Mutated DNA Restored to Normal in Gene Therapy Advance (𝗚𝗶𝗳𝘁 𝗔𝗿𝘁𝗶𝗰𝗹𝗲) www.nytimes.com/2025/03/10/h... @nytimes.com
𝗚𝗲𝘁 𝘄𝗲𝗲𝗸𝗹𝘆 𝘂𝗽𝗱𝗮𝘁𝗲𝘀: CanadaHealthwatch.ca/newsletter 🍁
𝗚𝗲𝘁 𝘄𝗲𝗲𝗸𝗹𝘆 𝘂𝗽𝗱𝗮𝘁𝗲𝘀: CanadaHealthwatch.ca/newsletter 🍁
March 11, 2025 at 2:42 AM
Mutated DNA Restored to Normal in Gene Therapy Advance (𝗚𝗶𝗳𝘁 𝗔𝗿𝘁𝗶𝗰𝗹𝗲) www.nytimes.com/2025/03/10/h... @nytimes.com
𝗚𝗲𝘁 𝘄𝗲𝗲𝗸𝗹𝘆 𝘂𝗽𝗱𝗮𝘁𝗲𝘀: CanadaHealthwatch.ca/newsletter 🍁
𝗚𝗲𝘁 𝘄𝗲𝗲𝗸𝗹𝘆 𝘂𝗽𝗱𝗮𝘁𝗲𝘀: CanadaHealthwatch.ca/newsletter 🍁
I'm dying to get this in my hands...~! And to read more AATD (your comics be peak)
September 27, 2026 at 7:34 PM
I'm dying to get this in my hands...~! And to read more AATD (your comics be peak)
Roads begin to flood at the Jersey Shore due to coastal storm
YouTube video by NBC10 Philadelphia
youtube.com
September 24, 2026 at 2:06 AM
Vous pouvez suivre AATDS sur cette plateforme : bsky.app/profile/aatd...
bsky.app
January 20, 2025 at 2:01 PM
Vous pouvez suivre AATDS sur cette plateforme : bsky.app/profile/aatd...
Rare liver and lung disorder is seen as a perfect, lucrative target for gene editing www.statnews.com/2026/07/28/b...
From ‘lost cause’ to gold rush: Biotechs swarm to cure AATD
Biotech companies are racing to cure alpha-1 antitrypsin deficiency, AATD, fueling patent disputes, startup defections, arbitration, and a U.S.-China rivalry.
www.statnews.com
July 28, 2026 at 4:47 PM
Rare liver and lung disorder is seen as a perfect, lucrative target for gene editing www.statnews.com/2026/07/28/b...
Good morning! Hope everyone’s #FlightDeckMonday is off to a good start. Here’s a sim version: the Piper Archer NXi AATD from Flight1 Tech… #flying #pilots #avgeeks #flightsims
March 3, 2025 at 2:32 PM
Good morning! Hope everyone’s #FlightDeckMonday is off to a good start. Here’s a sim version: the Piper Archer NXi AATD from Flight1 Tech… #flying #pilots #avgeeks #flightsims
1/ In the last five years, over half a dozen biotech executives have come to the same conclusion: AATD is the perfect gene therapy candidate.
So how did a rare liver disorder become the latest biotech gold rush?
www.statnews.com/2026/07/28/b...
So how did a rare liver disorder become the latest biotech gold rush?
www.statnews.com/2026/07/28/b...
From ‘lost cause’ to gold rush: Biotechs swarm to cure AATD
Biotech companies are racing to cure alpha-1 antitrypsin deficiency, AATD, fueling patent disputes, startup defections, arbitration, and a U.S.-China rivalry.
www.statnews.com
July 29, 2026 at 2:19 PM
1/ In the last five years, over half a dozen biotech executives have come to the same conclusion: AATD is the perfect gene therapy candidate.
So how did a rare liver disorder become the latest biotech gold rush?
www.statnews.com/2026/07/28/b...
So how did a rare liver disorder become the latest biotech gold rush?
www.statnews.com/2026/07/28/b...
The @fda.gov has approved the Investigational New Drug (#IND) application for YOLT-202, an in vivo gene-editing therapy for alpha-1 antitrypsin deficiency (#AATD), according to a recent press release.
Read more: https://bit.ly/4draiFV
#RareDisease #YOLT202 #GeneEditingTherapy #Alpha1
Read more: https://bit.ly/4draiFV
#RareDisease #YOLT202 #GeneEditingTherapy #Alpha1
FDA Gives Clearance to In Vivo Gene-Editing Therapy for AATD
The FDA has approved the Investigational New Drug application for YOLT-202, an in vivo gene-editing therapy for AATD.
bit.ly
April 3, 2026 at 3:20 PM
The @fda.gov has approved the Investigational New Drug (#IND) application for YOLT-202, an in vivo gene-editing therapy for alpha-1 antitrypsin deficiency (#AATD), according to a recent press release.
