Gatto & coll from Mayo clinic investigated the origins of off-target tau-PET binding in frontotemporal lobar degeneration, esp the contributions of TDP-43 and annexin A11. 🧠
www.thelancet.com/journals/lan...
#neurosky
Gatto & coll from Mayo clinic investigated the origins of off-target tau-PET binding in frontotemporal lobar degeneration, esp the contributions of TDP-43 and annexin A11. 🧠
www.thelancet.com/journals/lan...
#neurosky
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
Elizabeth M. McNally & team discover (mouse) muscle lacking two proteins critical for resealing damaged sarcolemma (dysferlin & annexin A6) cause leaky membranes and invite macrophages to come take a bite.
@the-asci.org
Elizabeth M. McNally & team discover (mouse) muscle lacking two proteins critical for resealing damaged sarcolemma (dysferlin & annexin A6) cause leaky membranes and invite macrophages to come take a bite.
@the-asci.org
The ALS- and FTD-associated proteins annexin A11 and CHMP2B act sequentially in plasma membrane repair
www.cell.com/developmenta...
The ALS- and FTD-associated proteins annexin A11 and CHMP2B act sequentially in plasma membrane repair
www.cell.com/developmenta...
All plasmids are on @addgene.bsky.social
www.addgene.org/Michael_Marty/
There's also a very useful plasmid for GFP-Annexin hidden in here
All plasmids are on @addgene.bsky.social
www.addgene.org/Michael_Marty/
There's also a very useful plasmid for GFP-Annexin hidden in here
Elizabeth M. McNally & team discover (mouse) muscle lacking two proteins critical for resealing damaged sarcolemma (dysferlin & annexin A6) cause leaky membranes and invite macrophages to come take a bite.
@the-asci.org
Elizabeth M. McNally & team discover (mouse) muscle lacking two proteins critical for resealing damaged sarcolemma (dysferlin & annexin A6) cause leaky membranes and invite macrophages to come take a bite.
@the-asci.org
四個核心評分標記是 CD11c、CD103、CD123、CD25,3–4 分見於約 98% 的 HCL;再加 annexin A1(最具特異性)與 CD200。
CD27 不在其中,而且典型為陰性或弱 —— 把它列入特徵標記就錯了。
CD5、CD10、CD23 也都是陰性。
#血液專科
https://hema-2026.hsiehting.com/q/110-048
四個核心評分標記是 CD11c、CD103、CD123、CD25,3–4 分見於約 98% 的 HCL;再加 annexin A1(最具特異性)與 CD200。
CD27 不在其中,而且典型為陰性或弱 —— 把它列入特徵標記就錯了。
CD5、CD10、CD23 也都是陰性。
#血液專科
https://hema-2026.hsiehting.com/q/110-048
HCL:CD11c/CD25/CD103/CD123 四陽、annexin A1 陽性、monocytopenia、BRAF V600E。
HCL variant:CD25 與 CD123 陰性、annexin A1 陰性、無 BRAF V600E、單核球正常。
SMZL:NOTCH2、KLF2、del(7q)。
SDRPL:cyclin D3 過度表現。
#血液專科
https://hema-2026.hsiehting.com/q/112-036
HCL:CD11c/CD25/CD103/CD123 四陽、annexin A1 陽性、monocytopenia、BRAF V600E。
HCL variant:CD25 與 CD123 陰性、annexin A1 陰性、無 BRAF V600E、單核球正常。
SMZL:NOTCH2、KLF2、del(7q)。
SDRPL:cyclin D3 過度表現。
#血液專科
https://hema-2026.hsiehting.com/q/112-036
CD11c、CD103、CD123、CD25 四項各 1 分,3–4 分支持 classic HCL。
再加 B 細胞標記 CD19/CD20 強陽,而 CD5、CD10、CD23、CD27 陰性以排除 CLL 與 FL。
IHC 佐證:annexin A1 陽性(高度特異)、DBA-44 陽性、TRAP 陽性。
#血液專科
https://hema-2026.hsiehting.com/q/112-036
CD11c、CD103、CD123、CD25 四項各 1 分,3–4 分支持 classic HCL。
再加 B 細胞標記 CD19/CD20 強陽,而 CD5、CD10、CD23、CD27 陰性以排除 CLL 與 FL。
IHC 佐證:annexin A1 陽性(高度特異)、DBA-44 陽性、TRAP 陽性。
#血液專科
https://hema-2026.hsiehting.com/q/112-036