Very proud of this work we just published in Acta Cryst F ! Done by undergrad students in my protein crystallography Spring '23 CURE - they analyzed an unpublished SSGCID structure, then designed/ran experiments to test function. #StructuralGenomics
doi.org/10.1107/S205...
doi.org/10.1107/S205...
September 27, 2023 at 8:10 PM
Very proud of this work we just published in Acta Cryst F ! Done by undergrad students in my protein crystallography Spring '23 CURE - they analyzed an unpublished SSGCID structure, then designed/ran experiments to test function. #StructuralGenomics
doi.org/10.1107/S205...
doi.org/10.1107/S205...
The E. histolytica endoribonuclease L-PSP has a prototypical YjgF/YER057c/UK114 family structure with a large allosteric site that can be targeted for rational drug-discovery efforts #StructuralGenomics #EndoribonucleaseLPSP #EntamoebaHistolytica doi.org/10.1107/S205...
June 17, 2025 at 1:35 PM
The E. histolytica endoribonuclease L-PSP has a prototypical YjgF/YER057c/UK114 family structure with a large allosteric site that can be targeted for rational drug-discovery efforts #StructuralGenomics #EndoribonucleaseLPSP #EntamoebaHistolytica doi.org/10.1107/S205...
Differences in the binding pocket provide insight for the development of selective inhibitors that target bacterial TrpRS without interfering with the human cytosolic form #StructuralGenomics #NeisseriaGonorrhoeae #TryptophanylTRNASynthetase doi.org/10.1107/S205...
April 8, 2025 at 2:22 PM
Differences in the binding pocket provide insight for the development of selective inhibitors that target bacterial TrpRS without interfering with the human cytosolic form #StructuralGenomics #NeisseriaGonorrhoeae #TryptophanylTRNASynthetase doi.org/10.1107/S205...
Chi Nguyen et al.: Structures of Legionella pneumophila serogroup 1 peptide deformylase bound to nickel(II) and actinonin ##SSGCID##StructuralGenomics##>PeptideDeformylases... ##IUCrhttps://journals.iucr.org/paper?S2053230X25001876
Structures of Legionella pneumophila serogroup 1 peptide deformylase bound to nickel(II) and actinonin
Peptide deformylases (PDFs) are of interest as viable drug targets for the development of new antimicrobials. Two crystal structures of PDF from L. pneumophila serogroup 1, the causative agent of Legionnaires' disease, bound to Ni2+ or to actinonin and Zn2+, were solved at 1.5 and 1.65 Å resolution, respectively.
journals.iucr.org
March 18, 2025 at 1:00 AM
Chi Nguyen et al.: Structures of Legionella pneumophila serogroup 1 peptide deformylase bound to nickel(II) and actinonin ##SSGCID##StructuralGenomics##>PeptideDeformylases... ##IUCrhttps://journals.iucr.org/paper?S2053230X25001876
Chi L. Nguyen et al.: Structural characterization of dUTPase from Legionella pneumophila ##SSGCID##StructuralGenomics##SeattleStructuralGenomicsCenterForInfectiousDisease... ##IUCrhttps://journals.iucr.org/paper?S2053230X25001815
Structural characterization of dUTPase from Legionella pneumophila
L. pneumophila serogroup 1 is the causative agent of Legionnaires' disease. Two crystal structures of apo and dUMP-bound deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase) were determined to 1.80 and 1.95 Å resolution, respectively. dUTPases have been investigated as a potential druggable target in several pathogens.
journals.iucr.org
March 18, 2025 at 1:00 AM
Chi L. Nguyen et al.: Structural characterization of dUTPase from Legionella pneumophila ##SSGCID##StructuralGenomics##SeattleStructuralGenomicsCenterForInfectiousDisease... ##IUCrhttps://journals.iucr.org/paper?S2053230X25001815
1️⃣ 𝘛𝘩𝘦 𝘤𝘰𝘯𝘵𝘦𝘹𝘵
In mammals, the Y-chromosome gene Sry triggers testis development, while its absence leads to ovary formation. Although this is well known, scientists continue to ask how epigenetic regulation and 3D genome organisation control this process
#CNAG #StructuralGenomics #SexDetermination
In mammals, the Y-chromosome gene Sry triggers testis development, while its absence leads to ovary formation. Although this is well known, scientists continue to ask how epigenetic regulation and 3D genome organisation control this process
#CNAG #StructuralGenomics #SexDetermination
February 24, 2026 at 10:21 AM
1️⃣ 𝘛𝘩𝘦 𝘤𝘰𝘯𝘵𝘦𝘹𝘵
In mammals, the Y-chromosome gene Sry triggers testis development, while its absence leads to ovary formation. Although this is well known, scientists continue to ask how epigenetic regulation and 3D genome organisation control this process
#CNAG #StructuralGenomics #SexDetermination
In mammals, the Y-chromosome gene Sry triggers testis development, while its absence leads to ovary formation. Although this is well known, scientists continue to ask how epigenetic regulation and 3D genome organisation control this process
#CNAG #StructuralGenomics #SexDetermination
Aruesha Srivastava et al.: Crystal structure of carbon–nitrogen hydrolase from Helicobacter pylori G27 ##Ssgcid##StructuralGenomics##HelicobacterPylori@_hamptonu...##IUCrhttps://journals.iucr.org/paper?S2053230X26001330
