Phillip Grote
@phillipgrote.bsky.social
Scientist, mostly interested in genetics, lncRNAs and .... well, in everything that I deem relevant. (he/him), find me at https://georg-speyer-haus.de/en/
Reposted by Phillip Grote
🎉 TT2026 is officially underway!
What a fantastic start to TT2026 Meeting in Leiden!
It’s been a busy few days of insightful talks, great discussions, networking and plenty of opportunities to catch up with colleagues from around the world.
We’re looking forward to an exciting few more days!
What a fantastic start to TT2026 Meeting in Leiden!
It’s been a busy few days of insightful talks, great discussions, networking and plenty of opportunities to catch up with colleagues from around the world.
We’re looking forward to an exciting few more days!
September 16, 2026 at 10:04 AM
🎉 TT2026 is officially underway!
What a fantastic start to TT2026 Meeting in Leiden!
It’s been a busy few days of insightful talks, great discussions, networking and plenty of opportunities to catch up with colleagues from around the world.
We’re looking forward to an exciting few more days!
What a fantastic start to TT2026 Meeting in Leiden!
It’s been a busy few days of insightful talks, great discussions, networking and plenty of opportunities to catch up with colleagues from around the world.
We’re looking forward to an exciting few more days!
Reposted by Phillip Grote
Now online! 4D spatiotemporal landscape of mitochondrial phenotypes across cellular states unlocked through representation learning
4D spatiotemporal landscape of mitochondrial phenotypes across cellular states unlocked through representation learning
Agarwal et al. introduce MitoSpace, a self-supervised model trained on 4D lattice light-sheet microscopy data. The model resolves drug-induced mitochondrial phenotypes without labels, predicts membrane potential from morphology and dynamics, generalizes to unseen perturbations and lung organoids, and shows that representation quality improves progressively from 2D to 4D.
dlvr.it
September 10, 2026 at 6:51 PM
Now online! 4D spatiotemporal landscape of mitochondrial phenotypes across cellular states unlocked through representation learning
Reposted by Phillip Grote
"It will not be the tyrants in pretty costumes, but our daughters and sons who will suffer and perish in the trenches of hatred and war. If we did not learn that from history and recent events, we will relearn it from experience." Anonymous
September 8, 2026 at 5:27 AM
"It will not be the tyrants in pretty costumes, but our daughters and sons who will suffer and perish in the trenches of hatred and war. If we did not learn that from history and recent events, we will relearn it from experience." Anonymous
Reposted by Phillip Grote
Join us in Frankfurt on 20 November 2026 for an exciting meeting on spatial RNA regulation!
Exciting topics, a fantastic lineup of speakers, and free registration 👇
Exciting topics, a fantastic lineup of speakers, and free registration 👇
Drop your pipettes; we have an exciting meeting for you
**The Spatial Logic of RNA in Health and Disease**
When: 20.11.2026
Venue : Goethe University Frankfurt, Niederrad Campus, Haus 22, H22-1
Participation is free, but registration is required.
Registration
bit.ly/4gaXOBL
🫶Spread the word
**The Spatial Logic of RNA in Health and Disease**
When: 20.11.2026
Venue : Goethe University Frankfurt, Niederrad Campus, Haus 22, H22-1
Participation is free, but registration is required.
Registration
bit.ly/4gaXOBL
🫶Spread the word
September 1, 2026 at 9:17 PM
Join us in Frankfurt on 20 November 2026 for an exciting meeting on spatial RNA regulation!
Exciting topics, a fantastic lineup of speakers, and free registration 👇
Exciting topics, a fantastic lineup of speakers, and free registration 👇
Reposted by Phillip Grote
Reposted by Phillip Grote
Ever wondered why snake embryos coil?🐍
A beautifully simple question with a fascinating answer: a growth mismatch between body & gut shapes the coil
Our study from @helsinki-biotech.bsky.social @helsinki.fi with T. Miyashita & R.E. Diaz in @currentbiology.bsky.social
www.cell.com/current-biol...
A beautifully simple question with a fascinating answer: a growth mismatch between body & gut shapes the coil
Our study from @helsinki-biotech.bsky.social @helsinki.fi with T. Miyashita & R.E. Diaz in @currentbiology.bsky.social
www.cell.com/current-biol...
How snake embryos coil
Snake embryos coil, but how and why they corkscrew remains unexplored. Weber et al.
find that the embryos wind up clockwise via buckling of the rapidly elongating axial
body against the slow-growing, ...
www.cell.com
August 31, 2026 at 3:47 PM
Ever wondered why snake embryos coil?🐍
A beautifully simple question with a fascinating answer: a growth mismatch between body & gut shapes the coil
Our study from @helsinki-biotech.bsky.social @helsinki.fi with T. Miyashita & R.E. Diaz in @currentbiology.bsky.social
www.cell.com/current-biol...
