis.bsky.social @pierceogden.bsky.social
www.biorxiv.org/content/10.6...
Reposted by Marcin J. Suskiewicz
I'm excited to share our new preprint, where we show that fine-tuning gold nanoparticle conjugation to different Fab structural elements can produce powerful, rigidly coupled, labeling tools for in-situ cryo-ET. Take a look if you want to see an AuNP in an EM map!🔬🧠
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
September 22, 2026 at 8:18 PM
I'm excited to share our new preprint, where we show that fine-tuning gold nanoparticle conjugation to different Fab structural elements can produce powerful, rigidly coupled, labeling tools for in-situ cryo-ET. Take a look if you want to see an AuNP in an EM map!🔬🧠
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Marcin J. Suskiewicz
Very proud of our new publication in EMBO Molecular Medicine 🥳, where we describe an antimitotic that selectively inhibits tumor growth without affecting normal tissues.
Big congratulations to Eva Pangou, Sushil Awal, Ksenia Krupina and all authors, and many thanks to our amazing collaborators! 🔬🥳
Big congratulations to Eva Pangou, Sushil Awal, Ksenia Krupina and all authors, and many thanks to our amazing collaborators! 🔬🥳
Pharmacological inhibition of UBASH3B induces mitotic arrest and selectively reduces tumor growth - EMBO Molecular Medicine
Cancer cells tolerate mitotic errors to sustain proliferation, yet the molecular dependencies enabling this tolerance remain poorly understood and largely unexploited therapeutically. UBASH3B ensures ...
link.springer.com
September 22, 2026 at 8:46 PM
Very proud of our new publication in EMBO Molecular Medicine 🥳, where we describe an antimitotic that selectively inhibits tumor growth without affecting normal tissues.
Big congratulations to Eva Pangou, Sushil Awal, Ksenia Krupina and all authors, and many thanks to our amazing collaborators! 🔬🥳
Big congratulations to Eva Pangou, Sushil Awal, Ksenia Krupina and all authors, and many thanks to our amazing collaborators! 🔬🥳
Reposted by Marcin J. Suskiewicz
ColabFold 1.6.3 is out! 2.5x faster, pip-installable, ipSAE+pDockQ2 scores. Thanks Choonghwan Lee, Marielle Russo, Gyuri Kim
🐍pip install colabfold[alphafold]
CF2 Sneak Peak with AF3/Boltz/Protenix/ESMFold2…
🐍pip install "colabfold[alphafold3]@git+https://github.com/sokrypton/ColabFold@af3-preview"
🐍pip install colabfold[alphafold]
CF2 Sneak Peak with AF3/Boltz/Protenix/ESMFold2…
🐍pip install "colabfold[alphafold3]@git+https://github.com/sokrypton/ColabFold@af3-preview"
September 16, 2026 at 5:14 PM
ColabFold 1.6.3 is out! 2.5x faster, pip-installable, ipSAE+pDockQ2 scores. Thanks Choonghwan Lee, Marielle Russo, Gyuri Kim
🐍pip install colabfold[alphafold]
CF2 Sneak Peak with AF3/Boltz/Protenix/ESMFold2…
🐍pip install "colabfold[alphafold3]@git+https://github.com/sokrypton/ColabFold@af3-preview"
🐍pip install colabfold[alphafold]
CF2 Sneak Peak with AF3/Boltz/Protenix/ESMFold2…
🐍pip install "colabfold[alphafold3]@git+https://github.com/sokrypton/ColabFold@af3-preview"
It's always a treat to actually sit down and read a paper. This one's really nice. Unlike some plant hormones such as auxins that act through ubiquitylation + protein degradation, salicylic acid (SA) activates gene expression via its receptor/transcription factor NPR1. The paper elucidates
Transcriptional activation of plant immunity by salicylic acid - Nature
A mechanistic basis for how the hormone salicylic acid promotes transcriptional activation during plant immune responses is described.
www.nature.com
September 22, 2026 at 9:26 PM
It's always a treat to actually sit down and read a paper. This one's really nice. Unlike some plant hormones such as auxins that act through ubiquitylation + protein degradation, salicylic acid (SA) activates gene expression via its receptor/transcription factor NPR1. The paper elucidates
Reposted by Marcin J. Suskiewicz
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use.
