Maria Fernanda P Fialho
@mariafialho.bsky.social
MSc and PhD in Biochemistry from the Federal University of Santa Maria - Pain Research Group (Brazil). Currently, I am Post Doctoral Associate at Bunnett Lab (Pain Research Center - New York University).
Reposted by Maria Fernanda P Fialho
Fialho et al. find that neuropilin-1 drives nerve growth factor-dependent sensitization in trigeminal nociceptors and oral cancer pain. Targeting neuropilin-1 blocks tumor-derived algogens, offering a safer, nonopioid therapeutic strategy #PAIN bit.ly/4wCwhzq
September 16, 2026 at 12:02 PM
Fialho et al. find that neuropilin-1 drives nerve growth factor-dependent sensitization in trigeminal nociceptors and oral cancer pain. Targeting neuropilin-1 blocks tumor-derived algogens, offering a safer, nonopioid therapeutic strategy #PAIN bit.ly/4wCwhzq
Reposted by Maria Fernanda P Fialho
NEW PRC PAPER 🚨: The Bunnett lab identified Neuropilin-1 (NRP1) as a key mediator of NGF signaling driving oral cancer pain. Targeting NRP1 disrupts NGF/TrkA signaling, reduces nociceptor sensitization, and alleviates pain without directly blocking NGF!
buff.ly/NmyrTLy
buff.ly/NmyrTLy
July 6, 2026 at 1:15 PM
NEW PRC PAPER 🚨: The Bunnett lab identified Neuropilin-1 (NRP1) as a key mediator of NGF signaling driving oral cancer pain. Targeting NRP1 disrupts NGF/TrkA signaling, reduces nociceptor sensitization, and alleviates pain without directly blocking NGF!
buff.ly/NmyrTLy
buff.ly/NmyrTLy
Reposted by Maria Fernanda P Fialho
📣Excited to share our new preprint!
We identify synaptic vesicle endocytosis in nociceptors as a key driver of ongoing pain, and show that LNP‑delivered CRISPR/dCas9 repression of this pathway produces durable analgesia across multiple pain models.
www.biorxiv.org/content/10.6...
We identify synaptic vesicle endocytosis in nociceptors as a key driver of ongoing pain, and show that LNP‑delivered CRISPR/dCas9 repression of this pathway produces durable analgesia across multiple pain models.
www.biorxiv.org/content/10.6...
Targeting Synaptic Vesicle Endocytosis in Nociceptors Provides Sustained Pain Relief
Endocytosis replenishes synaptic vesicle (SV) pools that are required for persistent transmission of chronic pain signals within nociceptive spinal circuits. The nociceptor-specific contribution of SV...
www.biorxiv.org
June 23, 2026 at 1:37 PM
📣Excited to share our new preprint!
We identify synaptic vesicle endocytosis in nociceptors as a key driver of ongoing pain, and show that LNP‑delivered CRISPR/dCas9 repression of this pathway produces durable analgesia across multiple pain models.
www.biorxiv.org/content/10.6...
We identify synaptic vesicle endocytosis in nociceptors as a key driver of ongoing pain, and show that LNP‑delivered CRISPR/dCas9 repression of this pathway produces durable analgesia across multiple pain models.
www.biorxiv.org/content/10.6...
Reposted by Maria Fernanda P Fialho
Amazing day so far at the PRC symposium! So much exciting science from our research community and awesome keynote speakers. @karapedsgastrodoc.bsky.social @jimr-1.bsky.social @sarahanajjar.bsky.social @tonelloraquel.bsky.social @elisadamo.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social
May 28, 2026 at 7:29 PM
Amazing day so far at the PRC symposium! So much exciting science from our research community and awesome keynote speakers. @karapedsgastrodoc.bsky.social @jimr-1.bsky.social @sarahanajjar.bsky.social @tonelloraquel.bsky.social @elisadamo.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social
Reposted by Maria Fernanda P Fialho
📢🔬Check out our latest study on the specific role of endocytic mediators in pain-related synaptic transmission, now out in PAIN. @mariafialho.bsky.social #PainResearch #Neuroscience #SynapticTransmission
Fialho et al. find that synaptojanin 1, endophilin A1, dynamin 1, and adaptor-associated protein kinase-1 mediate synaptic vesicle recycling and neurotransmission in nociceptive circuits in the spinal cord. Learn more in #PAIN bit.ly/3WIf08B
November 13, 2025 at 6:53 PM
📢🔬Check out our latest study on the specific role of endocytic mediators in pain-related synaptic transmission, now out in PAIN. @mariafialho.bsky.social #PainResearch #Neuroscience #SynapticTransmission
My first postdoc paper published 🎉🥳, and Raquel’s first as first senior author! Happy to be part of this! @nyupainresearch.bsky.social @tonelloraquel.bsky.social
Excited to share my first senior author paper in Pain! 🎉 We identify Synaptojanin 1 & Endophilin A1 as key endocytic mediators of nociception. Silencing them blocks spinal synaptic transmission and relieves pain in cancer & postoperative models, without affecting normal behavior.
