Volker Boehm
@volkerboehm.bsky.social
RNA-centric Staff Scientist | Nonsense-mediated decay | Exon junction complex | RBPs | Gehring Lab @ University of Cologne 🧫 https://orcid.org/0000-0001-7588-9842
Pinned
Volker Boehm
@volkerboehm.bsky.social
· Feb 24
Composite SMG5-SMG6 PIN domain formation is essential for NMD - Nature Communications
Execution of mRNA cleavage in nonsense-mediated decay remained elusive. The authors show that SMG5 complements SMG6 to form a highly active, composite endonuclease with expanded catalytic center that ...
www.nature.com
How are faulty #RNA degraded?
New mechanistic insight into NMD:
1️⃣SMG5 & SMG6 PIN domains form a composite endonuclease (cPIN)
2️⃣ SMG5 completes the SMG6 active site, enabling efficient mRNA cleavage
Fantastic collaboration with @labconti.bsky.social 🙏
👉 www.nature.com/articles/s41...
1/n
New mechanistic insight into NMD:
1️⃣SMG5 & SMG6 PIN domains form a composite endonuclease (cPIN)
2️⃣ SMG5 completes the SMG6 active site, enabling efficient mRNA cleavage
Fantastic collaboration with @labconti.bsky.social 🙏
👉 www.nature.com/articles/s41...
1/n
Reposted by Volker Boehm
Review by the Mühlemann Lab with first author Wojciech Teodorowicz "Molecular determinants and therapeutic targeting of stop codon readthrough in eukaryotic translation" @jmolbiol.bsky.social
nccr-rna-and-disease.ch/news/article...
@omuhlemann-lab.bsky.social
@unibe.ch
nccr-rna-and-disease.ch/news/article...
@omuhlemann-lab.bsky.social
@unibe.ch
March 30, 2026 at 7:01 AM
Review by the Mühlemann Lab with first author Wojciech Teodorowicz "Molecular determinants and therapeutic targeting of stop codon readthrough in eukaryotic translation" @jmolbiol.bsky.social
nccr-rna-and-disease.ch/news/article...
@omuhlemann-lab.bsky.social
@unibe.ch
nccr-rna-and-disease.ch/news/article...
@omuhlemann-lab.bsky.social
@unibe.ch
Reposted by Volker Boehm
🌱 Two of our labs have achieved the highest My Green Lab Certificate rating! We are excited to share that the Schaefer/Frentz department and the Huppertz lab have received the Green rating - the highest level possible! 👏
www.age.mpg.de/456869/Green...
@inahuppertz.bsky.social
www.age.mpg.de/456869/Green...
@inahuppertz.bsky.social
Top Marks for Sustainable Research
Two biology labs achieved the highest Green Lab certification, showcasing excellence in sustainable research practices.
www.age.mpg.de
September 2, 2026 at 12:25 PM
🌱 Two of our labs have achieved the highest My Green Lab Certificate rating! We are excited to share that the Schaefer/Frentz department and the Huppertz lab have received the Green rating - the highest level possible! 👏
www.age.mpg.de/456869/Green...
@inahuppertz.bsky.social
www.age.mpg.de/456869/Green...
@inahuppertz.bsky.social
Reposted by Volker Boehm
Two PhD positions in the Feldbrügge Lab at HHU Düsseldorf within nEXt-RNA:
🔬 DC1: Live-cell imaging of RNA transfer and function
📦 DC10: Mechanisms and applications of RNA delivery
RNA biology, fungi, extracellular vesicles and advanced imaging.
www.mikrobiologie.hhu.de/en/
🔬 DC1: Live-cell imaging of RNA transfer and function
📦 DC10: Mechanisms and applications of RNA delivery
RNA biology, fungi, extracellular vesicles and advanced imaging.
www.mikrobiologie.hhu.de/en/
September 2, 2026 at 10:28 AM
Two PhD positions in the Feldbrügge Lab at HHU Düsseldorf within nEXt-RNA:
🔬 DC1: Live-cell imaging of RNA transfer and function
📦 DC10: Mechanisms and applications of RNA delivery
RNA biology, fungi, extracellular vesicles and advanced imaging.
www.mikrobiologie.hhu.de/en/
🔬 DC1: Live-cell imaging of RNA transfer and function
📦 DC10: Mechanisms and applications of RNA delivery
RNA biology, fungi, extracellular vesicles and advanced imaging.
www.mikrobiologie.hhu.de/en/
Reposted by Volker Boehm
Reposted by Volker Boehm
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne.
