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ssolo.bsky.social
ssolo.bsky.social
@ssolo.bsky.social
Physicist turned Evolutionary Biologist, Model-Based Evolutionary Genomics Research Unit @oistedu.bsky.social phylogenomics, HGT, somatic evolution (http://ssolo.bsky.social)
Pinned
Dating Bacteria is hard due to the lack of maxima. Assuming aerobes likely postdated the GOE gave us better resolved ages, but also surprised us, but not Dr Dayhoff, showing O2 use predated its atmospheric rise by 900 Mys and helped oxygenic photosynthesis to evolve. www.science.org/doi/10.1126/...
Reposted by ssolo.bsky.social
1 month left to apply!
Faculty Positions Open! OIST is now inviting applications for tenure-track assistant professor positions in two broad areas:

- Chemistry & Materials Science
- Life Sciences & Neuroscience

Learn more and apply by October 1st: www.oist.jp/careers/facu...

#FacultySearch
September 1, 2026 at 2:45 AM
Ancestral genome reconstructions get noisier the deeper in time you go. The usual response: distrust them and joke about reading entrails. Ours is to train on the noise! The result is calibrated phenotype prediction back to the LBCA deep in the Archaean. New preprint

www.biorxiv.org/content/10.6...
Models trained with noisy genomes extend bacterial phenotype prediction into deep time
Predicting phenotype from genotype in extant organisms is increasingly tractable through the accumulation of genome sequences and the development of machine-learning algorithms. Here we show that mach...
www.biorxiv.org
July 4, 2026 at 6:33 AM
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Faculty Positions Open! OIST is now inviting applications for tenure-track assistant professor positions in two broad areas:

- Chemistry & Materials Science
- Life Sciences & Neuroscience

Learn more and apply by October 1st: www.oist.jp/careers/facu...

#FacultySearch
July 2, 2026 at 3:57 AM
Reposted by ssolo.bsky.social
Decomposers are nature’s recyclers, keeping Earth habitable. Now, a new Nature Ecology & Evolution study reveals that gene swapping between species helped eukaryotic decomposers evolve some of their common traits, adding new insights into how complex life evolves. www.oist.jp/news-center/...
Gene swapping helped build the planet's decomposers
A new study reveals that horizontal gene transfer contributed to the repeated evolution of fungi-like, absorption-feeding life across eukaryotes.
www.oist.jp
June 11, 2026 at 4:30 AM
Reposted by ssolo.bsky.social
We can now also predict the difficulty of the multiple sequence alignment task with our new ALDiScore tool www.biorxiv.org/content/10.6...
The plot shows MSA difficulty prediction performance on completely unseen data
June 3, 2026 at 3:49 AM
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Interested in working on the evolution of photosynthetic endosymbioses? Come join us!

I have 2 open positions in my new group @cemess.bsky.social in Vienna

3yr postdoc info: tinyurl.com/4emkjpn4

4yr PhD info: tinyurl.com/mtxmsjpy

Apply by 1st June!

