Clausen Lab
@clausenlab.bsky.social
Molecular machines, Proteostasis, Ubiquitin Signaling, Cell Autonomous Defense, Protein Disorders and Team Nematode
@IMP Vienna
www.imp.ac.at/groups/tim-clausen/
@IMP Vienna
www.imp.ac.at/groups/tim-clausen/
Reposted by Clausen Lab
1/ 🧵 Two classic mitochondrial pathways the TCA cycle and OXPHOS are taught as linked but distinct pathways. I’m happy to share our new work out in @cp-cell.bsky.social showing that in Acanthamoeba they're physically linked—with a TCA enzyme incorporated in ATP synthase. www.cell.com/cell/fulltex...
Acanthamoeba ATP synthase structure reveals the TCA cycle is tethered to OXPHOS
Acanthamoeba castellanii, a pathogenic amoeba, belongs to an evolutionary branch distinctly
removed from humans and fungi. Cryo-EM of the organism’s ATP synthase enzyme using
raw mitochondrial lysates...
www.cell.com
October 2, 2026 at 2:09 PM
1/ 🧵 Two classic mitochondrial pathways the TCA cycle and OXPHOS are taught as linked but distinct pathways. I’m happy to share our new work out in @cp-cell.bsky.social showing that in Acanthamoeba they're physically linked—with a TCA enzyme incorporated in ATP synthase. www.cell.com/cell/fulltex...
Reposted by Clausen Lab
Those who had a careful look at the methods section of our work on the #cryoEM structure of the CDK11-cyclin L-SAP30BP complex will have noticed that we added a short peptide to our sample before freezing. If you wonder why...
Have a look at our latest results on #CDK regulation, just posted as a pre-print! This study was spearheaded by PhD student Amy McGeoch. Amy has determined the #cryoEM structure of the CDK11-cyclin L-SAP30B complex, an important regulator of #spliceosome activation.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
October 1, 2026 at 11:57 AM
Those who had a careful look at the methods section of our work on the #cryoEM structure of the CDK11-cyclin L-SAP30BP complex will have noticed that we added a short peptide to our sample before freezing. If you wonder why...
Reposted by Clausen Lab
Exciting news for the Perutz: @mschuhmacher.bsky.social will join the institute as a new group leader in 2027! 🎉 Currently leading an independent group at EPFL Lausanne, Milena brings an innovative chemical biology approach to lipid research ➡️ tinyurl.com/4x9xm24m
September 30, 2026 at 8:50 PM
Exciting news for the Perutz: @mschuhmacher.bsky.social will join the institute as a new group leader in 2027! 🎉 Currently leading an independent group at EPFL Lausanne, Milena brings an innovative chemical biology approach to lipid research ➡️ tinyurl.com/4x9xm24m
Reposted by Clausen Lab
I'll save you the click-through:
A lab at University of Copenhagen had been feeding draft manuscripts & data into "Claude Science" & then Anthropic announces a discovery that this lab made a year ago but hasn't published yet.
It's plausible that Claude found the same signatures independently...
A lab at University of Copenhagen had been feeding draft manuscripts & data into "Claude Science" & then Anthropic announces a discovery that this lab made a year ago but hasn't published yet.
It's plausible that Claude found the same signatures independently...
Four days ago, a scientist was surprised by the news that Anthropic discovered new virus genes for making DNA. He says he’s been studying them for years—and feeding his data to Anthropic’s AI as part of his own research. Coincidence? Here’s my story. nyti.ms/3VSWayc
Did Anthropic’s A.I. Really Make a Scientific Discovery on Its Own? (Gift Article)
An expert at the University of Copenhagen said his team had been sharing its research with the company’s A.I. model, Claude, and that its new finding matched their work.
nyti.ms
September 27, 2026 at 10:25 PM
I'll save you the click-through:
A lab at University of Copenhagen had been feeding draft manuscripts & data into "Claude Science" & then Anthropic announces a discovery that this lab made a year ago but hasn't published yet.
It's plausible that Claude found the same signatures independently...
A lab at University of Copenhagen had been feeding draft manuscripts & data into "Claude Science" & then Anthropic announces a discovery that this lab made a year ago but hasn't published yet.
It's plausible that Claude found the same signatures independently...
Reposted by Clausen Lab
Wow. Amazing, prescient vision of the future of academia by @giorgio.gilest.ro You don’t need to agree, but read and consider.
Academia has seen inflation in the past 30 years but it is now entering Republic of Weimar territory, with value of knowledge moving from "paper to land".
