Cool result: Transposon insertion sequencing reveals novel hypermutator genes in Acinetobacter baumannii
"Exposure of a transposon insertion mutant library to extended weak antibiotic selection ... revealed genes that indirectly increased fitness due to elevated general mutation rates"
"Exposure of a transposon insertion mutant library to extended weak antibiotic selection ... revealed genes that indirectly increased fitness due to elevated general mutation rates"
Transposon insertion sequencing reveals novel hypermutator genes in Acinetobacter baumannii | mBio
All organisms have the capacity for evolution through mutation. Bacteria with high
mutation rates have a survival advantage in some stressful environments because they
generate beneficial mutations mo...
journals.asm.org
June 29, 2025 at 4:58 AM
Cool result: Transposon insertion sequencing reveals novel hypermutator genes in Acinetobacter baumannii
"Exposure of a transposon insertion mutant library to extended weak antibiotic selection ... revealed genes that indirectly increased fitness due to elevated general mutation rates"
"Exposure of a transposon insertion mutant library to extended weak antibiotic selection ... revealed genes that indirectly increased fitness due to elevated general mutation rates"
1/ Excited to share our latest opinion piece published today in Trends in Microbiology (@cp-trendsmicrobiol.bsky.social):
Hypermutator fungal pathogens: from threat to meltdown
Here, we argue that the origin of hypermutation follows defined principles, rather than...
Hypermutator fungal pathogens: from threat to meltdown
Here, we argue that the origin of hypermutation follows defined principles, rather than...
August 7, 2025 at 8:05 AM
1/ Excited to share our latest opinion piece published today in Trends in Microbiology (@cp-trendsmicrobiol.bsky.social):
Hypermutator fungal pathogens: from threat to meltdown
Here, we argue that the origin of hypermutation follows defined principles, rather than...
Hypermutator fungal pathogens: from threat to meltdown
Here, we argue that the origin of hypermutation follows defined principles, rather than...
"The fungal RIP hypermutator mechanism has deep eukaryotic roots"
by Thomas Badet & colleagues
authors.elsevier.com/sd/article/S...
by Thomas Badet & colleagues
authors.elsevier.com/sd/article/S...
June 10, 2026 at 10:15 PM
"The fungal RIP hypermutator mechanism has deep eukaryotic roots"
by Thomas Badet & colleagues
authors.elsevier.com/sd/article/S...
by Thomas Badet & colleagues
authors.elsevier.com/sd/article/S...
Nearly a year after our symposium on Repeat-Induced Point (RIP) mutations, I’m happy to share the fruit of some of our discussions.
The fungal RIP hypermutator mechanism has deep eukaryotic roots www.sciencedirect.com/science/arti...
We hope to spark interest in this underappreciated mechanism.
The fungal RIP hypermutator mechanism has deep eukaryotic roots www.sciencedirect.com/science/arti...
We hope to spark interest in this underappreciated mechanism.
June 11, 2026 at 9:02 AM
Nearly a year after our symposium on Repeat-Induced Point (RIP) mutations, I’m happy to share the fruit of some of our discussions.
The fungal RIP hypermutator mechanism has deep eukaryotic roots www.sciencedirect.com/science/arti...
We hope to spark interest in this underappreciated mechanism.
The fungal RIP hypermutator mechanism has deep eukaryotic roots www.sciencedirect.com/science/arti...
We hope to spark interest in this underappreciated mechanism.
Check out our latest work: Non-hypermutator cancers access driver mutations through reversals in germline mutational bias. doi.org/10.1101/2024...
Non-hypermutator cancers access driver mutations through reversals in germline mutational bias
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
doi.org
May 16, 2024 at 9:18 AM
Check out our latest work: Non-hypermutator cancers access driver mutations through reversals in germline mutational bias. doi.org/10.1101/2024...
DNA-damaging combination treatments impose genotype-specific constraints on hypermutator evolvability https://www.biorxiv.org/content/10.64898/2026.02.20.706947v1
February 21, 2026 at 3:17 AM
DNA-damaging combination treatments impose genotype-specific constraints on hypermutator evolvability https://www.biorxiv.org/content/10.64898/2026.02.20.706947v1
Hypermutator fungal pathogens: from threat to meltdown
Hypermutator fungal pathogens: from threat to meltdown
Recent research on human and crop fungal pathogens has highlighted a set of unexpected and seemingly unrelated mechanisms fuelling adaptation to drugs and the host immune system. These mechanisms include the loss of RNA interference (RNAi) in human pathogens, the rapid accumulation of point mutations, and the activity of transposable elements. Despite mechanistic differences driving the extreme accumulation of mutations (i.e., hypermutation) in some pathogens, we argue that the origins follow defined principles. The appearance of hypermutation phenotypes puts pathogens on a unique evolutionary trajectory, and mitigation strategies need to be carefully adapted.
dlvr.it
August 7, 2025 at 11:38 PM
Hypermutator fungal pathogens: from threat to meltdown
Looks fascinating! Some unexpected behaviour of hypermutator populations…
January 3, 2024 at 11:22 PM
Looks fascinating! Some unexpected behaviour of hypermutator populations…
DNA-damaging combination treatments impose genotype-specific constraints on hypermutator evolvability https://www.biorxiv.org/content/10.64898/2026.02.20.706947v1
February 21, 2026 at 3:17 AM
DNA-damaging combination treatments impose genotype-specific constraints on hypermutator evolvability https://www.biorxiv.org/content/10.64898/2026.02.20.706947v1
I think our preprint on mutation spectra and cancer evolution makes wonderful connections between theory and experiments in asexual bacteria and somatic evolution data from tumors. But we're struggling finding the right target journal. Any suggestions?
doi.org/10.1101/2024...
doi.org/10.1101/2024...
