You call it duplicate therapy, I call it total nephron domination #SequentialNephronBlockade
November 29, 2024 at 2:17 PM
You call it duplicate therapy, I call it total nephron domination #SequentialNephronBlockade
Acetazolamide, but you can call me Diamox for short ✨
March 9, 2026 at 5:28 PM
Acetazolamide, but you can call me Diamox for short ✨
Morning meds!:
Potassium
Acetazolamide (Diamox)
Vraylar
Zoloft (Sertraline)
Jencycla
Aspirin
Plavix
Evening meds!:
Acetazolamide
Prazosin
Pepcid
Optional/As needed!:
Propranolol
Zofran
Imodium
I AM HEAVILY MEDICATED BINTCHES
Meds are for IIH, side effects of diamox, bc, vocal chord polyps, ptsd
Potassium
Acetazolamide (Diamox)
Vraylar
Zoloft (Sertraline)
Jencycla
Aspirin
Plavix
Evening meds!:
Acetazolamide
Prazosin
Pepcid
Optional/As needed!:
Propranolol
Zofran
Imodium
I AM HEAVILY MEDICATED BINTCHES
Meds are for IIH, side effects of diamox, bc, vocal chord polyps, ptsd
June 20, 2026 at 7:26 PM
Morning meds!:
Potassium
Acetazolamide (Diamox)
Vraylar
Zoloft (Sertraline)
Jencycla
Aspirin
Plavix
Evening meds!:
Acetazolamide
Prazosin
Pepcid
Optional/As needed!:
Propranolol
Zofran
Imodium
I AM HEAVILY MEDICATED BINTCHES
Meds are for IIH, side effects of diamox, bc, vocal chord polyps, ptsd
Potassium
Acetazolamide (Diamox)
Vraylar
Zoloft (Sertraline)
Jencycla
Aspirin
Plavix
Evening meds!:
Acetazolamide
Prazosin
Pepcid
Optional/As needed!:
Propranolol
Zofran
Imodium
I AM HEAVILY MEDICATED BINTCHES
Meds are for IIH, side effects of diamox, bc, vocal chord polyps, ptsd
Not a perfect comparison but interesting nonetheless. Augmented UOP with the intervention vs placebo in CLOROTIC, EMPAG-HF and ADVOR
HCTZ: 26%
Empagliflozin: 25%
Acetazolamide: 12%
HCTZ: 26%
Empagliflozin: 25%
Acetazolamide: 12%
February 19, 2025 at 9:08 PM
Not a perfect comparison but interesting nonetheless. Augmented UOP with the intervention vs placebo in CLOROTIC, EMPAG-HF and ADVOR
HCTZ: 26%
Empagliflozin: 25%
Acetazolamide: 12%
HCTZ: 26%
Empagliflozin: 25%
Acetazolamide: 12%
1) acetazolamide for iatrogenic contraction alkalosis is standard tx IMHO (most drugs are "off label") along with K repletion etc
2) PO acetazolamide probably fine, great bioavailability
3) prevention with amiloride is great, I love amiloride
4) triamterene is maybe nephrotoxic so less of a fan
2) PO acetazolamide probably fine, great bioavailability
3) prevention with amiloride is great, I love amiloride
4) triamterene is maybe nephrotoxic so less of a fan
February 13, 2026 at 5:23 PM
1) acetazolamide for iatrogenic contraction alkalosis is standard tx IMHO (most drugs are "off label") along with K repletion etc
2) PO acetazolamide probably fine, great bioavailability
3) prevention with amiloride is great, I love amiloride
4) triamterene is maybe nephrotoxic so less of a fan
2) PO acetazolamide probably fine, great bioavailability
3) prevention with amiloride is great, I love amiloride
4) triamterene is maybe nephrotoxic so less of a fan
#acetazolamide have been shown in multiple studies to be favourable in sleep apnoea, here is one RCT in OSA , vs CPAP or both jcsm.aasm.org/doi/10.5664/... #RespSky #medsky
November 23, 2024 at 10:13 PM
#acetazolamide have been shown in multiple studies to be favourable in sleep apnoea, here is one RCT in OSA , vs CPAP or both jcsm.aasm.org/doi/10.5664/... #RespSky #medsky
People in the USA only know brand names for medicines and it’s wild. They never take acetaminophen, only Tylenol. It’s never acetazolamide, it’s Diamox. It’s wild.