1/🧵
1/🧵
August 25, 2026 at 1:06 PM
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne.
1/🧵
1/🧵
Reposted by Volker Boehm
Vacant postdoc position in RNA biology available in our lab - Århus, Denmark. Please inquire with any questions or simply apply using this link: international.au.dk/about/profil...
Postdoc position in Nuclear RNA Biology - Vacancy at Aarhus University
Vacancy at RNA Biology and Innovation, Aarhus University
international.au.dk
August 18, 2026 at 10:19 AM
Vacant postdoc position in RNA biology available in our lab - Århus, Denmark. Please inquire with any questions or simply apply using this link: international.au.dk/about/profil...
Reposted by Volker Boehm
New bioRxiv preprint from our lab: www.biorxiv.org/content/10.6...: RNA recognition by tandem RRM RBPs is governed by a finely balanced conformational equilibrium. Both weakening and strengthening transient interdomain coupling reduce RNA binding. #NMR #RNABiology #StructuralBiology #bioRxiv
August 8, 2026 at 6:23 AM
New bioRxiv preprint from our lab: www.biorxiv.org/content/10.6...: RNA recognition by tandem RRM RBPs is governed by a finely balanced conformational equilibrium. Both weakening and strengthening transient interdomain coupling reduce RNA binding. #NMR #RNABiology #StructuralBiology #bioRxiv
Reposted by Volker Boehm
👀 Keep cutting-edge RNA research running behind the scenes! The @sebastianfalk.bsky.social lab is looking for a Research Technician/Lab Manager to support research on the molecular machines that process RNA using structural biology, biochemistry, and biophysics ➡️ tinyurl.com/nrjj6bvt
August 3, 2026 at 9:24 AM
👀 Keep cutting-edge RNA research running behind the scenes! The @sebastianfalk.bsky.social lab is looking for a Research Technician/Lab Manager to support research on the molecular machines that process RNA using structural biology, biochemistry, and biophysics ➡️ tinyurl.com/nrjj6bvt
Reposted by Volker Boehm
The Bacterial RNA Biology Group in Jena is hiring a new PhD student! 🔬🧫🧬
We are looking for a motivated candidate to study bacteriophages of the opportunistic pathogen Klebsiella pneumoniae.
🔥 Apply by July 26, 2026 🔥
Details on the position and application: jobs.uni-jena.de/jobposting/9...
We are looking for a motivated candidate to study bacteriophages of the opportunistic pathogen Klebsiella pneumoniae.
🔥 Apply by July 26, 2026 🔥
Details on the position and application: jobs.uni-jena.de/jobposting/9...
Doctoral Researcher in Molecular Microbiology (m/f/d)
jobs.uni-jena.de
July 9, 2026 at 2:28 PM
The Bacterial RNA Biology Group in Jena is hiring a new PhD student! 🔬🧫🧬
We are looking for a motivated candidate to study bacteriophages of the opportunistic pathogen Klebsiella pneumoniae.
🔥 Apply by July 26, 2026 🔥
Details on the position and application: jobs.uni-jena.de/jobposting/9...
We are looking for a motivated candidate to study bacteriophages of the opportunistic pathogen Klebsiella pneumoniae.
🔥 Apply by July 26, 2026 🔥
Details on the position and application: jobs.uni-jena.de/jobposting/9...
Reposted by Volker Boehm
🚴 City Cycling 2026 – Thank you for riding with us!
