Brave employees continue coming forward to report what’s really happening inside U.S. animal research laboratories, and their attestations make clear that animal researchers’ actions do not match thei...

All studies involving the use of animals were conducted in compliance with animal care and use protocols approved by institutional animal care and use committees (IACUC) of corresponding testing facilities: Wuxi Apptec, nChroma Bio and AltaSciences. The health assessment of animals was performed in accordance with IACUC standard operating procedures and guidelines of each testing facility. In silico HBV conservation and gRNA designs Guide target conservation analysis was performed by assessing exact matches between the target sequence including presence of the dSpCas9 NGG PAM and the reference genomes with A–E genotypes found in HBVdb21 using NCBI BLAST40. The percentage of exact matches per genotype was used to assess conservation. RNA production Using standard methods by commercial suppliers, 100-mer gRNAs were chemically synthesized. The gRNAs used for in vitro screens contain 2′-O-methylation and phosphorothioate linkages at the three terminal nucleotides of both the 5′ and 3′ ends, as previously described15. Subsequent studies in vitro and in vivo employed gRNAs containing both end-modifications as well as a proprietary pattern of 2′-O-methylation throughout the sequence. All gRNA target sequence used in this study are presented in Supplementary Table 1. mRNA was produced via in vitro transcription and purification. Plasmids containing an epigenetic silencer...

Altasciences LA, a clinical research organization in Cypress, California, is seeking volunteers who are on treatments for type 2 diabetes or obesity to participate in upcoming paid clinical trials.

Reported Thursday, May 7 - 8:15am EDT (TheFly subscription required to read more.)

Fewer than half of preclinical candidates reach first-in-human trials. The tie-up aims to refine dosing, optimize study design and speed proof of mechanism.

LAVAL, Québec–(BUSINESS WIRE)–#AI—Altasciences, a fully integrated CRO/CDMO offering comprehensive early-phase drug development solutions, is pleased to announce a strategic collaboration with Evidence Matters, a pioneer in clinical trial data science and document engineering. This partnership combines Altasciences’ real-world drug development expertise with Evidence Matters’ innovative, patent-pending Text Engineering technology—a breakthrough that delivers near-deterministic accuracy in …

Cell and Gene Therapy CRO Market Top Companies Study - Altasciences, Allucent, CMIC, Labcorp, Linical, Medpace.  openPR