❕Join us at CNIO from June 8 to 10, 2027, for an intensive training week on mTOR signaling, disease mechanisms and preclinical models.
We are pleased to announce our upcoming Summer School, taking place in Madrid from June 8 to 10, 2027.
🌐More info :
mentor-program.eu/save-the-dat...
We are pleased to announce our upcoming Summer School, taking place in Madrid from June 8 to 10, 2027.
🌐More info :
mentor-program.eu/save-the-dat...
Save the date: menTOR Summer School 2027 in Madrid! - MENTOR - Metabolic control of cell growth by mTOR in health and disease: a multi-disciplinary training
Join us at CNIO from June 8 to 10, 2027, for an intensive training week on mTOR […]
mentor-program.eu
November 3, 2026 at 5:10 PM
❕Join us at CNIO from June 8 to 10, 2027, for an intensive training week on mTOR signaling, disease mechanisms and preclinical models.
We are pleased to announce our upcoming Summer School, taking place in Madrid from June 8 to 10, 2027.
🌐More info :
mentor-program.eu/save-the-dat...
We are pleased to announce our upcoming Summer School, taking place in Madrid from June 8 to 10, 2027.
🌐More info :
mentor-program.eu/save-the-dat...
Can excess salt worsen #AtopicDermatitis?
#HighSalt activates SGK-1–mTOR signaling, weakening the #SkinBarrier and promoting inflammation; combined SGK-1 and JAK inhibition eased symptoms in preclinical models.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
#HighSalt activates SGK-1–mTOR signaling, weakening the #SkinBarrier and promoting inflammation; combined SGK-1 and JAK inhibition eased symptoms in preclinical models.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
November 3, 2026 at 10:30 PM
Can excess salt worsen #AtopicDermatitis?
#HighSalt activates SGK-1–mTOR signaling, weakening the #SkinBarrier and promoting inflammation; combined SGK-1 and JAK inhibition eased symptoms in preclinical models.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
#HighSalt activates SGK-1–mTOR signaling, weakening the #SkinBarrier and promoting inflammation; combined SGK-1 and JAK inhibition eased symptoms in preclinical models.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
Fatty acid synthase coordinates mTOR signaling and histone crotonylation during cardiomyocyte hypertrophy https://www.biorxiv.org/content/10.64898/2026.10.26.762072v1
October 30, 2026 at 10:30 PM
Fatty acid synthase coordinates mTOR signaling and histone crotonylation during cardiomyocyte hypertrophy https://www.biorxiv.org/content/10.64898/2026.10.26.762072v1
Finally, he found a clue: mTOR was overactive in his blood.
mTOR is a protein that helps control cell growth, including immune cell activation.
With his doctors, he started taking sirolimus, a drug already approved to prevent kidney transplant rejection.
mTOR is a protein that helps control cell growth, including immune cell activation.
With his doctors, he started taking sirolimus, a drug already approved to prevent kidney transplant rejection.
November 2, 2026 at 1:03 PM
Finally, he found a clue: mTOR was overactive in his blood.
mTOR is a protein that helps control cell growth, including immune cell activation.
With his doctors, he started taking sirolimus, a drug already approved to prevent kidney transplant rejection.
mTOR is a protein that helps control cell growth, including immune cell activation.
With his doctors, he started taking sirolimus, a drug already approved to prevent kidney transplant rejection.
"When adult mice inhaled air containing 10 per cent CO2, mTOR activity restarted across a range of tissues including brain, heart and muscle, and their neurons’ ability to regenerate after injury was restored."
Inhaling CO2 may rescue nerves’ ability to regrow | New Scientist
Breathing out after birth switches off the ability of tissues to regenerate, a study in mice suggests. But the pathway seems to be reversible
www.newscientist.com
October 31, 2026 at 9:07 AM
"When adult mice inhaled air containing 10 per cent CO2, mTOR activity restarted across a range of tissues including brain, heart and muscle, and their neurons’ ability to regenerate after injury was restored."