We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition.
github.com/PacesaLab/Bi...
We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition.
github.com/PacesaLab/Bi...
September 21, 2026 at 9:55 AM
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use.
We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition.
github.com/PacesaLab/Bi...
We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition.
github.com/PacesaLab/Bi...
Reposted by Marcin J. Suskiewicz
El-Hadji is a gem of a person and a great scientist. One won't regret having a person with rare combo of kindness and scientific brilliance.
The manuscript is currently in revision and we thank Editor and Reviewers for their input -- the paper will further improve! El Hadji, who is great and has a rare combination of chemistry and biochemistry skiils, has more almost-finished projects up his sleave and is looking for jobs/fellowships!
September 17, 2026 at 2:22 PM
El-Hadji is a gem of a person and a great scientist. One won't regret having a person with rare combo of kindness and scientific brilliance.
Reposted by Marcin J. Suskiewicz
Reposted by Marcin J. Suskiewicz
🔍 Curious about how the proteolytic enzymes of the ubiquitin system work—and how these mechanisms can inspire new therapeutic strategies? Apply for a #PhDposition in the Gersch lab @maltegersch.bsky.social at @imprs-lm.bsky.social
#proteolysis #ubiquitin #biochemistry #proteinchemistry
#proteolysis #ubiquitin #biochemistry #proteinchemistry
September 15, 2026 at 3:34 PM
🔍 Curious about how the proteolytic enzymes of the ubiquitin system work—and how these mechanisms can inspire new therapeutic strategies? Apply for a #PhDposition in the Gersch lab @maltegersch.bsky.social at @imprs-lm.bsky.social
#proteolysis #ubiquitin #biochemistry #proteinchemistry
#proteolysis #ubiquitin #biochemistry #proteinchemistry
Reposted by Marcin J. Suskiewicz
📢 #Annonce CNRS Chimie arrive sur Bluesky !
🧪 L’un des dix instituts du @cnrs.fr, CNRS Chimie anime et coordonne la recherche en chimie en s’appuyant sur près de 14 000 personnes, 150 laboratoires et une cinquantaine de partenaires industriels.
#Chimie #CNRS #Fierd’êtrechimiste
🧪 L’un des dix instituts du @cnrs.fr, CNRS Chimie anime et coordonne la recherche en chimie en s’appuyant sur près de 14 000 personnes, 150 laboratoires et une cinquantaine de partenaires industriels.
#Chimie #CNRS #Fierd’êtrechimiste
September 15, 2026 at 9:00 AM
📢 #Annonce CNRS Chimie arrive sur Bluesky !
🧪 L’un des dix instituts du @cnrs.fr, CNRS Chimie anime et coordonne la recherche en chimie en s’appuyant sur près de 14 000 personnes, 150 laboratoires et une cinquantaine de partenaires industriels.
#Chimie #CNRS #Fierd’êtrechimiste
🧪 L’un des dix instituts du @cnrs.fr, CNRS Chimie anime et coordonne la recherche en chimie en s’appuyant sur près de 14 000 personnes, 150 laboratoires et une cinquantaine de partenaires industriels.
#Chimie #CNRS #Fierd’êtrechimiste
Reposted by Marcin J. Suskiewicz
This paper was a nice side quest that started as a random encounter with @hrbridges.bsky.social at the poster session of the 2025 @ccpem.bsky.social Spring Symposium.
It was very satisfying to finally see the macro domain of ALC1 that had escaped all previous structures of ALC1-nucleosome complexes!
It was very satisfying to finally see the macro domain of ALC1 that had escaped all previous structures of ALC1-nucleosome complexes!
Through extensive classification of a previously deposited cryoEM dataset, a previously unresolved ALC1–nucleosome complex characterized by a more open conformation of ALC1 was identified #DNADamageResponse #ChromatinRemodeling #ALC1 doi.org/10.1107/S205...
September 2, 2026 at 2:00 PM
This paper was a nice side quest that started as a random encounter with @hrbridges.bsky.social at the poster session of the 2025 @ccpem.bsky.social Spring Symposium.
It was very satisfying to finally see the macro domain of ALC1 that had escaped all previous structures of ALC1-nucleosome complexes!
