Raquel Tonello
@tonelloraquel.bsky.social
Research Scientist at NYU Pain Research Center, expert in pain and neuroinflammation.
Reposted by Raquel Tonello
Fialho et al. find that neuropilin-1 drives nerve growth factor-dependent sensitization in trigeminal nociceptors and oral cancer pain. Targeting neuropilin-1 blocks tumor-derived algogens, offering a safer, nonopioid therapeutic strategy #PAIN bit.ly/4wCwhzq
September 16, 2026 at 12:02 PM
Fialho et al. find that neuropilin-1 drives nerve growth factor-dependent sensitization in trigeminal nociceptors and oral cancer pain. Targeting neuropilin-1 blocks tumor-derived algogens, offering a safer, nonopioid therapeutic strategy #PAIN bit.ly/4wCwhzq
Reposted by Raquel Tonello
Thanks for having me, I had a great time! Wonderful community you have built with awesome science underway.
Great to have Dr. Ishmail Abdus-Saboor visit the PRC today! It was exciting to hear about his work on the skin-brain axis and to spend the day talking science. Thank you @ishmailsaboor.bsky.social!
September 17, 2026 at 1:17 AM
Thanks for having me, I had a great time! Wonderful community you have built with awesome science underway.
Reposted by Raquel Tonello
Great new review article from Ru-Rong Ji, Temugin Berta, and colleagues, on neuron-glia interactions in pain! Microglia, astrocytes, and satellite glial cells actively shape pain by driving neuroinflammation, sensitizing neurons, and remodeling pain circuits. journals.physiology.org/doi/full/10....
journals.physiology.org
July 21, 2026 at 4:24 PM
Great new review article from Ru-Rong Ji, Temugin Berta, and colleagues, on neuron-glia interactions in pain! Microglia, astrocytes, and satellite glial cells actively shape pain by driving neuroinflammation, sensitizing neurons, and remodeling pain circuits. journals.physiology.org/doi/full/10....
Reposted by Raquel Tonello
NEW PRC PAPER 🚨: The Jensen lab discovered that disrupting synaptic vesicle recycling via AAK1, Dnm1, and Dnm3 targets chronic itch at its source. Amazing work @pazduran.bsky.social @tonelloraquel.bsky.social and the team! www.frontiersin.org/journals/mol...
Frontiers | The contribution of endocytic mediators to itch transmission
IntroductionChronic itch is a major burden, impacting the quality of life for one in four adults, and is closely associated with increased levels of anxiety,...
www.frontiersin.org
July 14, 2026 at 5:14 PM
NEW PRC PAPER 🚨: The Jensen lab discovered that disrupting synaptic vesicle recycling via AAK1, Dnm1, and Dnm3 targets chronic itch at its source. Amazing work @pazduran.bsky.social @tonelloraquel.bsky.social and the team! www.frontiersin.org/journals/mol...
Reposted by Raquel Tonello
NEW PRC PAPER 🚨: The Bunnett lab identified Neuropilin-1 (NRP1) as a key mediator of NGF signaling driving oral cancer pain. Targeting NRP1 disrupts NGF/TrkA signaling, reduces nociceptor sensitization, and alleviates pain without directly blocking NGF!
buff.ly/NmyrTLy
buff.ly/NmyrTLy
July 6, 2026 at 1:15 PM
NEW PRC PAPER 🚨: The Bunnett lab identified Neuropilin-1 (NRP1) as a key mediator of NGF signaling driving oral cancer pain. Targeting NRP1 disrupts NGF/TrkA signaling, reduces nociceptor sensitization, and alleviates pain without directly blocking NGF!
buff.ly/NmyrTLy
buff.ly/NmyrTLy
📣Excited to share our new preprint!
We identify synaptic vesicle endocytosis in nociceptors as a key driver of ongoing pain, and show that LNP‑delivered CRISPR/dCas9 repression of this pathway produces durable analgesia across multiple pain models.
www.biorxiv.org/content/10.6...
We identify synaptic vesicle endocytosis in nociceptors as a key driver of ongoing pain, and show that LNP‑delivered CRISPR/dCas9 repression of this pathway produces durable analgesia across multiple pain models.
www.biorxiv.org/content/10.6...
Targeting Synaptic Vesicle Endocytosis in Nociceptors Provides Sustained Pain Relief
Endocytosis replenishes synaptic vesicle (SV) pools that are required for persistent transmission of chronic pain signals within nociceptive spinal circuits. The nociceptor-specific contribution of SV...
www.biorxiv.org
June 23, 2026 at 1:37 PM
📣Excited to share our new preprint!
We identify synaptic vesicle endocytosis in nociceptors as a key driver of ongoing pain, and show that LNP‑delivered CRISPR/dCas9 repression of this pathway produces durable analgesia across multiple pain models.
www.biorxiv.org/content/10.6...