Fatty acid synthase coordinates mTOR signaling and histone crotonylation during cardiomyocyte hypertrophy
https://www.biorxiv.org/content/10.64898/2026.10.26.762072v1
November 2, 2026 at 9:38 AM
Fatty acid synthase coordinates mTOR signaling and histone crotonylation during cardiomyocyte hypertrophy
https://www.biorxiv.org/content/10.64898/2026.10.26.762072v1
Cardio Before or After Weights: 20-Minute Cutoff to Limit AMPK-mTOR Clash — https://healtho.io/blog/cardio-before-or-after-weights-20-minute-cutoff-to-limit-ampk-mtor-clash.php
October 31, 2026 at 1:45 AM
Cardio Before or After Weights: 20-Minute Cutoff to Limit AMPK-mTOR Clash — https://healtho.io/blog/cardio-before-or-after-weights-20-minute-cutoff-to-limit-ampk-mtor-clash.php
Cardio Before or After Weights: 20-Minute Cutoff to Limit AMPK-mTOR Clash — https://healtho.io/blog/cardio-before-or-after-weights-20-minute-cutoff-to-limit-ampk-mtor-clash.php
October 31, 2026 at 1:45 AM
Cardio Before or After Weights: 20-Minute Cutoff to Limit AMPK-mTOR Clash — https://healtho.io/blog/cardio-before-or-after-weights-20-minute-cutoff-to-limit-ampk-mtor-clash.php
Single-cell discovery of mTOR-associated microglial clusters in human mTORopathies #NeuroDegeneration 🧪🧠
https://link.springer.com/10.1186/s40478-026-02467-9
https://link.springer.com/10.1186/s40478-026-02467-9
November 2, 2026 at 8:03 AM
Single-cell discovery of mTOR-associated microglial clusters in human mTORopathies #NeuroDegeneration 🧪🧠
https://link.springer.com/10.1186/s40478-026-02467-9
https://link.springer.com/10.1186/s40478-026-02467-9
A fascinating pre-print, with some muscle data, on CO2 activating mTORC1 signaling:
The Onset of Breathing at Birth Switches Off Regenerative Capacity
www.biorxiv.org/content/10.6...
The Onset of Breathing at Birth Switches Off Regenerative Capacity
www.biorxiv.org/content/10.6...
The Onset of Breathing at Birth Switches Off Regenerative Capacity
Many mammalian tissues, including the central nervous system (CNS), lose regenerative capacity in adulthood1-3, but when and how this transition is initiated remains unclear. By monitoring mTOR activi...
www.biorxiv.org
November 3, 2026 at 11:33 PM
A fascinating pre-print, with some muscle data, on CO2 activating mTORC1 signaling:
The Onset of Breathing at Birth Switches Off Regenerative Capacity
www.biorxiv.org/content/10.6...
The Onset of Breathing at Birth Switches Off Regenerative Capacity
www.biorxiv.org/content/10.6...
Fatty acid synthase coordinates mTOR signaling and histone crotonylation during cardiomyocyte hypertrophy https://www.biorxiv.org/content/10.64898/2026.10.26.762072v1
October 30, 2026 at 10:30 PM
Fatty acid synthase coordinates mTOR signaling and histone crotonylation during cardiomyocyte hypertrophy https://www.biorxiv.org/content/10.64898/2026.10.26.762072v1
🟢 #$FTH — Regulatory Designation
Fast Track Designation - PIKTOR plus paclitaxel
FDA granted Fast Track designation to PIKTOR in combination with paclitaxel for advanced or recurrent endometrial cancer with a PI3K/AKT/mTOR pathway alteration after platinum chemo…
https://biostock.app/symbols/FTH
Fast Track Designation - PIKTOR plus paclitaxel
FDA granted Fast Track designation to PIKTOR in combination with paclitaxel for advanced or recurrent endometrial cancer with a PI3K/AKT/mTOR pathway alteration after platinum chemo…
https://biostock.app/symbols/FTH
November 3, 2026 at 2:58 PM
🟢 #$FTH — Regulatory Designation
Fast Track Designation - PIKTOR plus paclitaxel
FDA granted Fast Track designation to PIKTOR in combination with paclitaxel for advanced or recurrent endometrial cancer with a PI3K/AKT/mTOR pathway alteration after platinum chemo…
https://biostock.app/symbols/FTH
Fast Track Designation - PIKTOR plus paclitaxel
FDA granted Fast Track designation to PIKTOR in combination with paclitaxel for advanced or recurrent endometrial cancer with a PI3K/AKT/mTOR pathway alteration after platinum chemo…
https://biostock.app/symbols/FTH
Uterine aging can impair fertility by disrupting endometrial function.
#Ginsenoside Rb1 activates #AMPK to suppress #mTOR–NF-κB signaling, alleviating senescence, #Inflammation and #Apoptosis in endometrial stromal cells. @pku1898.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
#Ginsenoside Rb1 activates #AMPK to suppress #mTOR–NF-κB signaling, alleviating senescence, #Inflammation and #Apoptosis in endometrial stromal cells. @pku1898.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
October 30, 2026 at 10:00 AM
Uterine aging can impair fertility by disrupting endometrial function.
#Ginsenoside Rb1 activates #AMPK to suppress #mTOR–NF-κB signaling, alleviating senescence, #Inflammation and #Apoptosis in endometrial stromal cells. @pku1898.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
#Ginsenoside Rb1 activates #AMPK to suppress #mTOR–NF-κB signaling, alleviating senescence, #Inflammation and #Apoptosis in endometrial stromal cells. @pku1898.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
Protein activates mTOR, one of the body's main growth switches. You need it to build and maintain muscle, but chronic overstimulation is linked to faster ageing.
That's why grazing on high-protein meals and snacks from morning to night may not be the best strategy for longevity.
