Drosophila eIF4E paralogs: a paradigm of functional divergence
#Drosophila
#Drosophila
Drosophila eIF4E paralogs: a paradigm of functional divergence
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
October 29, 2026 at 10:23 AM
Drosophila eIF4E paralogs: a paradigm of functional divergence
#Drosophila
#Drosophila
Drug repurposing by TUMS & UT in Eur J Pharmacol identifies ibrutinib & entrectinib as MNK/eIF4E inhibitors in ovarian cancer.
بازکاربرد دارو؛ مطالعه TUMS و تهران در Eur J Pharmacol نشان داد ایبروتینیب و انتراکتینیب مسیر MNK/eIF4E را مهار میکنند.
www.sciencedirect.com/science/arti...
بازکاربرد دارو؛ مطالعه TUMS و تهران در Eur J Pharmacol نشان داد ایبروتینیب و انتراکتینیب مسیر MNK/eIF4E را مهار میکنند.
www.sciencedirect.com/science/arti...
Repurposing Entrectinib and Ibrutinib as MNK/eIF4E pathway modulators in ovarian cancer
The ERK/MNK/eIF4E signaling axis is critically involved in cap-dependent translation and significantly impacts survival and chemotherapy resistance in…
www.sciencedirect.com
October 29, 2026 at 8:57 AM
Drug repurposing by TUMS & UT in Eur J Pharmacol identifies ibrutinib & entrectinib as MNK/eIF4E inhibitors in ovarian cancer.
بازکاربرد دارو؛ مطالعه TUMS و تهران در Eur J Pharmacol نشان داد ایبروتینیب و انتراکتینیب مسیر MNK/eIF4E را مهار میکنند.
www.sciencedirect.com/science/arti...
بازکاربرد دارو؛ مطالعه TUMS و تهران در Eur J Pharmacol نشان داد ایبروتینیب و انتراکتینیب مسیر MNK/eIF4E را مهار میکنند.
www.sciencedirect.com/science/arti...
Translational control of microglial metabolism, inflammatory responses, and survival by the eIF4E-binding proteins #NeuroDegeneration 🧪🧠
https://www.pnas.org/doi/abs/10.1073/pnas.2610766123?af=R
https://www.pnas.org/doi/abs/10.1073/pnas.2610766123?af=R
October 28, 2026 at 11:04 AM
Translational control of microglial metabolism, inflammatory responses, and survival by the eIF4E-binding proteins #NeuroDegeneration 🧪🧠
https://www.pnas.org/doi/abs/10.1073/pnas.2610766123?af=R
https://www.pnas.org/doi/abs/10.1073/pnas.2610766123?af=R
Translational control of microglial metabolism, inflammatory responses, and survival by the eIF4E-binding proteins pubmed.ncbi.nlm.nih.gov/42905554/
October 24, 2026 at 1:58 AM
Translational control of microglial metabolism, inflammatory responses, and survival by the eIF4E-binding proteins pubmed.ncbi.nlm.nih.gov/42905554/
RRIDs were included in this in Journal of Clinical Investigation paper. RRIDs improve reproducibility in scientific research. #STMpublishing #BetterScience #OpenScience
Therapeutic targeting of the eIF4E cap-binding domain reveals control of lineage fate in prostate cancer
Read the full paper: Therapeutic targeting of the eIF4E cap-binding domain reveals control of lineage fate in prostate cancer
doi.org
October 10, 2026 at 7:00 AM
RRIDs were included in this in Journal of Clinical Investigation paper. RRIDs improve reproducibility in scientific research. #STMpublishing #BetterScience #OpenScience
Structural basis of eIF4E recognition of synthetic mRNA 5' cap analogues links cap architecture to affinity and biological activity https://www.biorxiv.org/content/10.64898/2026.10.05.756672v1
October 6, 2026 at 10:45 AM
Structural basis of eIF4E recognition of synthetic mRNA 5' cap analogues links cap architecture to affinity and biological activity https://www.biorxiv.org/content/10.64898/2026.10.05.756672v1
Structural basis of eIF4E recognition of synthetic mRNA 5' cap analogues links cap architecture to affinity and biological activity https://www.biorxiv.org/content/10.64898/2026.10.05.756672v1
October 6, 2026 at 10:45 AM
Structural basis of eIF4E recognition of synthetic mRNA 5' cap analogues links cap architecture to affinity and biological activity https://www.biorxiv.org/content/10.64898/2026.10.05.756672v1
🧪 S3E2 with Dr. Katherine Borden to look at 4E and how her lab is turning its own mechanisms against cancer.
4E exhibits high selectivity. It acts as a cellular micromanager, orchestrating specific genetic programs to rapidly adapt to physiological stress, tissue repair, & cellular remodeling. 1/2
4E exhibits high selectivity. It acts as a cellular micromanager, orchestrating specific genetic programs to rapidly adapt to physiological stress, tissue repair, & cellular remodeling. 1/2
September 28, 2026 at 4:54 PM
🧪 S3E2 with Dr. Katherine Borden to look at 4E and how her lab is turning its own mechanisms against cancer.
