Izabela Sumara
@sumaralab.bsky.social
Cell cycle, mitosis, nuclear pores, ubiquitin, disease.
Group leader @igbmc.bsky.social, research director DR1 @cnrs.fr, Strasbourg, France.
Alumna @JagiellonskiUni.bsky.social @impvienna.bsky.social @ethz.ch
Hobby cook and occasional runner.
Group leader @igbmc.bsky.social, research director DR1 @cnrs.fr, Strasbourg, France.
Alumna @JagiellonskiUni.bsky.social @impvienna.bsky.social @ethz.ch
Hobby cook and occasional runner.
Pinned
Izabela Sumara
@sumaralab.bsky.social
· Mar 30
RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion - Nature Communications
Whether annulate lamellae (AL) occur in normal somatic cells was an open question. Here, the authors demonstrate that AL drive nuclear pore complex assembly and nuclear expansion during G1, defining a...
www.nature.com
Our new study is out! 🎉🚀
Annulate lamellae aren’t just static reservoirs, they dynamically supply pre-assembled nuclear pores to the nucleus (~1/3 of new NPCs) in normal somatic cells. A new pathway for nuclear pore assembly supporting nuclear expansion.
Annulate lamellae aren’t just static reservoirs, they dynamically supply pre-assembled nuclear pores to the nucleus (~1/3 of new NPCs) in normal somatic cells. A new pathway for nuclear pore assembly supporting nuclear expansion.
Reposted by Izabela Sumara
Online this week ➡️ Pharmacological inhibition of #UBASH3B induces #MitoticArrest and selectively reduces #TumorGrowth
By E. Pangou, @sumaralab.bsky.social and colleagues @igbmc.bsky.social
🗞️ doi.org/10.1038/s44321-026-00519-0
By E. Pangou, @sumaralab.bsky.social and colleagues @igbmc.bsky.social
🗞️ doi.org/10.1038/s44321-026-00519-0
September 25, 2026 at 12:58 PM
Online this week ➡️ Pharmacological inhibition of #UBASH3B induces #MitoticArrest and selectively reduces #TumorGrowth
By E. Pangou, @sumaralab.bsky.social and colleagues @igbmc.bsky.social
🗞️ doi.org/10.1038/s44321-026-00519-0
By E. Pangou, @sumaralab.bsky.social and colleagues @igbmc.bsky.social
🗞️ doi.org/10.1038/s44321-026-00519-0
Very proud of our new publication in EMBO Molecular Medicine 🥳, where we describe an antimitotic that selectively inhibits tumor growth without affecting normal tissues.
Big congratulations to Eva Pangou, Sushil Awal, Ksenia Krupina and all authors, and many thanks to our amazing collaborators! 🔬🥳
Big congratulations to Eva Pangou, Sushil Awal, Ksenia Krupina and all authors, and many thanks to our amazing collaborators! 🔬🥳
Pharmacological inhibition of UBASH3B induces mitotic arrest and selectively reduces tumor growth - EMBO Molecular Medicine
Cancer cells tolerate mitotic errors to sustain proliferation, yet the molecular dependencies enabling this tolerance remain poorly understood and largely unexploited therapeutically. UBASH3B ensures ...
link.springer.com
September 22, 2026 at 8:46 PM
Very proud of our new publication in EMBO Molecular Medicine 🥳, where we describe an antimitotic that selectively inhibits tumor growth without affecting normal tissues.
