After a review of substantial literature, scientists publishing in Aging Cell have concluded that poor sleep quality and inflammaging worsen each other in a vicious cycle, reducing quality of life and fueling other age-related diseases. More than a peripheral link This review begins with a brief discussion of inflammaging, including the seminal paper by Franceschi

Scientists have long known that aging drives inflammation in the heart, but exactly how those changes are distributed throughout the organ has remained unclear. Now, a team from The Jackson Laboratory (JAX) has pinpointed hotspots where these "inflammaging" signals concentrate, providing a new map of cardiac aging and a foundation for future studies of cardiovascular health and decline.

Scientists have long known that aging drives inflammation in the heart, but exactly how those changes are distributed throughout the organ has remained unclear.

In this episode of BrightPath, hosts Lisa Jones and Johnnie Aycock welcome Dr. David Figge, Director of Clinical Immunology at the University of Alabama at Birmingham (UAB) and Assistant Professor in the Department of Pathology. Dr. Figge discusses the fascinating connections between the brain, immune system, and aging, sharing insights from his research on neuroscience, immunology, epigenetics, and cellular behavior. Dr. Figge also explores how understanding the body's memory systems may help advance medical research and open new possibilities for addressing age-related diseases.

Sleep disruption and circadian decline drive inflammaging and immune aging via the gut-brain axis, NLRP3, and TLR4, forming a vicious cycle that accelerates cognitive decline and epigenetic aging. Ta...

Taurine controls an inflammatory response of the innate immune system. Manipulating it could be a target for inflammaging.

Inflammaging: The Quiet Fire Fueling the Aging Process At AgingDecoded.com, we're dedicated to exploring the science of living a long, healthy, and..

Senescent MSCs do more than fuel inflammaging: they disrupt the chemokine signals that maintain stem cell function. We propose that restoring this signaling balance through senolytics, senomorphics, ...

Taurine levels increase with age in mice and humans. Boosting taurine levels even further in aged mice increases health span and dampens inflammation through its regulation of the NLRP3 inflammasome.

Taurine controls an inflammatory response of the innate immune system. Manipulating it could be a target for inflammaging.

Sustained low-level inflammation is a hallmark of the aging process. The accumulating damage persistently activates the innate immune system—the body's first line of defense—leading to what is known as inflammaging, functional decline and chronic diseases of old age.

Sustained low-level inflammation is a hallmark of the aging process. The accumulating damage persistently activates the innate immune system—the body's first line of defense—leading to what is known a...

Sustained low-level inflammation is a hallmark of the aging process. The accumulating damage persistently activates the innate immune system—the body's first line of defense—leading to what is known as inflammaging, functional decline and chronic diseases of old age.

Taurine levels increase with age in mice and humans. Boosting taurine levels even further in aged mice increases health span and dampens inflammation through its regulation of the NLRP3 inflammasome.

Taurine controls an inflammatory response of the innate immune system. Manipulating it could be a target for inflammaging.

Read the full paper: Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages

Taurine levels increase with age in mice and humans. Boosting taurine levels even further in aged mice increases health span and dampens inflammation through its regulation of the NLRP3 inflammasome.

Taurine controls an inflammatory response of the innate immune system. Manipulating it could be a target for inflammaging.