4E exhibits high selectivity. It acts as a cellular micromanager, orchestrating specific genetic programs to rapidly adapt to physiological stress, tissue repair, & cellular remodeling. 1/2
4E exhibits high selectivity. It acts as a cellular micromanager, orchestrating specific genetic programs to rapidly adapt to physiological stress, tissue repair, & cellular remodeling. 1/2
@thermofishersci.bsky.social's resource, RRID:AB_2534069, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #OpenResearch #STMpublishing #methodsmatter
Altered striatal long-term potentiation in the eIF4E-TG mouse model of autism spectrum disorder
Read the full paper: Altered striatal long-term potentiation in the eIF4E-TG mouse model of autism spectrum disorder
doi.org
September 16, 2026 at 7:38 PM
@thermofishersci.bsky.social's resource, RRID:AB_2534069, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #OpenResearch #STMpublishing #methodsmatter
IPK Gatersleben researchers established the first base editing platform in barley, targeting HvEIF4E to create novel BE alleles 7 & 8 that confer robust BaMMV resistance without sacrificing grain yield. 🌾🤖 #BarleyGenomics #BaseEditing #bioRxiv2026 #PlantBiotech #CropProtection #EIF4E
September 14, 2026 at 5:00 AM
IPK Gatersleben researchers established the first base editing platform in barley, targeting HvEIF4E to create novel BE alleles 7 & 8 that confer robust BaMMV resistance without sacrificing grain yield. 🌾🤖 #BarleyGenomics #BaseEditing #bioRxiv2026 #PlantBiotech #CropProtection #EIF4E
Base editing of EIF4E creates novel resistance alleles against bymoviruses in winter barley
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Base editing of EIF4E creates novel resistance alleles against bymoviruses in winter barley
The barley yellow mosaic virus disease is one of the most important threats of barley production in Europe and Asia. Transmitted by the soil-borne plasmodiophorid Polymyxa graminis , there are no dire...
www.biorxiv.org
September 11, 2026 at 6:49 AM
Base editing of EIF4E creates novel resistance alleles against bymoviruses in winter barley
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Base editing of EIF4E creates novel resistance alleles against bymoviruses in winter barley https://www.biorxiv.org/content/10.64898/2026.09.04.749431v1
September 8, 2026 at 10:00 AM
Base editing of EIF4E creates novel resistance alleles against bymoviruses in winter barley https://www.biorxiv.org/content/10.64898/2026.09.04.749431v1
Base editing of EIF4E creates novel resistance alleles against bymoviruses in winter barley https://www.biorxiv.org/content/10.64898/2026.09.04.749431v1
September 8, 2026 at 10:00 AM
Base editing of EIF4E creates novel resistance alleles against bymoviruses in winter barley https://www.biorxiv.org/content/10.64898/2026.09.04.749431v1
Sexual dimorphism of autism-like phenotypes in microglial eIF4E overexpression mice https://www.biorxiv.org/content/10.64898/2026.09.03.748596v1
September 7, 2026 at 10:30 AM
Sexual dimorphism of autism-like phenotypes in microglial eIF4E overexpression mice https://www.biorxiv.org/content/10.64898/2026.09.03.748596v1
Sexual dimorphism of autism-like phenotypes in microglial eIF4E overexpression mice https://www.biorxiv.org/content/10.64898/2026.09.03.748596v1
September 7, 2026 at 10:30 AM
Sexual dimorphism of autism-like phenotypes in microglial eIF4E overexpression mice https://www.biorxiv.org/content/10.64898/2026.09.03.748596v1
RRIDs were included in this in International Journal of Molecular Sciences paper. We value the author's support of reproducibility. #ReproducibleResearch #methodsmatter #BetterScience
Med9 Is a Novel eIF4E-Interacting Protein in Saccharomyces cerevisiae
Read the full paper: Med9 Is a Novel eIF4E-Interacting Protein in Saccharomyces cerevisiae
doi.org
August 16, 2026 at 7:01 AM
RRIDs were included in this in International Journal of Molecular Sciences paper. We value the author's support of reproducibility. #ReproducibleResearch #methodsmatter #BetterScience
RRIDs were included in this in Nature Communications paper. We value the author's support of reproducibility. #BetterScience #OpenScience #accelerateopenscience
Heat stress promotes pre-tRNA capping to modulate cap-dependent translation in Saccharomyces cerevisiae - Nature Communications
Precursors of transfer RNA (pre-tRNAs) undergo multiple maturation steps. Here, the authors show that pre-tRNAs from nearly all yeast tRNA genes can acquire a 5′ cap, that capping increases under heat stress, and that capped pre-tRNAs modulate cap dependent translation through eIF4E interaction.