Big congratulations to Eva Pangou, Sushil Awal, Ksenia Krupina and all authors, and many thanks to our amazing collaborators! 🔬🥳
Big congratulations to Eva Pangou, Sushil Awal, Ksenia Krupina and all authors, and many thanks to our amazing collaborators! 🔬🥳
I’m very happy to share a press release about our recent publication on how annulate lamellae build new nuclear pores. 🔬🥳
Grateful to @cnrs.fr for highlighting our work and helping share these findings! 🙏✨
Grateful to @cnrs.fr for highlighting our work and helping share these findings! 🙏✨
#ResultatScientifique🔎| Comment les cellules construisent-elles les milliers de pores qui assurent les échanges entre le noyau et le cytoplasme ? Dans @natcomms.nature.com des scientifiques révèlent le rôle insoupçonné des lamelles annelées
✍️ @sumaralab.bsky.social
buff.ly/qLaqasN
✍️ @sumaralab.bsky.social
buff.ly/qLaqasN
Des neurones qui changent la donne face au cancer
Pourquoi certa
buff.ly
September 8, 2026 at 6:31 AM
I’m very happy to share a press release about our recent publication on how annulate lamellae build new nuclear pores. 🔬🥳
Grateful to @cnrs.fr for highlighting our work and helping share these findings! 🙏✨
Grateful to @cnrs.fr for highlighting our work and helping share these findings! 🙏✨
Our new study is out! 🎉🚀
Annulate lamellae aren’t just static reservoirs, they dynamically supply pre-assembled nuclear pores to the nucleus (~1/3 of new NPCs) in normal somatic cells. A new pathway for nuclear pore assembly supporting nuclear expansion.
Annulate lamellae aren’t just static reservoirs, they dynamically supply pre-assembled nuclear pores to the nucleus (~1/3 of new NPCs) in normal somatic cells. A new pathway for nuclear pore assembly supporting nuclear expansion.
RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion - Nature Communications
Whether annulate lamellae (AL) occur in normal somatic cells was an open question. Here, the authors demonstrate that AL drive nuclear pore complex assembly and nuclear expansion during G1, defining a...
www.nature.com
March 30, 2026 at 8:00 PM
Our new study is out! 🎉🚀
Annulate lamellae aren’t just static reservoirs, they dynamically supply pre-assembled nuclear pores to the nucleus (~1/3 of new NPCs) in normal somatic cells. A new pathway for nuclear pore assembly supporting nuclear expansion.
Annulate lamellae aren’t just static reservoirs, they dynamically supply pre-assembled nuclear pores to the nucleus (~1/3 of new NPCs) in normal somatic cells. A new pathway for nuclear pore assembly supporting nuclear expansion.
We are extremely happy to welcome Xiao Lyu to our team! She will pursue her PhD focusing on cancer-specific vulnerabilities. We wish you every success, Xiao! 🤞💪😄
February 3, 2026 at 10:44 AM
We are extremely happy to welcome Xiao Lyu to our team! She will pursue her PhD focusing on cancer-specific vulnerabilities. We wish you every success, Xiao! 🤞💪😄
We had a little champagne and some delicious cakes to celebrate the acceptance of our new paper 🤩 We also killed a snowman…🫣😉
January 15, 2026 at 7:15 PM
We had a little champagne and some delicious cakes to celebrate the acceptance of our new paper 🤩 We also killed a snowman…🫣😉
I have the great pleasure of hosting Dirk Görlich at the IGBMC this Friday, and I very much look forward to the stimulating and insightful discussions.
FRIDAY LECTURES: Dirk Görlich (Lasker Prize 2025) reveals the “dark proteome” and the selective sorting of molecules within the cell.
An exceptional event on Friday, January 9, at 3:00 p.m., IGBMC Auditorium.
Organized by Izabela Sumara.
A deep dive into the heart of the cell not to be missed!
An exceptional event on Friday, January 9, at 3:00 p.m., IGBMC Auditorium.
Organized by Izabela Sumara.
A deep dive into the heart of the cell not to be missed!
January 7, 2026 at 7:46 PM
I have the great pleasure of hosting Dirk Görlich at the IGBMC this Friday, and I very much look forward to the stimulating and insightful discussions.
Secret Santa paid a visit to the Sumara Lab today! 🌟🎅🎄
December 3, 2025 at 7:16 PM
Secret Santa paid a visit to the Sumara Lab today! 🌟🎅🎄
We are excited to share the revised version of our preprint elucidating the role of Annulate Lamellae in the assembly of Nuclear Pore Complexes #NPCs during early interphase.
Big thanks to Junyan Lin and all collaborators for their fantastic work! 🙏🎉
Big thanks to Junyan Lin and all collaborators for their fantastic work! 🙏🎉
RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion
Nuclear pore complexes (NPCs) enable nucleocytoplasmic transport. While NPCs primarily localize to the nuclear envelope (NE), they also appear in cytoplasmic endoplasmic reticulum (ER) membranes calle...
www.biorxiv.org
November 27, 2025 at 3:25 PM
We are excited to share the revised version of our preprint elucidating the role of Annulate Lamellae in the assembly of Nuclear Pore Complexes #NPCs during early interphase.
