Virulence protein J domain 1 maintains the canonical α/β-hydrolase fold but is likely to lack a functional catalytic triad, suggesting functional divergence from classical hydrolases of this superfamily #BacterialPathogens #TypeIVSecretionSystem doi.org/10.1107/S205...
September 9, 2025 at 2:50 PM
Virulence protein J domain 1 maintains the canonical α/β-hydrolase fold but is likely to lack a functional catalytic triad, suggesting functional divergence from classical hydrolases of this superfamily #BacterialPathogens #TypeIVSecretionSystem doi.org/10.1107/S205...
Peroxiredoxins are some of the coolest enzymes out there—they don’t just protect cells from oxidative stress, they also form awesome donut-shaped structures! 🍩 Targeting them could lead to new antibiotics. #Microbiology #antibiotics #AMR #Antioxidants #BacterialPathogens
March 7, 2025 at 2:50 AM
Peroxiredoxins are some of the coolest enzymes out there—they don’t just protect cells from oxidative stress, they also form awesome donut-shaped structures! 🍩 Targeting them could lead to new antibiotics. #Microbiology #antibiotics #AMR #Antioxidants #BacterialPathogens
Chloé Dugelay et al.: Crystal structure of the virulence protein J (VirJ) domain 1 from Brucella abortus ##BacterialPathogens##EsteraseFold##TypeIVSecretionSystem... ##IUCrhttps://journals.iucr.org/paper?S2053230X25006697
Crystal structure of the virulence protein J (VirJ) domain 1 from Brucella abortus
Virulence protein J (VirJ) is produced by the bacterial pathogen Brucella abortus and contains two domains, D1 and D2. The crystal structure of VirJD1 is presented at a resolution of 1.7 Å and displays an α/β-hydrolase fold with a central β-sheet surrounded by α-helices. Structural comparison with other members of the family suggests that VirJD1 lacks the characteristic catalytic triad.
journals.iucr.org
August 19, 2025 at 12:00 AM
Chloé Dugelay et al.: Crystal structure of the virulence protein J (VirJ) domain 1 from Brucella abortus ##BacterialPathogens##EsteraseFold##TypeIVSecretionSystem... ##IUCrhttps://journals.iucr.org/paper?S2053230X25006697
Learn key bacterial virulence factors and their role in infection and immune evasion. #BacterialVirulence #VirulenceFactors #Microbiology #Pathogenesis #Toxins #Capsules #Adhesins #Enzymes #SecretionSystems #USMLE #MedicalEducation #ClinicalMicrobiology #ImmuneEvasion #BacterialPathogens
U01.03.013 Bacterial virulence factor
Bacterial virulence factors are specialized molecules or structures that enable bacteria to colonize hosts, evade immune responses, and cause disease. These include capsules, toxins, adhesins, enzymes, and secretion systems that enhance pathogenicity and determine disease severity.
mymedschool.org
November 9, 2025 at 8:23 PM
Learn key bacterial virulence factors and their role in infection and immune evasion. #BacterialVirulence #VirulenceFactors #Microbiology #Pathogenesis #Toxins #Capsules #Adhesins #Enzymes #SecretionSystems #USMLE #MedicalEducation #ClinicalMicrobiology #ImmuneEvasion #BacterialPathogens
Accurate genotyping of three major respiratory bacterial pathogens with ONT R10.4.1 long-read sequencing. #BacteriaGenotyping #BacterialPathogens #Nanopore #LongRead #Sequencing @genomeresearch.bsky.social @nanoporetech.com
genome.cshlp.org/content/earl...
genome.cshlp.org/content/earl...
Accurate genotyping of three major respiratory bacterial pathogens with ONT R10.4.1 long-read sequencing
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
genome.cshlp.org
June 5, 2025 at 4:32 PM
Accurate genotyping of three major respiratory bacterial pathogens with ONT R10.4.1 long-read sequencing. #BacteriaGenotyping #BacterialPathogens #Nanopore #LongRead #Sequencing @genomeresearch.bsky.social @nanoporetech.com
genome.cshlp.org/content/earl...
genome.cshlp.org/content/earl...