Researchers evaluated long-term outcomes in patients with stable corneal ectasia undergoing intrastromal ring segment insertion.

Doudna-Founded Caribou Biosciences Considers Merger, Sale

The management of keratoconus has evolved substantially over 3 decades. While corneal transplantation was historically the only surgical option for advanced disease, intracorneal ring segments (ICRS), first implanted by Walton Nosé in 1993 and later popularized by Joseph Colin, offered a less invasive way to improve corneal symmetry and reduce irregular astigmatism. Conventional ICRS are made of synthetic PMMA, and despite their efficacy, they carry substantial risks, including extrusion, corneal melt, neovascularization and stress-induced stromal necrosis, particularly when placed

The management of keratoconus has evolved substantially over 3 decades. While corneal transplantation was historically the only surgical option for advanced disease, intracorneal ring segments (ICRS), first implanted by Walton Nosé in 1993 and later popularized by Joseph Colin, offered a less invasive way to improve corneal symmetry and reduce irregular astigmatism. Conventional ICRS are made of synthetic PMMA, and despite their efficacy, they carry substantial risks, including extrusion, corneal melt, neovascularization and stress-induced stromal necrosis, particularly when placed

Here, the authors suggest that, when major histocompatibility complex class I is downregulated on allogenic or tumor cells, they are more susceptible to CD4+ T cell-mediated ferroptosis.

The French biotech will advance two preclinical gene-editing therapies for severe lipid disorders as lead programs.

While analyzing a published single-cell (sc)RNA-seq dataset from the 4T1 mouse mammary carcinoma model20,21, we noticed that transcripts for a canonical epithelial-cell-restricted protein, epithelial cell adhesion molecule (EpCAM), were detectable in a subset of TAMs (Extended Data Fig. 1). This was consistent with a report observing human epithelial markers in RNA-seq of macrophages from an allogenic A549 xenograft mouse model; the authors suggest that this RNA is indicative of phagocytosis of human cancer cells22. By flow cytometry, a subset of macrophages in 4T1 tumors stained positive for surface EpCAM (Fig. 1a and Supplementary Fig. 1a). EpCAM positivity was only observed on macrophages isolated from tumors and not from bone-marrow-derived macrophages (BMDMs) (Fig. 1a and Supplementary Fig. 1b), indicating that a tumor-microenvironment-specific mechanism was responsible for tumor-restricted EpCAM being present on TAMs. Curious as to the origins of EpCAM transcript and protein, we engineered 4T1 cancer cells to express intracellular GFP and evaluated CD45+CD11b+Ly6G− TAMs that had or had not ingested 4T1-derived GFP in engrafted tumors (Fig. 1b). We observed increased anti-EpCAM surface staining of GFP+ TAMs compared to GFP− TAMs (Fig. 1b and Supplementary Fig. 2), suggestive of an association between cell uptake and anti-EpCAM staining. We reasoned that additional...

Corneal transplantation is the most common allogenic transplant performed worldwide.1 Although the use of Descemet’s membrane endothelial keratoplasty (DMEK) and Descemet’s stripping automated endothelial keratoplasty (DSAEK) has increased for the treatment of corneal endothelial disorders, full-thickness replacement via penetrating keratoplasty (PK) remains a common method of transplantation for pathology involving the stroma or the entire cornea.2 Commonly reported indications for PK include keratoconus, postinfectious corneal scarring or thinning, and pseudophakic bullous keratopathy.

KIAWAH ISLAND, S.C. — Surgeons who perform corneal allogenic intrastromal ring segment procedures should keep planning simple, according to a speaker at Kiawah Eye & Retina. In a presentation, Neel R. Desai, MD, shared pearls and what he wished he knew before he started using corneal allogenic intrastromal ring segments (CAIRS) in patients with keratoconus, specifically when placing the ring segments using manual dissection. “When you conceptually think about dissecting or cross planes with a femtosecond laser, it is indiscriminate with respect to the femtosecond laser plane being a fixed

KIAWAH ISLAND, S.C. — Surgeons who perform corneal allogenic intrastromal ring segment procedures should keep planning simple, according to a speaker at Kiawah Eye & Retina. In a presentation, Neel R. Desai, MD, shared pearls and what he wished he knew before he started using corneal allogenic intrastromal ring segments (CAIRS) in patients with keratoconus, specifically when placing the ring segments using manual dissection. “When you conceptually think about dissecting or cross planes with a femtosecond laser, it is indiscriminate with respect to the femtosecond laser plane being a fixed

- Intriguing work from our friend and colleague Prof. Beata Rakowska and coworkers from Poland Although encouraging results of adipose-derived stem cell (ADSC) use in wound healing are available, the mechanism of action has been studied mainly in vitro and in animals. This work aimed to examine the safety and efficacy of allogenic ADSCs in human Intriguing work from our friend and colleague Prof. Beata Rakowska and coworkers from Poland Although encouraging results of adipose-derived stem cell (ADSC) use in wound healing are available, the mechanism of action has been studied mainly in vitro and in animals. This work aimed to examine the safety and efficacy of allogenic ADSCs in human Intriguing work from our friend and colleague Prof. Beata Rakowska and coworkers from Poland Although encouraging results of adipose-derived stem cell (ADSC) use in wound healing are available, the mechanism of action has been studied mainly in vitro and in animals. This work aimed to examine the safety and efficacy of allogenic ADSCs in human - -

This approval represents an important advancement for patients with blood cancers, demonstrating the potential to improve the safety and effectiveness of...

Chronic wounds, especially in diabetic patients, pose a significant clinical challenge due to impaired microvasculature and delayed healing. This stud…