In all this, Open hardware is an act of armed resistance to Technofeudalism.
giorgio.gilest.ro/the-weimar-o...
In all this, Open hardware is an act of armed resistance to Technofeudalism.
giorgio.gilest.ro/the-weimar-o...
The Weimar of knowledge – la bottega
giorgio.gilest.ro
September 20, 2026 at 8:33 PM
Wow. Amazing, prescient vision of the future of academia by @giorgio.gilest.ro You don’t need to agree, but read and consider.
Reposted by Clausen Lab
🎉Preprint out! In our new manuscript, we reveal that, much like us, wake up (proliferation) and sleeping (quiescence) patterns of adult neural stem cells are controlled by the circadian clock machinery. www.biorxiv.org/content/10.6...
PER2- and state-dependent transcriptional programs gate neural stem cell proliferation with niche-specific circadian autonomy
Adult neural stem cells (NSCs) in the mouse brain are predominantly quiescent, with activation tightly regulated to balance neurogenesis and stem cell maintenance. Circadian clocks temporally organize...
www.biorxiv.org
September 17, 2026 at 10:33 PM
🎉Preprint out! In our new manuscript, we reveal that, much like us, wake up (proliferation) and sleeping (quiescence) patterns of adult neural stem cells are controlled by the circadian clock machinery. www.biorxiv.org/content/10.6...
Reposted by Clausen Lab
Stunning cryo-ET analysis from the Harrison Lab capturing every stage of how non-membrane viruses infect animal cells
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
September 10, 2026 at 6:55 PM
Stunning cryo-ET analysis from the Harrison Lab capturing every stage of how non-membrane viruses infect animal cells
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Clausen Lab
Time to share some exciting news! 🎉
I am very happy to announce that my project UbiAge has been awarded an ERC Starting Grant. I am incredibly grateful to everyone who has supported me throughout this journey: my mentors, colleagues, friends, and, most importantly, my family.
I am very happy to announce that my project UbiAge has been awarded an ERC Starting Grant. I am incredibly grateful to everyone who has supported me throughout this journey: my mentors, colleagues, friends, and, most importantly, my family.
September 3, 2026 at 10:15 AM
Time to share some exciting news! 🎉
I am very happy to announce that my project UbiAge has been awarded an ERC Starting Grant. I am incredibly grateful to everyone who has supported me throughout this journey: my mentors, colleagues, friends, and, most importantly, my family.
I am very happy to announce that my project UbiAge has been awarded an ERC Starting Grant. I am incredibly grateful to everyone who has supported me throughout this journey: my mentors, colleagues, friends, and, most importantly, my family.
Reposted by Clausen Lab
1/5 How much phosphorylation can a single kinase deposit? In our new study with @typaslab.bsky.social out in @nature.com, phage T7's kinase (T7K) modifies almost all the E. coli proteome + more densely than all ~500 kinases do our own proteomes 🤯 www.nature.com/articles/s41...
Pervasive phosphorylation by phage T7 kinase disarms bacterial defences - Nature
The T7 bacteriophage deactivates bacterial defence systems through T7K phosphorylation of nearly all host and phage proteins during infection.
www.nature.com
August 20, 2026 at 5:15 AM
1/5 How much phosphorylation can a single kinase deposit? In our new study with @typaslab.bsky.social out in @nature.com, phage T7's kinase (T7K) modifies almost all the E. coli proteome + more densely than all ~500 kinases do our own proteomes 🤯 www.nature.com/articles/s41...
Reposted by Clausen Lab
A stress response can be a great starting point for discovering new biology!
By following genes regulated during the chloroplast unfolded protein response, we’re discovering novel factors involved in chloroplast homeostasis.
Here’s the first one we characterized: www.pnas.org/doi/10.1073/...
By following genes regulated during the chloroplast unfolded protein response, we’re discovering novel factors involved in chloroplast homeostasis.
Here’s the first one we characterized: www.pnas.org/doi/10.1073/...
VIA1 is a conserved regulator of thylakoid membrane integrity that acts through VIPP1 | PNAS
Thylakoid membranes are indispensable for oxygenic photosynthesis, yet the mechanisms
that protect these membranes from photooxidative damage remai...
www.pnas.org
August 19, 2026 at 3:16 AM
A stress response can be a great starting point for discovering new biology!
By following genes regulated during the chloroplast unfolded protein response, we’re discovering novel factors involved in chloroplast homeostasis.
Here’s the first one we characterized: www.pnas.org/doi/10.1073/...
By following genes regulated during the chloroplast unfolded protein response, we’re discovering novel factors involved in chloroplast homeostasis.
