Unlocking Silenced Brain Genes: Is Sodium Butyrate the Ultimate Epigenetic Breakthrough?

Source: www.frontiersin.org/articles/10....
Source: www.mdpi.com/1422-0067/22...
Source: pubmed.ncbi.nlm.nih.gov/33895475/

#epigenetics #4PBA #sodiumbutyrate #BDNF #neuroscience #geneexpression #brainhealth

The Extreme Receptor Hack: Can CX-614 Force Synaptic Rebirth?

Source: www.mdpi.com/1422-0067/22...
Source: www.frontiersin.org/articles/10....
Source: pubmed.ncbi.nlm.nih.gov/12893840/

#ampakines #epigenetics #cx614 #cx546 #4pba #sodiumbutyrate #bdnf #glutamate

And here's the Spotify link. Enjoy!: open.spotify.com/episode/4PbA...

#SFP2025 Amandine Le Ruyet from @inrae-bioger.bsky.social on the mode of action of a biocontrol molecule, the 4PBA

really loved this convo about all things BROUGHTUPSY — such smart questions about how the novel came to be, what i hope to write next & what it means to be queer in jamaica. listen in!

apple: podcasts.apple.com/us/podcast/8...

spotify: open.spotify.com/episode/4PbA...

YT: youtu.be/5pJdvK8QYI4?...

"Past" Their Mistakes.

In This World Brothers Can "Prevail".

Tranparency.
www.youtube.com/watch?v=4Pba...

Thank you for sharing this, Tom! I added it to my reading list 🙂 Also, your 4PBA and collagen III mutation paper is in there✌️ See you at collagen GRC!

Using a knock-in mouse model, the authors show that 4PBA restores cell-surface localization of mutant DSCAML1, improves neurodevelopmental abnormalities, and reduces epileptic discharges, highlighting a promising therapeutic strategy for DSCAML1-associated disorders. (Mikio Hoshino)

This study examines whether 4-phenylbutyric acid (4PBA), a chemical chaperone, can correct abnormal DSCAML1 localization caused by the patient-specific A2105T mutation.

Genes to Cells
Volume 31, Issue 3 , 2026.

"Pharmacological Correction of Aberrant DSCAML1 Localization by 4-Phenylbutyrate Ameliorates Epileptic Phenotypes in a Mouse Model Harboring the Patient-Specific A2105T Mutation"

doi.org/10.1111/gtc....

Author's Comment ➡️