Researchers at the University of Illinois have found a potential method to treat Huntington’s disease in mice.
https://www.wcia.com/news/health-news/u-of-i-researchers-engineer-innovative-way-to-treat-huntingtons-disease/?utm_medium=social&utm_source=bluesky_
https://www.wcia.com/news/health-news/u-of-i-researchers-engineer-innovative-way-to-treat-huntingtons-disease/?utm_medium=social&utm_source=bluesky_
August 1, 2026 at 8:28 AM
Proud of Kaisa Pakari @kpakari.bsky.social to receive the 2025 Schmeil young researcher award for her #PhD thesis. She established 🐟 models to address disorders of #glycosylation #CDG by advancing #baseediting range for precise genome editing @wittbrodtlab.bsky.social @cos.uni-heidelberg.de
July 3, 2025 at 4:04 PM
Proud of Kaisa Pakari @kpakari.bsky.social to receive the 2025 Schmeil young researcher award for her #PhD thesis. She established 🐟 models to address disorders of #glycosylation #CDG by advancing #baseediting range for precise genome editing @wittbrodtlab.bsky.social @cos.uni-heidelberg.de
Exciting opportunity for @astarsg.bsky.social student @cggoh.bsky.social to exchange new ideas on #CRISPR and #BaseEditing with @spjacksongroup.bsky.social alumnus Dan Durocher @durocher1.bsky.social, with postdoc Dr Simon Lam at #CRISPR25 @eventswcs.bsky.social
April 7, 2025 at 2:59 PM
Exciting opportunity for @astarsg.bsky.social student @cggoh.bsky.social to exchange new ideas on #CRISPR and #BaseEditing with @spjacksongroup.bsky.social alumnus Dan Durocher @durocher1.bsky.social, with postdoc Dr Simon Lam at #CRISPR25 @eventswcs.bsky.social
CRISPR technologies for genome, epigenome & transcriptome editing
Dazzling ever-expanding Cas-verse😎
#BaseEditing
#PrimeEditing
Large insertions/deletion kb
Transient/Stable transcriptional activation/inhibition
RNA degradation/editing/methylation🤠
#NatRevMCB 2024
www.nature.com/articles/s41...
Dazzling ever-expanding Cas-verse😎
#BaseEditing
#PrimeEditing
Large insertions/deletion kb
Transient/Stable transcriptional activation/inhibition
RNA degradation/editing/methylation🤠
#NatRevMCB 2024
www.nature.com/articles/s41...
February 14, 2024 at 8:25 PM
CRISPR technologies for genome, epigenome & transcriptome editing
Dazzling ever-expanding Cas-verse😎
#BaseEditing
#PrimeEditing
Large insertions/deletion kb
Transient/Stable transcriptional activation/inhibition
RNA degradation/editing/methylation🤠
#NatRevMCB 2024
www.nature.com/articles/s41...
Dazzling ever-expanding Cas-verse😎
#BaseEditing
#PrimeEditing
Large insertions/deletion kb
Transient/Stable transcriptional activation/inhibition
RNA degradation/editing/methylation🤠
#NatRevMCB 2024
www.nature.com/articles/s41...
"Redefining Healthcare with
Artificial
Intelligence."
#Raredisease
#medical #health #bio #biotech #Geneticengineering #Artificalintelligence #stemcells #stemcell #stem
#crispr #baseediting #humanity #dna #news #healthy
Artificial
Intelligence."
#Raredisease
#medical #health #bio #biotech #Geneticengineering #Artificalintelligence #stemcells #stemcell #stem
#crispr #baseediting #humanity #dna #news #healthy
July 12, 2026 at 2:08 PM
"Redefining Healthcare with
Artificial
Intelligence."
#Raredisease
#medical #health #bio #biotech #Geneticengineering #Artificalintelligence #stemcells #stemcell #stem
#crispr #baseediting #humanity #dna #news #healthy
Artificial
Intelligence."
