Online Now: Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin Online now:
Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin
Huang et al. find that H3K27ac acetylase p300 mainly acetylates METTL3 on H3K27ac-marked chromatin, resulting in specific m6A inhibition of enhancer and promoter RNAs through METTL14-mediated disassociation from H3K27ac. PAK2 promotes METTL3 acetylation…
dlvr.it
March 18, 2025 at 1:09 PM
This specific paper transformed the understanding of EP300 from a general transcriptional co-activator into a definitive cancer-preventing gene by proving it follows Knudson's "two-hit" hypothesis!
500 citations!
@caldaslab.bsky.social h
walking the walk for over 25y!
www.nature.com/articles/ng0...
500 citations!
@caldaslab.bsky.social h
walking the walk for over 25y!
www.nature.com/articles/ng0...
Mutations truncating the EP300 acetylase in human cancers - Nature Genetics
Nature Genetics - Mutations truncating the EP300 acetylase in human cancers
www.nature.com
July 14, 2026 at 8:41 AM
This specific paper transformed the understanding of EP300 from a general transcriptional co-activator into a definitive cancer-preventing gene by proving it follows Knudson's "two-hit" hypothesis!
500 citations!
@caldaslab.bsky.social h
walking the walk for over 25y!
www.nature.com/articles/ng0...
500 citations!
@caldaslab.bsky.social h
walking the walk for over 25y!
www.nature.com/articles/ng0...
Bacillus cereus PelADA is a polysaccharide de-N-acetylase required for Pel-dependent biofilm formation
#JBiolChem from Lynne Howell
www.jbc.org/article/S002...
#JBiolChem from Lynne Howell
www.jbc.org/article/S002...
Bacillus cereus PelADA is a polysaccharide de-N-acetylase required for Pel-dependent biofilm formation
Exopolysaccharides are key matrix determinants that provide structural integrity and
regulate biomechanical properties of microbial biofilms. Biofilm exopolysaccharides
often undergo modifications tha...
www.jbc.org
May 9, 2026 at 10:43 AM
Bacillus cereus PelADA is a polysaccharide de-N-acetylase required for Pel-dependent biofilm formation
#JBiolChem from Lynne Howell
www.jbc.org/article/S002...
#JBiolChem from Lynne Howell
www.jbc.org/article/S002...
Another @caldaslab.bsky.social citations landmark (500!!) for this @natgenet.nature.com paper which reported mutations truncating the EP300 histone acetylase in human epithelial malignancies. Seminal discovery back in 2000!
🫡💯💢💥💫
www.nature.com/articles/ng0...
🫡💯💢💥💫
www.nature.com/articles/ng0...
Mutations truncating the EP300 acetylase in human cancers - Nature Genetics
Nature Genetics - Mutations truncating the EP300 acetylase in human cancers
www.nature.com
May 10, 2026 at 4:16 PM
Another @caldaslab.bsky.social citations landmark (500!!) for this @natgenet.nature.com paper which reported mutations truncating the EP300 histone acetylase in human epithelial malignancies. Seminal discovery back in 2000!
🫡💯💢💥💫
www.nature.com/articles/ng0...
🫡💯💢💥💫
www.nature.com/articles/ng0...
Very interesting paper by Philipp Voigt about nucleosomal asymmetry at bivalent domains. "Bivalency recruits H3K27me3 but not H3K4me3 readers, promoting a poised state" www.cell.com/molecular-ce...
Nucleosomal asymmetry shapes histone mark binding and promotes poising at bivalent domains
Bivalent promoters are thought to poise developmental genes for expression. Bryan et al. show that asymmetric bivalent nucleosomes recruit repressive H3K27me3 but not activating H3K4me3 readers, thereby promoting poising. Bivalency further attracts specific factors, including the acetylase KAT6B, which is required for proper activation of bivalent genes during differentiation.
www.cell.com
December 29, 2024 at 3:58 AM
Very interesting paper by Philipp Voigt about nucleosomal asymmetry at bivalent domains. "Bivalency recruits H3K27me3 but not H3K4me3 readers, promoting a poised state" www.cell.com/molecular-ce...
And, yes, temporal dynamics. For instance, quite classically, the histone acetylase Gcn5 in yeast is not required for induction of the phosphate-responsive PHO5, but it is required for quicker induction. Plenty of other examples, albeit less sophisticated than this specific case, which is cool ...
May 9, 2026 at 7:23 PM
And, yes, temporal dynamics. For instance, quite classically, the histone acetylase Gcn5 in yeast is not required for induction of the phosphate-responsive PHO5, but it is required for quicker induction. Plenty of other examples, albeit less sophisticated than this specific case, which is cool ...