September 2, 2025 at 5:28 PM
People in the USA only know brand names for medicines and it’s wild. They never take acetaminophen, only Tylenol. It’s never acetazolamide, it’s Diamox. It’s wild.
acetazolamide is absolutely destroying me because of course not only do i get the various common side effects but some weird bad ones too 😭
October 2, 2025 at 7:07 PM
acetazolamide is absolutely destroying me because of course not only do i get the various common side effects but some weird bad ones too 😭
lead to daytime hypoventilation and hypoxemia. Thoughtful use of acetazolamide in this scenario may help by lowering bicarbonate and restoring respiratory drive
February 6, 2026 at 8:07 PM
lead to daytime hypoventilation and hypoxemia. Thoughtful use of acetazolamide in this scenario may help by lowering bicarbonate and restoring respiratory drive
I'm working on creating a critical care drug handbook (embedded into the IBCC, for free).
Working version here: emcrit.org/ibcc/drugs/
Are there other drugs that you'd like to see included?
(Apologies in advance for not including drugs that are exclusively available outside the USA) #EMIMCC
Working version here: emcrit.org/ibcc/drugs/
Are there other drugs that you'd like to see included?
(Apologies in advance for not including drugs that are exclusively available outside the USA) #EMIMCC
Critical Care Drug Handbook
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Acetaminophen Acetazolamide Acetylcysteine Acyclovir […]
emcrit.org
July 30, 2025 at 2:34 PM
I'm working on creating a critical care drug handbook (embedded into the IBCC, for free).
Working version here: emcrit.org/ibcc/drugs/
Are there other drugs that you'd like to see included?
(Apologies in advance for not including drugs that are exclusively available outside the USA) #EMIMCC
Working version here: emcrit.org/ibcc/drugs/
Are there other drugs that you'd like to see included?
(Apologies in advance for not including drugs that are exclusively available outside the USA) #EMIMCC
It depends, what’s the cause and volume status? If there’s hypovolemia, give NS, if hypervolemic, acetazolamide works well.
February 12, 2026 at 7:24 PM
It depends, what’s the cause and volume status? If there’s hypovolemia, give NS, if hypervolemic, acetazolamide works well.
"Retro" is usually reserved for fashion and music. Typically not something you see in medicine - unless it's acetazolamide I guess.
December 12, 2024 at 5:53 PM
"Retro" is usually reserved for fashion and music. Typically not something you see in medicine - unless it's acetazolamide I guess.
ICYMI
@captainchloride.bsky.social on the art of decongestion in heart failure
Embracing hypercreatininemia
Flozins or Acetazolamide
How to use Urine Na+
Do we believe the Italian HTS RCTs?
www.youtube.com/watch?v=3m2b...
#NephGR
@captainchloride.bsky.social on the art of decongestion in heart failure
Embracing hypercreatininemia
Flozins or Acetazolamide
How to use Urine Na+
Do we believe the Italian HTS RCTs?
www.youtube.com/watch?v=3m2b...
#NephGR
The Art of Decongestion with Dr. Nayan Arora
YouTube video by Ottawa Nephrology
www.youtube.com
May 27, 2025 at 11:41 AM
ICYMI
@captainchloride.bsky.social on the art of decongestion in heart failure
Embracing hypercreatininemia
Flozins or Acetazolamide
How to use Urine Na+
Do we believe the Italian HTS RCTs?
www.youtube.com/watch?v=3m2b...
#NephGR
@captainchloride.bsky.social on the art of decongestion in heart failure
Embracing hypercreatininemia
Flozins or Acetazolamide
How to use Urine Na+
Do we believe the Italian HTS RCTs?
www.youtube.com/watch?v=3m2b...
#NephGR
Is it? Where do you draw the line on what you condider 'cheating'? Dexamethasone? Acetazolamide? Ibuprofen? Oxygen?
May 27, 2025 at 12:52 PM
Is it? Where do you draw the line on what you condider 'cheating'? Dexamethasone? Acetazolamide? Ibuprofen? Oxygen?
