SchottdorfLab
@schottdorflab.bsky.social
We are a quantitative behavioral neuroscience lab at the Department of Psychological & Brain Sciences at the University of Delaware. http://www.schottdorflab.com PI: Manuel Schottdorf
Reposted by SchottdorfLab
Thrilled to share this with the world! In this work led by Zihan Bai, we asked how episodic memory interacts with working memory and found evidence for a tight integration between the two systems. Zihan walks you through it in his thread 🧵🧠 🔥
Excited to share the first first-author preprint of my PhD at NYU with @s-michelmann.bsky.social andDaryl Fougnie. Using eye-tracking in a novel behavioral paradigm, we reveal the mechanisms by which episodic memory (EM) and working memory (WM) interact. 🧠
doi: doi.org/10.64898/202...
doi: doi.org/10.64898/202...
September 2, 2026 at 11:44 PM
Thrilled to share this with the world! In this work led by Zihan Bai, we asked how episodic memory interacts with working memory and found evidence for a tight integration between the two systems. Zihan walks you through it in his thread 🧵🧠 🔥
Reposted by SchottdorfLab
My behavioral neuroscience lab at Northeastern is looking to recruit two new research techs! Job description and link to apply is here: northeastern.wd1.myworkdayjobs.com/careers/job/...
Laboratory Technician - The Shansky Lab
About the Opportunity Job Summary The Shansky Lab is seeking a full-time technician to conduct National Institutes of Health (NIH)-funded behavioral neuroscience research. The position includes lab ma...
northeastern.wd1.myworkdayjobs.com
August 26, 2026 at 4:31 PM
My behavioral neuroscience lab at Northeastern is looking to recruit two new research techs! Job description and link to apply is here: northeastern.wd1.myworkdayjobs.com/careers/job/...
New preprint from the lab: We reproduced our 2p data in the accumulating towers task with e-phys and found low-dimensional neural manifolds in the frontal cortex that were aligned timepoint-by-timepoint with the hippocampus. www.biorxiv.org/content/10.6...
The geometry of knowledge in the hippocampal-prefrontal system
Decision making is associated with frontal brain circuits and spatial navigation with the hippocampus. In addition, recent work in spatial decision making tasks found single neurons in both areas enco...
www.biorxiv.org
August 25, 2026 at 5:09 PM
New preprint from the lab: We reproduced our 2p data in the accumulating towers task with e-phys and found low-dimensional neural manifolds in the frontal cortex that were aligned timepoint-by-timepoint with the hippocampus. www.biorxiv.org/content/10.6...
Reposted by SchottdorfLab
My main postdoc work is now published: www.nature.com/articles/s41...! We (myself, Isabel Low, Frances Cho, and @lgiocomo.bsky.social) discovered task-relevant remote representations in entorhinal cortex independent of CA1. #paperthread below! 1/13
Entorhinal cortex represents task-relevant remote locations independently of CA1 - Nature Neuroscience
Neurons in medial entorhinal cortex collectively represent discrete nonlocal positions during immobility. During this nonlocal coding, CA1 is uncoupled from entorhinal cortex. These representations ar...
www.nature.com
April 1, 2026 at 2:50 PM
My main postdoc work is now published: www.nature.com/articles/s41...! We (myself, Isabel Low, Frances Cho, and @lgiocomo.bsky.social) discovered task-relevant remote representations in entorhinal cortex independent of CA1. #paperthread below! 1/13
Reposted by SchottdorfLab
Our latest publication grapples with how the brain could implement gradient descent by sending learning targets top-down, gating plasticity with dendritic inhibition, and updating synaptic weights with biologically observed learning rules like BTSP.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
March 27, 2026 at 10:29 AM
Our latest publication grapples with how the brain could implement gradient descent by sending learning targets top-down, gating plasticity with dendritic inhibition, and updating synaptic weights with biologically observed learning rules like BTSP.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by SchottdorfLab
“Facilitatory surrounds resembled naturalistic continuations of the optimal center stimulus”
Excellent: this physiology data supports our recent finding using patterned stimulation—together suggesting that visual cortex neurons go beyond the classical RF and reflect the structure of natural vision.