#Raredisease
#medical #health #bio #biotech #Geneticengineering #Artificalintelligence #stemcells #stemcell #stem
#crispr #baseediting #humanity #dna #news #healthy
Latest research from my group. We activated BDNF protein expression by disrupting a repressive uORF using a CRISPR base editing strategy: www.sciencedirect.com/science/arti...
#OxfordPaediatrics #IDRMOxford #BDNF #uORF #CRISPR #BaseEditing
#OxfordPaediatrics #IDRMOxford #BDNF #uORF #CRISPR #BaseEditing
Targeted BDNF upregulation via upstream open reading frame disruption
To understand the relative contributions of 5ʹ UTR elements to translation output, we performed a comprehensive analysis of upstream open reading fram…
www.sciencedirect.com
January 6, 2026 at 4:36 PM
Latest research from my group. We activated BDNF protein expression by disrupting a repressive uORF using a CRISPR base editing strategy: www.sciencedirect.com/science/arti...
#OxfordPaediatrics #IDRMOxford #BDNF #uORF #CRISPR #BaseEditing
#OxfordPaediatrics #IDRMOxford #BDNF #uORF #CRISPR #BaseEditing
🌟New hope for vision restoration: Congratulations to Bence György on his 5-year @erc.europa.eu Consolidator Grant. His proposal was selected among 3121 applications from across Europe - a strong vote of confidence in our work at IOB!
#ERCCoG #BaseEditing #VisionResearch #Blindness #AcademicBlueSky
#ERCCoG #BaseEditing #VisionResearch #Blindness #AcademicBlueSky
December 9, 2025 at 5:09 PM
🌟New hope for vision restoration: Congratulations to Bence György on his 5-year @erc.europa.eu Consolidator Grant. His proposal was selected among 3121 applications from across Europe - a strong vote of confidence in our work at IOB!
#ERCCoG #BaseEditing #VisionResearch #Blindness #AcademicBlueSky
#ERCCoG #BaseEditing #VisionResearch #Blindness #AcademicBlueSky
Gene Editing at Scale: ARPA-H Awards $160M to Mass-Produce Rare Disease Cures
www.techtimes.com
#Raredisease
#medical #health #bio #biotech #Geneticengineering #Artificalintelligence #stemcells #stemcell #stem
#crispr #baseediting #humanity #dna #news #healthy
www.techtimes.com
#Raredisease
#medical #health #bio #biotech #Geneticengineering #Artificalintelligence #stemcells #stemcell #stem
#crispr #baseediting #humanity #dna #news #healthy
July 12, 2026 at 1:32 PM
Gene Editing at Scale: ARPA-H Awards $160M to Mass-Produce Rare Disease Cures
www.techtimes.com
#Raredisease
#medical #health #bio #biotech #Geneticengineering #Artificalintelligence #stemcells #stemcell #stem
#crispr #baseediting #humanity #dna #news #healthy
www.techtimes.com
#Raredisease
#medical #health #bio #biotech #Geneticengineering #Artificalintelligence #stemcells #stemcell #stem
#crispr #baseediting #humanity #dna #news #healthy
This remarkable new RNA-based adenine and cytosine #BaseEditing system achieves targeted and efficient A-to-G and C-to-T conversions in lettuce, with potential applications in #crop breeding and #PlantBiotechnology.
doi.org/10.1111/jipb...
#PlantScience
doi.org/10.1111/jipb...
#PlantScience
December 31, 2024 at 2:28 PM
This remarkable new RNA-based adenine and cytosine #BaseEditing system achieves targeted and efficient A-to-G and C-to-T conversions in lettuce, with potential applications in #crop breeding and #PlantBiotechnology.
doi.org/10.1111/jipb...
#PlantScience
doi.org/10.1111/jipb...
#PlantScience
Do you want to know why #ABE 8e is the most efficient adenine base editor? Read our paper with the amazing
Audrey Lapinaite!