A beautifully simple question with a fascinating answer: a growth mismatch between body & gut shapes the coil
Our study from @helsinki-biotech.bsky.social @helsinki.fi with T. Miyashita & R.E. Diaz in @currentbiology.bsky.social
www.cell.com/current-biol...
Reposted by Phillip Grote
Q: What is the only known planet in the Universe to be inhabited entirely by Alien Robots?
A: Mars.
A: Mars.
June 29, 2026 at 9:10 AM
Q: What is the only known planet in the Universe to be inhabited entirely by Alien Robots?
A: Mars.
A: Mars.
Reposted by Phillip Grote
#Splicing dysfunction may represent a cryptic form of #genome erosion. This study shows that intron retention freq is much higher in #recombination -suppressed #MatingType regions in 4 #phytoplankton species, producing aberrant transcripts & functional decay @plosbiology.org 🧪 plos.io/44vbDFI
June 29, 2026 at 7:55 AM
#Splicing dysfunction may represent a cryptic form of #genome erosion. This study shows that intron retention freq is much higher in #recombination -suppressed #MatingType regions in 4 #phytoplankton species, producing aberrant transcripts & functional decay @plosbiology.org 🧪 plos.io/44vbDFI
Reposted by Phillip Grote
Die AfD ist verfassungswidrig und könnte verboten werden – das ist das Ergebnis unseres umfassenden Rechtsgutachtens.
Ein Grund dafür: Die AfD will politische Gegner\*innen unterdrücken. 🧵
Ein Grund dafür: Die AfD will politische Gegner\*innen unterdrücken. 🧵
June 26, 2026 at 6:11 AM
Die AfD ist verfassungswidrig und könnte verboten werden – das ist das Ergebnis unseres umfassenden Rechtsgutachtens.
Ein Grund dafür: Die AfD will politische Gegner\*innen unterdrücken. 🧵
Ein Grund dafür: Die AfD will politische Gegner\*innen unterdrücken. 🧵
Reposted by Phillip Grote
"Sie ist wieder da - die Debatte um ein Verbotsverfahren gegen die AfD. Anlass ist ein Gutachten, das zu dem Schluss kommt: Die Partei ist klar verfassungsfeindlich."
www.zdfheute.de/politik/afd-...
www.zdfheute.de/politik/afd-...
AfD-Verbotsverfahren: Gutachten löst eine neue Debatte aus
Sie ist wieder da - die Debatte um ein Verbotsverfahren gegen die AfD. Anlass ist ein Gutachten, das die AfD als verfassungsfeindlich einstuft.
www.zdfheute.de
June 25, 2026 at 3:32 PM
"Sie ist wieder da - die Debatte um ein Verbotsverfahren gegen die AfD. Anlass ist ein Gutachten, das zu dem Schluss kommt: Die Partei ist klar verfassungsfeindlich."
www.zdfheute.de/politik/afd-...
www.zdfheute.de/politik/afd-...
Reposted by Phillip Grote
Interested in hearing about mechanisms of cohesin-dependent vs. -independent enhancer regulation?
@karissalhansen.bsky.social will be presenting her work
**Tues June 23rd 8am CET**
www.biorxiv.org/content/10.6...
www.science.org/doi/10.1126/...
Thank you @genome-org-aus.bsky.social !
👇
@karissalhansen.bsky.social will be presenting her work
**Tues June 23rd 8am CET**
www.biorxiv.org/content/10.6...
www.science.org/doi/10.1126/...
Thank you @genome-org-aus.bsky.social !
👇
Only one week to go until our next GOA seminar! @karissalhansen.bsky.social will present here work on the mechanisms of long-range enhancer-promoter communication.
Registration link: unimelb.zoom.us/webinar/regi...
Registration link: unimelb.zoom.us/webinar/regi...
June 16, 2026 at 11:09 AM
Interested in hearing about mechanisms of cohesin-dependent vs. -independent enhancer regulation?
@karissalhansen.bsky.social will be presenting her work
**Tues June 23rd 8am CET**
www.biorxiv.org/content/10.6...
www.science.org/doi/10.1126/...
Thank you @genome-org-aus.bsky.social !
👇
@karissalhansen.bsky.social will be presenting her work
**Tues June 23rd 8am CET**
www.biorxiv.org/content/10.6...
www.science.org/doi/10.1126/...
Thank you @genome-org-aus.bsky.social !
