Medical nutrition therapy for the management of type 2 diabetes mellitus
"Underlying mechanisms, clinical efficacy and potential for sustainable long-term implementation."
www.nature.com/articles/s41...
"Underlying mechanisms, clinical efficacy and potential for sustainable long-term implementation."
www.nature.com/articles/s41...
November 23, 2025 at 7:59 AM
So are the going to be our new hashtags on BlueSky?
#LiverSky #MedSky #PancSky #HPBSky #SurgerySky
What else??
@augishealth.bsky.social @ihpba.bsky.social @eahpba.bsky.social @collegeofsurgeons.bsky.social
@bjsacademy.bsky.social
@sages.org
#LiverSky #MedSky #PancSky #HPBSky #SurgerySky
What else??
@augishealth.bsky.social @ihpba.bsky.social @eahpba.bsky.social @collegeofsurgeons.bsky.social
@bjsacademy.bsky.social
@sages.org
November 27, 2024 at 9:55 AM
So are the going to be our new hashtags on BlueSky?
#LiverSky #MedSky #PancSky #HPBSky #SurgerySky
What else??
@augishealth.bsky.social @ihpba.bsky.social @eahpba.bsky.social @collegeofsurgeons.bsky.social
@bjsacademy.bsky.social
@sages.org
#LiverSky #MedSky #PancSky #HPBSky #SurgerySky
What else??
@augishealth.bsky.social @ihpba.bsky.social @eahpba.bsky.social @collegeofsurgeons.bsky.social
@bjsacademy.bsky.social
@sages.org
Important new work for type 1 diabetes progression using spatial transcriptomics #pancsky
Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes https://www.biorxiv.org/content/10.1101/2025.05.19.654940v1
May 25, 2025 at 6:04 AM
Important new work for type 1 diabetes progression using spatial transcriptomics #pancsky
Such a cool paper!! #PancSky
Somatostatin released by pancreatic δ-cells triggers local cAMP and Ca2+ signaling in primary cilia of nearby β-cells, to modulate their function beyond acute suppression of hormone release
Olof Idevall-Hagren and coworkers
www.embopress.org/doi/full/10....
Olof Idevall-Hagren and coworkers
www.embopress.org/doi/full/10....
February 24, 2025 at 4:10 PM
Such a cool paper!! #PancSky
Interesting work on cystic fibrosis and endocrine cell phenotypes #PancSky
It was a pleasure for our team to be able to contribute to this manuscript on Vimentin+ alpha cells in CF 👇🏻
joe.bioscientifica.com/view/journal...
joe.bioscientifica.com/view/journal...
joe.bioscientifica.com
February 19, 2025 at 5:34 AM
Interesting work on cystic fibrosis and endocrine cell phenotypes #PancSky
Just posting this starter pack for #PancSky again as I have added more people - let me know any other islet/pancreas scientists I've missed! go.bsky.app/3wdSpdi
March 6, 2025 at 5:09 PM
Just posting this starter pack for #PancSky again as I have added more people - let me know any other islet/pancreas scientists I've missed! go.bsky.app/3wdSpdi
New evidence for bmp7 in islet regeneration #PancSky
Where do islet beta cells come from and how to regenerate? The answers depend on how one utilizes distinct neogenesis and proliferative pathways #diabetes www.nature.com/articles/s41...
Pancreatic β-cell regeneration in situ by the ALK3 agonist THR-123 - Nature Communications
Álvarez-Cubela et al. show that a BMP-7-like peptide induces β-cell regeneration and lowers hyperglycemia in diabetic mice, and reveal the transition of ductal cells into insulin-expressing cells. The...
www.nature.com
July 4, 2025 at 4:58 AM
New evidence for bmp7 in islet regeneration #PancSky
One of the many ongoing projects in our #PancreaticCancer initiatives @SylvesterCancer at the Univ of Miami Miller SOM. Thx @letswinpc.bsky.social for amplifying this important topic #PancSky #SurgSky #OncSky #HPBSky
There has been a notable increase in cases of young onset pancreatic cancer. Dr. Jash Datta (@drjashdatta.bsky.social) and team are exploring why this is happening. https://letswinpc.org/research/molecular-differences-young-onset-pancreatic-cancer/
Study Reveals Molecular Differences in Young-Onset Pancreatic Cancer
There has been a notable increase in cases of young onset pancreatic cancer. Dr. Jashodeep Datta and team are exploring why.
letswinpc.org
December 3, 2024 at 12:41 AM
One of the many ongoing projects in our #PancreaticCancer initiatives @SylvesterCancer at the Univ of Miami Miller SOM. Thx @letswinpc.bsky.social for amplifying this important topic #PancSky #SurgSky #OncSky #HPBSky
Check it out a lot of human islet work in this preprint! #PancSky
Proud to share a new preprint from my lab that is the product of hard work from several talented lab members and collaboration with valued colleagues: www.biorxiv.org/content/10.1...