@narjournal.bsky.social
The dimerization of TadA8e and its exclusive interactions with #CRISPR Cas9 boost #BaseEditing efficiency!
academic.oup.com/nar/article/...
Audrey Lapinaite!
@narjournal.bsky.social
The dimerization of TadA8e and its exclusive interactions with #CRISPR Cas9 boost #BaseEditing efficiency!
academic.oup.com/nar/article/...
Dimerization of the deaminase domain and locking interactions with Cas9 boost base editing efficiency in ABE8e
Abstract. CRISPR-based DNA adenine base editors (ABEs) hold remarkable promises to address human genetic diseases caused by point mutations. ABEs were deve
academic.oup.com
February 8, 2025 at 6:17 PM
Do you want to know why #ABE 8e is the most efficient adenine base editor? Read our paper with the amazing
Audrey Lapinaite!
@narjournal.bsky.social
The dimerization of TadA8e and its exclusive interactions with #CRISPR Cas9 boost #BaseEditing efficiency!
academic.oup.com/nar/article/...
Audrey Lapinaite!
@narjournal.bsky.social
The dimerization of TadA8e and its exclusive interactions with #CRISPR Cas9 boost #BaseEditing efficiency!
academic.oup.com/nar/article/...
Mohankumar et al. demonstrated that #truncatinggRNAs to 15–19 nt narrows the #baseediting window to suppress bystander mutations across ABE and CBE platforms, with 17 nt guides optimizing target precision during transient delivery in primary CD34+ HSPCs. 🩸🤖 #BystanderEditing #HSPCs #GeneTherapy
September 18, 2026 at 5:03 AM
Mohankumar et al. demonstrated that #truncatinggRNAs to 15–19 nt narrows the #baseediting window to suppress bystander mutations across ABE and CBE platforms, with 17 nt guides optimizing target precision during transient delivery in primary CD34+ HSPCs. 🩸🤖 #BystanderEditing #HSPCs #GeneTherapy
🌟New hope for vision restoration: Warm congratulations to Bence György on his 5-year @erc.europa.eu Consolidator Grant to advance base editing for genetic macular degeneration and explore therapies for corneal blindness.
#ERCCoG #BaseEditing #VisionResearch #Blindness #AcademicBlueSky
#ERCCoG #BaseEditing #VisionResearch #Blindness #AcademicBlueSky
December 9, 2025 at 11:18 AM
🌟New hope for vision restoration: Warm congratulations to Bence György on his 5-year @erc.europa.eu Consolidator Grant to advance base editing for genetic macular degeneration and explore therapies for corneal blindness.
#ERCCoG #BaseEditing #VisionResearch #Blindness #AcademicBlueSky
#ERCCoG #BaseEditing #VisionResearch #Blindness #AcademicBlueSky
🤖 One round of DNA shuffling + ML virtual screening of 10M sequences → base editors that beat ABE8e on activity, off-target, and size — no extra rounds of directed evolution needed. bioRxiv | Bowen lab, UCB. #BaseEditing #MachineLearning #CRISPR
May 18, 2026 at 6:39 AM
🤖 One round of DNA shuffling + ML virtual screening of 10M sequences → base editors that beat ABE8e on activity, off-target, and size — no extra rounds of directed evolution needed. bioRxiv | Bowen lab, UCB. #BaseEditing #MachineLearning #CRISPR
🧪I am thrilled to share that our work was just published in Methods in Enzymology!
HUGE thank you to all who contributed to this, but especially to my phenomenal co-first author, @natalie-z.bsky.social, and our mentor, Dr. Alexis Komor.
#baseediting #genomeediting #SciSky #AcademicSky
HUGE thank you to all who contributed to this, but especially to my phenomenal co-first author, @natalie-z.bsky.social, and our mentor, Dr. Alexis Komor.
