Masha Niv
@tastelabhuji.bsky.social
Prof. @The Hebrew U. #Taste, #GPCRs, drug discovery, sensory science, bitter, sweet, ML, AI. https://mashaniv.wixsite.com/niv-taste-lab
Pinned
Masha Niv
@tastelabhuji.bsky.social
· Dec 22
Several papers recently cited our #BitterDB paper from 2019 - I want also to bring to attention to the 2024 update in #NAR #Bitter #taste #ligands #receptors doi.org/10.1093/nar/...
bitterdb.agri.huji.ac.il/dbbitter.php
bitterdb.agri.huji.ac.il/dbbitter.php
New preprint by Evgenii Ziaikin - Where do the ligands bind? #Co-folding #bitter #taste #GPCRs with the #BitterDB chemical space www.biorxiv.org/content/10.6...
Where do the ligands bind? Co-folding bitter taste GPCRs with the BitterDB chemical space
Bitterness is a key taste modality mediated in vertebrates by TAS2R G protein coupled receptors, which also function in diverse extraoral tissues. Recent cryo EM structures have revealed a non classic...
www.biorxiv.org
June 28, 2026 at 4:07 PM
New preprint by Evgenii Ziaikin - Where do the ligands bind? #Co-folding #bitter #taste #GPCRs with the #BitterDB chemical space www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6... #Pharmaceutical Agonists of #bitter #taste receptor TAS2R14 Display Diverse Potency, Efficacy, and Binding-Site Sensitivity - #Tamoxifen, #Carbimazole in the low micromolar range, #Lidocaine required substantially higher concentrations.
Pharmaceutical TAS2R14 Agonists Display Diverse Potency, Efficacy, and Binding-Site Sensitivity
Bitter taste receptors (TAS2Rs) are G- protein coupled receptors that detect chemically diverse compounds, including many clinically used drugs. TAS2R14 is expressed in many extraoral tissues and is a...
www.biorxiv.org
June 23, 2026 at 5:15 PM
www.biorxiv.org/content/10.6... #Pharmaceutical Agonists of #bitter #taste receptor TAS2R14 Display Diverse Potency, Efficacy, and Binding-Site Sensitivity - #Tamoxifen, #Carbimazole in the low micromolar range, #Lidocaine required substantially higher concentrations.
Recent #cryoEM work reveals many ligands, pockets & states for #bitter #taste #GPCRs, from intracellular binding to ECL “lids” shaping aftertaste rdcu.be/ferTU News&Views with Evgenii Ziaikin, Nitsan Dallal
Many ligands and states of bitter taste GPCRs
Nature Structural & Molecular Biology - Bitter taste receptors are a subtype of G-protein receptors that are activated by a variety of ligands, leading to bitter taste sensation. Two studies...
rdcu.be
April 21, 2026 at 2:44 PM
Recent #cryoEM work reveals many ligands, pockets & states for #bitter #taste #GPCRs, from intracellular binding to ECL “lids” shaping aftertaste rdcu.be/ferTU News&Views with Evgenii Ziaikin, Nitsan Dallal
Reposted by Masha Niv
Dynamics of Ligand Binding Sites and Chloride Penetration in a Bitter Taste GPCR
Niv, M. Y. et al.
Paper
Details
#GPCR #LigandBinding #ChloridePenetration
Niv, M. Y. et al.
Paper
Details
#GPCR #LigandBinding #ChloridePenetration
December 30, 2025 at 9:03 AM
Dynamics of Ligand Binding Sites and Chloride Penetration in a Bitter Taste GPCR
Niv, M. Y. et al.
Paper
Details
#GPCR #LigandBinding #ChloridePenetration
Niv, M. Y. et al.
Paper
Details
#GPCR #LigandBinding #ChloridePenetration
Excited to share #Intracellular and Dual-Site #Inhibition of a #bitter #taste #GPCR. Congrats Nitsan Dallal and team!
December 9, 2025 at 1:14 PM
Excited to share #Intracellular and Dual-Site #Inhibition of a #bitter #taste #GPCR. Congrats Nitsan Dallal and team!
New Preprint alert!
Dynamics of Ligand Binding Sites and Chloride Penetration in a Bitter Taste GPCR, with Alon Rainish and Liel Sapir
lnkd.in/eXd4hUw8
Dynamics of Ligand Binding Sites and Chloride Penetration in a Bitter Taste GPCR, with Alon Rainish and Liel Sapir
lnkd.in/eXd4hUw8
December 3, 2025 at 3:19 PM
New Preprint alert!
