"It’s not surprising that lifestyles with less exposure to pollution [and inflammaging] are linked to lower rates of chronic disease."
Comment on the @nataging.nature.com report on inflammaging in 4 different places
www.nytimes.com/2025/06/30/w...
www.nature.com/articles/s43...
Comment on the @nataging.nature.com report on inflammaging in 4 different places
www.nytimes.com/2025/06/30/w...
www.nature.com/articles/s43...
July 1, 2025 at 3:43 PM
"It’s not surprising that lifestyles with less exposure to pollution [and inflammaging] are linked to lower rates of chronic disease."
Comment on the @nataging.nature.com report on inflammaging in 4 different places
www.nytimes.com/2025/06/30/w...
www.nature.com/articles/s43...
Comment on the @nataging.nature.com report on inflammaging in 4 different places
www.nytimes.com/2025/06/30/w...
www.nature.com/articles/s43...
Hormone replacement therapy helps restore immune function in menopausal women, reducing inflammaging and preserving monocyte function. open-access
onlinelibrary.wiley.com/doi/10.1111/...
Extends what I previously summarized from immune system clocks
erictopol.substack.com/p/new-anti-a...
onlinelibrary.wiley.com/doi/10.1111/...
Extends what I previously summarized from immune system clocks
erictopol.substack.com/p/new-anti-a...
October 9, 2025 at 10:45 PM
Hormone replacement therapy helps restore immune function in menopausal women, reducing inflammaging and preserving monocyte function. open-access
onlinelibrary.wiley.com/doi/10.1111/...
Extends what I previously summarized from immune system clocks
erictopol.substack.com/p/new-anti-a...
onlinelibrary.wiley.com/doi/10.1111/...
Extends what I previously summarized from immune system clocks
erictopol.substack.com/p/new-anti-a...
—How to prevent chronic inflammation that increases with aging ("inflammaging")?
—Exercise
www.nytimes.com/2025/03/19/w...
gift link
—Exercise
www.nytimes.com/2025/03/19/w...
gift link
Here’s One More Reason to Try to Exercise (Gift Article)
Consistent workouts can be a powerful way to fight chronic inflammation.
www.nytimes.com
March 25, 2025 at 7:48 PM
—How to prevent chronic inflammation that increases with aging ("inflammaging")?
—Exercise
www.nytimes.com/2025/03/19/w...
gift link
—Exercise
www.nytimes.com/2025/03/19/w...
gift link
Suppression of the inflammation that occurs with aging ("inflammaging") by blocking thrombospondin-1 (Thbs1), prevented age-related blood stem cell defects and expanded lifespan in the mouse model (KO-knockout)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 3, 2025 at 8:10 PM
Suppression of the inflammation that occurs with aging ("inflammaging") by blocking thrombospondin-1 (Thbs1), prevented age-related blood stem cell defects and expanded lifespan in the mouse model (KO-knockout)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A comparison of 2 industrialised populations (Italy, Singapore) with 2 indigenous populations (Tsimane, Bolivia & Orang Asli, Malaysia) suggests inflammaging - age-associated increase in chronic inflammation, considered a hallmark of aging - is a byproduct of industrialisation, not a human universal
Nonuniversality of inflammaging across human populations - Nature Aging
Analyzing readouts of inflammaging across four cohorts, Franck and colleagues identify strong variation and observe that inflammaging, in its known form, primarily emerges in industrialized—but not no...
www.nature.com
July 4, 2025 at 12:11 PM
A comparison of 2 industrialised populations (Italy, Singapore) with 2 indigenous populations (Tsimane, Bolivia & Orang Asli, Malaysia) suggests inflammaging - age-associated increase in chronic inflammation, considered a hallmark of aging - is a byproduct of industrialisation, not a human universal
This is part of the "inflammaging" story that drives cancer and other age-related diseases
gift link www.wsj.com/health/infla...
gift link www.wsj.com/health/infla...
How ‘Inflammaging’ Drives Cancer—and Points to New Treatments
Inflammation fuels the high rate of cancer in people over 50, researchers find, leading them to test anti-inflammatories like allergy drugs to fight it.
www.wsj.com
June 3, 2025 at 2:09 PM
This is part of the "inflammaging" story that drives cancer and other age-related diseases
gift link www.wsj.com/health/infla...
gift link www.wsj.com/health/infla...