#baseediting #genomeediting #SciSky #AcademicSky
Genome editing with programmable base editors in human cells
Genome editing has garnered significant attention over the last decade, resulting in a massive expansion of the genome engineering toolbox. Base edito…
www.sciencedirect.com
February 6, 2025 at 2:48 AM
🧪I am thrilled to share that our work was just published in Methods in Enzymology!
HUGE thank you to all who contributed to this, but especially to my phenomenal co-first author, @natalie-z.bsky.social, and our mentor, Dr. Alexis Komor.
#baseediting #genomeediting #SciSky #AcademicSky
HUGE thank you to all who contributed to this, but especially to my phenomenal co-first author, @natalie-z.bsky.social, and our mentor, Dr. Alexis Komor.
#baseediting #genomeediting #SciSky #AcademicSky
CRISPR ist in der Klinik angekommen – aber nur ein Produkt ist bislang zugelassen.
Was steckt hinter der Technologie und wer treibt sie voran?
🧬 Überblick zu #Casgevy, Base & Prime Editing, Unternehmen & Trends:
👉 www.blaubiologie.de/crispr-im-kl...
#CRISPR #Biotech #GeneEditing #Cas9 #BaseEditing
Was steckt hinter der Technologie und wer treibt sie voran?
🧬 Überblick zu #Casgevy, Base & Prime Editing, Unternehmen & Trends:
👉 www.blaubiologie.de/crispr-im-kl...
#CRISPR #Biotech #GeneEditing #Cas9 #BaseEditing
CRISPR im klinischen Kontext: Wie CRISPR die Medizin verändert
Die Entdeckung und Weiterentwicklung der CRISPR-Technologie hat das Feld der Genomeditierung grundlegend verändert. Ursprünglich als adaptives Immunsystem von Bakterien identifiziert, wurde das CRISPR...
www.blaubiologie.de
March 24, 2025 at 11:13 AM
CRISPR ist in der Klinik angekommen – aber nur ein Produkt ist bislang zugelassen.
Was steckt hinter der Technologie und wer treibt sie voran?
🧬 Überblick zu #Casgevy, Base & Prime Editing, Unternehmen & Trends:
👉 www.blaubiologie.de/crispr-im-kl...
#CRISPR #Biotech #GeneEditing #Cas9 #BaseEditing
Was steckt hinter der Technologie und wer treibt sie voran?
🧬 Überblick zu #Casgevy, Base & Prime Editing, Unternehmen & Trends:
👉 www.blaubiologie.de/crispr-im-kl...
#CRISPR #Biotech #GeneEditing #Cas9 #BaseEditing
🧬 One wrong letter in one gene. That's the whole disease.
HMSN-P, found in Okinawan families in 1983, comes down to a single DNA typo. A Japan-led team just corrected it in mice and patient cells — without cutting the DNA.
#BaseEditing #HMSNP #Okinawa #CiRA #GeneEditing
HMSN-P, found in Okinawan families in 1983, comes down to a single DNA typo. A Japan-led team just corrected it in mice and patient cells — without cutting the DNA.
#BaseEditing #HMSNP #Okinawa #CiRA #GeneEditing
September 22, 2026 at 12:00 PM
🧬 One wrong letter in one gene. That's the whole disease.
HMSN-P, found in Okinawan families in 1983, comes down to a single DNA typo. A Japan-led team just corrected it in mice and patient cells — without cutting the DNA.
#BaseEditing #HMSNP #Okinawa #CiRA #GeneEditing
HMSN-P, found in Okinawan families in 1983, comes down to a single DNA typo. A Japan-led team just corrected it in mice and patient cells — without cutting the DNA.