IFN-α Induces Heterogenous ROS Production in Human β-Cells
Type 1 diabetes (T1D) is a multifactorial disease involving genetic and environmental factors, including viral infection. We investigated the impact of interferon alpha (IFN-α), a cytokine produced du...
www.biorxiv.org
February 23, 2025 at 4:20 PM
Check it out a lot of human islet work in this preprint! #PancSky
Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔
🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n
🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n
LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes - Nature Metabolism
LONP1, whose expression is downregulated in islets from donors with type 2 diabetes, is vital to mediate efficient mitochondrial protein folding, thus preventing proteotoxicity and promoting islet β c...
nature.com
July 21, 2025 at 5:55 PM
I don't think IIDP is on Bluesky yet, so just reposting.
iidp.coh.org/funding
Applications Due: February 14, 2025.
#islet #PancSky
iidp.coh.org/funding
Applications Due: February 14, 2025.
#islet #PancSky
February 5, 2025 at 4:29 AM
I don't think IIDP is on Bluesky yet, so just reposting.
iidp.coh.org/funding
Applications Due: February 14, 2025.
#islet #PancSky
iidp.coh.org/funding
Applications Due: February 14, 2025.
#islet #PancSky
So cool embryonic pancreas epithelium modeling using stem cells by the Wells lab! #PancSky
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Human pancreatic organoids derived from pluripotent stem cells recapitulate pancreatic organogenesis
Pancreas organogenesis relies on sequential interactions between the pancreatic epithelium and surrounding mesodermal cell types that initiate epithelial budding and branching to form a complex ductal...
www.biorxiv.org
November 1, 2025 at 4:24 PM
So cool embryonic pancreas epithelium modeling using stem cells by the Wells lab! #PancSky
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reporting on successful use of SC-islets in drug development for #congenitalhyperinsulinism! We identified ghrelin analogues as novel candidate drugs, demonstrating reversal of hypoglycaemia in mice, which was caused by the hyperinsulinaemic human SC-islets #PancSky www.biorxiv.org/content/10.1...
October 23, 2025 at 12:49 PM
Reporting on successful use of SC-islets in drug development for #congenitalhyperinsulinism! We identified ghrelin analogues as novel candidate drugs, demonstrating reversal of hypoglycaemia in mice, which was caused by the hyperinsulinaemic human SC-islets #PancSky www.biorxiv.org/content/10.1...
November 24, 2024 at 6:30 PM
It was a tremendous honor to deliver #GrandRounds @UNCSurgery @unclineberger.bsky.social as the James Newsome Visiting Professor to an elite department with a storied history & exciting future #pancsky #MedSky #SurgSky #HPBSky
December 19, 2024 at 12:10 PM
It was a tremendous honor to deliver #GrandRounds @UNCSurgery @unclineberger.bsky.social as the James Newsome Visiting Professor to an elite department with a storied history & exciting future #pancsky #MedSky #SurgSky #HPBSky
I tried to make a feed for news and discussions on all things pancreas biology (exocrine and endocrine!). You can post with the hashtags #PancSky #BetaCellSky #EndocrineSky . Let me know if it is useful and how to modify to make it better!
bsky.app/profile/did:...
bsky.app/profile/did:...
January 2, 2025 at 6:23 PM
I tried to make a feed for news and discussions on all things pancreas biology (exocrine and endocrine!). You can post with the hashtags #PancSky #BetaCellSky #EndocrineSky . Let me know if it is useful and how to modify to make it better!
bsky.app/profile/did:...
bsky.app/profile/did:...
Cool work using spatial transcriptomics among other methods to discover new mesenchyme signaling on developing pancreas niche #PancSky
🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social
➡️ doi.org/10.1126/scia...
short 🧵 below & more acknowledgments ⤵️
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social
➡️ doi.org/10.1126/scia...
short 🧵 below & more acknowledgments ⤵️
Spatially organized cellular communities shape functional tissue architecture in the pancreas
Spatial maps reveal dynamic epithelial-mesenchymal niches shaping pancreatic development and function.
doi.org
November 13, 2025 at 5:14 PM
Cool work using spatial transcriptomics among other methods to discover new mesenchyme signaling on developing pancreas niche #PancSky
June 11, 2025 at 9:57 AM
Leading the pack: Glucokinase reinforces Ca2+-waves
#PancSky #BetaCellSky
elifesciences.org/articles/103...
#PancSky #BetaCellSky
elifesciences.org/articles/103...