Great effort from the #CRC1678 team this year! Together with the University Hospital Cologne team, we reached 2nd place across the city. Thanks to everyone who joined the ride and supported a healthier, more sustainable future 🌿💙
Great effort from the #CRC1678 team this year! Together with the University Hospital Cologne team, we reached 2nd place across the city. Thanks to everyone who joined the ride and supported a healthier, more sustainable future 🌿💙
July 9, 2026 at 3:13 PM
🚴 City Cycling 2026 – Thank you for riding with us!
Great effort from the #CRC1678 team this year! Together with the University Hospital Cologne team, we reached 2nd place across the city. Thanks to everyone who joined the ride and supported a healthier, more sustainable future 🌿💙
Great effort from the #CRC1678 team this year! Together with the University Hospital Cologne team, we reached 2nd place across the city. Thanks to everyone who joined the ride and supported a healthier, more sustainable future 🌿💙
Reposted by Volker Boehm
Interested in RNA and proteins?
Perfect! 😀
We seek to fill a fully funded 3+ years PhD position for a project on pre-mRNA splicing regulation using structural biochemistry in combination with cell biology and bioinformatics.
Find more information on our lab's homepage and get in contact via e-mail!
Perfect! 😀
We seek to fill a fully funded 3+ years PhD position for a project on pre-mRNA splicing regulation using structural biochemistry in combination with cell biology and bioinformatics.
Find more information on our lab's homepage and get in contact via e-mail!
Analytische Biochemie - Fakultät - Universität Greifswald
Universität Greifswald
biochemie.uni-greifswald.de
July 7, 2026 at 4:40 PM
Interested in RNA and proteins?
Perfect! 😀
We seek to fill a fully funded 3+ years PhD position for a project on pre-mRNA splicing regulation using structural biochemistry in combination with cell biology and bioinformatics.
Find more information on our lab's homepage and get in contact via e-mail!
Perfect! 😀
We seek to fill a fully funded 3+ years PhD position for a project on pre-mRNA splicing regulation using structural biochemistry in combination with cell biology and bioinformatics.
Find more information on our lab's homepage and get in contact via e-mail!
Reposted by Volker Boehm
Congratulations, Matthias Hentze!
The EMBL Director has been awarded the German Order of Merit for his outstanding achievements in life science research and in building scientific structures across Germany and beyond.
www.embl.org/news/awards-...
The EMBL Director has been awarded the German Order of Merit for his outstanding achievements in life science research and in building scientific structures across Germany and beyond.
www.embl.org/news/awards-...
July 6, 2026 at 2:13 PM
Congratulations, Matthias Hentze!
The EMBL Director has been awarded the German Order of Merit for his outstanding achievements in life science research and in building scientific structures across Germany and beyond.
www.embl.org/news/awards-...
The EMBL Director has been awarded the German Order of Merit for his outstanding achievements in life science research and in building scientific structures across Germany and beyond.
www.embl.org/news/awards-...
Reposted by Volker Boehm
Ina @inahuppertz.bsky.social and Kathrin @katleppek.bsky.social cordially invite all RNA enthusiasts based in the Rhineland region to attend our series of inspiring in-person talks on RNA-related topics by local and invited speakers. This time on Monday July 13th in the DZNE auditorium in Bonn.
June 22, 2026 at 8:44 PM
Ina @inahuppertz.bsky.social and Kathrin @katleppek.bsky.social cordially invite all RNA enthusiasts based in the Rhineland region to attend our series of inspiring in-person talks on RNA-related topics by local and invited speakers. This time on Monday July 13th in the DZNE auditorium in Bonn.