Please share/repost

#Protists #Symbiosis #PhD
April 30, 2026 at 10:59 AM
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Pisani et al. (2026-04, Molecular Biology and Evolution)(オープンアクセス open access)
「ゲノム系統学的混合モデルは,均質モデルと分割モデルよりも優れている」
Phylogenomic mixture models outperform homogeneous and partitioned models
academic.oup.com/mbe/advance-...
Phylogenomic mixture models outperform homogeneous and partitioned models
Abstract. Significant advances have been made in resolving the tree of life, but many nodes remain debated. The last two decades saw the emergence of mixtu
academic.oup.com
April 10, 2026 at 6:45 PM
Reposted by ssolo.bsky.social
“Our results dissipate doubts about the utility of models accounting for compositional heterogeneity across sites and identify CAT-GTR as one of the most flexible models in the phylogenomic arsenal.”
Pisani et al. (2026-04, Molecular Biology and Evolution)(オープンアクセス open access)
「ゲノム系統学的混合モデルは,均質モデルと分割モデルよりも優れている」
Phylogenomic mixture models outperform homogeneous and partitioned models
academic.oup.com/mbe/advance-...
Phylogenomic mixture models outperform homogeneous and partitioned models
Abstract. Significant advances have been made in resolving the tree of life, but many nodes remain debated. The last two decades saw the emergence of mixtu
academic.oup.com
April 10, 2026 at 6:46 PM
Reposted by ssolo.bsky.social
Our latest: Conflict in ant phylogeny results from complex interaction between multiple evolutionary signals and tree reconstruction artifacts.
Conflict in ant phylogeny results from complex interaction between multiple evolutionary signals and tree reconstruction artifacts
Abstract. Ants, Formicidae, are a group of small social insects that inhabit nearly all terrestrial environments. Three competing hypotheses of ant relatio
academic.oup.com
April 6, 2026 at 9:35 AM
Reposted by ssolo.bsky.social
Limited fossil records and genomic information has made it difficult to determine the evolutionary history of squid and cuttlefish, until now. Published in @natecoevo.nature.com, @cephagus.bsky.social and team identify the ‘long fuse’ that led to today’s diversity: www.oist.jp/news-center/...
100 million years ago, an ‘evolutionary fuse’ was lit in the deep ocean, sparking squid diversification
New evolutionary mapping suggests deep sea origins and mass extinction triggered diversification of modern squid and cuttlefish.
www.oist.jp
March 31, 2026 at 8:37 AM
Reposted by ssolo.bsky.social
New paper in mSystems! 🧵 - how much of your metagenome is actually bacterial/archaeal DNA? For many samples, nobody knows.

We built SingleM prokaryotic_fraction (SPF) to answer this, then ran it on >100,000 public metagenomes. 🧬🖥️🦠

Here's what we found 👇
doi.org/10.1128/msystems.01062-25
March 23, 2026 at 10:09 AM
Reposted by ssolo.bsky.social
Nature research paper: Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor

go.nature.com/4rSfRRw
Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor - Nature
Sequencing of marine sediments finds 136 newly identified Heimdallarchaeia and several novel lineages, and indicates that Heimdallarchaeia evolved distinct metabolic capabilities from other Asgardarchaeota, in conditions that may have given rise to early eukaryotes.
go.nature.com
February 23, 2026 at 4:37 PM
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Come join us! Soon I will be advertising a postdoc vacancy in my group as part of my @erc.europa.eu AdG project 'DARK ROOTS'. Focus of the project will be on phylo- and metagenomic mining of novel prokaryotic lineages. I will soon post a link here - stay tuned, and please repost! #asgardarchaea
a man walking in a field with an umbrella
ALT: a man walking in a field with an umbrella
media.tenor.com
November 26, 2025 at 3:39 PM
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I have a postdoc position in metagenomic exploration available in my group. Candidates with documented experience in phylo & metagenomics and preferably with petabase-scale data mining and GLM workflows are encouraged to apply. Come join us! 🧬🦠💻

Please repost

Apply here: www.wur.nl/en/vacancy/p...
January 5, 2026 at 10:45 PM
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In @currentbiology.bsky.social, scientists crack ambiguities in trees of life by using ‘jumping genes’. The new method can transform the way we evaluate evolutionary relationships in deep time. Learn more www.oist.jp/news-center/...