Glucokinase activity controls peripherally located subpopulations of β-cells that lead islet Ca2+ oscillations
3D light-sheet imaging identifies the location and metabolic sensitivity of β-cell subpopulations that lead and coordinate islet Ca2+ oscillations.
elifesciences.org
February 13, 2025 at 8:29 PM
Leading the pack: Glucokinase reinforces Ca2+-waves
#PancSky #BetaCellSky
elifesciences.org/articles/103...
#PancSky #BetaCellSky
elifesciences.org/articles/103...
Great work from my friend @lithoviusv.bsky.social with very nice combination of disease modeling and a drug gable solution to pair it with! @PancSky www.biorxiv.org/content/10.1...
Ghrelin and relamorelin alleviate hypoglycaemia in humanised mice with congenital hyperinsulinism
KATP-channel related hyperinsulinism (KATPHI) is a genetic disorder of the pancreatic beta cells, manifesting as life-threatening hypoglycaemia in neonates due to dysregulated insulin secretion. Manag...
www.biorxiv.org
October 15, 2025 at 6:43 PM
Great work from my friend @lithoviusv.bsky.social with very nice combination of disease modeling and a drug gable solution to pair it with! @PancSky www.biorxiv.org/content/10.1...
Wortham et al. identified the protein deacetylase Sirtuin 2 (SIRT2) as a regulator of β-cell proliferation whose inactivation results in controlled β-cell expansion. 🧪
#PancSky
www.jci.org/articles/vie...
#PancSky
www.jci.org/articles/vie...
JCI -
The protein deacetylase SIRT2 exerts metabolic control over adaptive β cell proliferation
www.jci.org
August 12, 2025 at 6:35 AM
Wortham et al. identified the protein deacetylase Sirtuin 2 (SIRT2) as a regulator of β-cell proliferation whose inactivation results in controlled β-cell expansion. 🧪
#PancSky
www.jci.org/articles/vie...
#PancSky
www.jci.org/articles/vie...
Happy to share our work on pancreatic ductal organoids from the human-relevant pig model across developmental stages ranging from embryonic to adult animals and using them for drug screening applications from the @heikolickert.bsky.social lab. #PancSky #devbio 🧪🧬 www.biorxiv.org/content/10.1... /1
Benchmarking porcine pancreatic ductal organoids for drug screening applications
Primary human pancreatic ductal organoids (HPDO) have emerged as a model to study pancreas biology and disease. Yet, donor material availability, and a lack of extensive benchmarking limits the range ...
www.biorxiv.org
March 14, 2025 at 8:29 AM
Happy to share our work on pancreatic ductal organoids from the human-relevant pig model across developmental stages ranging from embryonic to adult animals and using them for drug screening applications from the @heikolickert.bsky.social lab. #PancSky #devbio 🧪🧬 www.biorxiv.org/content/10.1... /1
Li et al. show that human-reprogrammed vascular endothelial cells vascularize #islets, support dynamic function in microfluidic chambers, and enable subcutaneous cotransplantation to reverse hyperglycemia in diabetic mice.
#PancSky #BetaCellSky #Diabetes
www.science.org/doi/10.1126/...
#PancSky #BetaCellSky #Diabetes
www.science.org/doi/10.1126/...
Vascularization of human islets by adaptable endothelium for durable and functional subcutaneous engraftment
Adaptable human blood vessel cells enable functional engraftment of pancreatic islets under the skin to treat diabetes.
www.science.org
February 3, 2025 at 9:22 AM
Li et al. show that human-reprogrammed vascular endothelial cells vascularize #islets, support dynamic function in microfluidic chambers, and enable subcutaneous cotransplantation to reverse hyperglycemia in diabetic mice.
#PancSky #BetaCellSky #Diabetes
www.science.org/doi/10.1126/...
#PancSky #BetaCellSky #Diabetes
www.science.org/doi/10.1126/...
⁉️ 🙋🏻♀️ Fellow HPB surgeons - any experience with choledocho-duodenal LAMS for biliary decompression in resectable pancreatic head cancer?
What is surgery like after? Risks for cancer seeding?
Came up a few times recently when ERCP stent not feasible 🤔
#HPBSky #PancSky #PancreasSky #SurgSky
What is surgery like after? Risks for cancer seeding?
Came up a few times recently when ERCP stent not feasible 🤔
#HPBSky #PancSky #PancreasSky #SurgSky
November 27, 2024 at 9:20 PM
⁉️ 🙋🏻♀️ Fellow HPB surgeons - any experience with choledocho-duodenal LAMS for biliary decompression in resectable pancreatic head cancer?
What is surgery like after? Risks for cancer seeding?
Came up a few times recently when ERCP stent not feasible 🤔
#HPBSky #PancSky #PancreasSky #SurgSky
What is surgery like after? Risks for cancer seeding?
Came up a few times recently when ERCP stent not feasible 🤔
#HPBSky #PancSky #PancreasSky #SurgSky