👇
Reposted by Phillip Grote
Exciting breakthrough technology from the lab, now live in
@cellcellpress.bsky.social
! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
@cellcellpress.bsky.social
! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
June 4, 2026 at 3:50 PM
Exciting breakthrough technology from the lab, now live in
@cellcellpress.bsky.social
! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
@cellcellpress.bsky.social
! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
Reposted by Phillip Grote
June 9, 2026 at 5:29 PM
Reposted by Phillip Grote
Finally out in @Cellcellpress!
Proteins with long IDRs are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
www.cell.com/cell/fulltex...
Proteins with long IDRs are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
www.cell.com/cell/fulltex...
mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically
disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis
of fully active proteins.
www.cell.com
June 9, 2026 at 7:39 AM
Reposted by Phillip Grote
Hi everyone!
I am a PhD student in virology and I built a completely free iOS app in my free time.
Please try it, any feedback is welcome!
A repost would help more scientists see it. 📱
apps.apple.com/us/app/cell-...
#Biology #PhD #AcademicSky #scicomm #virology #LabLife
I am a PhD student in virology and I built a completely free iOS app in my free time.
Please try it, any feedback is welcome!
A repost would help more scientists see it. 📱
apps.apple.com/us/app/cell-...
#Biology #PhD #AcademicSky #scicomm #virology #LabLife
Cell Culture and Lab Assistant App - App Store
Download Cell Culture and Lab Assistant by Umut Tank on the App Store. See screenshots, ratings and reviews, user tips, and more apps like Cell Culture and Lab…
apps.apple.com
May 14, 2026 at 8:22 PM
Hi everyone!
I am a PhD student in virology and I built a completely free iOS app in my free time.
Please try it, any feedback is welcome!
A repost would help more scientists see it. 📱
apps.apple.com/us/app/cell-...
#Biology #PhD #AcademicSky #scicomm #virology #LabLife
I am a PhD student in virology and I built a completely free iOS app in my free time.
Please try it, any feedback is welcome!
A repost would help more scientists see it. 📱
apps.apple.com/us/app/cell-...
#Biology #PhD #AcademicSky #scicomm #virology #LabLife
Reposted by Phillip Grote
Seminar Alert:
*Prof. Elena Conti*
'RNA exosome complex: Molecular Mechanisms of RNA degradation in health and disease'
When: 18.06.2026, 14:00
Where: Haus 22-1 (lecture hall H22-1), Neiderad Campus (Uni KliniK), Goethe University
RT🙏
@scale-cluster-ffm.bsky.social @goetheuni.bsky.social
*Prof. Elena Conti*
'RNA exosome complex: Molecular Mechanisms of RNA degradation in health and disease'
When: 18.06.2026, 14:00
Where: Haus 22-1 (lecture hall H22-1), Neiderad Campus (Uni KliniK), Goethe University
RT🙏
@scale-cluster-ffm.bsky.social @goetheuni.bsky.social
May 28, 2026 at 6:20 AM
Seminar Alert:
*Prof. Elena Conti*
'RNA exosome complex: Molecular Mechanisms of RNA degradation in health and disease'
When: 18.06.2026, 14:00
Where: Haus 22-1 (lecture hall H22-1), Neiderad Campus (Uni KliniK), Goethe University
RT🙏
@scale-cluster-ffm.bsky.social @goetheuni.bsky.social
*Prof. Elena Conti*
'RNA exosome complex: Molecular Mechanisms of RNA degradation in health and disease'
When: 18.06.2026, 14:00
Where: Haus 22-1 (lecture hall H22-1), Neiderad Campus (Uni KliniK), Goethe University
RT🙏
@scale-cluster-ffm.bsky.social @goetheuni.bsky.social
Reposted by Phillip Grote
Super happy to see our work published in @nature.com last week 🤩 By combining whole-body tissue clearing, light-sheet microscopy and AI, we mapped obesity-associated remodeling across the entire mouse body in 3D at cellular resolution.
www.nature.com/articles/s41...
@erturklab.bsky.social
www.nature.com/articles/s41...
@erturklab.bsky.social
May 25, 2026 at 7:57 PM
Super happy to see our work published in @nature.com last week 🤩 By combining whole-body tissue clearing, light-sheet microscopy and AI, we mapped obesity-associated remodeling across the entire mouse body in 3D at cellular resolution.
www.nature.com/articles/s41...
@erturklab.bsky.social
www.nature.com/articles/s41...
@erturklab.bsky.social
Reposted by Phillip Grote
TWO WEEKS to go!!!!!