We identify synaptic vesicle endocytosis in nociceptors as a key driver of ongoing pain, and show that LNP‑delivered CRISPR/dCas9 repression of this pathway produces durable analgesia across multiple pain models.
www.biorxiv.org/content/10.6...
Reposted by Raquel Tonello
Amazing day so far at the PRC symposium! So much exciting science from our research community and awesome keynote speakers. @karapedsgastrodoc.bsky.social @jimr-1.bsky.social @sarahanajjar.bsky.social @tonelloraquel.bsky.social @elisadamo.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social
May 28, 2026 at 7:29 PM
Amazing day so far at the PRC symposium! So much exciting science from our research community and awesome keynote speakers. @karapedsgastrodoc.bsky.social @jimr-1.bsky.social @sarahanajjar.bsky.social @tonelloraquel.bsky.social @elisadamo.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social
Reposted by Raquel Tonello
We are thrilled to bring together the NYU pain research community at our symposium tomorrow! Looking forward to a day of exciting science, connection, and collaboration.
May 27, 2026 at 8:38 PM
We are thrilled to bring together the NYU pain research community at our symposium tomorrow! Looking forward to a day of exciting science, connection, and collaboration.
Amazing opportunity to work with Dr. Gomez!
Excited (and a little emotional!) to share that I’m hiring my very first postdoc 🥹✨ This lab has been a dream in the making, and I can’t wait to welcome someone to grow, discover, and build something meaningful together.
tamus.wd1.myworkdayjobs.com/TAMU_Externa...
tamus.wd1.myworkdayjobs.com/TAMU_Externa...
Postdoctoral Research Associate
Job TitlePostdoctoral Research Associate Agency Texas A&M University Health Science Center Department Biomedical Sciences Proposed Minimum Salary$5,000.00 monthly Job LocationDallas, Texas Job Typ...
tamus.wd1.myworkdayjobs.com
April 7, 2026 at 7:18 PM
Amazing opportunity to work with Dr. Gomez!
Reposted by Raquel Tonello
Very proud of our group’s showing at #USASP2026! Thank you to the organizers of this fantastic meeting! @usasp.bsky.social @karapedsgastrodoc.bsky.social @sdavidson.bsky.social @sarahanajjar.bsky.social @yylab.bsky.social @goinsyeah.bsky.social @pazduran.bsky.social @keylinesc.bsky.social
March 27, 2026 at 3:47 PM
Very proud of our group’s showing at #USASP2026! Thank you to the organizers of this fantastic meeting! @usasp.bsky.social @karapedsgastrodoc.bsky.social @sdavidson.bsky.social @sarahanajjar.bsky.social @yylab.bsky.social @goinsyeah.bsky.social @pazduran.bsky.social @keylinesc.bsky.social
Reposted by Raquel Tonello
Please visit our posters today at #USASP! @karapedsgastrodoc.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @pazduran.bsky.social
March 24, 2026 at 12:54 PM
Please visit our posters today at #USASP! @karapedsgastrodoc.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @pazduran.bsky.social
Reposted by Raquel Tonello
We are thrilled to be at USASP in Philadelphia! Looking forward to a week of great science. @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social @sdavidson.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @mariafialho.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social
March 24, 2026 at 1:58 AM
We are thrilled to be at USASP in Philadelphia! Looking forward to a week of great science. @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social @sdavidson.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @mariafialho.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social
Reposted by Raquel Tonello
NEW PRC PAPER 🚨 This study led by @mariafialho.bsky.social from the Bunnett Lab reveals that tryptase from mast cells activates PAR2 on sensory neurons, sustaining painful symptoms induced by an aromatase inhibitor. buff.ly/lVAgUgO @tonelloraquel.bsky.social @karapedsgastrodoc.bsky.social
March 16, 2026 at 1:08 PM
NEW PRC PAPER 🚨 This study led by @mariafialho.bsky.social from the Bunnett Lab reveals that tryptase from mast cells activates PAR2 on sensory neurons, sustaining painful symptoms induced by an aromatase inhibitor. buff.ly/lVAgUgO @tonelloraquel.bsky.social @karapedsgastrodoc.bsky.social
Reposted by Raquel Tonello