That's why grazing on high-protein meals and snacks from morning to night may not be the best strategy for longevity.
October 29, 2026 at 5:27 PM
Protein activates mTOR, one of the body's main growth switches. You need it to build and maintain muscle, but chronic overstimulation is linked to faster ageing.
That's why grazing on high-protein meals and snacks from morning to night may not be the best strategy for longevity.
That's why grazing on high-protein meals and snacks from morning to night may not be the best strategy for longevity.
@solveme.bsky.social Research Funding: helped Simmaron get multi-year $780,000 NIH R01 grant to investigate ME/CFS mTOR dysfunction, building on earlier autophagy & rapamycin work reporter.nih.gov/search/lE5UW...
RePORT ⟩ RePORTER
reporter.nih.gov
October 30, 2026 at 4:40 AM
@solveme.bsky.social Research Funding: helped Simmaron get multi-year $780,000 NIH R01 grant to investigate ME/CFS mTOR dysfunction, building on earlier autophagy & rapamycin work reporter.nih.gov/search/lE5UW...
The authors included RRIDs in their in Nature Communications paper! Thanks for making your methods matter! #OpenResearch #BetterScience #OpenScience
In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapy - Nature Communications
Triple negative breast cancer (TNBC) lack effective therapies. Here, through an in vivo genome-wide CRISPR screen in TNBCs, the authors identify tumorigenic functions for components of the mTORC1/2 complex and of the YAP/Hippo pathway, and demonstrate that pharmacological inhibition of mTOR and YAP reduces tumour growth in vivo.
doi.org
October 30, 2026 at 7:00 AM
The authors included RRIDs in their in Nature Communications paper! Thanks for making your methods matter! #OpenResearch #BetterScience #OpenScience
✅ What if #Aging isn't simply the result of accumulating molecular damage, but also reflects developmental programs that continue later in life?
A new #Research perspective explores the hyperfunction theory, #Rapamycin & #Longevity.
🔗 https://bit.ly/4h4AW8J
#Aging #mTOR
A new #Research perspective explores the hyperfunction theory, #Rapamycin & #Longevity.
🔗 https://bit.ly/4h4AW8J
#Aging #mTOR
Developmental Programs Could Help Drive the Aging Process - Aging Research
Why do we age? For decades, one of the dominant explanations has been that cells and tissues gradually accumulate molecular damage until they can no longer function normally.
aging-us.org
November 2, 2026 at 11:00 PM
✅ What if #Aging isn't simply the result of accumulating molecular damage, but also reflects developmental programs that continue later in life?
A new #Research perspective explores the hyperfunction theory, #Rapamycin & #Longevity.
🔗 https://bit.ly/4h4AW8J
#Aging #mTOR
A new #Research perspective explores the hyperfunction theory, #Rapamycin & #Longevity.
🔗 https://bit.ly/4h4AW8J
#Aging #mTOR
"When adult mice inhaled air containing 10 per cent CO2, mTOR activity restarted across a range of tissues including brain, heart and muscle, and their neurons’ ability to regenerate after injury was restored."
Inhaling CO2 may rescue nerves’ ability to regrow | New Scientist
Breathing out after birth switches off the ability of tissues to regenerate, a study in mice suggests. But the pathway seems to be reversible
www.newscientist.com
October 31, 2026 at 9:07 AM
"When adult mice inhaled air containing 10 per cent CO2, mTOR activity restarted across a range of tissues including brain, heart and muscle, and their neurons’ ability to regenerate after injury was restored."
Auf jeden Fall. Dazu gibt es sogar schon eine Pilotstudie für MECFS
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Low-dose rapamycin alleviates clinical symptoms of fatigue and PEM in ME/CFS patients via improvement of autophagy: a pilot study - Journal of Translational Medicine
Background mTOR activation is associated with chronic inflammation in ME/CFS. Previous studies have shown that sustained mTOR activation may cause chronic muscle fatigue by inhibiting ATG13-mediated a...
link.springer.com
October 25, 2026 at 5:10 PM
Auf jeden Fall. Dazu gibt es sogar schon eine Pilotstudie für MECFS
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Online now: Engineered receptor-biased IL-2–drug immunoconjugates selectively expand Tregs and suppress effector cells for autoimmune therapy
Engineered receptor-biased IL-2–drug immunoconjugates selectively expand Tregs and suppress effector cells for autoimmune therapy
Li et al. identify Y31-20K-KU, a receptor-biased, site-specifically PEGylated IL-2-mTOR inhibitor immunoconjugate that selectively expands Treg cells, suppresses effector T cell activation, and ameliorates autoimmune inflammation in preclinical models.
dlvr.it
October 30, 2026 at 7:19 PM
Online now: Engineered receptor-biased IL-2–drug immunoconjugates selectively expand Tregs and suppress effector cells for autoimmune therapy