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ckarampelias.bsky.social
I tried to make a feed for news and discussions on all things pancreas biology (exocrine and endocrine!). You can post with the hashtags #PancSky #BetaCellSky #EndocrineSky . Let me know if it is useful and how to modify to make it better!

bsky.app/profile/did:...
January 2, 2025 at 6:23 PM
oliczarnecki.bsky.social
Leading the pack: Glucokinase reinforces Ca2+-waves
#PancSky #BetaCellSky

elifesciences.org/articles/103...
Glucokinase activity controls peripherally located subpopulations of β-cells that lead islet Ca2+ oscillations
3D light-sheet imaging identifies the location and metabolic sensitivity of β-cell subpopulations that lead and coordinate islet Ca2+ oscillations.
elifesciences.org
February 13, 2025 at 8:29 PM
isletbiologylab.bsky.social
Li et al. show that human-reprogrammed vascular endothelial cells vascularize #islets, support dynamic function in microfluidic chambers, and enable subcutaneous cotransplantation to reverse hyperglycemia in diabetic mice.
#PancSky #BetaCellSky #Diabetes

www.science.org/doi/10.1126/...
Vascularization of human islets by adaptable endothelium for durable and functional subcutaneous engraftment
Adaptable human blood vessel cells enable functional engraftment of pancreatic islets under the skin to treat diabetes.
www.science.org
February 3, 2025 at 9:22 AM
ckarampelias.bsky.social
Have a look at our latest summary of chemical biology tools and approaches for pancreatic beta-cell biology studies together with @o-andersson-lab.bsky.social at @nchembio.bsky.social.
@www.helmholtz-munich.de #Uppsalauniversity #BetaCellsky. 🧪

www.nature.com/articles/s41...
Mechanistic insights and approaches for beta cell regeneration - Nature Chemical Biology
This Review highlights recent advances in the identification of small-molecule mediators of beta cell regeneration, discussing the diverse pathways and cellular processes altered by these compounds.
www.nature.com
January 29, 2025 at 6:25 PM
isletbiologylab.bsky.social
To conclude the session, our PI, Laura Marroquí, presents our findings on protecting beta cells by modulating the innate immune system. 🧪
#SEDCIBERDEM2025 #DiabetesResearch #BetaCellSky
February 14, 2025 at 4:25 PM
isletbiologylab.bsky.social
Verschueren van Rees et al. exploited advances in immunostaining, spatial biology and machine learning to undertake a detailed, systematic analysis of adult human islet architecture in health and #type1diabetes. 🧪
#Pancsky #Betacellsky

link.springer.com/article/10.1...
Beyond the loss of beta cells: a quantitative analysis of islet architecture in adults with and without type 1 diabetes - Diabetologia
Aims/hypothesis The organisation and cellular architecture of islets of Langerhans are critical to the physiological regulation of hormone secretion but it is debated whether human islets adhere to th...
link.springer.com
February 28, 2025 at 10:35 AM
isletbiologylab.bsky.social
Campo et al. bioengineered an induced pluripotent stem cell-based version, fabricating a human iPSC-based vascularized endocrine pancreas using iPSC-derived β cells and endothelial cells. 🧪
#Diabetesresearch #T1D #PancSky #BetaCellSky

tinyurl.com/rkaunnv9
Bioengineering of a human iPSC-derived vascularized endocrine pancreas for type 1 diabetes
This study addresses the limitations of intrahepatic islet transplantation in type 1 diabetes by repurposing decellularized lungs into a human iPSC-based vascularized endocrine pancreas (iVEP). Campo ...
tinyurl.com
February 17, 2025 at 11:54 AM
ckarampelias.bsky.social
Interesting data on intermittent fasting and #BetacellSky! www.cell.com/cell-reports... Would be interesting if there was any Neurog3 reawakening in this model similar to previous observations from fasting that can account for the reduced islet cell mass! www.cell.com/cell-reports...
Chronic intermittent fasting impairs β cell maturation and function in adolescent mice
Intermittent fasting (IF) is generally associated with improved metabolism, but whether there are age-dependent limitations of IF needs to be explored. Matta et al. now demonstrate that while IF impro...
www.cell.com
January 21, 2025 at 6:01 AM
isletbiologylab.bsky.social
MacDonald et al. found that inhibition of the oxidase enzyme Renalase defends against loss of β cell mass and islet dysfunction in chronically stressed Akita mice in vivo.

#Pancsky #Betacellsky

www.sciencedirect.com/science/arti...
Renalase inhibition defends against acute and chronic β cell stress by regulating cell metabolism
Renalase (Rnls), annotated as an oxidase enzyme, is a GWAS gene associated with Type 1 diabetes (T1D) risk. We previously discovered that Rnls inhibit…
www.sciencedirect.com
March 3, 2025 at 6:15 AM
isletbiologylab.bsky.social
Nilsson et al. show that islet cell primary cilia constitute an important target of somatostatin action, which endows somatostatin with the ability to regulate islet cell function beyond acute suppression of hormone release. 🧪
#PancSky #BetaCellSky #diabetes

www.embopress.org/doi/full/10....
Somatostatin triggers local cAMP and Ca2+ signaling in primary cilia to modulate pancreatic β-cell function | The EMBO Journal
imageimagePancreatic δ-cells secrete somatostatin, a paracrine factor that inhibits insulin secretion from the islet β-cells. This study shows that somatostatin is locally detected by primary cilia on...
www.embopress.org
February 14, 2025 at 11:29 AM