Here’s the first one we characterized: www.pnas.org/doi/10.1073/...
Reposted by Clausen Lab
Huge effort from the Lab into the mechanics of the mysterious #ubiquitin like protein FAT10 – taking structural snapshots of FAT10 activation by UBA6 and transfer onto UBE2Z plus really interesting insights into InsP6 regulating FAT10 conjugation pathways: www.nature.com/articles/s41...
Structural determinants for FAT10 activation and transfer from UBA6 to E2 enzymes - Nature Communications
Cryo-EM captures FAT10 activation and transfer from UBA6 to E2 UBE2Z, revealing FAT10 monopolises UBA6. Efficient transfer requires E2 engagement of both FAT10 UBL domains, particularly UBL2, and co-o...
www.nature.com
August 14, 2026 at 12:59 PM
Huge effort from the Lab into the mechanics of the mysterious #ubiquitin like protein FAT10 – taking structural snapshots of FAT10 activation by UBA6 and transfer onto UBE2Z plus really interesting insights into InsP6 regulating FAT10 conjugation pathways: www.nature.com/articles/s41...
Reposted by Clausen Lab
What’s the function of embryonic ‘cytoplasmic lattices’? Using cryo-ET, @kashishsingh.bsky.social @carter-lab.bsky.social and coworkers reveal them as megadalton-size hubs of ubiquitination proteins/ubiquitin transfer
link.springer.com/article/10.1...
link.springer.com/article/10.1...
In-situ cryo-ET of mouse embryos reveals cytoplasmic lattices contain ubiquitin-charged E2-E3 ligase assemblies - The EMBO Journal
Cytoplasmic lattices (CPLs) are filamentous assemblies essential for mammalian embryonic development. They are known to regulate organelle organization, spindle assembly, and protein homeostasis, but ...
link.springer.com
August 11, 2026 at 1:49 PM
What’s the function of embryonic ‘cytoplasmic lattices’? Using cryo-ET, @kashishsingh.bsky.social @carter-lab.bsky.social and coworkers reveal them as megadalton-size hubs of ubiquitination proteins/ubiquitin transfer
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Virome-wide ubiquitin ligase discovery reveals diverse mechanisms of immune evasion | 🤩
July 12, 2026 at 6:54 PM
Virome-wide ubiquitin ligase discovery reveals diverse mechanisms of immune evasion | 🤩
Reposted by Clausen Lab
Reposted by Clausen Lab
Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells.
June 30, 2026 at 5:41 PM
Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells.
Reposted by Clausen Lab
I wanted to like QED's new 1% preprint ranking. I really did. But the more I looked at the data, the more uncomfortable it made me. Here is my full peer review.
open.substack.com/pub/blekhman...
open.substack.com/pub/blekhman...
My Peer Review of The 1%
I wanted to like QED's new 1% ranking. I don't.
open.substack.com
June 27, 2026 at 3:37 PM
I wanted to like QED's new 1% preprint ranking. I really did. But the more I looked at the data, the more uncomfortable it made me. Here is my full peer review.
open.substack.com/pub/blekhman...
open.substack.com/pub/blekhman...
Reposted by Clausen Lab
For the first time, we can see individual mRNAs in 3D inside cells at nm precision. Their shapes vary by gene and subcellular location. Congrats @fbzt.bsky.social & team @impvienna.bsky.social Top 1% @qedscience.bsky.social Edited by @lifescienceeditors.bsky.social www.biorxiv.org/content/10.6...
Super-resolved imaging of mRNA ultrastructure in cells
Messenger RNA (mRNA) is a central polymer of gene expression, whose ultrastructure and defining regulatory rules remain unclear. To visualize the ultrastructure of mRNA, we here develop Combi-PAINT, a...
www.biorxiv.org
June 24, 2026 at 10:44 PM
For the first time, we can see individual mRNAs in 3D inside cells at nm precision. Their shapes vary by gene and subcellular location. Congrats @fbzt.bsky.social & team @impvienna.bsky.social Top 1% @qedscience.bsky.social Edited by @lifescienceeditors.bsky.social www.biorxiv.org/content/10.6...