The inflammaging microenvironment induces dysfunctional rewiring of Tfh cell differentiation @jci-insight.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
March 4, 2025 at 9:27 PM
The inflammaging microenvironment induces dysfunctional rewiring of Tfh cell differentiation @jci-insight.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
#WeekendRead! #LiveForever! Ramalingam Butler &co show @ #Science #Immunology that during #inflammaging thrombospondin-1 drives #interferon signatures & reduces detoxification pathways in hematopoietic stem cells causing loss of self-renewal, increased myeloid differentiation & systemic inflammation
Suppression of thrombospondin-1–mediated inflammaging prolongs hematopoietic health span
Deletion of thrombospondin-1 prevents inflammaging and preserves blood stem cell fitness during aging.
www.science.org
January 4, 2025 at 2:51 PM
#WeekendRead! #LiveForever! Ramalingam Butler &co show @ #Science #Immunology that during #inflammaging thrombospondin-1 drives #interferon signatures & reduces detoxification pathways in hematopoietic stem cells causing loss of self-renewal, increased myeloid differentiation & systemic inflammation
Human populations with less industrialized lifestyles may not experience inflammaging, a chronic low-grade inflammation that is linked with ageing, according to research in Nature Aging. go.nature.com/3I8dI2t #medsky 🧪
June 30, 2025 at 7:24 PM
Human populations with less industrialized lifestyles may not experience inflammaging, a chronic low-grade inflammation that is linked with ageing, according to research in Nature Aging. go.nature.com/3I8dI2t #medsky 🧪
“Inflammaging,” or what researchers describe as “chronic, smoldering low-grade inflammation” is associated with a host of health issues, but new research suggests that not everyone may experience it.
Is ‘inflammaging’ part of getting older? Here’s what experts say.
This “chronic, smoldering low-grade inflammation,” as one researcher described it, is associated with many health issues.
www.washingtonpost.com
October 18, 2025 at 5:00 AM
“Inflammaging,” or what researchers describe as “chronic, smoldering low-grade inflammation” is associated with a host of health issues, but new research suggests that not everyone may experience it.
How exercise decreases the risk of cancer and cancer- related mortality by reducing immunosenescence and inflammaging
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Physical activity decreases cancer burden by alleviating immunosenescence-related inflammation and improving overall immunity
The associations between physical activity (PA) and the incidence and mortality of cancers and their underlying mechanisms remain largely unknown. Usi…
www.sciencedirect.com
December 16, 2025 at 3:59 PM
How exercise decreases the risk of cancer and cancer- related mortality by reducing immunosenescence and inflammaging
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Inflammation is a driver of age-related diseases (inflammaging) and this new NYT magazine article gets deep into the progress that is being made to track and block it
gift link
www.nytimes.com/interactive/...
gift link
www.nytimes.com/interactive/...
Inflammation Keeps Us Alive. It's Also Making Us Sick. (Gift Article)
The discovery that chronic inflammation is a cause of myriad illnesses could be this century's biggest medical breakthrough.
www.nytimes.com
July 30, 2026 at 2:25 PM
Inflammation is a driver of age-related diseases (inflammaging) and this new NYT magazine article gets deep into the progress that is being made to track and block it
gift link
www.nytimes.com/interactive/...
gift link
www.nytimes.com/interactive/...
Happy to share our recent preprint on inflammaging and HIV. HIV is known to cause premature aging, but how inflammaging and HIV persistence correlates remain unknown. In the MACS cohort, we found that markers of inflammaging can distinguish HIV serostatus and among these markers…
Senescence-related cytokine levels are associated with HIV-1 serostatus and persistence https://www.medrxiv.org/content/10.1101/2025.02.05.25321757v1
February 8, 2025 at 1:00 AM
Happy to share our recent preprint on inflammaging and HIV. HIV is known to cause premature aging, but how inflammaging and HIV persistence correlates remain unknown. In the MACS cohort, we found that markers of inflammaging can distinguish HIV serostatus and among these markers…
Nonuniversality of inflammaging across human populations
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Nonuniversality of inflammaging across human populations - Nature Aging
Analyzing readouts of inflammaging across four cohorts, Franck and colleagues identify strong variation and observe that inflammaging, in its known form, primarily emerges in industrialized—but not no...
www.nature.com
July 2, 2025 at 12:15 PM
Nonuniversality of inflammaging across human populations
www.nature.com/articles/s43...
www.nature.com/articles/s43...