#BaseEditing #HMSNP #Okinawa #CiRA #GeneEditing
I am very happy to share our latest manuscript in BMC Genome Biology 🥳: rdcu.be/d8weC We describe the engineering of the cytosine deaminase SsdA to build an efficient and small CRISPR/Cas9 base editor. #BaseEditing #Cas9 #CRISPR #GeneTherapy #GeneEditing Here is a short intro to a fun project 🧵🧪🧬
Engineering a bacterial toxin deaminase from the DYW-family into a novel cytosine base editor for plants and mammalian cells
rdcu.be
February 4, 2025 at 3:38 PM
I am very happy to share our latest manuscript in BMC Genome Biology 🥳: rdcu.be/d8weC We describe the engineering of the cytosine deaminase SsdA to build an efficient and small CRISPR/Cas9 base editor. #BaseEditing #Cas9 #CRISPR #GeneTherapy #GeneEditing Here is a short intro to a fun project 🧵🧪🧬
Chen Liang and Li Dali's teams engineered smACGmax, a tri-base editor fusing deaminases and glycosylases inside Cas9 to achieve up to 41% simultaneous A, C, and G editing for multi-residue saturation screening. 🧬🤖 #BaseEditing #CRISPR #NatureComms2026 #TriBaseEditor #DirectedEvolution #Genomics
July 31, 2026 at 7:37 AM
Chen Liang and Li Dali's teams engineered smACGmax, a tri-base editor fusing deaminases and glycosylases inside Cas9 to achieve up to 41% simultaneous A, C, and G editing for multi-residue saturation screening. 🧬🤖 #BaseEditing #CRISPR #NatureComms2026 #TriBaseEditor #DirectedEvolution #Genomics
#UCBerkeley researchers profiled 12,000 ML-designed ABE variants, revealing that target editing saturates at a site-specific plateau and that "high-specificity" variants simply lower intrinsic activity to eliminate excess bystander and off-target spillover. 🧬🤖 #BaseEditing #CRISPR #ABE8e
July 30, 2026 at 8:56 AM
#UCBerkeley researchers profiled 12,000 ML-designed ABE variants, revealing that target editing saturates at a site-specific plateau and that "high-specificity" variants simply lower intrinsic activity to eliminate excess bystander and off-target spillover. 🧬🤖 #BaseEditing #CRISPR #ABE8e
Sungkyunkwan University researchers engineered AI-derived Deam-P32 into OpenABE1.1/1.2 by grafting a missing C-terminal domain and 3 key mutations, matching ABE8e's 41.7% efficiency while slashing ATC bystander edits up to 12-fold. 🧬🤖 #BaseEditing #CRISPR #OpenABE #NAR2026 #AIProteinDesign #Biotech
July 30, 2026 at 5:44 AM
Sungkyunkwan University researchers engineered AI-derived Deam-P32 into OpenABE1.1/1.2 by grafting a missing C-terminal domain and 3 key mutations, matching ABE8e's 41.7% efficiency while slashing ATC bystander edits up to 12-fold. 🧬🤖 #BaseEditing #CRISPR #OpenABE #NAR2026 #AIProteinDesign #Biotech
🌿 TadA8e-derived GhTad-CDd achieves ~80% average C-to-T editing in cotton, while GhTadDE simultaneously delivers C-to-T and A-to-G edits at up to 85.95% total efficiency — with GhWOX1-edited T0 plants showing diverse leaf shapes confirmed by transcriptome rewiring. #BaseEditing #Cotton #CRISPR
May 26, 2026 at 6:06 AM
🌿 TadA8e-derived GhTad-CDd achieves ~80% average C-to-T editing in cotton, while GhTadDE simultaneously delivers C-to-T and A-to-G edits at up to 85.95% total efficiency — with GhWOX1-edited T0 plants showing diverse leaf shapes confirmed by transcriptome rewiring. #BaseEditing #Cotton #CRISPR
🌽#Biotech breakthrough!🧬
Robust #genetic mods without yield loss? Fu et al. show it's possible in new work that enhances #herbicide tolerance in #maize using cytosine and adenine #BaseEditing!
Read the entire article for #free right here!⬇️
doi.org/10.1111/jipb...
#PlantScience #OpenAccess
Robust #genetic mods without yield loss? Fu et al. show it's possible in new work that enhances #herbicide tolerance in #maize using cytosine and adenine #BaseEditing!
