Switch Lab
@vib-switch-lab.bsky.social
Researching aggregation-specific interactions in human disease
Reposted by Switch Lab
🤸♂️ Researchers from the @vib-switch-lab.bsky.social , co-led by Frederic Rousseau & Joost Schymkowitz, show that microglia can actively promote plaque formation in Alzheimer’s disease—challenging the long-standing view that these cells only defend the brain by clearing plaques.
Published in @pnas.org
Published in @pnas.org
March 10, 2026 at 9:53 AM
🤸♂️ Researchers from the @vib-switch-lab.bsky.social , co-led by Frederic Rousseau & Joost Schymkowitz, show that microglia can actively promote plaque formation in Alzheimer’s disease—challenging the long-standing view that these cells only defend the brain by clearing plaques.
Published in @pnas.org
Published in @pnas.org
#ProAgg26 is coming!
Abstract submission is open - invitations to register will be sent after abstract review, making sure all selected participants can attend.
All info: vibbio.tech/ProAgg26
Abstract submission is open - invitations to register will be sent after abstract review, making sure all selected participants can attend.
All info: vibbio.tech/ProAgg26
🧪Announcing the 3rd Leuven Protein Aggregation Meeting, 9-11 Sept 2026!
📍Great Beguinage of Leuven
🔬150 participants | Abstract review required, invite upon acceptance
🗓️Submit your abstract until 25 May 2026
🌍Come listen to leading experts in protein aggregation
More info: vibbio.tech/ProAgg26
📍Great Beguinage of Leuven
🔬150 participants | Abstract review required, invite upon acceptance
🗓️Submit your abstract until 25 May 2026
🌍Come listen to leading experts in protein aggregation
More info: vibbio.tech/ProAgg26
February 17, 2026 at 2:48 PM
#ProAgg26 is coming!
Abstract submission is open - invitations to register will be sent after abstract review, making sure all selected participants can attend.
All info: vibbio.tech/ProAgg26
Abstract submission is open - invitations to register will be sent after abstract review, making sure all selected participants can attend.
All info: vibbio.tech/ProAgg26
Reposted by Switch Lab
We are hiring a research assistant 👉 tinyurl.com/yxebtjbj to join our lab working on healthy #ageing and protein #aggregation in C. elegans 🪱. Deadline August 4th. 🙏 RT. #proteostasis @babrahaminst.bsky.social
hireful.
tinyurl.com
July 4, 2025 at 9:51 AM
We are hiring a research assistant 👉 tinyurl.com/yxebtjbj to join our lab working on healthy #ageing and protein #aggregation in C. elegans 🪱. Deadline August 4th. 🙏 RT. #proteostasis @babrahaminst.bsky.social
This weekend temperatures soared... perfect for the 4th CBD-CCB-NERF Beachvolley tournament. And here's the Switch team in action - well done to @ramonduran.bsky.social
@brajabandhu.bsky.social Alex, Sara, Fleur and Wouter!
@brajabandhu.bsky.social Alex, Sara, Fleur and Wouter!
June 16, 2025 at 10:43 AM
This weekend temperatures soared... perfect for the 4th CBD-CCB-NERF Beachvolley tournament. And here's the Switch team in action - well done to @ramonduran.bsky.social
@brajabandhu.bsky.social Alex, Sara, Fleur and Wouter!
@brajabandhu.bsky.social Alex, Sara, Fleur and Wouter!
Last week Switchie Valeria successfully defended her PhD! Congratulations, Dr Narykina, and all our best wishes for the future. We'll miss you!
June 12, 2025 at 1:59 PM
Last week Switchie Valeria successfully defended her PhD! Congratulations, Dr Narykina, and all our best wishes for the future. We'll miss you!
Congratulations to Switchies @ramonduran.bsky.social & Gemma Martinez-Rivas on securing Post Doc funding from @fwovlaanderen.bsky.social. Gemma's project focuses on AL amyloidosis and Ramon will look at co-translational protein folding (and more) during ageing. Wishing them much success!
June 12, 2025 at 12:50 PM
Congratulations to Switchies @ramonduran.bsky.social & Gemma Martinez-Rivas on securing Post Doc funding from @fwovlaanderen.bsky.social. Gemma's project focuses on AL amyloidosis and Ramon will look at co-translational protein folding (and more) during ageing. Wishing them much success!
This promises to be a great meeting!
Exciting News! We’re thrilled to announce the first Functional Amyloid Meeting at DESY!
Join us for a deep dive into the latest breakthroughs in functional fibrils, with a spotlight on amyloid molecular and cellular mechanisms and their biomedical applications.
landau-cssb.de/meeting-of-f...
Join us for a deep dive into the latest breakthroughs in functional fibrils, with a spotlight on amyloid molecular and cellular mechanisms and their biomedical applications.
landau-cssb.de/meeting-of-f...
March 27, 2025 at 11:11 AM
This promises to be a great meeting!
Drug-resistant bacteria are a global threat. In our study, we reveal a new antibacterial strategy: a peptide that disrupts protein homeostasis by causing co-translational aggregation, killing a wide range of pathogenic bacteria 🦠💥.
📄 Full paper here: www.nature.com/articles/s41...
📄 Full paper here: www.nature.com/articles/s41...
Co-translational protein aggregation and ribosome stalling as a broad-spectrum antibacterial mechanism - Nature Communications
Protein biosynthesis is a major target of existing antibiotics that inhibit the efficiency or fidelity of the bacterial ribosome. Here, the authors show that a synthetic peptide displays bactericidal ...
www.nature.com
February 17, 2025 at 12:55 PM
Drug-resistant bacteria are a global threat. In our study, we reveal a new antibacterial strategy: a peptide that disrupts protein homeostasis by causing co-translational aggregation, killing a wide range of pathogenic bacteria 🦠💥.
📄 Full paper here: www.nature.com/articles/s41...
📄 Full paper here: www.nature.com/articles/s41...
Most proteins fold co-translationally, but what if key residues aren’t available in time? Our new study introduces Native Fold Delay, a metric that links protein topology and translation rates to quantify folding delays. ⏳
Read more here www.nature.com/articles/s41...
Read more here www.nature.com/articles/s41...
Native Fold Delay and its implications for co-translational chaperone binding and protein aggregation - Nature Communications
During vectorial protein translation, native interactions are temporarily unsatisfied. Here, authors introduce “Native Fold Delay”, integrating protein topology with translation kinetics to quantify t...
www.nature.com
February 17, 2025 at 12:22 PM
Most proteins fold co-translationally, but what if key residues aren’t available in time? Our new study introduces Native Fold Delay, a metric that links protein topology and translation rates to quantify folding delays. ⏳
Read more here www.nature.com/articles/s41...
Read more here www.nature.com/articles/s41...
And another new team member :-) Welcoming Gerd Van der Hoeven to Switch, as a research technician. Our heterotypics team is at full strength!
January 9, 2025 at 12:08 PM
And another new team member :-) Welcoming Gerd Van der Hoeven to Switch, as a research technician. Our heterotypics team is at full strength!
The new year starts with new Switchies :-) Very happy to welcome post doc Kevin Muwonge to our lab - Kevin joins our team working on heterotypic amyloid interactions.
January 7, 2025 at 8:46 AM
The new year starts with new Switchies :-) Very happy to welcome post doc Kevin Muwonge to our lab - Kevin joins our team working on heterotypic amyloid interactions.