Is this account a bot? Anyhow, here is the table - see my other comment
August 21, 2026 at 2:53 PM
Is this account a bot? Anyhow, here is the table - see my other comment
Next, Minou Nowrousian on a favorite of mine: fungal multicellularity. How does Sordaria makes perithecia? Histone chaperone Asf1 and histone acetylase RTT109 are required. TF Pro44 has a GATA domain needed for fertility and a disordered region, without which fruiting bodis are stuck in agar
#ecfg17
#ecfg17
March 5, 2025 at 10:40 AM
Next, Minou Nowrousian on a favorite of mine: fungal multicellularity. How does Sordaria makes perithecia? Histone chaperone Asf1 and histone acetylase RTT109 are required. TF Pro44 has a GATA domain needed for fertility and a disordered region, without which fruiting bodis are stuck in agar
#ecfg17
#ecfg17
Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin
Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin
Huang et al. find that H3K27ac acetylase p300 mainly acetylates METTL3 on H3K27ac-marked chromatin, resulting in specific m6A inhibition of enhancer and promoter RNAs through METTL14-mediated disassociation from H3K27ac. PAK2 promotes METTL3 acetylation by phosphorylating METTL3 to inhibit ferroptosis and promote cancer cell survival. This study reveals a spatial-selective way of regulating m6A.
dlvr.it
April 7, 2025 at 11:33 AM
Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin
This makes a lot of sense!
In a coevolution experiment of ours (bacteria+phage) we observed that resistance in some clones emerged by a mutation in a capsule acetylase , probably precluding infection of a phage with a SGNH-domain
Must check!
doi.org/10.7554/eLif...
In a coevolution experiment of ours (bacteria+phage) we observed that resistance in some clones emerged by a mutation in a capsule acetylase , probably precluding infection of a phage with a SGNH-domain
Must check!
doi.org/10.7554/eLif...
Competition between lysogenic and sensitive bacteria is determined by the fitness costs of the different emerging phage-resistance strategies
The emergence and evolution of different phage-resistance strategies during coevolution between a phage-sensitive strain and a polylysogenic competitor depend on the amount of phage pressure, the fitn...
doi.org
April 29, 2026 at 3:35 PM
This makes a lot of sense!
In a coevolution experiment of ours (bacteria+phage) we observed that resistance in some clones emerged by a mutation in a capsule acetylase , probably precluding infection of a phage with a SGNH-domain
Must check!
doi.org/10.7554/eLif...
In a coevolution experiment of ours (bacteria+phage) we observed that resistance in some clones emerged by a mutation in a capsule acetylase , probably precluding infection of a phage with a SGNH-domain
Must check!
doi.org/10.7554/eLif...
Online Now: Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin Online now:
Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin
Huang et al. find that H3K27ac acetylase p300 mainly acetylates METTL3 on H3K27ac-marked chromatin, resulting in specific m6A inhibition of enhancer and promoter RNAs through METTL14-mediated disassociation from H3K27ac. PAK2 promotes METTL3 acetylation…
dlvr.it
March 17, 2025 at 3:20 PM
Online Now: Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin Online now:
Super paper out of the Voigt group, that answers some longstanding questions about bivalent #histone marks!
They show asymmetric bivalency recruits repressive readers (but not H3K4me3 readers) and have emergent properties that neither of the two alone do (e.g. recruitment of KAT6B complex)!
🧪
They show asymmetric bivalency recruits repressive readers (but not H3K4me3 readers) and have emergent properties that neither of the two alone do (e.g. recruitment of KAT6B complex)!
🧪
February 24, 2025 at 11:22 PM
Super paper out of the Voigt group, that answers some longstanding questions about bivalent #histone marks!
They show asymmetric bivalency recruits repressive readers (but not H3K4me3 readers) and have emergent properties that neither of the two alone do (e.g. recruitment of KAT6B complex)!
🧪
They show asymmetric bivalency recruits repressive readers (but not H3K4me3 readers) and have emergent properties that neither of the two alone do (e.g. recruitment of KAT6B complex)!
🧪
Chitin, the planet's second-most common biopolymer, breaks down into a unique sugar. Some microbes have an enzyme, OngB, to process this sugar, and it's unlike any de-acetylase seen before. OngB uses a unique barrel-like structure and metals to work its magic. It might have evolved from old enzym...
Carbohydrate deacetylase, a key enzyme in oxidative chitin degradation, is evolutionarily linked to amino acid deacetylase.
Published in The Journal of biological chemistry
doi.org
March 23, 2025 at 7:23 PM
Chitin, the planet's second-most common biopolymer, breaks down into a unique sugar. Some microbes have an enzyme, OngB, to process this sugar, and it's unlike any de-acetylase seen before. OngB uses a unique barrel-like structure and metals to work its magic. It might have evolved from old enzym...
SBGrid's eLife paper received a citation in May from Lynne Howell at @utoronto.ca in Journal of Biological Chemistry: Bacillus cereus PelADA is a polysaccharide de-N-acetylase required for Pel-dependent biofilm formation.
Read more here: buff.ly/851Xyt2
#SBGrid #ScienceMatters
Read more here: buff.ly/851Xyt2
#SBGrid #ScienceMatters
Bacillus cereus PelADA is a polysaccharide de-N-acetylase required for Pel-dependent biofilm formation
Exopolysaccharides are key matrix determinants that provide structural integrity and regulate biomechanical properties of microbial biofilms. Biofilm exopolysaccharides often undergo modifications…
buff.ly
June 22, 2026 at 4:06 PM
SBGrid's eLife paper received a citation in May from Lynne Howell at @utoronto.ca in Journal of Biological Chemistry: Bacillus cereus PelADA is a polysaccharide de-N-acetylase required for Pel-dependent biofilm formation.
Read more here: buff.ly/851Xyt2
#SBGrid #ScienceMatters
Read more here: buff.ly/851Xyt2
#SBGrid #ScienceMatters