The distinct active-site architecture of Burkholderia cenocepacia short-chain dehydrogenase (SDR) suggests that it is most appropriately classed as a divergent SDR #ResearchExperiencesForUndergraduates #SSGCID doi.org/10.1107/S205...
December 16, 2024 at 5:11 PM
The distinct active-site architecture of Burkholderia cenocepacia short-chain dehydrogenase (SDR) suggests that it is most appropriately classed as a divergent SDR #ResearchExperiencesForUndergraduates #SSGCID doi.org/10.1107/S205...
Chi Nguyen et al.: Structures of Legionella pneumophila serogroup 1 peptide deformylase bound to nickel(II) and actinonin ##SSGCID##StructuralGenomics##>PeptideDeformylases... ##IUCrhttps://journals.iucr.org/paper?S2053230X25001876
Structures of Legionella pneumophila serogroup 1 peptide deformylase bound to nickel(II) and actinonin
Peptide deformylases (PDFs) are of interest as viable drug targets for the development of new antimicrobials. Two crystal structures of PDF from L. pneumophila serogroup 1, the causative agent of Legionnaires' disease, bound to Ni2+ or to actinonin and Zn2+, were solved at 1.5 and 1.65 Å resolution, respectively.
journals.iucr.org
March 18, 2025 at 1:00 AM
Chi Nguyen et al.: Structures of Legionella pneumophila serogroup 1 peptide deformylase bound to nickel(II) and actinonin ##SSGCID##StructuralGenomics##>PeptideDeformylases... ##IUCrhttps://journals.iucr.org/paper?S2053230X25001876
The structure of Helicobacter pylori biotin protein ligase reveals a conserved catalytic cavity and structural similarity to the Mycobacterium tuberculosis enzyme, which is promising for repurposing inhibitors #UndergraduateEducationAndTraining #SSGCID #InfectiousDiseases doi.org/10.1107/S205...
January 14, 2025 at 3:01 PM
The structure of Helicobacter pylori biotin protein ligase reveals a conserved catalytic cavity and structural similarity to the Mycobacterium tuberculosis enzyme, which is promising for repurposing inhibitors #UndergraduateEducationAndTraining #SSGCID #InfectiousDiseases doi.org/10.1107/S205...
This structure of macrophage migration inhibitory factor is a contribution to our cross-journal Early Career Scientists in Structural Science special issue. Find out more at journals.iucr.org/early-career... #SSGCID #MacrophageMigrationInhibitoryFactor doi.org/10.1107/S205...
July 8, 2026 at 3:25 PM
This structure of macrophage migration inhibitory factor is a contribution to our cross-journal Early Career Scientists in Structural Science special issue. Find out more at journals.iucr.org/early-career... #SSGCID #MacrophageMigrationInhibitoryFactor doi.org/10.1107/S205...
Chi L. Nguyen et al.: Structural characterization of dUTPase from Legionella pneumophila ##SSGCID##StructuralGenomics##SeattleStructuralGenomicsCenterForInfectiousDisease... ##IUCrhttps://journals.iucr.org/paper?S2053230X25001815
Structural characterization of dUTPase from Legionella pneumophila
L. pneumophila serogroup 1 is the causative agent of Legionnaires' disease. Two crystal structures of apo and dUMP-bound deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase) were determined to 1.80 and 1.95 Å resolution, respectively. dUTPases have been investigated as a potential druggable target in several pathogens.