Non-hypermutator cancers access driver mutations through reversals in germline mutational bias
Cancer is an evolutionary disease driven by mutations in asexually-reproducing somatic cells. In asexual microbes, bias reversals in the mutation spectrum can speed adaptation by increasing access to ...
doi.org
December 16, 2024 at 4:05 PM
I think our preprint on mutation spectra and cancer evolution makes wonderful connections between theory and experiments in asexual bacteria and somatic evolution data from tumors. But we're struggling finding the right target journal. Any suggestions?
doi.org/10.1101/2024...
doi.org/10.1101/2024...
2/ ...emerging from a set of unexpected and unrelated mechanisms. This emergence can occur through two main pathways: historical contingency or a consequence of lifestyle.
Following hypermutator emergence, selection is expected to favour a return to ground state, and...
Following hypermutator emergence, selection is expected to favour a return to ground state, and...
August 7, 2025 at 8:05 AM
2/ ...emerging from a set of unexpected and unrelated mechanisms. This emergence can occur through two main pathways: historical contingency or a consequence of lifestyle.
Following hypermutator emergence, selection is expected to favour a return to ground state, and...
Following hypermutator emergence, selection is expected to favour a return to ground state, and...
Pòster a #Docusalut: Dual ceftriaxone/azithromycin pressure shapes distinct evolutionary trajectories and selects a hypermutator phenotype in Neisseria gonorrhoeae https://hdl.handle.net/20.500.13003/27320 @idisba.bsky.social #PublicaSalutIB #ESCMIDGlobal #ESCMIDGlobal2026
September 11, 2026 at 10:01 AM
Pòster a #Docusalut: Dual ceftriaxone/azithromycin pressure shapes distinct evolutionary trajectories and selects a hypermutator phenotype in Neisseria gonorrhoeae https://hdl.handle.net/20.500.13003/27320 @idisba.bsky.social #PublicaSalutIB #ESCMIDGlobal #ESCMIDGlobal2026
Researchers engineered A&GBE and the QBMM hypermutator (dTAGBE+AID) to achieve concurrent, balanced four-base (A, T, G, C) mutagenesis across a ~100 bp window in mammalian cells. 🧬🤖 #BaseEditing #NatComms2026 #GenomeEditing #DirectedEvolution #Hypermutator #MAP2K1
August 31, 2026 at 8:37 AM
Researchers engineered A&GBE and the QBMM hypermutator (dTAGBE+AID) to achieve concurrent, balanced four-base (A, T, G, C) mutagenesis across a ~100 bp window in mammalian cells. 🧬🤖 #BaseEditing #NatComms2026 #GenomeEditing #DirectedEvolution #Hypermutator #MAP2K1
#AMR #Acinetobacter
Transposon insertion sequencing reveals novel hypermutator genes in Acinetobacter baumannii | mBio journals.asm.org/doi/10.1128/...
Transposon insertion sequencing reveals novel hypermutator genes in Acinetobacter baumannii | mBio journals.asm.org/doi/10.1128/...
Transposon insertion sequencing reveals novel hypermutator genes in Acinetobacter baumannii | mBio
All organisms have the capacity for evolution through mutation. Bacteria with high
mutation rates have a survival advantage in some stressful environments because they
generate beneficial mutations mo...
journals.asm.org
August 27, 2026 at 3:27 AM
#AMR #Acinetobacter
Transposon insertion sequencing reveals novel hypermutator genes in Acinetobacter baumannii | mBio journals.asm.org/doi/10.1128/...
Transposon insertion sequencing reveals novel hypermutator genes in Acinetobacter baumannii | mBio journals.asm.org/doi/10.1128/...
Immunotherapy for Metastatic #Pancreatic Neuroendocrine #Tumors with High Mutational Burden and Mismatch Repair Alterations Following Treatment with Alkylating Chemotherapy link.springer.com/article/10.1... #hvhebron #onco
Immunotherapy for Metastatic Pancreatic Neuroendocrine Tumors with High Mutational Burden and Mismatch Repair Alterations Following Treatment with Alkylating Chemotherapy - Endocrine Pathology
Alkylating agent-based chemotherapy is one of the main treatment options for patients with metastatic pancreatic neuroendocrine tumors (PanNETs).However, it favors the acquisition of a hypermutator ph...