Reposted by Volker Boehm
Now published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)
June 18, 2026 at 8:08 AM
Now published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)
Reposted by Volker Boehm
*today at 14:00*
Elena Conti
Niederrad Lecture, Goethe University,
Medical Campus, House 22, Lecture hall 22-1
"The RNA exosome complex: molecular mechanisms of RNA degradation in health and disease"
Elena Conti
Niederrad Lecture, Goethe University,
Medical Campus, House 22, Lecture hall 22-1
"The RNA exosome complex: molecular mechanisms of RNA degradation in health and disease"
June 18, 2026 at 5:03 AM
*today at 14:00*
Elena Conti
Niederrad Lecture, Goethe University,
Medical Campus, House 22, Lecture hall 22-1
"The RNA exosome complex: molecular mechanisms of RNA degradation in health and disease"
Elena Conti
Niederrad Lecture, Goethe University,
Medical Campus, House 22, Lecture hall 22-1
"The RNA exosome complex: molecular mechanisms of RNA degradation in health and disease"
Reposted by Volker Boehm
Check out our latest research, just published in Nature @nature.com
@molbiolau.bsky.social
@au.dk
Molecular basis of polyadenylated RNA fate determination in the nucleus
www.nature.com/articles/s41...
@molbiolau.bsky.social
@au.dk
Molecular basis of polyadenylated RNA fate determination in the nucleus
www.nature.com/articles/s41...
Molecular basis of polyadenylated RNA fate determination in the nucleus - Nature
Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradati...
www.nature.com
June 17, 2026 at 8:46 PM
Check out our latest research, just published in Nature @nature.com
@molbiolau.bsky.social
@au.dk
Molecular basis of polyadenylated RNA fate determination in the nucleus
www.nature.com/articles/s41...
@molbiolau.bsky.social
@au.dk
Molecular basis of polyadenylated RNA fate determination in the nucleus
www.nature.com/articles/s41...
Reposted by Volker Boehm
How can a splicing factor bind to thousands of exons but regulate only a few of them? In our new preprint, we show that SRSF6 resolves this paradox through two distinct binding modes. @lab-nmr.bsky.social & @julianvonehr.bsky.social. Check it out:
www.researchsquare.com/article/rs-9...
www.researchsquare.com/article/rs-9...
June 17, 2026 at 1:59 PM
How can a splicing factor bind to thousands of exons but regulate only a few of them? In our new preprint, we show that SRSF6 resolves this paradox through two distinct binding modes. @lab-nmr.bsky.social & @julianvonehr.bsky.social. Check it out:
www.researchsquare.com/article/rs-9...
www.researchsquare.com/article/rs-9...
Reposted by Volker Boehm
🚨 Publication Alert 🚨
New review from our #CRC1678 member @riemerlab.bsky.social explores how redox conditions and ROS dynamics shape mitochondrial protein import mapping the redox‑dependent mechanisms linking metabolism, stress, and organelle homeostasis. 🥳
👉 doi.org/10.1002/pro....
New review from our #CRC1678 member @riemerlab.bsky.social explores how redox conditions and ROS dynamics shape mitochondrial protein import mapping the redox‑dependent mechanisms linking metabolism, stress, and organelle homeostasis. 🥳
👉 doi.org/10.1002/pro....
Redox signals and oxidative stress in the control of mitochondrial protein import
Mitochondrial protein import is essential for organelle biogenesis and cellular homeostasis. It operates in an environment that is intrinsically shaped by redox chemistry. Mitochondria are major sour...
doi.org
June 12, 2026 at 11:32 AM
🚨 Publication Alert 🚨
New review from our #CRC1678 member @riemerlab.bsky.social explores how redox conditions and ROS dynamics shape mitochondrial protein import mapping the redox‑dependent mechanisms linking metabolism, stress, and organelle homeostasis. 🥳
👉 doi.org/10.1002/pro....
New review from our #CRC1678 member @riemerlab.bsky.social explores how redox conditions and ROS dynamics shape mitochondrial protein import mapping the redox‑dependent mechanisms linking metabolism, stress, and organelle homeostasis. 🥳
👉 doi.org/10.1002/pro....
Reposted by Volker Boehm
🎉Now OPEN FOR REGISTRATION - join us Sep 14-16 in Giessen for the RTG 2355 International Conference as we explore RNA’s critical functions!
Register 👉tinyurl.com/rtg2355conf
We have slots for short talks and a poster session in the "Palmenhaus", so submit an abstract to present your own work!