Dynamics of Ligand Binding Sites and Chloride Penetration in a Bitter Taste GPCR, with Alon Rainish and Liel Sapir
lnkd.in/eXd4hUw8
Dynamics of Ligand Binding Sites and Chloride Penetration in a Bitter Taste GPCR, with Alon Rainish and Liel Sapir
lnkd.in/eXd4hUw8
Several papers recently cited our #BitterDB paper from 2019 - I want also to bring to attention to the 2024 update in #NAR #Bitter #taste #ligands #receptors doi.org/10.1093/nar/...
bitterdb.agri.huji.ac.il/dbbitter.php
bitterdb.agri.huji.ac.il/dbbitter.php
December 22, 2024 at 8:33 AM
Several papers recently cited our #BitterDB paper from 2019 - I want also to bring to attention to the 2024 update in #NAR #Bitter #taste #ligands #receptors doi.org/10.1093/nar/...
bitterdb.agri.huji.ac.il/dbbitter.php
bitterdb.agri.huji.ac.il/dbbitter.php
Reposted by Masha Niv
First post on bsky to highlight our latest work on smell receptors (www.nature.com/articles/s41...). Odorant receptors are notoriously challenging to work with - we used a classic strategy from protein engineering to get a peek into how these receptors recognize such a diversity of smells.
December 4, 2024 at 4:59 AM
First post on bsky to highlight our latest work on smell receptors (www.nature.com/articles/s41...). Odorant receptors are notoriously challenging to work with - we used a classic strategy from protein engineering to get a peek into how these receptors recognize such a diversity of smells.
Reposted by Masha Niv
The Human Cell Atlas is yielding detailed maps of human tissues and systems throughout life, along with methods to handle single-cell data. Four scientists reflect in Nature on how the project is transforming our understanding of human biology. 🧪
Cellular atlases are unlocking the mysteries of the human body
Scientists reflect on insights from the Human Cell Atlas.
go.nature.com
November 26, 2024 at 3:06 PM
The Human Cell Atlas is yielding detailed maps of human tissues and systems throughout life, along with methods to handle single-cell data. Four scientists reflect in Nature on how the project is transforming our understanding of human biology. 🧪
Congratulations, Dr. Lior Peri! What a cool coincidence to receive the official notification of the Doctorate within a week from a publication of her paper "A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR" www.nature.com/articles/s41...
November 25, 2024 at 6:03 PM
Congratulations, Dr. Lior Peri! What a cool coincidence to receive the official notification of the Doctorate within a week from a publication of her paper "A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR" www.nature.com/articles/s41...
Reposted by Masha Niv
If you really love your protein of interest commit to a tattoo @ardemp.bsky.social
November 22, 2024 at 2:29 AM
If you really love your protein of interest commit to a tattoo @ardemp.bsky.social
Reposted by Masha Niv
Congrats @tastelabhuji.bsky.social and team!
Sometimes a ligand can bind to two different sites at the same target — like in these interesting structures of the taste receptor TAS2R14 with gustducin by Peri et al.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR - Nature Communications
Bitter taste receptors (TAS2Rs) are a subfamily of G-protein coupled receptors (GPCRs). Here, the authors report a cryo-EM structure of the human TAS2R14 in complex with its signaling partner gustduci...
www.nature.com
November 21, 2024 at 12:26 AM
Congrats @tastelabhuji.bsky.social and team!
Reposted by Masha Niv
Download our database of 313 different postdoctoral fellowships.
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...
November 16, 2024 at 7:05 PM
Download our database of 313 different postdoctoral fellowships.
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...
Reposted by Masha Niv
A first attempt to assemble GPCR aficionados here on 🦋 Let me know who I missed by replying below!
go.bsky.app/75ukb81
go.bsky.app/75ukb81
November 16, 2024 at 6:05 PM
A first attempt to assemble GPCR aficionados here on 🦋 Let me know who I missed by replying below!
go.bsky.app/75ukb81
go.bsky.app/75ukb81
Hi. New here. We study taste, and just published an update of our database of #bitter #molecules and their #receptors, doi.org/10.1093/nar/...
please visit BitterDB for more info bitterdb.agri.huji.ac.il/dbbitter.php
please visit BitterDB for more info bitterdb.agri.huji.ac.il/dbbitter.php
BitterDB: 2024 update on bitter ligands and taste receptors
Abstract. BitterDB (http://bitterdb.agri.huji.ac.il) was introduced in 2012 as a central resource for information on bitter-tasting molecules and their rec
doi.org
November 17, 2024 at 9:15 AM
Hi. New here. We study taste, and just published an update of our database of #bitter #molecules and their #receptors, doi.org/10.1093/nar/...
please visit BitterDB for more info bitterdb.agri.huji.ac.il/dbbitter.php
please visit BitterDB for more info bitterdb.agri.huji.ac.il/dbbitter.php