There are no shortcuts in drug discovery. And it takes incredible efforts to make sense of what you can find in the scientific literature. This is an excellent piece of work to quality check what has been claimed as a new avenue in targeted protein degradation (TPD). www.nature.com/articles/s41...
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets - Nature Communications
Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but e...
www.nature.com
November 25, 2024 at 10:09 PM
There are no shortcuts in drug discovery. And it takes incredible efforts to make sense of what you can find in the scientific literature. This is an excellent piece of work to quality check what has been claimed as a new avenue in targeted protein degradation (TPD). www.nature.com/articles/s41...
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets
Refreshing to see papers that go to great pains to set the record straight being published in a high profile setting
Refreshing to see papers that go to great pains to set the record straight being published in a high profile setting
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets - Nature Communications
Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but e...
www.nature.com
November 29, 2024 at 12:39 PM
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets
Refreshing to see papers that go to great pains to set the record straight being published in a high profile setting
Refreshing to see papers that go to great pains to set the record straight being published in a high profile setting
Rational design of the linkers in targeting chimeras
Rational design of the linkers in targeting chimeras
Targeting chimeras (TACs), such as PROTACs, LYTACs, AUTACs, and ATTECs, have emerged as promising strategies for selectively degrading proteins, including undruggable targets. These approaches leverag...
pubs.rsc.org
October 7, 2025 at 10:29 AM
Rational design of the linkers in targeting chimeras
Quality control is often overlooked in novel pathways, and we demonstrate this using ATTECs (Autophagy Tethering Compounds) as a case study. Our new study highlights what’s frequently missing in research!
#ProteinDegradation
Just out in @naturecomms.bsky.social
www.nature.com/articles/s41...
#ProteinDegradation
Just out in @naturecomms.bsky.social
www.nature.com/articles/s41...
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets - Nature Communications
Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but e...
www.nature.com
December 6, 2024 at 10:24 AM
Quality control is often overlooked in novel pathways, and we demonstrate this using ATTECs (Autophagy Tethering Compounds) as a case study. Our new study highlights what’s frequently missing in research!
#ProteinDegradation
Just out in @naturecomms.bsky.social
www.nature.com/articles/s41...
#ProteinDegradation
Just out in @naturecomms.bsky.social
www.nature.com/articles/s41...
The paper
"Surprisingly none of the ligands used for the development of ATTECs showed measurable affinity for the proposed targets LC3/GABARAP using a diversity of biophysical methods, suggesting that reported LC3-ligand based degraders cause degradation not due to a LC3/GABARAP mediated mechanism"
"Surprisingly none of the ligands used for the development of ATTECs showed measurable affinity for the proposed targets LC3/GABARAP using a diversity of biophysical methods, suggesting that reported LC3-ligand based degraders cause degradation not due to a LC3/GABARAP mediated mechanism"
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets - Nature Communications
Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but e...
www.nature.com
December 11, 2024 at 10:22 AM
The paper
"Surprisingly none of the ligands used for the development of ATTECs showed measurable affinity for the proposed targets LC3/GABARAP using a diversity of biophysical methods, suggesting that reported LC3-ligand based degraders cause degradation not due to a LC3/GABARAP mediated mechanism"
"Surprisingly none of the ligands used for the development of ATTECs showed measurable affinity for the proposed targets LC3/GABARAP using a diversity of biophysical methods, suggesting that reported LC3-ligand based degraders cause degradation not due to a LC3/GABARAP mediated mechanism"
“Rational design of the linkers in targeting chimeras” by Jinyi Xu, Quanyin Hu, et al. (doi.org/10.1039/D5SC...)
Rational design of the linkers in targeting chimeras
Targeting chimeras (TACs), such as PROTACs, LYTACs, AUTACs, and ATTECs, have emerged as promising strategies for selectively degrading proteins, including undruggable targets. These approaches leverage bifunctional molecules or molecular glues to selectively degrade specific proteins, offering new therapeuti
doi.org
October 14, 2025 at 11:11 AM
“Rational design of the linkers in targeting chimeras” by Jinyi Xu, Quanyin Hu, et al. (doi.org/10.1039/D5SC...)
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets - Nature Communications
Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but e...
www.nature.com
November 30, 2024 at 10:58 PM
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Excited about how targeted protein degradation could change the game in treating #neurodegenerative diseases?
Don’t miss Boxun Lu at #NHND25, he'll dive into utophagosome-tethering compound (ATTECs), novel manipulation strategies & uncover new therapeutic targets.
See you there, vibbio.tech/4kQjd4C!