Big thanks to Junyan Lin and all collaborators for their fantastic work! 🙏🎉
Big thanks to Junyan Lin and all collaborators for their fantastic work! 🙏🎉
Our own Dr. Xiaotian Liu presented a talk on the role of asymmetric dimethylation in nuclear pore assembly at the #EESNucleus EMBO meeting. We couldn’t be prouder 🤓😎😁😁
November 21, 2025 at 3:11 PM
Our own Dr. Xiaotian Liu presented a talk on the role of asymmetric dimethylation in nuclear pore assembly at the #EESNucleus EMBO meeting. We couldn’t be prouder 🤓😎😁😁
It was a fantastic #EESNucleus meeting! Thank you so much to the organizers and the entire supporting team 🙏😁
🙌 Hello from #EESNucleus.
The organisers Simone Köhler, Patrick Lusk,
Thomas Quail, @sarawickstrom.bsky.social and Karo Wolkersdorfer are welcoming all participants to the four day symposium in Heidelberg.
The organisers Simone Köhler, Patrick Lusk,
Thomas Quail, @sarawickstrom.bsky.social and Karo Wolkersdorfer are welcoming all participants to the four day symposium in Heidelberg.
November 21, 2025 at 2:57 PM
It was a fantastic #EESNucleus meeting! Thank you so much to the organizers and the entire supporting team 🙏😁
Reposted by Izabela Sumara
This was indeed a fantastic trip, thanks so much for hosting me! I very much enjoyed learning about fantastic science from you and your amazing @sumatalab.bsky.social team and the great IGBMC community!
I had the great pleasure of hosting Christian Schlieker @schliekerlab.bsky.social for a seminar at IGBMC @igbmc.bsky.social
Thank you 🙏, Christian, for sharing your inspiring science and ideas, and for such engaging discussions with PIs and my team. A truly wonderful visit! 🤩😁
Thank you 🙏, Christian, for sharing your inspiring science and ideas, and for such engaging discussions with PIs and my team. A truly wonderful visit! 🤩😁
November 7, 2025 at 4:16 PM
This was indeed a fantastic trip, thanks so much for hosting me! I very much enjoyed learning about fantastic science from you and your amazing @sumatalab.bsky.social team and the great IGBMC community!
A new photo of my amazing team! 🤩🌟🥰
November 7, 2025 at 3:45 PM
A new photo of my amazing team! 🤩🌟🥰
I had the great pleasure of hosting Christian Schlieker @schliekerlab.bsky.social for a seminar at IGBMC @igbmc.bsky.social
Thank you 🙏, Christian, for sharing your inspiring science and ideas, and for such engaging discussions with PIs and my team. A truly wonderful visit! 🤩😁
Thank you 🙏, Christian, for sharing your inspiring science and ideas, and for such engaging discussions with PIs and my team. A truly wonderful visit! 🤩😁
November 7, 2025 at 3:23 PM
I had the great pleasure of hosting Christian Schlieker @schliekerlab.bsky.social for a seminar at IGBMC @igbmc.bsky.social
Thank you 🙏, Christian, for sharing your inspiring science and ideas, and for such engaging discussions with PIs and my team. A truly wonderful visit! 🤩😁
Thank you 🙏, Christian, for sharing your inspiring science and ideas, and for such engaging discussions with PIs and my team. A truly wonderful visit! 🤩😁
Minimal CDK and maximal Damien Coudreuse lab! Big congrats 🎉🎈🍾
October 30, 2025 at 8:25 AM
Minimal CDK and maximal Damien Coudreuse lab! Big congrats 🎉🎈🍾
Today we welcomed our new postdoc, Dr. Marintia Nava @marintianava.bsky.social, to the lab! We’re so happy to have her on board and wish her the best of luck as she begins her exciting work on Annulate Lamellae. Welcome, Marintia! 😁🤩🌟
October 1, 2025 at 5:42 PM
Today we welcomed our new postdoc, Dr. Marintia Nava @marintianava.bsky.social, to the lab! We’re so happy to have her on board and wish her the best of luck as she begins her exciting work on Annulate Lamellae. Welcome, Marintia! 😁🤩🌟
Reposted by Izabela Sumara
Liao et al. @sumaralab.bsky.social show that UBAP2L ensures homeostasis of nuclear pore complexes at the intact nuclear envelope. rupress.org/jcb/article/...
