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Epstein Web

@epsteinweb.bsky.social

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https://epsteinweb.org
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EFTA01113695 | EFTA01113695
Science recently learned —50% of medications work
through GPCR signaling.
But, 99% of existing drugs were discovered by luck:
trial, error, observation and testing, over years.

Imagine a world in which we could
target-design medications to signal
through specific GPCR channels.

It would change medicin

.9

OH2 Laboratories
Re-engineering Drug Discovery

The ability to produce stable water-soluble protein replicants
is a fundamental new tool that opens many doors:
Drug Discovery
Our technology provides a critical revitalization of drying
pharma pipelines: (i) Addresses compounds with poor solubility (over 40% of drugs) offering increased efficacy and faster,
cheaper development. (ii) Enables novel drug candidates for
GPCR-mediated diseases:
*Examples include:
Alzheimer's (GPR3)
Parkinson's (GPCR 37)
Prostate cancer (GPR68/0GRI)
Arteriosclerosis (GPRS 176) Asthma (CCR3.CXCR2)
Cancer metastasis (CXCR4)
Colon cancer (MASI)
Ovarian Cancer (OCRI) Leukemia (P2Y8/P2 R Y8)
Diabetes (GPCR 21)
Autism (GPCR 63)
Bipolar disorder (GPRS 78)
Osteoarthritis (GPR22)
Lung cancer (GPR87)
Breast Cancer (CXCR4)
(Plus over 700 others and the list grows almost daily.)

Research Tools - Provide our synthetic GPCRQTY materials,
duplicating native GPCR functionality in a water-soluble form
to research laboratories.
Diagnostics - Water-soluble GPCRQTY materials maintain ligand
binding ability to specific antigens/receptors, providing a new
class of novel, low-cost diagnostics.

Company Structure
OH2 is an IP development and holding company,
structured to form subsidiaries to monetize the
benefits our technologies bring to a range of fields:
• Drug Discovery
• Research Tools
• Diagnostics
• mAB-Similar Products
• Autoimmune/Allergy Therapy
• Viral Therapeutics
• Molecular Sensors
Market Size (Pharma only)
GPCR-related pharma is —$425B/year globally.
Our technology will grow the market considerably.
Our Scientists
Shuguang Zhang, Ph.D - Lead Investigator
MIT

Researcher for 26 years
160 papers, 36 patents issued and pending
Last company (3DMatrix) valued at 5800M

Prof. Robert Langer
mAB-Similar Products - New molecular therapeutics: (i)
Target-designed to be similar to monoclonal antibodies, but
easier to produce; (ii) Engineering mAbQTY to reduce mAb
aggregation and increase long-term storage.

MIT Professor for 36 years
1,250+ articles. 220+ major awards
1,030+ patents. 250+ licenses

Autoimmune/Allergy Therapy - Use GPCRQTY as decoy treatment (similar to Enbrel/Etanercept), theoretically for any disease
or condition associated with GPCR signaling.

David Jin, M.D.

Viral Therapeutics - Use Receptors QTY to trap viruses including:
HIV, Ebola, Marburg & Lassa - for rapid reduction of viral loads.
Molecular Sensors - Use Receptors QTY to create ultra-sensitive
bionic detectors. (e.g. a chip-based bionic nose.)
For more information contact David Levy

Alexander Rich, M.D.
MIT Professor for 56 years
550+ articles. Many awards and honors
Practicing Oncologist and Researcher
2012 Top Chief Medical Officer in America
2014 Leading Physicians in the World

Our Board
David Levy, Ph.D - General Manager and Chairman
Marc Rioult, Ph.D - Man. Director, 3DMatrix US & Europe
Kevin Munnelly, Ph.D - President and CEO, Gen9
Steve Yang, Ph.D. - Director, Sentilia

+1

EFTA01113695

May 9, 2026 at 9:29 PM

lostjared

@lostjared.bsky.social

This demo was supposed to be like a Matrix green Rain, but in 3D. It didn't turn out that great. I will have to try again because I don't think it should work the way this program does. You can turn the Web Assembly version of this program here: lostsidedead.biz/3DMatrix/ #matrix #greenrain #3D

December 29, 2025 at 5:01 PM

meagandavid73.bsky.social

@meagandavid73.bsky.social

Dead dying in a dream simulation #3DMatrix thanks to @cern.bsky.social end of the Mayan calendar in 2025. CERN killed us only way out is #YahushuaBenDavid

December 10, 2025 at 2:14 AM

Lesley Smith

@lesleysmith.bsky.social

Please support Lawrence Wade and colleagues from 3DMatrix who are running the Royal Parks Half Marathon in aid of @prda.org.uk this weekend 👏👏 Every little counts!

www.justgiving.com/fundraising/...

Pelvic Radiation Disease PRDA

Help Lawrence Wade raise money to support PRDA (Pelvic Radiation Disease Association)

www.justgiving.com

October 7, 2025 at 4:02 PM

Gregor lab

@gregorlab.bsky.social

Gamechanger for vesicle Control! We present an approach to remotely control endosomal distribution in living cells (even in #3Dmatrix) with high precision.