Granzyme K (GzmK) drives age-related tissue decline across organs independently of immune aging and systemic inflammation, with its effects being context-dependent.
#Immunology #Aging #Inflammaging #TissueAging #ImmuneAging
🔗 www.cell.com/immunity/ful...

3/10 Different tissues age at dramatically different rates.

Retina and stomach accumulate more ageing-related changes than cervix or skin.

Mean methylation ranges from 35% in cervix to 63% in retina.

"Each tissue has a different shift that happens."

#TissueAging