Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera | Collaboration with @georgwinter.bsky.social and Kristin Riching labs. Now published in Journal of the American Chemical Society @acsjacs.bsky.social pubs.acs.org/doi/10.1021/...
Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera
Proteolysis targeting chimera (PROTAC) degraders are typically bifunctional with one E3 ligase ligand connected to one target protein ligand via a linker. While augmented valency has been shown with t...
pubs.acs.org
November 30, 2024 at 4:35 PM
Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera | Collaboration with @georgwinter.bsky.social and Kristin Riching labs. Now published in Journal of the American Chemical Society @acsjacs.bsky.social pubs.acs.org/doi/10.1021/...
Thrilled to have the opportunity to investigate the role of membrane protein proteolysis in plant immunity through the ERC Starting Grant FRONTERA!
A heartfelt thank you to my mentors, friends, and family whose support, encouragement, and guidance made this possible.
#ERCStG @erc.europa.eu
A heartfelt thank you to my mentors, friends, and family whose support, encouragement, and guidance made this possible.
#ERCStG @erc.europa.eu
📣 Good news! 📣
Results of the ERC 2026 Starting Grant call are out!
Funding worth a total of €705 million will go to 421 early-career researchers across Europe.
Discover who, what and where 👉 link.europa.eu/9M3MmN
🧪 #ERCStG #FrontierResearch #HorizonEurope
🇪🇺 @scienceinnovation.ec.europa.eu
Results of the ERC 2026 Starting Grant call are out!
Funding worth a total of €705 million will go to 421 early-career researchers across Europe.
Discover who, what and where 👉 link.europa.eu/9M3MmN
🧪 #ERCStG #FrontierResearch #HorizonEurope
🇪🇺 @scienceinnovation.ec.europa.eu
September 3, 2026 at 1:32 PM
Thrilled to have the opportunity to investigate the role of membrane protein proteolysis in plant immunity through the ERC Starting Grant FRONTERA!
A heartfelt thank you to my mentors, friends, and family whose support, encouragement, and guidance made this possible.
#ERCStG @erc.europa.eu
A heartfelt thank you to my mentors, friends, and family whose support, encouragement, and guidance made this possible.
#ERCStG @erc.europa.eu
I'm excited to share that my newly funded #ERCStG FRONTERA is recruiting two postdoctoral researchers at @ipbhalle.bsky.social 🌱🔬
If you are passionate about plant immunity, proteolysis, membrane proteins, or proteomics, I'd love to hear from you. 🧵
Please RT/share!
If you are passionate about plant immunity, proteolysis, membrane proteins, or proteomics, I'd love to hear from you. 🧵
Please RT/share!
September 7, 2026 at 9:46 AM
I'm excited to share that my newly funded #ERCStG FRONTERA is recruiting two postdoctoral researchers at @ipbhalle.bsky.social 🌱🔬
If you are passionate about plant immunity, proteolysis, membrane proteins, or proteomics, I'd love to hear from you. 🧵
Please RT/share!
If you are passionate about plant immunity, proteolysis, membrane proteins, or proteomics, I'd love to hear from you. 🧵
Please RT/share!
Synthetic hypoxia sensing in Arabidopsis from @syno2xis.bsky.social & @vinayshukla.bsky.social
Prolyl hydroxylase-dependent proteolysis enables the orthogonal hypoxia responses in plants
www.nature.com/articles/s41...
Prolyl hydroxylase-dependent proteolysis enables the orthogonal hypoxia responses in plants
www.nature.com/articles/s41...
April 10, 2026 at 10:35 AM
Synthetic hypoxia sensing in Arabidopsis from @syno2xis.bsky.social & @vinayshukla.bsky.social
Prolyl hydroxylase-dependent proteolysis enables the orthogonal hypoxia responses in plants
www.nature.com/articles/s41...
Prolyl hydroxylase-dependent proteolysis enables the orthogonal hypoxia responses in plants
www.nature.com/articles/s41...
Proteolysis crunch: a sound effect, a cereal, a lifestyle
#3dThursday
#3dThursday
June 27, 2025 at 5:40 AM
Proteolysis crunch: a sound effect, a cereal, a lifestyle
#3dThursday
#3dThursday
Salicylic acid-triggered apoplastic proteolysis releases cryptic phytocytokines with distinct immunogenic functions https://www.biorxiv.org/content/10.64898/2026.09.01.748544v1
September 3, 2026 at 10:02 AM
Salicylic acid-triggered apoplastic proteolysis releases cryptic phytocytokines with distinct immunogenic functions https://www.biorxiv.org/content/10.64898/2026.09.01.748544v1
It is nice to see proteolysis being included in reviews like this one :)
Receptor-like protein kinases in plants: Post-translational regulation and functional effects #review #MolecularPlant cell.com/molecular-pl...
