Margo Le
@margole.bsky.social
New preprint! 🧠🐭🔬
Reward-predictive cues can bias action selection, but can they also influence the *rules* we use to complete a sequence of actions? sPRInT through this thread to find out!
www.biorxiv.org/content/10.6...
Reward-predictive cues can bias action selection, but can they also influence the *rules* we use to complete a sequence of actions? sPRInT through this thread to find out!
www.biorxiv.org/content/10.6...
Reward Memories Bias Instrumental Rule Selection via the Orbitofrontal-to-Secondary Motor cortex Pathway
Reward-predictive cues can influence decision-making and promote the pursuit of specific outcomes. This influence is classically studied using specific Pavlovian-to-instrumental transfer (sPIT), in wh...
www.biorxiv.org
September 4, 2026 at 10:18 PM
New preprint! 🧠🐭🔬
Reward-predictive cues can bias action selection, but can they also influence the *rules* we use to complete a sequence of actions? sPRInT through this thread to find out!
www.biorxiv.org/content/10.6...
Reward-predictive cues can bias action selection, but can they also influence the *rules* we use to complete a sequence of actions? sPRInT through this thread to find out!
www.biorxiv.org/content/10.6...
Reposted by Margo Le
Had fun working with @margole.bsky.social on this eLife Insight piece. Also check out the original paper by Zong et al. (Schoenbaum lab): elifesciences.org/articles/109...
Cocaine disrupts hidden states in the brain
Orbitofrontal Cortex: Cocaine disrupts hidden states in the brain
Cocaine use disrupts the encoding of abstract states in the orbitofrontal cortex.
buff.ly
April 23, 2026 at 7:49 PM
Had fun working with @margole.bsky.social on this eLife Insight piece. Also check out the original paper by Zong et al. (Schoenbaum lab): elifesciences.org/articles/109...
Reposted by Margo Le
Excited to share our new publication, out today in @currentbiology.bsky.social . Project lead by the amazing @sophiepeterson.bsky.social
🧠 🔬🐀
www.cell.com/current-biol...
🧠 🔬🐀
www.cell.com/current-biol...
Partially dissociable roles of the orbitofrontal cortex and dorsal hippocampus in context-dependent hierarchical associations
Animals use contextual information to interpret ambiguous cues. Using chemogenetic
silencing in rats, Peterson et al. show that the orbitofrontal cortex and dorsal hippocampus
are both involved in thi...
www.cell.com
November 20, 2024 at 11:34 PM
Excited to share our new publication, out today in @currentbiology.bsky.social . Project lead by the amazing @sophiepeterson.bsky.social
🧠 🔬🐀
www.cell.com/current-biol...
🧠 🔬🐀
www.cell.com/current-biol...