journals.iucr.org
March 18, 2025 at 1:00 AM
Chi L. Nguyen et al.: Structural characterization of dUTPase from Legionella pneumophila ##SSGCID##StructuralGenomics##SeattleStructuralGenomicsCenterForInfectiousDisease... ##IUCrhttps://journals.iucr.org/paper?S2053230X25001815
Aruesha Srivastava et al.: Crystal structure of carbon–nitrogen hydrolase from Helicobacter pylori G27 ##Ssgcid##StructuralGenomics##HelicobacterPylori@_hamptonu...##IUCrhttps://journals.iucr.org/paper?S2053230X26001330
Crystal structure of carbon–nitrogen hydrolase from Helicobacter pylori G27
H. pylori carbon–nitrogen hydrolase was produced and crystallized, and its 2.1 Å resolution structure is reported.
journals.iucr.org
February 19, 2026 at 1:00 AM
Aruesha Srivastava et al.: Crystal structure of carbon–nitrogen hydrolase from Helicobacter pylori G27 ##Ssgcid##StructuralGenomics##HelicobacterPylori@_hamptonu...##IUCrhttps://journals.iucr.org/paper?S2053230X26001330
Two structures of Legionella pneumophila serogroup 1 peptide deformylase (PDF) provide insight into PDF inhibition and support continued anti-PDF drug-development efforts #SSGCID #StructuralGenomics #>PeptideDeformylases doi.org/10.1107/S205...
April 15, 2025 at 3:17 PM
Two structures of Legionella pneumophila serogroup 1 peptide deformylase (PDF) provide insight into PDF inhibition and support continued anti-PDF drug-development efforts #SSGCID #StructuralGenomics #>PeptideDeformylases doi.org/10.1107/S205...
Apo and dUMP-bound structures of Legionella pneumophila dUTPase revealed a potential new binding site and active-site structural differences when compared with human dUTPase #SSGCID #StructuralGenomics doi.org/10.1107/S205...
April 14, 2025 at 1:55 PM
Apo and dUMP-bound structures of Legionella pneumophila dUTPase revealed a potential new binding site and active-site structural differences when compared with human dUTPase #SSGCID #StructuralGenomics doi.org/10.1107/S205...
Two structures of Brucella ovis leucine-, isoleucine-, valine-, threonine- and alanine-binding protein are reported that show its conformational flexibility in the absence of bound amino acids
#SSGCID #StructuralGenomics #Brucellosis t.co/aDI9PPMCdu
#SSGCID #StructuralGenomics #Brucellosis t.co/aDI9PPMCdu
September 10, 2024 at 2:31 PM
Two structures of Brucella ovis leucine-, isoleucine-, valine-, threonine- and alanine-binding protein are reported that show its conformational flexibility in the absence of bound amino acids
#SSGCID #StructuralGenomics #Brucellosis t.co/aDI9PPMCdu
#SSGCID #StructuralGenomics #Brucellosis t.co/aDI9PPMCdu
Three crystal structures of two NAD(P)H nitroreductases from Klebsiella pneumoniae are presented and an analysis of their structures and their flavin mononucleotide-binding mode is provided. #Nitroreductase #SSGCID #StructuralGenomics t.co/0dFO1nRWzB
August 8, 2024 at 2:55 PM
Three crystal structures of two NAD(P)H nitroreductases from Klebsiella pneumoniae are presented and an analysis of their structures and their flavin mononucleotide-binding mode is provided. #Nitroreductase #SSGCID #StructuralGenomics t.co/0dFO1nRWzB
Abhishek D. Kancherla et al.: Crystal structures of NAD(P)H nitroreductases from Klebsiella pneumoniae ##Nitroreductase##SSGCID##StructuralGenomics... ##IUCrhttps://journals.iucr.org/paper?S2053230X24006472
Crystal structures of NAD(P)H nitroreductases from Klebsiella pneumoniae
Structures of NAD(P)H nitroreductases from Klebsiella pneumoniae have been determined at resolutions of 1.97, 1.90 and 1.35 Å.
journals.iucr.org
July 12, 2024 at 12:00 AM
Abhishek D. Kancherla et al.: Crystal structures of NAD(P)H nitroreductases from Klebsiella pneumoniae ##Nitroreductase##SSGCID##StructuralGenomics... ##IUCrhttps://journals.iucr.org/paper?S2053230X24006472