Vasculopathy occurs early in systemic sclerosis, but intervention strategies are lacking.
Colin Jamora & team reveal ANGPTL2 as an inducer of vasculopathy that drives cutaneous fibrogenesis in mice—mirroring SSc—and present a therapueutic approach: UAS03:
buff.ly/SpOiuCc
Colin Jamora & team reveal ANGPTL2 as an inducer of vasculopathy that drives cutaneous fibrogenesis in mice—mirroring SSc—and present a therapueutic approach: UAS03:
buff.ly/SpOiuCc
August 4, 2025 at 1:20 PM
Vasculopathy occurs early in systemic sclerosis, but intervention strategies are lacking.
Colin Jamora & team reveal ANGPTL2 as an inducer of vasculopathy that drives cutaneous fibrogenesis in mice—mirroring SSc—and present a therapueutic approach: UAS03:
buff.ly/SpOiuCc
Colin Jamora & team reveal ANGPTL2 as an inducer of vasculopathy that drives cutaneous fibrogenesis in mice—mirroring SSc—and present a therapueutic approach: UAS03:
buff.ly/SpOiuCc
Adipokines like #ANGPTL2, #FGF21, and #Osteopontin are pivotal in #HeartFailure pathogenesis, offering potential for advanced #Biomarkers in prediction, diagnosis, and prognosis.
#openaccess: cvia-journal.org/adipokines-p...
#Cardiology #MedicalResearch #HealthInnovation @scienceopen.bsky.social
#openaccess: cvia-journal.org/adipokines-p...
#Cardiology #MedicalResearch #HealthInnovation @scienceopen.bsky.social
Adipokines Pathogenesis in Heart Failure
Explore the role of adipokines in heart failure pathogenesis, including ANGPTL2, FGF21, and osteopontin, and their impact on prediction, diagnosis, and prognosis.
cvia-journal.org
January 21, 2025 at 6:04 AM
Adipokines like #ANGPTL2, #FGF21, and #Osteopontin are pivotal in #HeartFailure pathogenesis, offering potential for advanced #Biomarkers in prediction, diagnosis, and prognosis.
#openaccess: cvia-journal.org/adipokines-p...
#Cardiology #MedicalResearch #HealthInnovation @scienceopen.bsky.social
#openaccess: cvia-journal.org/adipokines-p...
#Cardiology #MedicalResearch #HealthInnovation @scienceopen.bsky.social
ICYMI: Vasculopathy occurs early in systemic sclerosis, but intervention strategies are lacking.
Colin Jamora & team reveal ANGPTL2 as an inducer of vasculopathy that drives cutaneous fibrogenesis in mice—mirroring SSc—and present a therapeutic approach: UAS03.
buff.ly/xNYvnRj
Colin Jamora & team reveal ANGPTL2 as an inducer of vasculopathy that drives cutaneous fibrogenesis in mice—mirroring SSc—and present a therapeutic approach: UAS03.
buff.ly/xNYvnRj
August 10, 2025 at 3:33 PM
ICYMI: Vasculopathy occurs early in systemic sclerosis, but intervention strategies are lacking.
Colin Jamora & team reveal ANGPTL2 as an inducer of vasculopathy that drives cutaneous fibrogenesis in mice—mirroring SSc—and present a therapeutic approach: UAS03.
buff.ly/xNYvnRj
Colin Jamora & team reveal ANGPTL2 as an inducer of vasculopathy that drives cutaneous fibrogenesis in mice—mirroring SSc—and present a therapeutic approach: UAS03.
buff.ly/xNYvnRj
Aging reshapes the melanoma microenvironment 🧬 A study from our customer Yash Chhabra, Laura Hüser, and the Weeraratna Lab at @jhu.edu, showed fibroblast-derived EVs lose CD9 and gain pro-angiogenic ANGPTL2 -- promoting tumor growth.