Reposted by Clausen Lab
Congratulations to Gautam Dey (EMBL) and Omaya Dudin (University of Geneva) for being awarded the EMBO Gold Medal 2026 in recognition of their outstanding contributions to the #LifeSciences in Europe! 🧪 https://www.embo.org/press-releases/embo-gold-medal-2026-awarded-to-gautam-dey-and-omaya-dudin/
June 9, 2026 at 12:05 PM
Congratulations to Gautam Dey (EMBL) and Omaya Dudin (University of Geneva) for being awarded the EMBO Gold Medal 2026 in recognition of their outstanding contributions to the #LifeSciences in Europe! 🧪 https://www.embo.org/press-releases/embo-gold-medal-2026-awarded-to-gautam-dey-and-omaya-dudin/
Reposted by Clausen Lab
New study published in Science! Led by @thevirusmc.bsky.social and @plantophagy.bsky.social, former group leader at the GMI of the @oeaw.bsky.social, the researchers set out to understand how autophagy – the cell’s clean-up and recycling system – mediates plant immune response to viral infection.
May 28, 2026 at 6:22 PM
New study published in Science! Led by @thevirusmc.bsky.social and @plantophagy.bsky.social, former group leader at the GMI of the @oeaw.bsky.social, the researchers set out to understand how autophagy – the cell’s clean-up and recycling system – mediates plant immune response to viral infection.
Reposted by Clausen Lab
"I would like to emphasize the importance of question-driven science...young scientists might enjoy science more if they are thinking about questions rather than just collecting data" journals.biologists.com/jcs/article/...
Interview with Noboru Mizushima – President of the Japan Society for Cell Biology
Noboru Mizushima is Professor of Biochemistry and Molecular Biology at the University of Tokyo, Japan, where he runs a laboratory studying the mechanisms and physiological functions of autophagy and o...
journals.biologists.com
May 24, 2026 at 2:44 PM
"I would like to emphasize the importance of question-driven science...young scientists might enjoy science more if they are thinking about questions rather than just collecting data" journals.biologists.com/jcs/article/...
Open Postdoc Position - Giant E3 ligases: mysterious mechanisms & non‑protein substrates. Interested? Join us to uncover how these molecular giants tag lipids, RNAs, sugars beyond proteins, on organelles and pathogens, to defend the cell. Details & Application here www.imp.ac.at/career/open-...
May 21, 2026 at 8:19 AM
Open Postdoc Position - Giant E3 ligases: mysterious mechanisms & non‑protein substrates. Interested? Join us to uncover how these molecular giants tag lipids, RNAs, sugars beyond proteins, on organelles and pathogens, to defend the cell. Details & Application here www.imp.ac.at/career/open-...
Reposted by Clausen Lab
May 12, 2026 at 7:04 AM
Reposted by Clausen Lab
Our paper is finally out! 🥳 If you want to know how a single Salmonella effector rewires the whole macrophage transcriptional landscape by hijacking one host transcription factor, check our latest research!
Thanks to the @thurstonlab.bsky.social and @peterwshill.bsky.social labs for an amazing work!
Thanks to the @thurstonlab.bsky.social and @peterwshill.bsky.social labs for an amazing work!
Salmonella effector SteE reprograms the macrophage regulatory network to drive specific hyperactivation of STAT3 target genes
The ability of Salmonella Typhimurium to exploit macrophages as a niche for survival, replication, and dissemination is central to its pathogenesis. T…
www.sciencedirect.com
May 11, 2026 at 7:49 AM
Our paper is finally out! 🥳 If you want to know how a single Salmonella effector rewires the whole macrophage transcriptional landscape by hijacking one host transcription factor, check our latest research!
Thanks to the @thurstonlab.bsky.social and @peterwshill.bsky.social labs for an amazing work!
Thanks to the @thurstonlab.bsky.social and @peterwshill.bsky.social labs for an amazing work!
Reposted by Clausen Lab
We offer a PostDoc position for a fully funded project on lipid-encoded #lipidtime protein quality-control checkpoints at the Golgi: great collaborators, excellent working & living conditions & benchspace with a view ;) Please share and repost!
April 7, 2026 at 11:05 AM
We offer a PostDoc position for a fully funded project on lipid-encoded #lipidtime protein quality-control checkpoints at the Golgi: great collaborators, excellent working & living conditions & benchspace with a view ;) Please share and repost!
Reposted by Clausen Lab
Structure-function analysis of the bacterial ClpE/ClpP AAA+ protease - Journal of Biological Chemistry www.jbc.org/article/S002...
Structure-function analysis of the bacterial ClpE/ClpP AAA+ protease
General and regulatory proteolysis in bacteria is executed by a set of ATP-dependent
proteases composed of hexameric ring-forming AAA+ proteins and associated peptidase
barrels (e.g. ClpP). These AAA+...
www.jbc.org
March 28, 2026 at 9:50 PM
Structure-function analysis of the bacterial ClpE/ClpP AAA+ protease - Journal of Biological Chemistry www.jbc.org/article/S002...