Excellent: this physiology data supports our recent finding using patterned stimulation—together suggesting that visual cortex neurons go beyond the classical RF and reflect the structure of natural vision.
March 27, 2026 at 1:20 PM
“Facilitatory surrounds resembled naturalistic continuations of the optimal center stimulus”
Excellent: this physiology data supports our recent finding using patterned stimulation—together suggesting that visual cortex neurons go beyond the classical RF and reflect the structure of natural vision.
Excellent: this physiology data supports our recent finding using patterned stimulation—together suggesting that visual cortex neurons go beyond the classical RF and reflect the structure of natural vision.
Reposted by SchottdorfLab
First preprint from the lab! Using intracellular recordings & analysis of 2-photon imaging data, we show that spiking & neuromodulatory input during experience drive a reorganization of visuomotor inputs in V1 layer 2/3 neurons, consistent with enhanced visuomotor cancellation - bioRxiv link below.
March 5, 2026 at 9:06 AM
First preprint from the lab! Using intracellular recordings & analysis of 2-photon imaging data, we show that spiking & neuromodulatory input during experience drive a reorganization of visuomotor inputs in V1 layer 2/3 neurons, consistent with enhanced visuomotor cancellation - bioRxiv link below.
Reposted by SchottdorfLab
Two-photon calcium imaging at 24,000 lines/s, with the resonant axis spanning 4x what other systems can do. Inertia-free. Diffraction-limited. No tradeoffs. Che-Hang Yu developed a 4x angle multiplier for laser scanning. His paper is out today: opg.optica.org/optica/fullt... 1/n #fluorescenceFriday
February 27, 2026 at 8:16 PM
Two-photon calcium imaging at 24,000 lines/s, with the resonant axis spanning 4x what other systems can do. Inertia-free. Diffraction-limited. No tradeoffs. Che-Hang Yu developed a 4x angle multiplier for laser scanning. His paper is out today: opg.optica.org/optica/fullt... 1/n #fluorescenceFriday
Reposted by SchottdorfLab
DNN models of the brain are getting bigger. Are we replacing one complicated system in vivo with another in silico?
In new work, we seek the *smallest* DNN models of visual cortex, balancing prediction with parsimony.
It turns out these compact models are surprisingly small!
rdcu.be/e5H8G
In new work, we seek the *smallest* DNN models of visual cortex, balancing prediction with parsimony.
It turns out these compact models are surprisingly small!
rdcu.be/e5H8G
Compact deep neural network models of the visual cortex
Nature - Parsimonious deep neural network models can be used for prediction of visual neuron responses.
rdcu.be
February 26, 2026 at 10:32 PM
DNN models of the brain are getting bigger. Are we replacing one complicated system in vivo with another in silico?
In new work, we seek the *smallest* DNN models of visual cortex, balancing prediction with parsimony.
It turns out these compact models are surprisingly small!
rdcu.be/e5H8G
In new work, we seek the *smallest* DNN models of visual cortex, balancing prediction with parsimony.
It turns out these compact models are surprisingly small!
rdcu.be/e5H8G
Reposted by SchottdorfLab
hey team! I need advice! If there were theoretically an organization whose sole purpose was to systematically identify and break nuisance and stupid IP in the biomedical space, creating shareware equivalents, what would be the highest value targets? e.g., AAV serotypes, antibodies, CRISPR, 1/n
February 25, 2026 at 4:52 PM
hey team! I need advice! If there were theoretically an organization whose sole purpose was to systematically identify and break nuisance and stupid IP in the biomedical space, creating shareware equivalents, what would be the highest value targets? e.g., AAV serotypes, antibodies, CRISPR, 1/n
Reposted by SchottdorfLab
Interested in deep learning-based spike inference with Cascade? We re-implemented the code in Torch -previously in Tensorflow - for better compatibility.
Blog: gcamp6f.com/2026/02/17/c...
GitHub: github.com/PTRRupprecht...
Blog: gcamp6f.com/2026/02/17/c...
GitHub: github.com/PTRRupprecht...
