#BaseEditing
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wimi-bio-tech.bsky.social
CAU researchers launched WheatTarget, a subgenome-specific webserver unifying CRISPR knockout, base editing, prime editing, large-fragment engineering, and multiplex design for hexaploid wheat. 🌾🤖 #WheatGenomics #CRISPR #WheatTarget #BaseEditing #PrimeEditing #PlantCommunications2026
October 20, 2026 at 3:44 AM
wimi-bio-tech.bsky.social
Henan University researchers engineered 5'UTR uORFs in hexaploid wheat via CRISPR and ABE, achieving precise translational tuning to enhance salt, cold, and drought tolerance without yield penalties. 🌾🤖 #WheatGenomics #CRISPR #uORF #BaseEditing #NewPhytologist2026 #AgBiotech
October 20, 2026 at 3:41 AM
wimi-bio-tech.bsky.social
Hao et al. engineered #dCas12b sgRNA stem-loops with MS2/PP7 aptamers to create MSBE, enabling programmable shifting of cytidine #baseediting hotspots between PAM-proximal and PAM-distal sites in bacteria. 🧫🤖 #CRISPR #MicrobiologyResearch #MSBE #DirectedEvolution
October 16, 2026 at 7:47 AM
realfeedapp.com
Researchers developed the CONCORD platform combining conjugation and base editing to write data directly into living cells. The system successfully encoded 45,689 bits of information, including artifacts from NASA missions.

#SyntheticBiology #DNAEncoding #BaseEditing
CONCORD platform encodes 45 689 bits into DNA
Source: bioRxiv Synthetic Biology
realfeedapp.com
October 9, 2026 at 4:40 PM
wimi-bio-tech.bsky.social
Seung Hwan Lee’s team developed dBhCas12b-ABE, a Cas12b adenine base editor targeting T-rich PAMs that suppresses indels to 0–0.04% and offers tunable editing windows. 🧬🤖 #CRISPR #BaseEditing #Cas12b #MolecularTherapy #GeneEditing #ChungAngUniversity
October 9, 2026 at 10:06 AM
wimi-bio-tech.bsky.social
#UCBerkeley researchers developed PERCEPT, using self-immolative reduction-sensitive linkers to decorate #CRISPR #RNPs with PEG, escape peptides, and targeting ligands for targeted in vivo editing across brain, retina, muscle, and lung tissues. 🧠🤖 #GeneEditing #bioRxiv2026 #PERCEPT #BaseEditing
September 28, 2026 at 8:51 AM
oddlytruejp.bsky.social
🧬 One wrong letter in one gene. That's the whole disease.

HMSN-P, found in Okinawan families in 1983, comes down to a single DNA typo. A Japan-led team just corrected it in mice and patient cells — without cutting the DNA.

#BaseEditing #HMSNP #Okinawa #CiRA #GeneEditing
September 22, 2026 at 12:00 PM
horticulturer.bsky.social
Synergistic optimization nearly triples cytosine base-editing efficiency in potato and enables efficient dual editing of StALS1 and StALS2 #PotatoEditing #BaseEditing #PrecisionBreeding @academic.oup.com
Details: doi.org/10.1093/hr/u...
Boosting cytosine base editing in potato through synergistic optimization
Abstract. Base editing enables precise substitution of single nucleotides and is a promising technology for improvement of agronomic traits, including thos
doi.org
September 21, 2026 at 12:31 PM
wimi-bio-tech.bsky.social
Mohankumar et al. demonstrated that #truncatinggRNAs to 15–19 nt narrows the #baseediting window to suppress bystander mutations across ABE and CBE platforms, with 17 nt guides optimizing target precision during transient delivery in primary CD34+ HSPCs. 🩸🤖 #BystanderEditing #HSPCs #GeneTherapy
September 18, 2026 at 5:03 AM
wimi-bio-tech.bsky.social
The UK has approved its first precision-bred crop — a vitamin D–biofortified tomato from the #JohnInnesCentre delivering roughly the vitamin D of 2 eggs per fruit — while #WiMi supports #knockout, #baseediting, and #knock-in transformation across 30+ crop species and genetic backgrounds.
September 18, 2026 at 8:25 AM
wimi-bio-tech.bsky.social
IPK Gatersleben researchers established the first base editing platform in barley, targeting HvEIF4E to create novel BE alleles 7 & 8 that confer robust BaMMV resistance without sacrificing grain yield. 🌾🤖 #BarleyGenomics #BaseEditing #bioRxiv2026 #PlantBiotech #CropProtection #EIF4E
September 14, 2026 at 5:00 AM
wimi-bio-tech.bsky.social
UT Health San Antonio researchers engineered U-report, a CBE/AMBER biosensor that quantifies live-cell chromosomal UNG activity in real time, revealing that mitochondrial UNG1 actively participates in nuclear uracil repair. 🧬🤖 #DNArepair #Ureport #BaseEditing #GenomicStability #Epigenetics
September 1, 2026 at 7:43 AM
wimi-bio-tech.bsky.social
Researchers engineered A&GBE and the QBMM hypermutator (dTAGBE+AID) to achieve concurrent, balanced four-base (A, T, G, C) mutagenesis across a ~100 bp window in mammalian cells. 🧬🤖 #BaseEditing #NatComms2026 #GenomeEditing #DirectedEvolution #Hypermutator #MAP2K1
August 31, 2026 at 8:37 AM
wimi-bio-tech.bsky.social
Researchers engineered #Barley stripe mosaic virus (BSMV-BE) to deliver sgRNAs into stable CBE/ABE #wheat lines, achieving up to 87.7% somatic editing, 30.2% virus-free M1 heritable transmission, and nicosulfuron-resistant TaALS mutants without tissue culture. 🌾🤖 #BaseEditing #BSMV #CRISPR
August 28, 2026 at 7:05 AM
wimi-bio-tech.bsky.social
Krishanu Saha's team identified 6 cellular gatekeeper genes via genome-wide screening, showing that transient GJB2 knockdown boosts non-viral base editing 8-fold to 46.6% in LCA16 patient RPE microtissues. 👁️🤖 #CRISPR #BaseEditing #NatureComms2026 #GeneTherapy #NonViralDelivery #LCA16 #UWMadison
August 20, 2026 at 1:27 AM
mikrobenjaeger.bsky.social
I am very happy to share our latest manuscript in BMC Genome Biology 🥳: rdcu.be/d8weC We describe the engineering of the cytosine deaminase SsdA to build an efficient and small CRISPR/Cas9 base editor. #BaseEditing #Cas9 #CRISPR #GeneTherapy #GeneEditing Here is a short intro to a fun project 🧵🧪🧬
Engineering a bacterial toxin deaminase from the DYW-family into a novel cytosine base editor for plants and mammalian cells
rdcu.be
February 4, 2025 at 3:38 PM
kaiblau.bsky.social
CRISPR ist in der Klinik angekommen – aber nur ein Produkt ist bislang zugelassen.
Was steckt hinter der Technologie und wer treibt sie voran?