Glucosamine
Acetazolamide
Azithromycin
Sertraline HCl
Sodium valproate
Amitriptyline
Betahistine
Ipatropium bromide
Budesonide
Paracetamol
Metamizole
These are a few of my favorite things
Acetazolamide
Azithromycin
Sertraline HCl
Sodium valproate
Amitriptyline
Betahistine
Ipatropium bromide
Budesonide
Paracetamol
Metamizole
These are a few of my favorite things
November 3, 2023 at 9:11 AM
Glucosamine
Acetazolamide
Azithromycin
Sertraline HCl
Sodium valproate
Amitriptyline
Betahistine
Ipatropium bromide
Budesonide
Paracetamol
Metamizole
These are a few of my favorite things
Acetazolamide
Azithromycin
Sertraline HCl
Sodium valproate
Amitriptyline
Betahistine
Ipatropium bromide
Budesonide
Paracetamol
Metamizole
These are a few of my favorite things
It's a known off-target effect of acetazolamide
September 12, 2025 at 11:21 PM
It's a known off-target effect of acetazolamide
Melanoma rapid oral #9 ➡️ OBX-115, engineered TIL with membrane bound IL15 regulated with acetazolamide
-for 6pt receiving RP2D, 67% ORR, 1 CR, 100% DCR
-mDOR not reached
Jason Chesney U Louisville and @drbetofmdphd.bsky.social @stanford-cancer.bsky.social
#ASCO25 @ascocancer.bsky.social
-for 6pt receiving RP2D, 67% ORR, 1 CR, 100% DCR
-mDOR not reached
Jason Chesney U Louisville and @drbetofmdphd.bsky.social @stanford-cancer.bsky.social
#ASCO25 @ascocancer.bsky.social
June 2, 2025 at 4:19 PM
Melanoma rapid oral #9 ➡️ OBX-115, engineered TIL with membrane bound IL15 regulated with acetazolamide
-for 6pt receiving RP2D, 67% ORR, 1 CR, 100% DCR
-mDOR not reached
Jason Chesney U Louisville and @drbetofmdphd.bsky.social @stanford-cancer.bsky.social
#ASCO25 @ascocancer.bsky.social
-for 6pt receiving RP2D, 67% ORR, 1 CR, 100% DCR
-mDOR not reached
Jason Chesney U Louisville and @drbetofmdphd.bsky.social @stanford-cancer.bsky.social
#ASCO25 @ascocancer.bsky.social
#NephSky How acetazolamide works in case of nephrogenic DI? What is the mechanism? @kidneyboy.bsky.social @caulimovirus.bsky.social @edgarvlermamd.bsky.social @hswapnil.medsky.social @nephrosparks.bsky.social @juancarlosqvelez.bsky.social @renaltubules.bsky.social @captainchloride.bsky.social
April 24, 2025 at 1:48 PM
#NephSky How acetazolamide works in case of nephrogenic DI? What is the mechanism? @kidneyboy.bsky.social @caulimovirus.bsky.social @edgarvlermamd.bsky.social @hswapnil.medsky.social @nephrosparks.bsky.social @juancarlosqvelez.bsky.social @renaltubules.bsky.social @captainchloride.bsky.social
Rather than an algorithmic approach, try to tailor your adjunctive agents to the patient's biochemical milieu.
The patient w rising bicarb who needs ongoing diuresis? Great candidate for acetazolamide.
The patient w recurrent hypoK? Try adding a potassium-sparing diuretic (ie spironolactone).
The patient w rising bicarb who needs ongoing diuresis? Great candidate for acetazolamide.
The patient w recurrent hypoK? Try adding a potassium-sparing diuretic (ie spironolactone).
January 17, 2025 at 6:19 PM
Rather than an algorithmic approach, try to tailor your adjunctive agents to the patient's biochemical milieu.
The patient w rising bicarb who needs ongoing diuresis? Great candidate for acetazolamide.
The patient w recurrent hypoK? Try adding a potassium-sparing diuretic (ie spironolactone).
The patient w rising bicarb who needs ongoing diuresis? Great candidate for acetazolamide.
The patient w recurrent hypoK? Try adding a potassium-sparing diuretic (ie spironolactone).
Carbonic anhydrase activity contributes to lithium-NDI development, and acetazolamide attenuates lithium-NDI development in mice similar to thiazide/ amiloride but with fewer adverse effects 🐁
#Nephpearls #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/26574046/
#Nephpearls #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/26574046/
April 24, 2025 at 5:24 PM
Carbonic anhydrase activity contributes to lithium-NDI development, and acetazolamide attenuates lithium-NDI development in mice similar to thiazide/ amiloride but with fewer adverse effects 🐁
#Nephpearls #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/26574046/
#Nephpearls #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/26574046/