📕 In our Intermediate Filaments collection: rupress.org/jcb/collecti...
📕 In our Intermediate Filaments collection: rupress.org/jcb/collecti...
September 26, 2025 at 12:31 PM
Liao et al. @sumaralab.bsky.social show that UBAP2L ensures homeostasis of nuclear pore complexes at the intact nuclear envelope. rupress.org/jcb/article/...
📕 In our Intermediate Filaments collection: rupress.org/jcb/collecti...
📕 In our Intermediate Filaments collection: rupress.org/jcb/collecti...
Reposted by Izabela Sumara
Last day to submit abstracts! Nuclear cell biologists, mechanobiologists, et al. don’t miss out - amazing interdisciplinary line up: computational biology, biophysics, development, genomics - we will have it all!
Final call to register and submit abstracts for the @faseborg.bsky.social conference on the Mechanobiology of the Cell Nucleus (#MBNSRC) to be considered for platform presentations. The conference takes place in Melbourne, FL, Oct. 26-30, 2025. See more info at: events.faseb.org/event/Mechan...
August 31, 2025 at 5:06 PM
Last day to submit abstracts! Nuclear cell biologists, mechanobiologists, et al. don’t miss out - amazing interdisciplinary line up: computational biology, biophysics, development, genomics - we will have it all!
Reposted by Izabela Sumara
Did you know that all nuclear pore complexes (NPCs) are not the same? @luskinglab.bsky.social propose a new hypothesis for how nuclear mechanics may impact the compositional plasticity of NPCs with implications for tissue-specific diseases caused by NPC dysfunction.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nuclear mechanics as a determinant of nuclear pore complex plasticity - Nature Cell Biology
In this Review, Lusk et al. discuss emerging insights into nuclear pore complex variability with regard to composition and dilation state, and propose nuclear mechanics as a key determinant of driving...
www.nature.com
September 19, 2025 at 3:50 PM
Did you know that all nuclear pore complexes (NPCs) are not the same? @luskinglab.bsky.social propose a new hypothesis for how nuclear mechanics may impact the compositional plasticity of NPCs with implications for tissue-specific diseases caused by NPC dysfunction.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Izabela Sumara
Why are low-complexity domains (LCDs) in proteins important?
#LaskerAward winners Dirk Görlich & Steven McKnight showed that they are critical for intracellular transport and organization. #Lasker2025
#structuralbiology #phaseseparation
@mpi-nat.bsky.social
#LaskerAward winners Dirk Görlich & Steven McKnight showed that they are critical for intracellular transport and organization. #Lasker2025
#structuralbiology #phaseseparation
@mpi-nat.bsky.social
Low-complexity domains: structures & functions
The 2025 Albert Lasker Basic Medical Research Award honors Dirk Görlich and Steven McKnight for discoveries that exposed the structures and functions of low-complexity domains within protein…
www.youtube.com
September 12, 2025 at 12:45 PM
Why are low-complexity domains (LCDs) in proteins important?