buff.ly/caKMGY3
buff.ly/caKMGY3
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June 11, 2025 at 7:52 PM
My first postdoc paper published 🎉🥳, and Raquel’s first as first senior author! Happy to be part of this! @nyupainresearch.bsky.social @tonelloraquel.bsky.social
Reposted by Maria Fernanda P Fialho
Kicked off the USASP meeting last night with a mega pretzel at the NYU Pain Research Center dinner. Great start to a great week!
#USASP2025 #PainResearch #NYUPRC #NetworkingAndPretzels
#USASP2025 #PainResearch #NYUPRC #NetworkingAndPretzels
April 30, 2025 at 2:44 PM
Kicked off the USASP meeting last night with a mega pretzel at the NYU Pain Research Center dinner. Great start to a great week!
#USASP2025 #PainResearch #NYUPRC #NetworkingAndPretzels
#USASP2025 #PainResearch #NYUPRC #NetworkingAndPretzels
Reposted by Maria Fernanda P Fialho
@nyupainresearch.bsky.social Shoutout 📢 to The NYU Molecular Pathobiology for #hosting an amazing tea time #Mardi #Gras style! #Brazil #Zamba #Turnupthursdays #Happymardigras 🪅🎉🎊🪩💃🕺🏼 #NYUDental #newyorkuniversity
March 6, 2025 at 10:36 PM
@nyupainresearch.bsky.social Shoutout 📢 to The NYU Molecular Pathobiology for #hosting an amazing tea time #Mardi #Gras style! #Brazil #Zamba #Turnupthursdays #Happymardigras 🪅🎉🎊🪩💃🕺🏼 #NYUDental #newyorkuniversity
Reposted by Maria Fernanda P Fialho
A non-opioid alternative in the treatment of chronic pain!
Chloe J. Peach @tonelloraquel.bsky.social & team discover inhibition of Neuropilin-1 suppresses NGF-evoked pain in preclinical models: https://www.jci.org/articles/view/183873
Chloe J. Peach @tonelloraquel.bsky.social & team discover inhibition of Neuropilin-1 suppresses NGF-evoked pain in preclinical models: https://www.jci.org/articles/view/183873
February 20, 2025 at 2:31 PM
A non-opioid alternative in the treatment of chronic pain!
Chloe J. Peach @tonelloraquel.bsky.social & team discover inhibition of Neuropilin-1 suppresses NGF-evoked pain in preclinical models: https://www.jci.org/articles/view/183873
Chloe J. Peach @tonelloraquel.bsky.social & team discover inhibition of Neuropilin-1 suppresses NGF-evoked pain in preclinical models: https://www.jci.org/articles/view/183873
Reposted by Maria Fernanda P Fialho
@tedpricethepainguy.bsky.social @utdpaincenter.bsky.social Great visit today from Dr. Ted Price! Thank you for wowing us with your team’s exciting data on human DRG tissue, very inspiring and insightful seminar! #painresearch #dorsalrootganglia #humanDRG #nyudental #nyuniversity #nyupainresearch
February 19, 2025 at 6:53 PM
@tedpricethepainguy.bsky.social @utdpaincenter.bsky.social Great visit today from Dr. Ted Price! Thank you for wowing us with your team’s exciting data on human DRG tissue, very inspiring and insightful seminar! #painresearch #dorsalrootganglia #humanDRG #nyudental #nyuniversity #nyupainresearch