Crystal structure of carbon–nitrogen hydrolase from Helicobacter pylori G27
H. pylori carbon–nitrogen hydrolase was produced and crystallized, and its 2.1 Å resolution structure is reported.
journals.iucr.org
February 19, 2026 at 1:00 AM
Aruesha Srivastava et al.: Crystal structure of carbon–nitrogen hydrolase from Helicobacter pylori G27 ##Ssgcid##StructuralGenomics##HelicobacterPylori@_hamptonu...##IUCrhttps://journals.iucr.org/paper?S2053230X26001330
Oladele T. Ojuromi et al.: Crystal structures of the putative endoribonuclease L-PSP from Entamoeba histolytica ##StructuralGenomics##EndoribonucleaseLPSP##EntamoebaHistolytica... ##IUCrhttps://journals.iucr.org/paper?S2053230X25003875
Crystal structures of the putative endoribonuclease L-PSP from Entamoeba histolytica
The purification, crystallization and three crystal structures of the putative endoribonuclease L-PSP from E. histolytica are reported.
journals.iucr.org
May 3, 2025 at 12:00 AM
Oladele T. Ojuromi et al.: Crystal structures of the putative endoribonuclease L-PSP from Entamoeba histolytica ##StructuralGenomics##EndoribonucleaseLPSP##EntamoebaHistolytica... ##IUCrhttps://journals.iucr.org/paper?S2053230X25003875
Two structures of Legionella pneumophila serogroup 1 peptide deformylase (PDF) provide insight into PDF inhibition and support continued anti-PDF drug-development efforts #SSGCID #StructuralGenomics #>PeptideDeformylases doi.org/10.1107/S205...
April 15, 2025 at 3:17 PM
Two structures of Legionella pneumophila serogroup 1 peptide deformylase (PDF) provide insight into PDF inhibition and support continued anti-PDF drug-development efforts #SSGCID #StructuralGenomics #>PeptideDeformylases doi.org/10.1107/S205...
Apo and dUMP-bound structures of Legionella pneumophila dUTPase revealed a potential new binding site and active-site structural differences when compared with human dUTPase #SSGCID #StructuralGenomics doi.org/10.1107/S205...
April 14, 2025 at 1:55 PM
Apo and dUMP-bound structures of Legionella pneumophila dUTPase revealed a potential new binding site and active-site structural differences when compared with human dUTPase #SSGCID #StructuralGenomics doi.org/10.1107/S205...
Two structures of Brucella ovis leucine-, isoleucine-, valine-, threonine- and alanine-binding protein are reported that show its conformational flexibility in the absence of bound amino acids
#SSGCID #StructuralGenomics #Brucellosis t.co/aDI9PPMCdu
#SSGCID #StructuralGenomics #Brucellosis t.co/aDI9PPMCdu
September 10, 2024 at 2:31 PM
Two structures of Brucella ovis leucine-, isoleucine-, valine-, threonine- and alanine-binding protein are reported that show its conformational flexibility in the absence of bound amino acids
#SSGCID #StructuralGenomics #Brucellosis t.co/aDI9PPMCdu
#SSGCID #StructuralGenomics #Brucellosis t.co/aDI9PPMCdu
Three crystal structures of two NAD(P)H nitroreductases from Klebsiella pneumoniae are presented and an analysis of their structures and their flavin mononucleotide-binding mode is provided. #Nitroreductase #SSGCID #StructuralGenomics t.co/0dFO1nRWzB
August 8, 2024 at 2:55 PM
Three crystal structures of two NAD(P)H nitroreductases from Klebsiella pneumoniae are presented and an analysis of their structures and their flavin mononucleotide-binding mode is provided. #Nitroreductase #SSGCID #StructuralGenomics t.co/0dFO1nRWzB
Abhishek D. Kancherla et al.: Crystal structures of NAD(P)H nitroreductases from Klebsiella pneumoniae ##Nitroreductase##SSGCID##StructuralGenomics... ##IUCrhttps://journals.iucr.org/paper?S2053230X24006472
Crystal structures of NAD(P)H nitroreductases from Klebsiella pneumoniae
Structures of NAD(P)H nitroreductases from Klebsiella pneumoniae have been determined at resolutions of 1.97, 1.90 and 1.35 Å.
journals.iucr.org
July 12, 2024 at 12:00 AM
Abhishek D. Kancherla et al.: Crystal structures of NAD(P)H nitroreductases from Klebsiella pneumoniae ##Nitroreductase##SSGCID##StructuralGenomics... ##IUCrhttps://journals.iucr.org/paper?S2053230X24006472