It was very satisfying to finally see the macro domain of ALC1 that had escaped all previous structures of ALC1-nucleosome complexes!
Today, the day of the 100th anniversary symposium for Jean-Pierre Serre in Paris, I'm thinking of this quote from another mathematician, A. Connes. I do think it's important we foster confidence in our own expertise - as a nonsense filter and departure point for creativity.
September 15, 2026 at 5:44 AM
Today, the day of the 100th anniversary symposium for Jean-Pierre Serre in Paris, I'm thinking of this quote from another mathematician, A. Connes. I do think it's important we foster confidence in our own expertise - as a nonsense filter and departure point for creativity.
Reposted by Marcin J. Suskiewicz
New online: Cryo-EM structure, enzymatic activity and genome targeting of canonical PRC1
Cryo-EM structure, enzymatic activity and genome targeting of canonical PRC1
Nature Structural & Molecular Biology, Published online: 14 September 2026; doi:10.1038/s41594-026-01885-6Ciapponi et al. determine the cryo-electron microscopy structure of the canonical Polycomb repressive complex 1 holocomplex and show how its architecture coordinates complex assembly, H2A monoubiquitination and genomic targeting.
dlvr.it
September 14, 2026 at 7:24 PM
New online: Cryo-EM structure, enzymatic activity and genome targeting of canonical PRC1
Reposted by Marcin J. Suskiewicz
It is outrageous that these companies don't give back this trained model for others to make discoveries on. It is not like their competitive advantage is the model itself since they are willing to share the model among the participating companies. More info here: www.apheris.com/resources/fe...
September 14, 2026 at 1:55 PM
It is outrageous that these companies don't give back this trained model for others to make discoveries on. It is not like their competitive advantage is the model itself since they are willing to share the model among the participating companies. More info here: www.apheris.com/resources/fe...
Reposted by Marcin J. Suskiewicz
🚨 #Postdoc position open.
Want to understand non-canonical #epigenetic regulation of mammalian transcription? Come work @uoe-igc.bsky.social in Edinburgh!
We’re looking for a motivated & collaborative colleague with a strong track record.
📅 14 October 2026
📢 Please share
Apply here 👇
Want to understand non-canonical #epigenetic regulation of mammalian transcription? Come work @uoe-igc.bsky.social in Edinburgh!
We’re looking for a motivated & collaborative colleague with a strong track record.
📅 14 October 2026
📢 Please share
Apply here 👇
Post-Doctoral Research Associate
An exciting postdoctoral position is available to research the role of epigenetic marks in gene regulation.
elxw.fa.em3.oraclecloud.com
September 14, 2026 at 1:51 PM
🚨 #Postdoc position open.
Want to understand non-canonical #epigenetic regulation of mammalian transcription? Come work @uoe-igc.bsky.social in Edinburgh!
We’re looking for a motivated & collaborative colleague with a strong track record.
📅 14 October 2026
📢 Please share
Apply here 👇
Want to understand non-canonical #epigenetic regulation of mammalian transcription? Come work @uoe-igc.bsky.social in Edinburgh!
We’re looking for a motivated & collaborative colleague with a strong track record.
📅 14 October 2026
📢 Please share
Apply here 👇
Reposted by Marcin J. Suskiewicz
Huge effort from the Lab into the mechanics of the mysterious #ubiquitin like protein FAT10 – taking structural snapshots of FAT10 activation by UBA6 and transfer onto UBE2Z plus really interesting insights into InsP6 regulating FAT10 conjugation pathways: www.nature.com/articles/s41...
Structural determinants for FAT10 activation and transfer from UBA6 to E2 enzymes - Nature Communications
Cryo-EM captures FAT10 activation and transfer from UBA6 to E2 UBE2Z, revealing FAT10 monopolises UBA6. Efficient transfer requires E2 engagement of both FAT10 UBL domains, particularly UBL2, and co-o...
www.nature.com
August 14, 2026 at 12:59 PM
Huge effort from the Lab into the mechanics of the mysterious #ubiquitin like protein FAT10 – taking structural snapshots of FAT10 activation by UBA6 and transfer onto UBE2Z plus really interesting insights into InsP6 regulating FAT10 conjugation pathways: www.nature.com/articles/s41...