Submit your abstract for TT2026 today
#tt2026
#transgenic
#GEMM
tt2026.org/abstract-sub...
Submit your abstract for TT2026 today
#tt2026
#transgenic
#GEMM
tt2026.org/abstract-sub...
May 18, 2026 at 7:15 PM
TWO WEEKS to go!!!!!
Submit your abstract for TT2026 today
#tt2026
#transgenic
#GEMM
tt2026.org/abstract-sub...
Submit your abstract for TT2026 today
#tt2026
#transgenic
#GEMM
tt2026.org/abstract-sub...
Reposted by Phillip Grote
🚨 Excited to share a new paper in Cell! Human genetics led us to HOTSCRAMBL, a HOXA-locus lncRNA that regulates 🩸#stemcell self-renewal and HOXA9 splicing, with implications for AML.
Amazing work by @lvchosen1.bsky.social with many others!
www.cell.com/cell/fulltex...
Amazing work by @lvchosen1.bsky.social with many others!
www.cell.com/cell/fulltex...
May 1, 2026 at 7:05 PM
🚨 Excited to share a new paper in Cell! Human genetics led us to HOTSCRAMBL, a HOXA-locus lncRNA that regulates 🩸#stemcell self-renewal and HOXA9 splicing, with implications for AML.
Amazing work by @lvchosen1.bsky.social with many others!
www.cell.com/cell/fulltex...
Amazing work by @lvchosen1.bsky.social with many others!
www.cell.com/cell/fulltex...
Reposted by Phillip Grote
The authors of a Comment artcle in Nature outline four key aspects of the drug development and approval process that need updating to make the production of personalized CRISPR therapies economically viable. #medsky 🧬🧪
Personalized CRISPR therapies could soon reach thousands — here’s how
A fresh approach to trialling treatments for rare genetic diseases could make their production an economically viable prospect at last.
go.nature.com
April 28, 2026 at 7:09 PM
The authors of a Comment artcle in Nature outline four key aspects of the drug development and approval process that need updating to make the production of personalized CRISPR therapies economically viable. #medsky 🧬🧪
Reposted by Phillip Grote
Transcription termination safeguards quiescent chromatin for faithful cell-cycle re-entry https://www.biorxiv.org/content/10.64898/2026.03.28.714970v1
March 30, 2026 at 6:34 PM
Transcription termination safeguards quiescent chromatin for faithful cell-cycle re-entry https://www.biorxiv.org/content/10.64898/2026.03.28.714970v1
A nice opportunity to repost some great work from Mary Lyon. Transmission Ratio Distortion in Mice - www.annualreviews.org/content/jour...
March 7, 2026 at 7:32 AM
A nice opportunity to repost some great work from Mary Lyon. Transmission Ratio Distortion in Mice - www.annualreviews.org/content/jour...
Reposted by Phillip Grote
If you want to explore ncRNA dynamics during mammalian development, love microscopy, and are not afaraid of transposons biology, apply‼️
We are looking for a postdoc to join our team at @imbavienna.bsky.social
More details 👇🏻
We are looking for a postdoc to join our team at @imbavienna.bsky.social
More details 👇🏻
We are hiring! Join the Jachowicz lab as a postdoctoral researcher. The project focuses on understanding the dynamics of ncRNAs using high-resolution and single-molecule microscopy approaches. Link below 👇
March 2, 2026 at 12:25 PM
If you want to explore ncRNA dynamics during mammalian development, love microscopy, and are not afaraid of transposons biology, apply‼️
We are looking for a postdoc to join our team at @imbavienna.bsky.social
More details 👇🏻
We are looking for a postdoc to join our team at @imbavienna.bsky.social
More details 👇🏻
Reposted by Phillip Grote
its amazing how chatgpt knows everything about subjects I know nothing about, but is wrong like 40% of the time in things im an expert on. not going to think about this any further
March 8, 2025 at 12:13 AM
its amazing how chatgpt knows everything about subjects I know nothing about, but is wrong like 40% of the time in things im an expert on. not going to think about this any further
Reposted by Phillip Grote
This is a fascinating paper that reveals defined and clear mechanism for a phenomenon that for some seemed unbelievable- the up regulation of genes paralogous to those with specific types of inactivating mutations. This is called transcriptional adaptation 1/ www.science.org/doi/10.1126/...
Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation
Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...
www.science.org
February 16, 2026 at 2:24 AM
This is a fascinating paper that reveals defined and clear mechanism for a phenomenon that for some seemed unbelievable- the up regulation of genes paralogous to those with specific types of inactivating mutations. This is called transcriptional adaptation 1/ www.science.org/doi/10.1126/...