Read the entire article for #free right here!⬇️
doi.org/10.1111/jipb...
#PlantScience #OpenAccess
September 2, 2025 at 11:48 AM
🌽#Biotech breakthrough!🧬
Robust #genetic mods without yield loss? Fu et al. show it's possible in new work that enhances #herbicide tolerance in #maize using cytosine and adenine #BaseEditing!
Read the entire article for #free right here!⬇️
doi.org/10.1111/jipb...
#PlantScience #OpenAccess
Robust #genetic mods without yield loss? Fu et al. show it's possible in new work that enhances #herbicide tolerance in #maize using cytosine and adenine #BaseEditing!
Read the entire article for #free right here!⬇️
doi.org/10.1111/jipb...
#PlantScience #OpenAccess
Zhou et al. report an adenine base-editing system developed to precisely modify the #sorghum SbALS #gene and generate transgene-free mutant #plants with #herbicide resistance and no significant tradeoffs in agronomic traits.
doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantSci #BaseEditing
doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantSci #BaseEditing
Engineering herbicide‐resistant sorghum with CRISPR/Cas9‐mediated adenine base editing
An adenine base-editing system was established to precisely modify the sorghum SbALS gene, generating transgene-free mutant plants. These plants exhibit strong herbicide resistance, with no significa...
doi.org
May 28, 2026 at 12:27 PM
Zhou et al. report an adenine base-editing system developed to precisely modify the #sorghum SbALS #gene and generate transgene-free mutant #plants with #herbicide resistance and no significant tradeoffs in agronomic traits.
doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantSci #BaseEditing
doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantSci #BaseEditing
You can find on LinkedIn our recent “ CRISPR in 180” .
Here we report the latest results from a study by @unibas.ch and @beamthx where they deploy base editing in mice and NHP to treat Stargadts condition!
#crispr #genetherapy #baseediting
www.linkedin.com/posts/wedocr...
Here we report the latest results from a study by @unibas.ch and @beamthx where they deploy base editing in mice and NHP to treat Stargadts condition!
#crispr #genetherapy #baseediting
www.linkedin.com/posts/wedocr...
WeDoCRISPR on LinkedIn: A new base editing treatment for Stargardt's disease!
Scientists in Bence…
A new base editing treatment for Stargardt's disease!
Scientists in Bence Gyorgy's lab at Basel University, in collaboration with Beam Therapeutics, have…
www.linkedin.com
January 22, 2025 at 8:36 AM
You can find on LinkedIn our recent “ CRISPR in 180” .
Here we report the latest results from a study by @unibas.ch and @beamthx where they deploy base editing in mice and NHP to treat Stargadts condition!
#crispr #genetherapy #baseediting
www.linkedin.com/posts/wedocr...
Here we report the latest results from a study by @unibas.ch and @beamthx where they deploy base editing in mice and NHP to treat Stargadts condition!
#crispr #genetherapy #baseediting
www.linkedin.com/posts/wedocr...
Scientists map cancer mutations in EGFR gene, revealing drug resistance paths 🔬🧬🧪 www.news-medical.net/news/2024111... #Cancer #GeneEditing #EGFR #PrecisionMedicine #DrugResistance #CancerProgression #BaseEditing #PrimeEditing #PersonalizedTreatment @naturebiotech.bsky.social
Scientists map cancer mutations in EGFR gene, revealing drug resistance paths
Researchers used base and prime editing to uncover new EGFR gene mutations that affect cancer progression and drug resistance, paving the way for personalized treatment strategies.
www.news-medical.net
November 14, 2024 at 10:46 PM
Scientists map cancer mutations in EGFR gene, revealing drug resistance paths 🔬🧬🧪 www.news-medical.net/news/2024111... #Cancer #GeneEditing #EGFR #PrecisionMedicine #DrugResistance #CancerProgression #BaseEditing #PrimeEditing #PersonalizedTreatment @naturebiotech.bsky.social