link.springer.com
November 6, 2025 at 3:26 PM
Immunotherapy for Metastatic #Pancreatic Neuroendocrine #Tumors with High Mutational Burden and Mismatch Repair Alterations Following Treatment with Alkylating Chemotherapy link.springer.com/article/10.1... #hvhebron #onco
Rainey: unfortunately looks like a hypermutator genotype is responsible for alternating life cycle of single cells/biofilm in P flu #ISME15
August 25, 2014 at 1:30 AM
Rainey: unfortunately looks like a hypermutator genotype is responsible for alternating life cycle of single cells/biofilm in P flu #ISME15
Emergence of mutHV76G among longitudinal carbapenem resistant Klebsiella pneumoniae causing long-term colonization and recurrent infection disrupts DNA mismatch repair and results in a hypermutator phenotype https://www.biorxiv.org/content/10.1101/2025.11.17.688822v1
November 17, 2025 at 11:17 PM
Emergence of mutHV76G among longitudinal carbapenem resistant Klebsiella pneumoniae causing long-term colonization and recurrent infection disrupts DNA mismatch repair and results in a hypermutator phenotype https://www.biorxiv.org/content/10.1101/2025.11.17.688822v1
Mutations in MMR (mismatch repair) genes do not predict an MMR phenotype, but a "trinucleotide mutational signature" does.
Mutational signature analysis predicts bacterial hypermutation and multidrug resistance - Nature Communications
Mutational signature analysis of Pseudomonas aeruginosa identifies hypermutator clinical strains and prognostically predicts multidrug resistance acquisiton, potentially serving as a tool to guide eff...
www.nature.com
February 28, 2025 at 6:52 PM
Mutations in MMR (mismatch repair) genes do not predict an MMR phenotype, but a "trinucleotide mutational signature" does.
Non-hypermutator cancers access driver mutations through reversals in germline mutational bias https://www.biorxiv.org/content/10.1101/2024.04.30.591900v1
Non-hypermutator cancers access driver mutations through reversals in germline mutational bias https://www.biorxiv.org/content/10.1101/2024.04.30.591900v1
Cancer is an evolutionary disease driven by mutations in asexually-reproducing somatic cells. In ase
www.biorxiv.org
May 3, 2024 at 4:49 PM
Non-hypermutator cancers access driver mutations through reversals in germline mutational bias https://www.biorxiv.org/content/10.1101/2024.04.30.591900v1
Matthew Andres Moreno of @umich.edu used the powerful capabilities of ACCESS-allocated #HPC resources, including Bridges-2 and the #AI system Neocortex at the Pittsburgh Supercomputing Center, to study hypermutator evolution.
#EnablingDiscoveryforAll
access-ci.org/hypermutants...
#EnablingDiscoveryforAll
access-ci.org/hypermutants...
Hypermutants in Hiding - Access
University of Michigan researcher uses ACCESS-allocated resources Bridges-2 and Neocortex at PSC to study hypermutator evolution.
access-ci.org
February 26, 2025 at 3:58 PM
Matthew Andres Moreno of @umich.edu used the powerful capabilities of ACCESS-allocated #HPC resources, including Bridges-2 and the #AI system Neocortex at the Pittsburgh Supercomputing Center, to study hypermutator evolution.
#EnablingDiscoveryforAll
access-ci.org/hypermutants...
#EnablingDiscoveryforAll
access-ci.org/hypermutants...
Emergence of mutHV76G among longitudinal carbapenem resistant Klebsiella pneumoniae causing long-term colonization and recurrent infection disrupts DNA mismatch repair and results in a hypermutator phenotype https://www.biorxiv.org/content/10.1101/2025.11.17.688822v1
November 17, 2025 at 11:17 PM
Emergence of mutHV76G among longitudinal carbapenem resistant Klebsiella pneumoniae causing long-term colonization and recurrent infection disrupts DNA mismatch repair and results in a hypermutator phenotype https://www.biorxiv.org/content/10.1101/2025.11.17.688822v1
Non-hypermutator cancers access driver mutations through reversals in germline mutational bias https://www.biorxiv.org/content/10.1101/2024.04.30.591900v1
Non-hypermutator cancers access driver mutations through reversals in germline mutational bias https://www.biorxiv.org/content/10.1101/2024.04.30.591900v1
Cancer is an evolutionary disease driven by mutations in asexually-reproducing somatic cells. In ase
www.biorxiv.org
May 3, 2024 at 4:49 PM
Non-hypermutator cancers access driver mutations through reversals in germline mutational bias https://www.biorxiv.org/content/10.1101/2024.04.30.591900v1
Emergence of mutH (V76G) among longitudinal carbapenem resistant Klebsiella pneumoniae causing long-term colonization and recurrent infection disrupts DNA mismatch repair and results in a hypermutator phenotype
https://doi.org/10.1101/2025.11.17.688822
https://doi.org/10.1101/2025.11.17.688822
December 3, 2025 at 4:21 PM
Emergence of mutH (V76G) among longitudinal carbapenem resistant Klebsiella pneumoniae causing long-term colonization and recurrent infection disrupts DNA mismatch repair and results in a hypermutator phenotype
https://doi.org/10.1101/2025.11.17.688822
https://doi.org/10.1101/2025.11.17.688822