NEW PRC PREPRINT 🚨 The Jensen Lab presents a new therapeutic target for itch: Blocking AAK1 and Dynamin in GRP neurons reduces scratching without behavioral side effects. buff.ly/rpfcj90 @tonelloraquel.bsky.social @pazduran.bsky.social
March 13, 2026 at 1:45 PM
NEW PRC PREPRINT 🚨 The Jensen Lab presents a new therapeutic target for itch: Blocking AAK1 and Dynamin in GRP neurons reduces scratching without behavioral side effects. buff.ly/rpfcj90 @tonelloraquel.bsky.social @pazduran.bsky.social
Reposted by Raquel Tonello
We had the honor of hosting Prof Jose Moron-Concepcion from @washumedicine.bsky.social yesterday! He gave a fantastic seminar on novel therapeutic approaches to prevent pain-induced opioid escalation and fentanyl overdoses. @linyhung.bsky.social @tonelloraquel.bsky.social @elisadamo.bsky.social
March 5, 2026 at 7:23 PM
We had the honor of hosting Prof Jose Moron-Concepcion from @washumedicine.bsky.social yesterday! He gave a fantastic seminar on novel therapeutic approaches to prevent pain-induced opioid escalation and fentanyl overdoses. @linyhung.bsky.social @tonelloraquel.bsky.social @elisadamo.bsky.social
📢🔬Check out our latest study on the specific role of endocytic mediators in pain-related synaptic transmission, now out in PAIN. @mariafialho.bsky.social #PainResearch #Neuroscience #SynapticTransmission
Fialho et al. find that synaptojanin 1, endophilin A1, dynamin 1, and adaptor-associated protein kinase-1 mediate synaptic vesicle recycling and neurotransmission in nociceptive circuits in the spinal cord. Learn more in #PAIN bit.ly/3WIf08B
November 13, 2025 at 6:53 PM
📢🔬Check out our latest study on the specific role of endocytic mediators in pain-related synaptic transmission, now out in PAIN. @mariafialho.bsky.social #PainResearch #Neuroscience #SynapticTransmission
Reposted by Raquel Tonello
NYU Pain Research Center is expanding! 💥 Seeking brilliant minds (Assistant or Associate Professor, tenure track) to explore chronic pain mechanisms & therapies. Join our mission to transform pain research. Apply now! 🧠✨ #Research #AcademicJobs apply.interfolio.com/176454
Apply - Interfolio
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apply.interfolio.com
November 11, 2025 at 4:19 PM
NYU Pain Research Center is expanding! 💥 Seeking brilliant minds (Assistant or Associate Professor, tenure track) to explore chronic pain mechanisms & therapies. Join our mission to transform pain research. Apply now! 🧠✨ #Research #AcademicJobs apply.interfolio.com/176454
Reposted by Raquel Tonello
🎉 Join us for the 1st NYC Area Pain Research Meet-Up!
🗓 Fri, Dec 5 | 3–6 PM
📍 NYU Pain Research Center, 433 1st Ave
Don’t miss Dr. Steve Davidson’s keynote: “Humanizing Pain Neurobiology for Translational Gain” — plus great company & treats!
See you there! 💫 #PainResearch #NYCScience #Neurobiology
🗓 Fri, Dec 5 | 3–6 PM
📍 NYU Pain Research Center, 433 1st Ave
Don’t miss Dr. Steve Davidson’s keynote: “Humanizing Pain Neurobiology for Translational Gain” — plus great company & treats!
See you there! 💫 #PainResearch #NYCScience #Neurobiology
November 11, 2025 at 7:33 PM
🎉 Join us for the 1st NYC Area Pain Research Meet-Up!
🗓 Fri, Dec 5 | 3–6 PM
📍 NYU Pain Research Center, 433 1st Ave
Don’t miss Dr. Steve Davidson’s keynote: “Humanizing Pain Neurobiology for Translational Gain” — plus great company & treats!
See you there! 💫 #PainResearch #NYCScience #Neurobiology
🗓 Fri, Dec 5 | 3–6 PM
📍 NYU Pain Research Center, 433 1st Ave
Don’t miss Dr. Steve Davidson’s keynote: “Humanizing Pain Neurobiology for Translational Gain” — plus great company & treats!
See you there! 💫 #PainResearch #NYCScience #Neurobiology
Excited to share my first senior author paper in Pain! 🎉 We identify Synaptojanin 1 & Endophilin A1 as key endocytic mediators of nociception. Silencing them blocks spinal synaptic transmission and relieves pain in cancer & postoperative models, without affecting normal behavior.
buff.ly/caKMGY3
buff.ly/caKMGY3
buff.ly
June 11, 2025 at 5:25 PM
Excited to share my first senior author paper in Pain! 🎉 We identify Synaptojanin 1 & Endophilin A1 as key endocytic mediators of nociception. Silencing them blocks spinal synaptic transmission and relieves pain in cancer & postoperative models, without affecting normal behavior.