The August issue of Science #Immunology is out!
This month's cover depicts the potential of transferred regulatory T cells to reverse age-associated inflammation, or inflammaging, in the gut.
Learn more about this research: scim.ag/3IXQJI8
This month's cover depicts the potential of transferred regulatory T cells to reverse age-associated inflammation, or inflammaging, in the gut.
Learn more about this research: scim.ag/3IXQJI8
August 4, 2025 at 9:03 PM
The August issue of Science #Immunology is out!
This month's cover depicts the potential of transferred regulatory T cells to reverse age-associated inflammation, or inflammaging, in the gut.
Learn more about this research: scim.ag/3IXQJI8
This month's cover depicts the potential of transferred regulatory T cells to reverse age-associated inflammation, or inflammaging, in the gut.
Learn more about this research: scim.ag/3IXQJI8
🤔 Schon mal vom Begriff „Inflammaging“ gehört?
🥵Gemeint ist die schleichende, chronische Entzündung, die mit dem Älterwerden zunimmt – und mit zahlreichen Krankheiten in Verbindung steht: Herzprobleme, Diabetes, Demenz.
👇🏻 Was hilft gegen den unsichtbaren Brandherd im Körper?
🧵
1/8
🥵Gemeint ist die schleichende, chronische Entzündung, die mit dem Älterwerden zunimmt – und mit zahlreichen Krankheiten in Verbindung steht: Herzprobleme, Diabetes, Demenz.
👇🏻 Was hilft gegen den unsichtbaren Brandherd im Körper?
🧵
1/8
March 30, 2025 at 6:17 PM
🤔 Schon mal vom Begriff „Inflammaging“ gehört?
🥵Gemeint ist die schleichende, chronische Entzündung, die mit dem Älterwerden zunimmt – und mit zahlreichen Krankheiten in Verbindung steht: Herzprobleme, Diabetes, Demenz.
👇🏻 Was hilft gegen den unsichtbaren Brandherd im Körper?
🧵
1/8
🥵Gemeint ist die schleichende, chronische Entzündung, die mit dem Älterwerden zunimmt – und mit zahlreichen Krankheiten in Verbindung steht: Herzprobleme, Diabetes, Demenz.
👇🏻 Was hilft gegen den unsichtbaren Brandherd im Körper?
🧵
1/8
Human populations with less industrialized lifestyles may not experience inflammaging, a chronic low-grade inflammation that is linked with ageing, according to research published in @nataging.nature.com:
#Ageing
#Ageing
Nonuniversality of inflammaging across human populations - Nature Aging
Analyzing readouts of inflammaging across four cohorts, Franck and colleagues identify strong variation and observe that inflammaging, in its known form, primarily emerges in industrialized—but not nonindustrialized—populations.
spklr.io
June 30, 2025 at 6:57 PM
Human populations with less industrialized lifestyles may not experience inflammaging, a chronic low-grade inflammation that is linked with ageing, according to research published in @nataging.nature.com:
#Ageing
#Ageing
Link to the above @wsj.com article on how inflammaging can cause cancer. apple.news/A5ZU088NUR06...
How ‘Inflammaging’ Drives Cancer—and Points to New Treatments — The Wall Street Journal
Inflammation fuels the high rate of cancer in people over 50, researchers find, leading them to test anti-inflammatories like allergy drugs to fight it
apple.news
June 7, 2025 at 1:12 PM
Link to the above @wsj.com article on how inflammaging can cause cancer. apple.news/A5ZU088NUR06...
The new special issue @science.org
features Immunity with 4 outstanding review papers, 5★ science.org/toc/science/...
Our immune system over the lifespan (figure at right on path to inflammaging and immunosenescence), sex differences, influence on physiology, and host antiviral defenses
features Immunity with 4 outstanding review papers, 5★ science.org/toc/science/...
Our immune system over the lifespan (figure at right on path to inflammaging and immunosenescence), sex differences, influence on physiology, and host antiviral defenses
August 7, 2025 at 7:24 PM
The new special issue @science.org
features Immunity with 4 outstanding review papers, 5★ science.org/toc/science/...