Register 👉tinyurl.com/rtg2355conf
We have slots for short talks and a poster session in the "Palmenhaus", so submit an abstract to present your own work!
May 5, 2026 at 9:55 AM
🎉Now OPEN FOR REGISTRATION - join us Sep 14-16 in Giessen for the RTG 2355 International Conference as we explore RNA’s critical functions!
Register 👉tinyurl.com/rtg2355conf
We have slots for short talks and a poster session in the "Palmenhaus", so submit an abstract to present your own work!
Register 👉tinyurl.com/rtg2355conf
We have slots for short talks and a poster session in the "Palmenhaus", so submit an abstract to present your own work!
Reposted by Volker Boehm
TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data.
@sholtodavid.bsky.social @johanduchene.bsky.social
reeserichardson.blog/2026/05/28/h...
@sholtodavid.bsky.social @johanduchene.bsky.social
reeserichardson.blog/2026/05/28/h...
How much of Thermo Fisher’s antibody data has been manipulated?
We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog
reeserichardson.blog
May 28, 2026 at 5:48 PM
TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data.
@sholtodavid.bsky.social @johanduchene.bsky.social
reeserichardson.blog/2026/05/28/h...
@sholtodavid.bsky.social @johanduchene.bsky.social
reeserichardson.blog/2026/05/28/h...
Reposted by Volker Boehm
For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
May 13, 2026 at 8:19 AM
For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Volker Boehm
Our preprint on how variant U1 snRNAs control transcriptional and splicing homeostasis of hiPSCs is now officially out in @natcomms.nature.com and accessible via this link:
www.nature.com/articles/s41...
This has been the culmination of our work as part of the SPP1935 program funded by @dfg.de
1/n
www.nature.com/articles/s41...
This has been the culmination of our work as part of the SPP1935 program funded by @dfg.de
1/n
May 13, 2026 at 8:50 AM
Our preprint on how variant U1 snRNAs control transcriptional and splicing homeostasis of hiPSCs is now officially out in @natcomms.nature.com and accessible via this link:
www.nature.com/articles/s41...
This has been the culmination of our work as part of the SPP1935 program funded by @dfg.de
1/n
www.nature.com/articles/s41...
This has been the culmination of our work as part of the SPP1935 program funded by @dfg.de
1/n
Reposted by Volker Boehm
We're hiring! Join our growing team at the @crg.eu as a postdoc.
Curious about how mRNA translation and decay cross-talk? We're looking for a postdoctoral researcher to lead a project in the field of RNA biology and gene regulation.
Apply here: recruitment.crg.eu/content/jobs...
Please share!
Curious about how mRNA translation and decay cross-talk? We're looking for a postdoctoral researcher to lead a project in the field of RNA biology and gene regulation.
Apply here: recruitment.crg.eu/content/jobs...
Please share!
Postdoc in the Dynamics of Protein Synthesis and RNA Decay Lab | CRG Online Recruitment Portal
recruitment.crg.eu
May 8, 2026 at 3:34 PM
We're hiring! Join our growing team at the @crg.eu as a postdoc.
Curious about how mRNA translation and decay cross-talk? We're looking for a postdoctoral researcher to lead a project in the field of RNA biology and gene regulation.
Apply here: recruitment.crg.eu/content/jobs...
Please share!
Curious about how mRNA translation and decay cross-talk? We're looking for a postdoctoral researcher to lead a project in the field of RNA biology and gene regulation.
Apply here: recruitment.crg.eu/content/jobs...
Please share!
Reposted by Volker Boehm
Our preprint describing the moonlighting functions of SEC13 in NMD and regulation of the UPR is out now in bioRxiv www.biorxiv.org/cgi/content/...
www.biorxiv.org
May 2, 2026 at 10:00 AM
Our preprint describing the moonlighting functions of SEC13 in NMD and regulation of the UPR is out now in bioRxiv www.biorxiv.org/cgi/content/...
Reposted by Volker Boehm