doi.org
August 14, 2026 at 7:01 AM
RRIDs were included in this in Nature Communications paper. We value the author's support of reproducibility. #BetterScience #OpenScience #accelerateopenscience
#CBGPSeminar
🗓️ 29/11/2019
⌚️ 12:00
🗣️ Dr. Jean-Luc Gallois
🌍 eIF4E‐mediated resistance to viruses: from natural variation to edited alleles
🖇️ Genetic and Plant Breeding Unit, INRA Avignon, France
#somosUPM
🗓️ 29/11/2019
⌚️ 12:00
🗣️ Dr. Jean-Luc Gallois
🌍 eIF4E‐mediated resistance to viruses: from natural variation to edited alleles
🖇️ Genetic and Plant Breeding Unit, INRA Avignon, France
#somosUPM
November 25, 2024 at 11:40 AM
#CBGPSeminar
🗓️ 29/11/2019
⌚️ 12:00
🗣️ Dr. Jean-Luc Gallois
🌍 eIF4E‐mediated resistance to viruses: from natural variation to edited alleles
🖇️ Genetic and Plant Breeding Unit, INRA Avignon, France
#somosUPM
🗓️ 29/11/2019
⌚️ 12:00
🗣️ Dr. Jean-Luc Gallois
🌍 eIF4E‐mediated resistance to viruses: from natural variation to edited alleles
🖇️ Genetic and Plant Breeding Unit, INRA Avignon, France
#somosUPM
Development of a Direct-to-Biology Platform to Discover Potent MNK Inhibitors | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...
Development of a Direct-to-Biology Platform to Discover Potent MNK Inhibitors
Eukaryotic translation initiation factor 4E (eIF4E) plays an essential role in driving the translation of mRNAs that promote cell proliferation. Its activity is regulated through phosphorylation at Se...
pubs.acs.org
May 13, 2026 at 3:18 PM
Development of a Direct-to-Biology Platform to Discover Potent MNK Inhibitors | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...
Happy to share a new paper from my team. Chemistry was led by talented medicinal chemist Purav Vagadia collaborating with @leonidasplatan1.bsky.social
Discovery of Potent and Selective MNK Kinase Inhibitors for the Treatment of Leukemia | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...
Discovery of Potent and Selective MNK Kinase Inhibitors for the Treatment of Leukemia | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...
Discovery of Potent and Selective MNK Kinase Inhibitors for the Treatment of Leukemia
MNK activity is regulated by the p38 and Erk MAPK pathways. Phosphorylation of MNK leads to its activation and binding to the eIF4G/eIF4E complex. MNK then phosphorylates eIF4E at Ser209, whose activa...
pubs.acs.org
March 4, 2025 at 3:24 PM
Happy to share a new paper from my team. Chemistry was led by talented medicinal chemist Purav Vagadia collaborating with @leonidasplatan1.bsky.social
Discovery of Potent and Selective MNK Kinase Inhibitors for the Treatment of Leukemia | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...
Discovery of Potent and Selective MNK Kinase Inhibitors for the Treatment of Leukemia | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...
A study in @nature.com by researchers at KI, @scilifelab.se and others reveals a new stress response mechanism in cells called split ISR (s-ISR). This may have implications for the treatment of #cancer and neurodegenerative diseases like leukodystrophies 🧪 #CellBiology www.nature.com/articles/s41...
Plasticity of the mammalian integrated stress response - Nature
A study describes the split integrated stress response, a cellular stress response mechanism characterized by reduced eIF2B activity without eIF2α phosphorylation, which activates the eIF4E–ATF4–PCK2 ...
www.nature.com
March 27, 2025 at 11:12 AM
A study in @nature.com by researchers at KI, @scilifelab.se and others reveals a new stress response mechanism in cells called split ISR (s-ISR). This may have implications for the treatment of #cancer and neurodegenerative diseases like leukodystrophies 🧪 #CellBiology www.nature.com/articles/s41...
Found FMRP directly interacts w eIF4E, but not other initiation factors or ribosomes.
May 28, 2025 at 10:01 PM
Found FMRP directly interacts w eIF4E, but not other initiation factors or ribosomes.
contributing to a prothrombotic state and microclot formation.
-The MAPK cascade is a key platelet signaling pathway affected by COVID . Upregulated phosphorylation of ERK1/2, p38, eIF4E, and JNK in platelets from severe COVID patients indicates extreme activation of MAPK signaling.
-The MAPK cascade is a key platelet signaling pathway affected by COVID . Upregulated phosphorylation of ERK1/2, p38, eIF4E, and JNK in platelets from severe COVID patients indicates extreme activation of MAPK signaling.
January 17, 2026 at 6:13 AM
contributing to a prothrombotic state and microclot formation.
-The MAPK cascade is a key platelet signaling pathway affected by COVID . Upregulated phosphorylation of ERK1/2, p38, eIF4E, and JNK in platelets from severe COVID patients indicates extreme activation of MAPK signaling.
-The MAPK cascade is a key platelet signaling pathway affected by COVID . Upregulated phosphorylation of ERK1/2, p38, eIF4E, and JNK in platelets from severe COVID patients indicates extreme activation of MAPK signaling.