Our immune system over the lifespan (figure at right on path to inflammaging and immunosenescence), sex differences, influence on physiology, and host antiviral defenses
features Immunity with 4 outstanding review papers, 5★ science.org/toc/science/...
Our immune system over the lifespan (figure at right on path to inflammaging and immunosenescence), sex differences, influence on physiology, and host antiviral defenses
Emerging biological therapies for healthy aging: targeting inflammaging, senescence, and regenerative decline
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Emerging biological therapies for healthy aging: targeting inflammaging, senescence, and regenerative decline - Stem Cell Research & Therapy
Aging is a complex, multifactorial biological process marked by progressive physiological decline and increased vulnerability to chronic disease. Advances in geroscience have expanded the hallmarks of...
link.springer.com
September 26, 2026 at 11:52 PM
Emerging biological therapies for healthy aging: targeting inflammaging, senescence, and regenerative decline
link.springer.com/article/10.1...
link.springer.com/article/10.1...
In other words, #inflammaging is environmental, and that makes it modifiable. #Longevity interventions targeting this hallmark of aging could make a large impact in industrialized nations. 🧪
📰 Full (paywalled) study: www.nature.com/articles/s43...
📰 Full (paywalled) study: www.nature.com/articles/s43...
Nonuniversality of inflammaging across human populations - Nature Aging
Analyzing readouts of inflammaging across four cohorts, Franck and colleagues identify strong variation and observe that inflammaging, in its known form, primarily emerges in industrialized—but not no...
www.nature.com
July 3, 2025 at 4:40 PM
In other words, #inflammaging is environmental, and that makes it modifiable. #Longevity interventions targeting this hallmark of aging could make a large impact in industrialized nations. 🧪
📰 Full (paywalled) study: www.nature.com/articles/s43...
📰 Full (paywalled) study: www.nature.com/articles/s43...
#WeekendRead! #EverycellIsAnImmuneCell! Allen, @ucsfpenglab.bsky.social &co show @cp-immunity.bsky.social that in #inflammaging, lung #fibroblasts activate NFkB & recruit monocytes/IMs that produce IL15 expanding dysfunctional CD8 T cells that drive excessive neutrophils, inflammation & lung damage!
NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells
While inflammaging supposedly drives some of the most common diseases affecting the elderly, little is known about the tissue drivers of inflammaging.…
www.sciencedirect.com
March 29, 2026 at 3:07 PM
#WeekendRead! #EverycellIsAnImmuneCell! Allen, @ucsfpenglab.bsky.social &co show @cp-immunity.bsky.social that in #inflammaging, lung #fibroblasts activate NFkB & recruit monocytes/IMs that produce IL15 expanding dysfunctional CD8 T cells that drive excessive neutrophils, inflammation & lung damage!
Deletion of thrombospondin-1 prevents inflammaging and preserves blood stem cell fitness during aging
@scienceimmuno.bsky.social
www.science.org/doi/10.1126/...
@scienceimmuno.bsky.social
www.science.org/doi/10.1126/...
January 3, 2025 at 7:28 PM
Deletion of thrombospondin-1 prevents inflammaging and preserves blood stem cell fitness during aging
@scienceimmuno.bsky.social
www.science.org/doi/10.1126/...
@scienceimmuno.bsky.social
www.science.org/doi/10.1126/...
"Inflammaging" fuels cancer, researchers discovered. So they are trying anti-inflammatory drugs for diseases like asthma and eczema to fight cancer in older people.
How ‘Inflammaging’ Drives Cancer—and Points to New Treatments
Inflammation fuels the high rate of cancer in people over 50, researchers find, leading them to test anti-inflammatories like allergy drugs to fight it.
buff.ly
June 3, 2025 at 6:13 PM
"Inflammaging" fuels cancer, researchers discovered. So they are trying anti-inflammatory drugs for diseases like asthma and eczema to fight cancer in older people.
The silent infection load: How lifelong asymptomatic infections may contribute to inflammaging as an evolutionary trade-off of longevity
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
www.sciencedirect.com
September 21, 2026 at 8:34 PM
The silent infection load: How lifelong asymptomatic infections may contribute to inflammaging as an evolutionary trade-off of longevity
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...