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SFB1361
@sfb1361.bsky.social
SFB1361 "Regulation of DNA Repair and Genome Stability"

Imprint: https://sfb1361.de/imprint
#SFB1361 postdocs, listen up! 🛣️

We're celebrating the Postdoc Appreciation Week 2026 with the event: "Research road bumps? You are not alone."

Come and join us on Tue, 22 Sep, 10-12h at IMB Mainz.

Register here: www.imb.de/seminars-mee...
September 15, 2026 at 12:16 PM
Publication alert!! 📑

Happy to share the Krämer lab's new paper titled:

"Mitochondrial checkpoint for interferon responses in macrophages."

🔎Read it here: www.explorationpub.com/Journals/eta...
September 15, 2026 at 11:55 AM
Congratulations to @reuterlm.bsky.social on his next publication! Excited to read more! 🎉
Happy to share a new review article from our group: “Timing the origin: chromatin, transcription, and the spatiotemporal control of eukaryotic DNA replication”.
I’m proud to see how the work of several students in my group has come together in this article.
@imbmainz.bsky.social @sfb1361.bsky.social
www.degruyterbrill.com
August 20, 2026 at 2:21 PM
Publication alert!! 📑

Happy to share the Luck lab's latest work covering

"Variant characterization in the intrinsically disordered human proteome"

🔎Check out the details: www.nature.com/articles/s41...
August 12, 2026 at 12:45 PM
Just published: New paper by our associated member, Dr Maximilian Reuter! 📃🧬

The article explores mechanisms of MCM2–7 helicase activation and initial DNA melting at near base-pair resolution.

🔎Find out more: www.nature.com/articles/s41...

Amazing work - Congratulations! 🎊🎉
July 24, 2026 at 2:06 PM
New publication!! 📑

Congrats to the Krämer lab on their latest work:

"Identification of dual-targeting PROTACs for ataxia telangiectasia and RAD3-related and aurora kinase A as chemo-sensitizers for leukemia cells."

🔎Read the article here: www.sciencedirect.com/science/arti...
July 22, 2026 at 8:04 AM
Summer publication alert!! 📃☀️

Happy to share the Carell lab's latest work covering

"Increasing TET Expression and 5-Hydroxymethylcytosine Formation by a Carbocyclic 5-Aza-2′-deoxy-cytidine Antimetabolite"

🏊Dive into the details: doi.org/10.1002/anie...
#SFB1361
Increasing TET Expression and 5‐Hydroxymethylcytosine Formation by a Carbocyclic 5‐Aza‐2′‐deoxy‐cytidine Antimetabolite
The carbocyclic Decitabine analog (cAzadC) incorporates as an antimetabolite weakly into the genome of growing tumor cells, where it triggers a genome-wide demethylation and a surprisingly strong hyd....
doi.org
July 14, 2026 at 7:34 AM
#SFB1361 in action in Würzburg!🥼

Great to see the programmes unite to spark curiosity about DNA in young students!🧬
Today, researchers from @nucleate-cluster.bsky.social, TRR 319, @sfb1551.bsky.social, and @sfb1361.bsky.social visited a primary school in Würzburg to show the fascinating world of DNA! 🧬

Thanks to the great team from the König and @zarnack-group.bsky.social labs at @uni-wuerzburg.de! #MissionDNA
July 13, 2026 at 9:06 AM
New publication!! 📃

Happy to share the new review by the Cardoso lab (@cardosolab.bsky.social) covering

"Spatial organization and dynamics of genome replication: from forks to foci"

🔎Read it here: doi.org/10.1093/nar/...

Congratulations on the great work! 🎊
#SFB1361
New review in NAR!
We connect the two halves of the DNA replication field — single-cell microscopy and genome-wide sequencing to show how each method’s strengths build one picture: from DNA fibers → replication foci → origin & timing maps.
🔗 doi.org/10.1093/nar/gkag550
@narjournal.bsky.social
Spatial organization and dynamics of genome replication: from forks to foci
Abstract. Genome replication is without doubt the most complex and critical activity of all living cells. Any error may not only affect the cell itself but
doi.org
July 10, 2026 at 7:51 AM
Publication alert!! 📃

Congrats to the Krämer lab on their new publication titled

"Dual FLT3/MAPK14 Proteolysis-Targeting Chimera (PROTAC) Induces Potent Acute Myeloid Leukemia Cell Death"

🔎Find out more: doi.org/10.3390/ph19...
#SFB1361
July 8, 2026 at 8:06 AM
Reposted by SFB1361
Registration for the 18th RNase H meeting is open!

Join us at IMB Mainz from 04–06 November 2026 for the “RNase H 2026”, organized by 4R RTG and IMB Mainz. Don't miss this conference and register now via: 4r-rtg.de/rnase-h-2026/

#IMB #RNASEH2026 #4R-RTG
June 23, 2026 at 9:56 AM
Heartfelt congratulations to our SFB 1361 PI, Thomas Carell from LMU München (@lmu.de) on receiving an ERC Advanced Grant for his project "RFrag - Synthesis and Function of Non-Canonical RNA Fragments"! 🎉🎉

#ERCAdG #SFB1361 #Science
June 24, 2026 at 1:33 PM
📃Just published: New #SFB1361 article by the Krämer lab!