CascadeTorch: a PyTorch version of Cascade for spike inference
I’m glad to share a PyTorch-based implementation of spike inference from calcium imaging data: CascadeTorch, now available on GitHub. The original Cascade repository remains fully supported. …
gcamp6f.com
February 17, 2026 at 3:17 PM
Interested in deep learning-based spike inference with Cascade? We re-implemented the code in Torch -previously in Tensorflow - for better compatibility.
Blog: gcamp6f.com/2026/02/17/c...
GitHub: github.com/PTRRupprecht...
Blog: gcamp6f.com/2026/02/17/c...
GitHub: github.com/PTRRupprecht...
Reposted by SchottdorfLab
Applications are now open for the summer school: 𝐌𝐚𝐭𝐡𝐞𝐦𝐚𝐭𝐢𝐜𝐚𝐥 𝐌𝐞𝐭𝐡𝐨𝐝𝐬 𝐢𝐧 𝐂𝐨𝐦𝐩𝐮𝐭𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐍𝐞𝐮𝐫𝐨𝐬𝐜𝐢𝐞𝐧𝐜𝐞
🧠 Apply before March 15: www.compneuronrsn.org
📍 Located in beautiful Eresfjord 🇳🇴
🗓️ Between July 6-24
Supported by the @kavlifoundation.org
In collaboration with @kavlintnu.bsky.social
🧠 Apply before March 15: www.compneuronrsn.org
📍 Located in beautiful Eresfjord 🇳🇴
🗓️ Between July 6-24
Supported by the @kavlifoundation.org
In collaboration with @kavlintnu.bsky.social
Mathematical Methods in Computational Neuroscience
Summer school in Eresfjord, Norway (July 8th - 26th, 2024)
www.compneuronrsn.org
February 17, 2026 at 10:22 PM
Applications are now open for the summer school: 𝐌𝐚𝐭𝐡𝐞𝐦𝐚𝐭𝐢𝐜𝐚𝐥 𝐌𝐞𝐭𝐡𝐨𝐝𝐬 𝐢𝐧 𝐂𝐨𝐦𝐩𝐮𝐭𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐍𝐞𝐮𝐫𝐨𝐬𝐜𝐢𝐞𝐧𝐜𝐞
🧠 Apply before March 15: www.compneuronrsn.org
📍 Located in beautiful Eresfjord 🇳🇴
🗓️ Between July 6-24
Supported by the @kavlifoundation.org
In collaboration with @kavlintnu.bsky.social
🧠 Apply before March 15: www.compneuronrsn.org
📍 Located in beautiful Eresfjord 🇳🇴
🗓️ Between July 6-24
Supported by the @kavlifoundation.org
In collaboration with @kavlintnu.bsky.social
Reposted by SchottdorfLab
@sebastianseung.bsky.social Did you follow through on your plan to visit Epstein island?
February 7, 2026 at 4:33 PM
@sebastianseung.bsky.social Did you follow through on your plan to visit Epstein island?
Reposted by SchottdorfLab
Here’s a trainee sticking their neck out to ask a fair and important question. Admiration! (And obviously, follow @juliecharlton.bsky.social).
Hey @eboyden3.bsky.social care to explain?
for fuck's sake
www.justice.gov/epstein/file...
www.justice.gov/epstein/file...
February 7, 2026 at 2:25 PM
Here’s a trainee sticking their neck out to ask a fair and important question. Admiration! (And obviously, follow @juliecharlton.bsky.social).
Reposted by SchottdorfLab
Hey @eboyden3.bsky.social care to explain?
February 7, 2026 at 1:28 PM
Hey @eboyden3.bsky.social care to explain?
Reposted by SchottdorfLab
New @pnas.org paper out 🎉
“Representational drift reflects ongoing balancing of stochastic changes by Hebbian learning”
👉 doi.org/10.1073/pnas...
What drives representational drift in neural populations? Here’s the short version. 👇
🧪🧠
1/5
“Representational drift reflects ongoing balancing of stochastic changes by Hebbian learning”
👉 doi.org/10.1073/pnas...
What drives representational drift in neural populations? Here’s the short version. 👇
🧪🧠
1/5
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
doi.org
February 3, 2026 at 5:37 PM
New @pnas.org paper out 🎉
“Representational drift reflects ongoing balancing of stochastic changes by Hebbian learning”
👉 doi.org/10.1073/pnas...