Read more: https://bit.ly/4draiFV
#RareDisease #YOLT202 #GeneEditingTherapy #Alpha1
Read more: https://bit.ly/4draiFV
#RareDisease #YOLT202 #GeneEditingTherapy #Alpha1
‼️Following first hepatic decompensation, patients with severe #AATD have a higher risk of complications vs. other aetiologies
👉Early listing for liver transplantation. #LiverSky
🔗https://doi.org/10.1016/j.jhepr.2024.101308
@easlnews.bsky.social @jhepatology.bsky.social
👉Early listing for liver transplantation. #LiverSky
🔗https://doi.org/10.1016/j.jhepr.2024.101308
@easlnews.bsky.social @jhepatology.bsky.social
March 21, 2025 at 3:19 PM
‼️Following first hepatic decompensation, patients with severe #AATD have a higher risk of complications vs. other aetiologies
👉Early listing for liver transplantation. #LiverSky
🔗https://doi.org/10.1016/j.jhepr.2024.101308
@easlnews.bsky.social @jhepatology.bsky.social
👉Early listing for liver transplantation. #LiverSky
🔗https://doi.org/10.1016/j.jhepr.2024.101308
@easlnews.bsky.social @jhepatology.bsky.social
Our paper is out in Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution.
Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time.
www.nature.com/articles/s41...
Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time.
www.nature.com/articles/s41...
Deep Visual Proteomics maps proteotoxicity in a genetic liver disease - Nature
High-resolution spatial proteomics were used to map molecular events during hepatocyte stress in pseudotime across all fibrosis stages, recapitulating known disease progression markers and revealing e...
www.nature.com
April 16, 2025 at 3:16 PM
Our paper is out in Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution.
Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time.
www.nature.com/articles/s41...
Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time.
www.nature.com/articles/s41...
New from us: Prognosis in alpha-1 antitrypsin deficiency (AATD). Out now in JIM - Journal of Internal Medicine: doi.org/10.1111/joim.... Briefly, we identified 2,286 patients with a diagnosis of AATD and compared selected outcomes to matched reference individuals from the general population.
<em>Journal of Internal Medicine</em> | Wiley Online Library
Objective
To estimate the incidence, prevalence, and outcomes of patients with diagnosed alpha-1-antitrypsin deficiency (AATD) in Sweden, 2002–2020.
Study design and setting
The Swedish National P.....
doi.org
January 8, 2025 at 6:39 PM
New from us: Prognosis in alpha-1 antitrypsin deficiency (AATD). Out now in JIM - Journal of Internal Medicine: doi.org/10.1111/joim.... Briefly, we identified 2,286 patients with a diagnosis of AATD and compared selected outcomes to matched reference individuals from the general population.
so, things i learned this week:
1. there's a doom wad that relies almost entirely on engine bugs www.youtube.com/watch?v=AatD...
2. gzdoom's lead absolutely lost his shit when it got a cacoward
3. there's a request to make it playable on uzdoom, and the reply to the request was "sorry, but no"
1. there's a doom wad that relies almost entirely on engine bugs www.youtube.com/watch?v=AatD...
2. gzdoom's lead absolutely lost his shit when it got a cacoward
3. there's a request to make it playable on uzdoom, and the reply to the request was "sorry, but no"
lilith.pk3 for Doom 2 (NO COMMENTARY FULL PLAY THROUGH)
YouTube video by ShallowVA
www.youtube.com
October 18, 2025 at 5:39 PM
so, things i learned this week:
1. there's a doom wad that relies almost entirely on engine bugs www.youtube.com/watch?v=AatD...
2. gzdoom's lead absolutely lost his shit when it got a cacoward
3. there's a request to make it playable on uzdoom, and the reply to the request was "sorry, but no"
1. there's a doom wad that relies almost entirely on engine bugs www.youtube.com/watch?v=AatD...
2. gzdoom's lead absolutely lost his shit when it got a cacoward
3. there's a request to make it playable on uzdoom, and the reply to the request was "sorry, but no"
BEAM-302: Rewriting Genes, Restoring Health – A Breakthrough in AATD The... youtu.be/frO2d1BrXiU?... via @YouTube
BEAM-302: Rewriting Genes, Restoring Health – A Breakthrough in AATD Therapy! 🔬🚀
YouTube video by MasterMedFacts
youtu.be
March 14, 2025 at 1:55 PM
BEAM-302: Rewriting Genes, Restoring Health – A Breakthrough in AATD The... youtu.be/frO2d1BrXiU?... via @YouTube
How does AATD impact pulmonary health? This #InternationalPodcastDay, tune in to episode 1 of ‘Understanding AATD’ to hear Pavel Strnad and Marc Miravitlles explore this rare disease’s pulmonary impact, from comorbidities to delayed diagnosis #MedSky #LiverSky #CME
ow.ly/YRXt50X4lUh
ow.ly/YRXt50X4lUh
September 30, 2025 at 2:25 PM
How does AATD impact pulmonary health? This #InternationalPodcastDay, tune in to episode 1 of ‘Understanding AATD’ to hear Pavel Strnad and Marc Miravitlles explore this rare disease’s pulmonary impact, from comorbidities to delayed diagnosis #MedSky #LiverSky #CME
ow.ly/YRXt50X4lUh
ow.ly/YRXt50X4lUh
making great progress today! coming back from break to color this piece. #oc #ocs #ocsky #rebell
➤ Youtube: www.youtube.com/watch?v=aatd...