buff.ly/caKMGY3
buff.ly/caKMGY3
Reposted by Raquel Tonello
PRC PRIMED! Thank you to @rachelepol.bsky.social for presenting Nanomedicine for Pain: Towards translation through advanced materials, manufacturing and in vitro strategies! Huge round of applause 👏to @linyhung.bsky.social & @tonelloraquel.bsky.social for being amazing hosts! #PinkertonLab #RachelP
April 10, 2025 at 3:31 PM
PRC PRIMED! Thank you to @rachelepol.bsky.social for presenting Nanomedicine for Pain: Towards translation through advanced materials, manufacturing and in vitro strategies! Huge round of applause 👏to @linyhung.bsky.social & @tonelloraquel.bsky.social for being amazing hosts! #PinkertonLab #RachelP
Reposted by Raquel Tonello
PRC PRIMED! #First event of the #year featuring a talk by #Dr. Kehinde Mary Taiwo, a Postdoctoral Fellow in #Dr. Candie Paulsen's lab at #Yale #University! @nyupainresearch.bsky.social #NYUDentistry #NewYorkUniversity
March 12, 2025 at 6:24 PM
PRC PRIMED! #First event of the #year featuring a talk by #Dr. Kehinde Mary Taiwo, a Postdoctoral Fellow in #Dr. Candie Paulsen's lab at #Yale #University! @nyupainresearch.bsky.social #NYUDentistry #NewYorkUniversity
Reposted by Raquel Tonello
A non-opioid alternative in the treatment of chronic pain!
Chloe J. Peach @tonelloraquel.bsky.social & team discover inhibition of Neuropilin-1 suppresses NGF-evoked pain in preclinical models: https://www.jci.org/articles/view/183873
Chloe J. Peach @tonelloraquel.bsky.social & team discover inhibition of Neuropilin-1 suppresses NGF-evoked pain in preclinical models: https://www.jci.org/articles/view/183873
February 20, 2025 at 2:31 PM
A non-opioid alternative in the treatment of chronic pain!
Chloe J. Peach @tonelloraquel.bsky.social & team discover inhibition of Neuropilin-1 suppresses NGF-evoked pain in preclinical models: https://www.jci.org/articles/view/183873
Chloe J. Peach @tonelloraquel.bsky.social & team discover inhibition of Neuropilin-1 suppresses NGF-evoked pain in preclinical models: https://www.jci.org/articles/view/183873
Reposted by Raquel Tonello
@tedpricethepainguy.bsky.social @utdpaincenter.bsky.social Great visit today from Dr. Ted Price! Thank you for wowing us with your team’s exciting data on human DRG tissue, very inspiring and insightful seminar! #painresearch #dorsalrootganglia #humanDRG #nyudental #nyuniversity #nyupainresearch
February 19, 2025 at 6:53 PM
@tedpricethepainguy.bsky.social @utdpaincenter.bsky.social Great visit today from Dr. Ted Price! Thank you for wowing us with your team’s exciting data on human DRG tissue, very inspiring and insightful seminar! #painresearch #dorsalrootganglia #humanDRG #nyudental #nyuniversity #nyupainresearch
I'm excited to share our groundbreaking findings on Neuripilin-1 and its role in NGF/TrkA pain signaling.
Neuropilin-1 (NRP1) is a co-receptor for NGF/TrkA pain signaling. Inhibiting NRP1 can reduce nociceptor activation and NGF-related pain. This important finding by the Bunnett lab and colleagues could lead to a non-opioid alternative for chronic pain treatment. www.jci.org/articles/vie...
JCI -
NEUROPILIN-1 INHIBITION SUPPRESSES NERVE-GROWTH FACTOR SIGNALING AND NOCICEPTION IN PAIN MODELS
www.jci.org
December 18, 2024 at 9:12 PM
I'm excited to share our groundbreaking findings on Neuripilin-1 and its role in NGF/TrkA pain signaling.
Reposted by Raquel Tonello
Congrats to the whole team for the paper published in Gastroenterology this week! 🎉🧠🌟
#gutserotonin #depression #anxiety #antidepressants
@tonelloraquel.bsky.social
@danielxjuarez.bsky.social
@karapedsgastrodoc.bsky.social
@sarahanajjar.bsky.social
👉
www.gastrojournal.org/article/S001...
#gutserotonin #depression #anxiety #antidepressants
@tonelloraquel.bsky.social
@danielxjuarez.bsky.social
@karapedsgastrodoc.bsky.social
@sarahanajjar.bsky.social
👉
www.gastrojournal.org/article/S001...
December 12, 2024 at 6:50 PM
Congrats to the whole team for the paper published in Gastroenterology this week! 🎉🧠🌟
#gutserotonin #depression #anxiety #antidepressants
@tonelloraquel.bsky.social
@danielxjuarez.bsky.social
@karapedsgastrodoc.bsky.social
@sarahanajjar.bsky.social
👉
www.gastrojournal.org/article/S001...
#gutserotonin #depression #anxiety #antidepressants
@tonelloraquel.bsky.social
@danielxjuarez.bsky.social
@karapedsgastrodoc.bsky.social
@sarahanajjar.bsky.social
👉
www.gastrojournal.org/article/S001...