Don’t miss Boxun Lu at #NHND25, he'll dive into utophagosome-tethering compound (ATTECs), novel manipulation strategies & uncover new therapeutic targets.
See you there, vibbio.tech/4kQjd4C!
June 18, 2025 at 1:09 PM
Excited about how targeted protein degradation could change the game in treating #neurodegenerative diseases?
Don’t miss Boxun Lu at #NHND25, he'll dive into utophagosome-tethering compound (ATTECs), novel manipulation strategies & uncover new therapeutic targets.
See you there, vibbio.tech/4kQjd4C!
Don’t miss Boxun Lu at #NHND25, he'll dive into utophagosome-tethering compound (ATTECs), novel manipulation strategies & uncover new therapeutic targets.
See you there, vibbio.tech/4kQjd4C!
Discovery of Alkenyl Oxindole as a Novel PROTAC Moiety for Targeted Protein Degradation via CRL4DCAF11 Recruitment https://www.biorxiv.org/content/10.1101/2024.02.15.580430v1
Discovery of Alkenyl Oxindole as a Novel PROTAC Moiety for Targeted Protein Degradation via CRL4DCAF11 Recruitment https://www.biorxiv.org/content/10.1101/2024.02.15.580430v1
Alkenyl oxindoles have been characterized as autophagosome-tethering compounds (ATTECs), which can t
www.biorxiv.org
February 16, 2024 at 2:46 AM
Discovery of Alkenyl Oxindole as a Novel PROTAC Moiety for Targeted Protein Degradation via CRL4DCAF11 Recruitment https://www.biorxiv.org/content/10.1101/2024.02.15.580430v1
Interesting review on TPD which still describes ATTECs as LC3 binding molecules. The paper was revised a month after we published our results that there is no binding to LC3...
www.sciencedirect.com/science/arti...
See our paper here:
www.nature.com/articles/s41...
www.sciencedirect.com/science/arti...
See our paper here:
www.nature.com/articles/s41...
Recent advances in developing targeted protein degraders
Targeted protein degradation (TPD) represents a promising therapeutic approach, encompassing several innovative strategies, including but not limited …
www.sciencedirect.com
January 6, 2025 at 8:43 AM
Interesting review on TPD which still describes ATTECs as LC3 binding molecules. The paper was revised a month after we published our results that there is no binding to LC3...
www.sciencedirect.com/science/arti...
See our paper here:
www.nature.com/articles/s41...
www.sciencedirect.com/science/arti...
See our paper here:
www.nature.com/articles/s41...
Discovery of Alkenyl Oxindole as a Novel PROTAC Moiety for Targeted Protein Degradation via CRL4DCAF11 Recruitment https://www.biorxiv.org/content/10.1101/2024.02.15.580430v1
Discovery of Alkenyl Oxindole as a Novel PROTAC Moiety for Targeted Protein Degradation via CRL4DCAF11 Recruitment https://www.biorxiv.org/content/10.1101/2024.02.15.580430v1
Alkenyl oxindoles have been characterized as autophagosome-tethering compounds (ATTECs), which can t
www.biorxiv.org
February 16, 2024 at 2:46 AM
Discovery of Alkenyl Oxindole as a Novel PROTAC Moiety for Targeted Protein Degradation via CRL4DCAF11 Recruitment https://www.biorxiv.org/content/10.1101/2024.02.15.580430v1
For aficionados of #fragments, #degraders & #ATTECs. Learn how biophysics approaches - spectral shift detection on #NanoTemper Dianthus characterised LC3/GABARAP interactions.
From #GoetheUniversity, #SGC, #DKTK, #DKFZ. #Fraunhofer #TUM #DiamondLightSource, Nathan Adams & Ivana Jaser
rdcu.be/d22DS
From #GoetheUniversity, #SGC, #DKTK, #DKFZ. #Fraunhofer #TUM #DiamondLightSource, Nathan Adams & Ivana Jaser
rdcu.be/d22DS
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets
Nature Communications - Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to...
rdcu.be
December 10, 2024 at 8:04 PM
For aficionados of #fragments, #degraders & #ATTECs. Learn how biophysics approaches - spectral shift detection on #NanoTemper Dianthus characterised LC3/GABARAP interactions.
From #GoetheUniversity, #SGC, #DKTK, #DKFZ. #Fraunhofer #TUM #DiamondLightSource, Nathan Adams & Ivana Jaser
rdcu.be/d22DS
From #GoetheUniversity, #SGC, #DKTK, #DKFZ. #Fraunhofer #TUM #DiamondLightSource, Nathan Adams & Ivana Jaser
rdcu.be/d22DS