Or read the full paper doi.org/10.1016/j.cu...
'Jumping genes’ help scientists resolve tree of life
Termite study provides researchers with template to solve ancient evolutionary mysteries.
www.oist.jp
December 15, 2025 at 3:04 AM
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The rare, mushroom-like Balanophora plant surprises researchers with their genetic makeup and unconventional role of plastids in biosynthesis, despite being entirely parasitic of a select few trees. New study in @newphyt.bsky.social 👇 www.oist.jp/news-center/...
The evolutionary mysteries of a rare parasitic plant
New study maps the strange genomes of Asia-Pacific Balanophora species, giving new insights into the evolution of parasitic plants and an unconventional role of plastids.
www.oist.jp
December 12, 2025 at 2:58 AM
Reposted by ssolo.bsky.social
Why? Because ELM was optimized by ML for use with C60 on a large pan-eukaryotic data set and fits much better than LG. See this paper: academic.oup.com/mbe/article/... /2
GTRpmix: A Linked General Time-Reversible Model for Profile Mixture Models
Abstract. Profile mixture models capture distinct biochemical constraints on the amino acid substitution process at different sites in proteins. These mode
academic.oup.com
December 9, 2025 at 6:30 PM
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Those interested in performing maximum likelihood phylogenomic analysis on data sets made up of eukaryotic nuclear genes using site heterogeneous mixture models like C60, I suggest you use the ELM model in IQ-TREE instead of the LG model /1
December 9, 2025 at 6:30 PM
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New evidence-based model of the evolution stretches out the differentiation of eukaryotes from prokaryotes over billions of years and places development of mitochondria much later than other cell structures. New @nature.com study 👇 @ssolo.bsky.social www.oist.jp/news-center/...
Complex life developed earlier than previously thought
New evidence-based evolutionary model provides access to the beginning of complex life with unprecedented accuracy.
www.oist.jp
December 4, 2025 at 6:01 AM
Reposted by ssolo.bsky.social
Our latest, led by the inimitable Chris Kay "Dated gene duplications elucidate the evolutionary assembly of eukaryotes" in which we used gene duplications to test hypotheses of eukaryogenesis. TLDR? They're all wrong. With @tweethinking.bsky.social @anya1.bsky.social @ssolo.bsky.social Davide Pisani
Dated gene duplications elucidate the evolutionary assembly of eukaryotes - Nature
Analysis of eukaryotic gene sequences using a relaxed molecular clock methodology indicate that eukaryotes emerged 3.0–2.25 billion years ago as a result of mitochondrial endosymbiosis with complex ar...
www.nature.com
December 3, 2025 at 5:05 PM
Reposted by ssolo.bsky.social
Eukaryogenesis was a billion year spree, but the acquisition of mitochondria happened when the party was winding down www.nature.com/articles/s41...
Dated gene duplications elucidate the evolutionary assembly of eukaryotes - Nature
Analysis of eukaryotic gene sequences using a relaxed molecular clock methodology indicate that eukaryotes emerged 3.0–2.25 billion years ago as a result of mitochondrial endosymbiosis with complex ar...
www.nature.com
December 3, 2025 at 7:55 PM
Reposted by ssolo.bsky.social
Applications are now open for the Buribushi Fellowship 2026!
OIST is offering a unique opportunity for early-career, theory-focused researchers to lead their own projects with full funding support.

Learn more & Apply by November 30th: https://www.oist.jp/research/buribushi
#Fellowship
October 31, 2025 at 6:00 AM
Reposted by ssolo.bsky.social
Our latest, led by Edu Ocaña-Pallarès and @ssolo.bsky.social, a timescale for fungal phylogeny that wrangles calibration from the unstructured fossil record of fungi and a history of horizontal gene transfers

www.nature.com/articles/s41...
A timetree of Fungi dated with fossils and horizontal gene transfers - Nature Ecology & Evolution
Combining fossil-based and molecular calibrations with data on horizontal gene transfer events, the authors develop a time-calibrated phylogeny of Fungi. This timescale, which integrates analytic uncertainties, suggests an older age of crown Fungi (1,401–896 million years ago), as well as a minimum age for ancient interactions involving fungi and the algal ancestors of embryophytes in terrestrial ecosystems (1,253–797 Ma).
www.nature.com
October 7, 2025 at 9:41 AM