April 28, 2026 at 2:11 PM
It is nice to see proteolysis being included in reviews like this one :)
Exploring protein conformations with limited proteolysis coupled to mass spectrometry www.cell.com/trends/...
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#proteomics #prot-paper
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#proteomics #prot-paper
December 22, 2024 at 3:20 PM
Exploring protein conformations with limited proteolysis coupled to mass spectrometry www.cell.com/trends/...
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#proteomics #prot-paper
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#proteomics #prot-paper
Online now - the Review "Interconnectivity of mitochondrial protein biogenesis and quality control" from @mitolab.bsky.social et al.
#ProteinImport #Proteaes #Proteolysis #Proteostasis
Read it here: authors.elsevier.com/sd/article/S...
#ProteinImport #Proteaes #Proteolysis #Proteostasis
Read it here: authors.elsevier.com/sd/article/S...
October 10, 2025 at 3:55 PM
Online now - the Review "Interconnectivity of mitochondrial protein biogenesis and quality control" from @mitolab.bsky.social et al.
#ProteinImport #Proteaes #Proteolysis #Proteostasis
Read it here: authors.elsevier.com/sd/article/S...
#ProteinImport #Proteaes #Proteolysis #Proteostasis
Read it here: authors.elsevier.com/sd/article/S...
Getting close to Luca (Toscana) for the GRC in Plant Proteolysis!
January 18, 2025 at 8:29 AM
Getting close to Luca (Toscana) for the GRC in Plant Proteolysis!
Nitric oxide promotes cysteine N-degron proteolysis through control of oxygen availability | Important finding by Kim, Tian, Ratcliffe and Keeley @ox.ac.uk @ispt-proteinterm.bsky.social #N-degron www.pnas.org/doi/10.1073/...
Nitric oxide promotes cysteine N-degron proteolysis through control of oxygen availability | PNAS
Selected proteins containing an N-terminal cysteine (Nt-Cys) are subjected to rapid,
O2-dependent proteolysis via the Cys/Arg-branch of the N-degro...
www.pnas.org
August 20, 2025 at 10:39 AM
Nitric oxide promotes cysteine N-degron proteolysis through control of oxygen availability | Important finding by Kim, Tian, Ratcliffe and Keeley @ox.ac.uk @ispt-proteinterm.bsky.social #N-degron www.pnas.org/doi/10.1073/...
Shedding light on plant proteolysis: genetically encoded fluorescent sensors as tools for profiling protease activities (Álvaro Daniel Fernández-Fernández , Simon Tack , et al) doi.org/10.1093/plce... #PlantScience @aspbofficial
Shedding light on plant proteolysis: genetically encoded fluorescent sensors as tools for profiling protease activities
Genetically encoded FRET-based fluorescent sensors enable real-time, high-resolution visualization of protease activity and proteolytic signaling in living
doi.org
August 5, 2026 at 6:52 PM
Shedding light on plant proteolysis: genetically encoded fluorescent sensors as tools for profiling protease activities (Álvaro Daniel Fernández-Fernández , Simon Tack , et al) doi.org/10.1093/plce... #PlantScience @aspbofficial
What an amazing venue in tuscany/Italy for the GRC plant proteolysis meeting - looking forward to meet our awesome community and for some amazing science on #proteostasis 🤗
January 19, 2025 at 9:19 AM
What an amazing venue in tuscany/Italy for the GRC plant proteolysis meeting - looking forward to meet our awesome community and for some amazing science on #proteostasis 🤗
Previously on @biorxiv-plants.bsky.social now in final published version: www.nature.com/articles/s41...
Diversification of functional requirements for proteolysis of auxin response factors - Nature Communications
Auxin-dependent ARF transcription factors are subject to proteolytic degradation. Using the liverwort Marchantia polymorpha, de Roij et al. show that this degradation evolved early in the ARF family, ...
www.nature.com
March 21, 2026 at 7:29 AM
Previously on @biorxiv-plants.bsky.social now in final published version: www.nature.com/articles/s41...
Kristina Jonas @krijonas.bsky.social starts #EMBOBacNet today with a talk on Lon-mediated proteolysis in bacterial pathogenicity and stress adaptation
September 16, 2026 at 7:03 AM
Kristina Jonas @krijonas.bsky.social starts #EMBOBacNet today with a talk on Lon-mediated proteolysis in bacterial pathogenicity and stress adaptation
Hypoxia-activated PROTACs (HAP-TACs) are online in @jacs.acspublications.org (pubs.acs.org/doi/10.1021/...)! Collborative work with Ester Hammond (@hammond-lab.bsky.social). Congrats to Marta Serafini, Sophie Twigger, George Delfas, Max Mallerman, Elliot Bailey & Ewen Calder (@ecalder.bsky.social).