What drives representational drift in neural populations? Here’s the short version. 👇
🧪🧠
1/5
“Representational drift reflects ongoing balancing of stochastic changes by Hebbian learning”
👉 doi.org/10.1073/pnas...
What drives representational drift in neural populations? Here’s the short version. 👇
🧪🧠
1/5
Reposted by SchottdorfLab
🚨 New preprint!
Why do some insights from spikes translate to field potentials while others don't? In this paper we compare visual memory representations in spikes and LFPs to propose a general framework that answers this question.
www.biorxiv.org/content/10.6...
🧵 (1/10)
🧠🟦 🧠💻
Why do some insights from spikes translate to field potentials while others don't? In this paper we compare visual memory representations in spikes and LFPs to propose a general framework that answers this question.
www.biorxiv.org/content/10.6...
🧵 (1/10)
🧠🟦 🧠💻
Neural representations of visual memory in inferotemporal cortex reveal a generalizable framework for translating between spikes and field potentials
Translating neurophysiological findings requires understanding the relationship between common measures of brain activity in animals (spiking activity) and humans (local field potentials, LFP). Prior ...
www.biorxiv.org
January 5, 2026 at 3:21 PM
🚨 New preprint!
Why do some insights from spikes translate to field potentials while others don't? In this paper we compare visual memory representations in spikes and LFPs to propose a general framework that answers this question.
www.biorxiv.org/content/10.6...
🧵 (1/10)
🧠🟦 🧠💻
Why do some insights from spikes translate to field potentials while others don't? In this paper we compare visual memory representations in spikes and LFPs to propose a general framework that answers this question.
www.biorxiv.org/content/10.6...
🧵 (1/10)
🧠🟦 🧠💻
Reposted by SchottdorfLab
With Masashi launching his new lab, we’ll be recruiting a new postdoc in the Oldenburg Lab.
Work: high-precision multiphoton holography, neural coding, motor cortex circuits, all-optical physiology.
If you’re interested, just reach out.
Work: high-precision multiphoton holography, neural coding, motor cortex circuits, all-optical physiology.
If you’re interested, just reach out.
December 1, 2025 at 2:38 PM
With Masashi launching his new lab, we’ll be recruiting a new postdoc in the Oldenburg Lab.
Work: high-precision multiphoton holography, neural coding, motor cortex circuits, all-optical physiology.
If you’re interested, just reach out.
Work: high-precision multiphoton holography, neural coding, motor cortex circuits, all-optical physiology.
If you’re interested, just reach out.
Reposted by SchottdorfLab
Proud to share that my first postdoc, Masashi Hasegawa, will be starting his own lab as a Chica and Heinz Schaller Research Group Leader at Heidelberg University! He’ll be continuing our holography-based work on cortical circuits. Phenomenal scientist, even better human.
December 1, 2025 at 2:37 PM
Proud to share that my first postdoc, Masashi Hasegawa, will be starting his own lab as a Chica and Heinz Schaller Research Group Leader at Heidelberg University! He’ll be continuing our holography-based work on cortical circuits. Phenomenal scientist, even better human.
*Fully funded PhD student positions available to discover what changes in 🧠 when we learn something new.*
You think virtual reality + laser scanning microscopy are cool? You like 💻 and 🐭? Come join us!
Apply either through
www.udel.edu/academics/co...
or
www.udel.edu/academics/co...
You think virtual reality + laser scanning microscopy are cool? You like 💻 and 🐭? Come join us!
Apply either through
www.udel.edu/academics/co...
or
www.udel.edu/academics/co...
December 1, 2025 at 11:02 PM
*Fully funded PhD student positions available to discover what changes in 🧠 when we learn something new.*
You think virtual reality + laser scanning microscopy are cool? You like 💻 and 🐭? Come join us!
Apply either through
www.udel.edu/academics/co...
or
www.udel.edu/academics/co...
You think virtual reality + laser scanning microscopy are cool? You like 💻 and 🐭? Come join us!
Apply either through
www.udel.edu/academics/co...
or
www.udel.edu/academics/co...