"Dual inhibition of PP2A and WEE1 induces apoptosis and mitotic catastrophe in cancer cells"

🔎Read the full paper here: www.sciencedirect.com/science/arti...
Dual inhibition of PP2A and WEE1 induces apoptosis and mitotic catastrophe in cancer cells
The serine/threonine phosphatase-2 (PP2A) controls mitogen-associated signaling and DNA replication. The WEE1 protein tyrosine kinase controls S phase…
www.sciencedirect.com
May 13, 2026 at 7:59 AM
Publication alert!!📃

Congrats to the Carell lab on their latest work!

The article focuses on structural and biochemical characterization of yeast Tcd enzymes installing the post-transcriptional modification ct6A in tRNA.

Find out more here: academic.oup.com/nar/article/...
Structural and biochemical characterization of yeast Tcd enzymes installing the post-transcriptional modification ct6A in tRNA
Abstract. Post-transcriptional modifications near the anticodon of transfer ribonucleic acids (tRNAs) ensure translation fidelity and accuracy. For instanc
academic.oup.com
May 13, 2026 at 7:53 AM
Huge thanks to everyone who joined our IMB & SFB 1361 conference in Mainz!🎊

“The Evil Within: Regulation and Repair of Endogenous DNA Damage” explored how cells detect, respond to & repair internal genetic threats.🧬

It was great seeing you all!
@imbmainz.bsky.social #ISC26DNArepair
April 23, 2026 at 12:07 PM
New publication!!📑

Congrats to the Hofmann lab on their new article exploring how Th17 cells require the DNA repair sensor xeroderma pigmentosum complementation Group C to control oxidative DNA damage in a murine model.

🔎Read more here: www.nature.com/articles/s41...
April 23, 2026 at 11:15 AM
Reposted by SFB1361
It was an absolute delight to attend the DNA damage and repair meeting at the SFB 1361 Conference.
Our students showcased their poster presentation and were thrilled to receive the prestigious best poster prize. Congratulations to all of them! 🎉
@imbmainz.bsky.social
March 19, 2026 at 1:59 PM
Publication alert!! 📃

Congratulations to the Hopfner lab (@hopfnerlab.bsky.social) on their new publication:

"Recognition and remodelling of nucleosomes and hexasomes by the human INO80 complex"

🔎Find out more here: doi.org/10.1093/nar/...
We are excited to share our latest cryo-EM study of the human INO80 remodeler, now featured as a Breakthrough article in NAR @narjournal.bsky.social Check it out here and a big shoutout to @priyanka-pdm.bsky.social and Manmohan et al. for their contributions! 🧬
March 31, 2026 at 12:00 PM
New publication!📃

Happy to share the new joint publication by our #SFB1361 PI's Julian Stingele (@jstingele.bsky.social) and Petra Beli,

covering how RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response.

Read more here: www.sciencedirect.com/science/arti...
RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response
Excessive RNA damage activates cellular stress responses, triggering cell death. However, pathways that negatively regulate RNA damage responses are l…
www.sciencedirect.com
March 31, 2026 at 11:50 AM
Reposted by SFB1361
IMB & SFB 1361 Conference 2026 taking place right now 🧬
#ISC26DNArepair
March 11, 2026 at 2:46 PM
New publication!!📑

Congrats to the Carell lab on their new paper:

"One-Step and universal Strategy for the Synthesis of Hypermodified Uracil Phosphoramidites acp3U and cmnm5U"

🔎Read more here: chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
February 16, 2026 at 12:54 PM
Publication alert!!📑

Congrats to the @dikiclab.bsky.social and Beli labs on their joint #SFB1361 publication, covering how DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic lethality.

🔎Read the paper here: www.science.org/doi/10.1126/...
February 16, 2026 at 12:49 PM
SFB 1361 member - Dr Andriana Kotini - will present a poster at "The Evil Within: Regulation and Repair of Endogenous DNA Damage" (IMB Mainz, 10-13 March 2026)👩‍🏫

Join us to connect, discuss and collaborate!
Details & registration: www.sfb1361.de/dnarepairconf2026

#SFB1361 #IMBMainz #ISC26DNArepair
February 2, 2026 at 10:57 AM
SFB 1361 member - Dr Natalie Schindler (@scientistwithheart.bsky.social) - shares a preview of her short talk at our upcoming conference 👩‍🏫

Dive into details at @imbmainz.bsky.social in Mainz this 10-13 March 2026!

Register now: www.sfb1361.de/dnarepairconf2026

#SFB1361 #IMBMainz #ISC26DNArepair
January 30, 2026 at 11:51 AM
Preprint alert!!📑

We're happy to share a new preprint from our associated member, Dr Maximilian Reuter (@reuterlm.bsky.social), on

"Mechanisms of MCM2-7 helicase activation and initial DNA melting at near base-pair resolution" 

🔎Read more here: www.biorxiv.org/content/10.6...
January 30, 2026 at 10:14 AM