Indolequinone-Based Hypoxia-Activated Proteolysis Targeting Chimeras Selectively Degrade BRD4 in Hypoxic Cancer Cells
Proteolysis targeting chimeras (PROTACs) have helped to establish proximity induction as an exciting strategy in drug discovery, and there are multiple clinical trials focused on this modality. Howeve...
pubs.acs.org
September 25, 2025 at 3:47 PM
Hypoxia-activated PROTACs (HAP-TACs) are online in @jacs.acspublications.org (pubs.acs.org/doi/10.1021/...)! Collborative work with Ester Hammond (@hammond-lab.bsky.social). Congrats to Marta Serafini, Sophie Twigger, George Delfas, Max Mallerman, Elliot Bailey & Ewen Calder (@ecalder.bsky.social).
Shedding light on plant proteolysis: genetically encoded fluorescent sensors as tools for profiling protease activities.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
“Shedding light on plant proteolysis: genetically encoded fluorescent sensors as tools for profiling protease activities.”
Proteolysis, a ubiquitous process in living organisms, is driven by proteases that regulate numerous signaling pathways through the hydrolysis of peptide bonds in protein substrates. Understanding the...
www.biorxiv.org
January 23, 2025 at 5:18 PM
Shedding light on plant proteolysis: genetically encoded fluorescent sensors as tools for profiling protease activities.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...
www.science.org
March 27, 2025 at 7:45 PM
SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...
Very happy to see our Zip1 work highlighted in Plant Physiology 🌽
Sequential proteolysis across compartments can shape where, when and in which form peptide signals act.
Thanks to @mamoonakhan.bsky.social for the insightful highlight!
academic.oup.com/plphys/artic...
Sequential proteolysis across compartments can shape where, when and in which form peptide signals act.
Thanks to @mamoonakhan.bsky.social for the insightful highlight!
academic.oup.com/plphys/artic...
A tale of 2 realms: spatial processing of the maize phytocytokine Zip1
Plants rely on sophisticated cell-to-cell communication to perceive environmental changes and coordinate appropriate responses. Among the signalling molecu
academic.oup.com
September 21, 2026 at 8:05 PM
Very happy to see our Zip1 work highlighted in Plant Physiology 🌽
Sequential proteolysis across compartments can shape where, when and in which form peptide signals act.
Thanks to @mamoonakhan.bsky.social for the insightful highlight!
academic.oup.com/plphys/artic...
Sequential proteolysis across compartments can shape where, when and in which form peptide signals act.
Thanks to @mamoonakhan.bsky.social for the insightful highlight!
academic.oup.com/plphys/artic...
Just starting the Autophagy session at Plant Proteolysis meeting with an introduction into the field by @plantophagy.bsky.social #GRC
January 21, 2025 at 5:09 PM
Just starting the Autophagy session at Plant Proteolysis meeting with an introduction into the field by @plantophagy.bsky.social #GRC
Early to the airport with Rory; off to Florence ahead of the GRC plant proteolysis meeting that starts on Sunday! 🌱🧬
January 17, 2025 at 3:51 PM
Early to the airport with Rory; off to Florence ahead of the GRC plant proteolysis meeting that starts on Sunday! 🌱🧬
PAPER from @vanbreusegemlab.bsky.social and @moritznowack.bsky.social in @theplantcell.bsky.social
academic.oup.com/plcell/advan...
academic.oup.com/plcell/advan...
Shedding light on plant proteolysis: genetically encoded fluorescent sensors as tools for profiling protease activities
Genetically encoded FRET-based fluorescent sensors enable real-time, high-resolution visualization of protease activity and proteolytic signaling in living
academic.oup.com
June 19, 2026 at 6:54 AM
lovably propagating wrongdoer delirium scandium badinage proteolysis magnified
For more images visit https://www.instagram.com/usartwork
#algorithmicart #generativeart #filtermania #imagemanipulation #polarefffect #mirromania #mirroreffect #opart #abstractart #videoscan
For more images visit https://www.instagram.com/usartwork
#algorithmicart #generativeart #filtermania #imagemanipulation #polarefffect #mirromania #mirroreffect #opart #abstractart #videoscan
May 22, 2026 at 12:01 PM
lovably propagating wrongdoer delirium scandium badinage proteolysis magnified
For more images visit https://www.instagram.com/usartwork
#algorithmicart #generativeart #filtermania #imagemanipulation #polarefffect #mirromania #mirroreffect #opart #abstractart #videoscan
For more images visit https://www.instagram.com/usartwork
#algorithmicart #generativeart #filtermania #imagemanipulation #polarefffect #mirromania #mirroreffect #opart #abstractart #videoscan
With a bit of delay, but my latest work on engineering a sensor for plant proteolysis was published online in The Plant Cell (1/5).
June 25, 2026 at 1:45 PM
With a bit of delay, but my latest work on engineering a sensor for plant proteolysis was published online in The Plant Cell (1/5).