#LaskerAward winners Dirk Görlich & Steven McKnight showed that they are critical for intracellular transport and organization. #Lasker2025
#structuralbiology #phaseseparation
@mpi-nat.bsky.social
#LaskerAward winners Dirk Görlich & Steven McKnight showed that they are critical for intracellular transport and organization. #Lasker2025
#structuralbiology #phaseseparation
@mpi-nat.bsky.social
We are very happy and proud to celebrate our freshly minted Dr. Xiaotian Liu! 🎉🥂🥳
Many thanks 🙏 to the jury members Ali Hamiche, Lionel Pintard @ccdlab.bsky.social and Charlène Boumendil @charleneboumendil.bsky.social, who also gave a wonderful seminar at the @igbmc.bsky.social
Many thanks 🙏 to the jury members Ali Hamiche, Lionel Pintard @ccdlab.bsky.social and Charlène Boumendil @charleneboumendil.bsky.social, who also gave a wonderful seminar at the @igbmc.bsky.social
September 10, 2025 at 7:04 PM
We are very happy and proud to celebrate our freshly minted Dr. Xiaotian Liu! 🎉🥂🥳
Many thanks 🙏 to the jury members Ali Hamiche, Lionel Pintard @ccdlab.bsky.social and Charlène Boumendil @charleneboumendil.bsky.social, who also gave a wonderful seminar at the @igbmc.bsky.social
Many thanks 🙏 to the jury members Ali Hamiche, Lionel Pintard @ccdlab.bsky.social and Charlène Boumendil @charleneboumendil.bsky.social, who also gave a wonderful seminar at the @igbmc.bsky.social
Reposted by Izabela Sumara
Call for papers: Cell Biology of the Nucleus
We invite you to submit your latest research to our special issue: Cell Biology of the Nucleus, guest edited by @abbybuch.bsky.social alongside JCS Editor Megan King @luskinglab.bsky.social.
Deadline: 3 November
journals.biologists.com/jcs/pages/nu...
We invite you to submit your latest research to our special issue: Cell Biology of the Nucleus, guest edited by @abbybuch.bsky.social alongside JCS Editor Megan King @luskinglab.bsky.social.
Deadline: 3 November
journals.biologists.com/jcs/pages/nu...
August 28, 2025 at 1:56 PM
Call for papers: Cell Biology of the Nucleus
We invite you to submit your latest research to our special issue: Cell Biology of the Nucleus, guest edited by @abbybuch.bsky.social alongside JCS Editor Megan King @luskinglab.bsky.social.
Deadline: 3 November
journals.biologists.com/jcs/pages/nu...
We invite you to submit your latest research to our special issue: Cell Biology of the Nucleus, guest edited by @abbybuch.bsky.social alongside JCS Editor Megan King @luskinglab.bsky.social.
Deadline: 3 November
journals.biologists.com/jcs/pages/nu...
Reposted by Izabela Sumara
postdoc opening in vienna: study lipid droplets (LDs) with integrative structural biology, uncover how LD proteins shuttle between cytosol & nucleus to regulate lipid metabolism, organelle architecture and immune response. #VIP3 #lipidtime #cryoEM #coffee training.vbc.ac.at/post-docs/vi...
VIP³ Post Doc Program (2025 - 2030)
VIP3 is a postdoctoral fellowship program at the Vienna BioCenter offering three – year fellowships that are open to candidates with backgrounds in life sciences, chemistry, physics, medicine, enginee...
training.vbc.ac.at
June 24, 2025 at 9:03 PM
postdoc opening in vienna: study lipid droplets (LDs) with integrative structural biology, uncover how LD proteins shuttle between cytosol & nucleus to regulate lipid metabolism, organelle architecture and immune response. #VIP3 #lipidtime #cryoEM #coffee training.vbc.ac.at/post-docs/vi...
Reposted by Izabela Sumara
New study showing the development of pan-Expansion Microscopy by Morgan et al. @luskinglab.bsky.social to reveal the molecular composition and structural plasticity of individual nuclear pore complexes including LINC complex-dependent dilation. rupress.org/jcb/article/...
June 12, 2025 at 4:20 PM
New study showing the development of pan-Expansion Microscopy by Morgan et al. @luskinglab.bsky.social to reveal the molecular composition and structural plasticity of individual nuclear pore complexes including LINC complex-dependent dilation. rupress.org/jcb/article/...
Reposted by Izabela Sumara
Important changes on @erc.europa.eu grants‼️Grant structure & most importantly eligibility timeframes (10 years for starting, 15 years for consolidator post PhD-but you can have them only once) changes: erc.europa.eu/news-events/...
Changes to the 2026 and 2027 Work Programmes
With the launch of the competitions for grants under ERC Work Programme 2026 in July of this year, several changes to the submission of applications and the evaluation of proposals will apply. The mai...
erc.europa.eu
June 2, 2025 at 2:18 PM
Important changes on @erc.europa.eu grants‼️Grant structure & most importantly eligibility timeframes (10 years for starting, 15 years for consolidator post PhD-but you can have them only once) changes: erc.europa.eu/news-events/...