➤ Picarto: picarto.tv/artgh0sts
➤ Peertube/Spectra: spectra.video/a/gh0sts
➤ Youtube: www.youtube.com/watch?v=aatd...
➤ Picarto: picarto.tv/artgh0sts
➤ Peertube/Spectra: spectra.video/a/gh0sts
May 11, 2025 at 10:58 PM
making great progress today! coming back from break to color this piece. #oc #ocs #ocsky #rebell
➤ Youtube: www.youtube.com/watch?v=aatd...
➤ Picarto: picarto.tv/artgh0sts
➤ Peertube/Spectra: spectra.video/a/gh0sts
➤ Youtube: www.youtube.com/watch?v=aatd...
➤ Picarto: picarto.tv/artgh0sts
➤ Peertube/Spectra: spectra.video/a/gh0sts
FDA Clears Prime Medicine to Start Gene Editing Trial After Beam Dispute
FDA Clears Prime Medicine to Start Gene Editing Trial After Beam Dispute
Prime Medicine, which won an arbitration dispute with Beam Therapeutics earlier this year, now has FDA clearance to begin a Phase I/II trial of its prime editor PM647 for AATD.
ebx.sh
September 25, 2026 at 10:23 PM
FDA Clears Prime Medicine to Start Gene Editing Trial After Beam Dispute
Nuevas zapatillas que ALTERAN LA MENTE
YouTube video by Canal Mitocondria
www.youtube.com
March 17, 2026 at 12:26 AM
is it Lincoln trying to kill him. is that the problem www.youtube.com/watch?v=AATD...
Abe Lincoln And His Time Machine
YouTube video by nickagneta
www.youtube.com
April 26, 2026 at 2:58 AM
is it Lincoln trying to kill him. is that the problem www.youtube.com/watch?v=AATD...
4/4 Commercially, there’s no opportunity like it.
And the race to be first is cutthroat, antagonistic — and a miracle for patients.
Read @jasonmast.bsky.social's full story here: www.statnews.com/2026/07/28/b...
And the race to be first is cutthroat, antagonistic — and a miracle for patients.
Read @jasonmast.bsky.social's full story here: www.statnews.com/2026/07/28/b...
From ‘lost cause’ to gold rush: Biotechs swarm to cure AATD
Biotech companies are racing to cure alpha-1 antitrypsin deficiency, AATD, fueling patent disputes, startup defections, arbitration, and a U.S.-China rivalry.
www.statnews.com
July 29, 2026 at 2:19 PM
4/4 Commercially, there’s no opportunity like it.
And the race to be first is cutthroat, antagonistic — and a miracle for patients.
Read @jasonmast.bsky.social's full story here: www.statnews.com/2026/07/28/b...
And the race to be first is cutthroat, antagonistic — and a miracle for patients.
Read @jasonmast.bsky.social's full story here: www.statnews.com/2026/07/28/b...
Today, it is one of the most active battlegrounds in biotechnology, with at least eight companies competing to cure it using completely different molecular approaches.
The race to cure alpha-1 antitrypsin deficiency now includes eight biotechs and surprising clinical results - Sinaptica
For decades, alpha-1 antitrypsin deficiency (AATD) was a genetic disease almost forgotten by the pharmaceutical industry. Today, it is one of the most active ba
sinapti.ca
July 28, 2026 at 9:22 AM
Today, it is one of the most active battlegrounds in biotechnology, with at least eight companies competing to cure it using completely different molecular approaches.
How does Alpha-1 antitrypsin therapy reduce inflammation?
Researchers at RCSI Department of Anaesthesia and Critical Care show it blocks a key immune signalling pathway, increasing our understanding of inflammation in Alpha-1 antitrypsin deficiency (AATD).
➡️ doi.org/10.1136/thor...
#RCSIdiscover
Researchers at RCSI Department of Anaesthesia and Critical Care show it blocks a key immune signalling pathway, increasing our understanding of inflammation in Alpha-1 antitrypsin deficiency (AATD).
➡️ doi.org/10.1136/thor...