🧬 Überblick zu #Casgevy, Base & Prime Editing, Unternehmen & Trends:
👉 www.blaubiologie.de/crispr-im-kl...

#CRISPR #Biotech #GeneEditing #Cas9 #BaseEditing
CRISPR im klinischen Kontext: Wie CRISPR die Medizin verändert
Die Entdeckung und Weiterentwicklung der CRISPR-Technologie hat das Feld der Genomeditierung grundlegend verändert. Ursprünglich als adaptives Immunsystem von Bakterien identifiziert, wurde das CRISPR...
www.blaubiologie.de
March 24, 2025 at 11:13 AM
hemehub.bsky.social
🩸 Facts about Hemophilia B:

Next-Generation Pipelines & Clinical Trials

#Hematology #Hemophilia #HemophiliaB #GeneTherapy #BaseEditing #GenomeEditing #LipidNanoparticles #NonViralGeneTherapy #CRISPR #CellTherapy #AAV #BloodDisorders #HEMEHUB
July 26, 2026 at 12:01 AM
iobswiss.bsky.social
🌟New hope for vision restoration: Congratulations to Bence György on his 5-year @erc.europa.eu Consolidator Grant. His proposal was selected among 3121 applications from across Europe - a strong vote of confidence in our work at IOB!
#ERCCoG #BaseEditing #VisionResearch #Blindness #AcademicBlueSky
December 9, 2025 at 5:09 PM
iobswiss.bsky.social
🌟New hope for vision restoration: Warm congratulations to Bence György on his 5-year @erc.europa.eu Consolidator Grant to advance base editing for genetic macular degeneration and explore therapies for corneal blindness.
#ERCCoG #BaseEditing #VisionResearch #Blindness #AcademicBlueSky
December 9, 2025 at 11:18 AM
jipb.bsky.social
Zhou et al. report an adenine base-editing system developed to precisely modify the #sorghum SbALS #gene and generate transgene-free mutant #plants with #herbicide resistance and no significant tradeoffs in agronomic traits.
doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantSci #BaseEditing
Engineering herbicide‐resistant sorghum with CRISPR/Cas9‐mediated adenine base editing
An adenine base-editing system was established to precisely modify the sorghum SbALS gene, generating transgene-free mutant plants. These plants exhibit strong herbicide resistance, with no significa...
doi.org
May 28, 2026 at 12:27 PM
jipb.bsky.social
🌽#Biotech breakthrough!🧬
Robust #genetic mods without yield loss? Fu et al. show it's possible in new work that enhances #herbicide tolerance in #maize using cytosine and adenine #BaseEditing!

Read the entire article for #free right here!⬇️
doi.org/10.1111/jipb...
#PlantScience #OpenAccess
Diagram illustrating how precise editing of the ZmACC1/2 genes generated herbicide-tolerant maize germplasm, offering a solution for weed management in maize-soybean intercropping systems.
September 2, 2025 at 11:48 AM
jipb.bsky.social
This remarkable new RNA-based adenine and cytosine #BaseEditing system achieves targeted and efficient A-to-G and C-to-T conversions in lettuce, with potential applications in #crop breeding and #PlantBiotechnology.
doi.org/10.1111/jipb...
#PlantScience
Diagram illustrating the 4 stages in DNA-free base editing: (1) in vitro transcription, (2) protoplast transfection, (3) protoplast regeneration, and (4) base-edited plants.
December 31, 2024 at 2:28 PM
jipb.bsky.social
Our latest JIPB Brief Comms feature highlights work by Liu et al. who are developing guanine base editors for G-to-T editing in #rice.
doi.org/10.1111/jipb...
#PlantScience #BaseEditing #CRISPR
Schematic diagram of the working model of the derivative guanine base editors at various loci in the rice genome.
August 30, 2024 at 7:35 PM
thomthum.bsky.social
Proud of Kaisa Pakari @kpakari.bsky.social to receive the 2025 Schmeil young researcher award for her #PhD thesis. She established 🐟 models to address disorders of #glycosylation #CDG by advancing #baseediting range for precise genome editing @wittbrodtlab.bsky.social @cos.uni-heidelberg.de
July 3, 2025 at 4:04 PM