Reposted by SchottdorfLab
Our work with @pawa-pawa.bsky.social is out in Nature Machine Intelligence! The choice of activation function affects the representations, dynamics, and circuit solutions that emerge in RNNs trained on cognitive tasks. Activation matters!
www.nature.com/articles/s42...
www.nature.com/articles/s42...
October 24, 2025 at 7:18 PM
Our work with @pawa-pawa.bsky.social is out in Nature Machine Intelligence! The choice of activation function affects the representations, dynamics, and circuit solutions that emerge in RNNs trained on cognitive tasks. Activation matters!
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by SchottdorfLab
Excited to share more widely: I am starting the Dorkenwald Lab at MIT (McGovern Institute + BCS) in January 2026. We study the organizational principles of neuronal circuits using connectomics.
And we are hiring postdocs & tech associates! dorkenwaldlab.com/join
And we are hiring postdocs & tech associates! dorkenwaldlab.com/join
MIT’s McGovern Institute and Department of Brain and Cognitive Sciences welcome new faculty member Sven Dorkenwald - MIT McGovern Institute
The McGovern Institute and the Department of Brain and Cognitive Sciences are pleased to announce the appointment of Sven Dorkenwald as an assistant professor starting in January 2026. A trailblazer i...
mcgovern.mit.edu
October 15, 2025 at 4:57 PM
Excited to share more widely: I am starting the Dorkenwald Lab at MIT (McGovern Institute + BCS) in January 2026. We study the organizational principles of neuronal circuits using connectomics.
And we are hiring postdocs & tech associates! dorkenwaldlab.com/join
And we are hiring postdocs & tech associates! dorkenwaldlab.com/join
Reposted by SchottdorfLab
Even colleagues who should know better are claiming that we are halting animal research. No, we're not. Now this NYT opinion piece appears (gift link) www.nytimes.com/2025/10/08/o... You can't just move everything to cell culture, organoids, and computers. Even this NYT piece admits that. 1/3
October 9, 2025 at 6:43 PM
Even colleagues who should know better are claiming that we are halting animal research. No, we're not. Now this NYT opinion piece appears (gift link) www.nytimes.com/2025/10/08/o... You can't just move everything to cell culture, organoids, and computers. Even this NYT piece admits that. 1/3
Reposted by SchottdorfLab
🚨Our NeurIPS 2025 competition Mouse vs. AI is LIVE!
We combine a visual navigation task + large-scale mouse neural data to test what makes visual RL agents robust and brain-like.
Top teams: featured at NeurIPS + co-author our summary paper. Join the challenge!
Whitepaper: arxiv.org/abs/2509.14446
We combine a visual navigation task + large-scale mouse neural data to test what makes visual RL agents robust and brain-like.
Top teams: featured at NeurIPS + co-author our summary paper. Join the challenge!
Whitepaper: arxiv.org/abs/2509.14446
Mouse vs. AI: A Neuroethological Benchmark for Visual Robustness and Neural Alignment
Visual robustness under real-world conditions remains a critical bottleneck for modern reinforcement learning agents. In contrast, biological systems such as mice show remarkable resilience to environ...
arxiv.org
September 22, 2025 at 11:13 PM
🚨Our NeurIPS 2025 competition Mouse vs. AI is LIVE!
We combine a visual navigation task + large-scale mouse neural data to test what makes visual RL agents robust and brain-like.
Top teams: featured at NeurIPS + co-author our summary paper. Join the challenge!
Whitepaper: arxiv.org/abs/2509.14446
We combine a visual navigation task + large-scale mouse neural data to test what makes visual RL agents robust and brain-like.
Top teams: featured at NeurIPS + co-author our summary paper. Join the challenge!
Whitepaper: arxiv.org/abs/2509.14446
From the popular series "Figures that look like Kraftwerk Albums". Fig. 3 in Georgopoulos et al. Science 1986. Contributions of individual neurons to a shared coding direction in state space — pubmed.ncbi.nlm.nih.gov/3749885/
October 3, 2025 at 1:38 PM
From the popular series "Figures that look like Kraftwerk Albums". Fig. 3 in Georgopoulos et al. Science 1986. Contributions of individual neurons to a shared coding direction in state space — pubmed.ncbi.nlm.nih.gov/3749885/