A possible rejuvenating cocktail for replicatively senescent Endothelial Cell

valproic acid HDACi
lithium carbonate GSK3i
Galunisertib ALK5i

Transient modulation of Yamanaka factors
Alleviating pro-inflamm SASP
Restoring angiogenic behaviors

#BasicResCardiol 2026
link.springer.com/article/10.1...

Diabetic #T2D db/db 🐭🫀coronary resistance microvessel multiomics

FFPE-scRNAseq
#SpatialTranscriptomics Visium
Proteomics Septal Resistance Microvessel🧐

Traits of Fatty acid β-oxidation & ketogenesis in diabetic intramyocardial vessels

#BasicResCardiol 2025
link.springer.com/article/10.1...

Landmark revisit

Smooth muscle cells from the anastomosed artery are the major precursors for neointima formation in both artery (90%) & vein (60%) grafts

Wnt1-Cre reporter🐭

Minimal contribution from bone marrow (BMT)

#BasicResCardiol 2014
link.springer.com/article/10.1...

Unveiling cellular & molecular aspects of #AscendingThoracicAorticAneurysms/Dissections

TGFβ
YAP
Notch
Calcification

Worth a read, but where're sc/snRNAseq studies🧐
Even @MarkELindsay ATVB 2022 is cited in a funny way😳

#AortaEd

#BasicResCardiol 2024
link.springer.com/article/10.1...