Read more: tinyurl.com/49yxxdk2
Read more: tinyurl.com/49yxxdk2
October 24, 2025 at 3:46 PM
Aging reshapes the melanoma microenvironment 🧬 A study from our customer Yash Chhabra, Laura Hüser, and the Weeraratna Lab at @jhu.edu, showed fibroblast-derived EVs lose CD9 and gain pro-angiogenic ANGPTL2 -- promoting tumor growth.
Read more: tinyurl.com/49yxxdk2
Read more: tinyurl.com/49yxxdk2
Network analysis highlighted EGR1, IL1B, TLR4, and ANGPTL2 as candidate hub-associated molecules. In vivo, the migraine model showed increased neuronal activation, persistent mechanical hypersensitivity, and reduced ZO-1 expression in the trigeminocervical complex, indicating (🧵 7/10)
July 11, 2026 at 9:52 AM
Network analysis highlighted EGR1, IL1B, TLR4, and ANGPTL2 as candidate hub-associated molecules. In vivo, the migraine model showed increased neuronal activation, persistent mechanical hypersensitivity, and reduced ZO-1 expression in the trigeminocervical complex, indicating (🧵 7/10)
혈관세포 및 섬유아세포 집단 간의 상호작용이 강화된 것으로 나타났다. 네트워크 분석 결과, EGR1, IL1B, TLR4 및 ANGPTL2가 허브 관련 후보 분자로 부각되었다. 생체 내(in vivo) 편두통 모델에서는 신경 세포 활성화 증가, 지속적인 기계적 과민성, 그리고 삼차경추 복합체(trigemino-cervical complex)에서 ZO-1 발현 감소가 관찰되었으며, 이는 혈관 밀착접합(tight junction)의 손상을 시사한다. (🧵 4/5)
July 11, 2026 at 9:43 AM
혈관세포 및 섬유아세포 집단 간의 상호작용이 강화된 것으로 나타났다. 네트워크 분석 결과, EGR1, IL1B, TLR4 및 ANGPTL2가 허브 관련 후보 분자로 부각되었다. 생체 내(in vivo) 편두통 모델에서는 신경 세포 활성화 증가, 지속적인 기계적 과민성, 그리고 삼차경추 복합체(trigemino-cervical complex)에서 ZO-1 발현 감소가 관찰되었으며, 이는 혈관 밀착접합(tight junction)의 손상을 시사한다. (🧵 4/5)
https://gregory-ms.com/articles/1251368/
ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiation
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #NeuroSkyence
ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiation
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #NeuroSkyence
June 3, 2024 at 8:20 AM
https://gregory-ms.com/articles/1251368/
ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiation
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #NeuroSkyence
ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiation
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #NeuroSkyence
A New Pathway Emerges: How ANGPTL2 Shields Immune Cells to Halt Arthritis Progression
A New Pathway Emerges: How ANGPTL2 Shields Immune Cells to Halt Arthritis Progression A recent study in *Cell Death & Disease* reveals a novel mechanism by which the protein ANGPTL2 inhibits macrophage…
A New Pathway Emerges: How ANGPTL2 Shields Immune Cells to Halt Arthritis Progression A recent study in *Cell Death & Disease* reveals a novel mechanism by which the protein ANGPTL2 inhibits macrophage…
A New Pathway Emerges: How ANGPTL2 Shields Immune Cells to Halt Arthritis Progression
A New Pathway Emerges: How ANGPTL2 Shields Immune Cells to Halt Arthritis Progression A recent study in *Cell Death & Disease* reveals a novel mechanism by which the protein ANGPTL2 inhibits macrophage pyroptosis, a form of inflammatory cell death, thereby alleviating the progression of rheumatoid arthritis. The research demonstrates that ANGPTL2 exerts its protective effect by regulating mitophagy—the selective removal of damaged mitochondria—through the intermediary protein IGFBP5.