#RCSIdiscover
June 13, 2025 at 11:39 AM
How does Alpha-1 antitrypsin therapy reduce inflammation?
Researchers at RCSI Department of Anaesthesia and Critical Care show it blocks a key immune signalling pathway, increasing our understanding of inflammation in Alpha-1 antitrypsin deficiency (AATD).
➡️ doi.org/10.1136/thor...
#RCSIdiscover
Researchers at RCSI Department of Anaesthesia and Critical Care show it blocks a key immune signalling pathway, increasing our understanding of inflammation in Alpha-1 antitrypsin deficiency (AATD).
➡️ doi.org/10.1136/thor...
#RCSIdiscover
$BEAM reports initial AATD data with its base-editing BEAM-302. Total serum AAT up to 12.4uM from 4.4: finance.yahoo.com/news/beam-th...
$WVE $KRRO
$WVE $KRRO
March 10, 2025 at 11:13 AM
$BEAM reports initial AATD data with its base-editing BEAM-302. Total serum AAT up to 12.4uM from 4.4: finance.yahoo.com/news/beam-th...
$WVE $KRRO
$WVE $KRRO
CONTROLLED BY THE DONOR CLASS: 🇺🇸🇮🇷 Negotiations w Former Director of the 🇺🇸 National Counterterrorism Center Joe Kent & Retired Lt Col Daniel Davis
🇺🇸
#ImpeachConvictTrump
#The25th
#SackWitkoff
#SackKushner
🇺🇸🇬🇧🇪🇺🌎
#CutTiesWithIsrael
#ArrestNetanyahu
FREE 🇮🇷🇱🇧🇵🇸
#ToriesGone673
youtube.com/watch?v=aaTD...
🇺🇸
#ImpeachConvictTrump
#The25th
#SackWitkoff
#SackKushner
🇺🇸🇬🇧🇪🇺🌎
#CutTiesWithIsrael
#ArrestNetanyahu
FREE 🇮🇷🇱🇧🇵🇸
#ToriesGone673
youtube.com/watch?v=aaTD...
CONTROLLED BY THE DONOR CLASS: US Iran Negotiations /Joe Kent & Lt Col Daniel Davis
YouTube video by Daniel Davis / Deep Dive
youtube.com
May 8, 2026 at 11:01 PM
CONTROLLED BY THE DONOR CLASS: 🇺🇸🇮🇷 Negotiations w Former Director of the 🇺🇸 National Counterterrorism Center Joe Kent & Retired Lt Col Daniel Davis
🇺🇸
#ImpeachConvictTrump
#The25th
#SackWitkoff
#SackKushner
🇺🇸🇬🇧🇪🇺🌎
#CutTiesWithIsrael
#ArrestNetanyahu
FREE 🇮🇷🇱🇧🇵🇸
#ToriesGone673
youtube.com/watch?v=aaTD...
🇺🇸
#ImpeachConvictTrump
#The25th
#SackWitkoff
#SackKushner
🇺🇸🇬🇧🇪🇺🌎
#CutTiesWithIsrael
#ArrestNetanyahu
FREE 🇮🇷🇱🇧🇵🇸
#ToriesGone673
youtube.com/watch?v=aaTD...
#$PRME can now begin U.S. clinical testing of PM647, a one-time gene-editing treatment for alpha-1 antitrypsin deficiency. Initial results are expected in 2027, while #$BEAM remains further ahead in human trials. notreload.xyz/xy/prme-gets...
Prime Medicine Gets FDA Clearance to Test PM647 in AATD
First human data are due in 2027. This is not an approval; Beam remains ahead in patients.
notreload.xyz
September 24, 2026 at 9:03 PM
#$PRME can now begin U.S. clinical testing of PM647, a one-time gene-editing treatment for alpha-1 antitrypsin deficiency. Initial results are expected in 2027, while #$BEAM remains further ahead in human trials. notreload.xyz/xy/prme-gets...
Alpha-1 antitrypsin deficiency (AATD) leaves lungs vulnerable to damage. Dr. Malik Khurram Khan, who leads UK's advanced COPD clinic, wants to see more people screened for the condition.
From @claywallace.bsky.social
From @claywallace.bsky.social
UK Healthcare earns designation as a resource center for alpha-1 antitrypsin deficiency
Alpha-1 antitrypsin deficiency (AATD) leaves lungs vulnerable to damage. Dr. Malik Khurram Khan, who leads UK's advanced COPD clinic, wants to see more people screened for the condition.
www.wuky.org
December 28, 2025 at 10:21 PM
Alpha-1 antitrypsin deficiency (AATD) leaves lungs vulnerable to damage. Dr. Malik Khurram Khan, who leads UK's advanced COPD clinic, wants to see more people screened for the condition.
From @claywallace.bsky.social
From @claywallace.bsky.social