blog.sciencebriefing.com
March 25, 2026 at 1:08 AM
A New Pathway Emerges: How ANGPTL2 Shields Immune Cells to Halt Arthritis Progression
A New Pathway Emerges: How ANGPTL2 Shields Immune Cells to Halt Arthritis Progression A recent study in *Cell Death & Disease* reveals a novel mechanism by which the protein ANGPTL2 inhibits macrophage…
A New Pathway Emerges: How ANGPTL2 Shields Immune Cells to Halt Arthritis Progression A recent study in *Cell Death & Disease* reveals a novel mechanism by which the protein ANGPTL2 inhibits macrophage…
This commentary highlights the role of adipokines, like ANGPTL2, C1q/TNF-related proteins 3 and 9, Fibroblast growth factor 21, Osteopontin, and Tumor necrosis factor-alpha observed in the pathogenesis of heart failure.
#OpenAccess: tinyurl.com/28yfyxug
#OpenAccess: tinyurl.com/28yfyxug
Adipokines Pathogenesis in Heart Failure
Explore the role of adipokines in heart failure pathogenesis, including ANGPTL2, FGF21, and osteopontin, and their impact on prediction, diagnosis, and prognosis.
tinyurl.com
July 31, 2025 at 3:00 PM
This commentary highlights the role of adipokines, like ANGPTL2, C1q/TNF-related proteins 3 and 9, Fibroblast growth factor 21, Osteopontin, and Tumor necrosis factor-alpha observed in the pathogenesis of heart failure.
#OpenAccess: tinyurl.com/28yfyxug
#OpenAccess: tinyurl.com/28yfyxug
ANGPTL2-driven inflammaging shapes aging by balancing tissue repair, pathology, and longevity.
11th Edition GCAG 2026
🗓April 20–21, 2026 |📍Dubai
Website: agingcongress.com/edition2
#Aging #Inflammaging #Longevity #AgeRelatedDiseases #TranslationalResearch #Dubai2026
11th Edition GCAG 2026
🗓April 20–21, 2026 |📍Dubai
Website: agingcongress.com/edition2
#Aging #Inflammaging #Longevity #AgeRelatedDiseases #TranslationalResearch #Dubai2026
January 10, 2026 at 4:11 AM
ANGPTL2-driven inflammaging shapes aging by balancing tissue repair, pathology, and longevity.
11th Edition GCAG 2026
🗓April 20–21, 2026 |📍Dubai
Website: agingcongress.com/edition2
#Aging #Inflammaging #Longevity #AgeRelatedDiseases #TranslationalResearch #Dubai2026
11th Edition GCAG 2026
🗓April 20–21, 2026 |📍Dubai
Website: agingcongress.com/edition2
#Aging #Inflammaging #Longevity #AgeRelatedDiseases #TranslationalResearch #Dubai2026
「老化細胞・老化細胞除去ワクチン」「SASP」「ANGPTL2」、最先端のキーワード3つ、細胞はなぜ老化する？第24回日本抗加齢医学会総会の尾池雄一会長講演@ヒフコNEWS biyouhifuko.com/news/japan/7...
「老化細胞・老化細胞除去ワクチン」「SASP」「ANGPTL2」、最先端のキーワード3つ、細胞はなぜ老化する？第24回日本抗加齢医学会総会の尾池雄一会長講演
顔はなぜたるみ、どうしてシワが刻まれていくのか。若返りを考えるためには、体を構成する細胞がなぜ老化するのかを理解することが欠かせない。2024年6月1日、第24回日本抗加齢医学会総会会長で、熊本大学分
biyouhifuko.com
June 7, 2024 at 10:15 AM
「老化細胞・老化細胞除去ワクチン」「SASP」「ANGPTL2」、最先端のキーワード3つ、細胞はなぜ老化する？第24回日本抗加齢医学会総会の尾池雄一会長講演@ヒフコNEWS biyouhifuko.com/news/japan/7...
