Happy Saturday #bluesky. Here’s one of my favorite benign breast lesions in watercolor: Fibroadenoma. #pathsky #pathart #artsky #breastpath
December 14, 2024 at 6:07 PM
Happy Saturday #bluesky. Here’s one of my favorite benign breast lesions in watercolor: Fibroadenoma. #pathsky #pathart #artsky #breastpath
A cute finding in apocrine metaplasia, do you know what it is? #breastpath #pathsky #pathtwitter #pathx #patologia
February 4, 2025 at 9:17 PM
A cute finding in apocrine metaplasia, do you know what it is? #breastpath #pathsky #pathtwitter #pathx #patologia
Breast core needle biopsy, 2cm from nipple. Thoughts or differential? #pathology #pathsky #pathologists #pathresidents #breastpath
January 16, 2025 at 5:04 PM
Breast core needle biopsy, 2cm from nipple. Thoughts or differential? #pathology #pathsky #pathologists #pathresidents #breastpath
Been waiting for the sky to clear so I can use my Dobsonian but for now enjoy Lobular Carcinoma In Situ done in watercolor. 😍 #pathart #pathartsky #breastpath #pathology
January 25, 2025 at 2:49 PM
Been waiting for the sky to clear so I can use my Dobsonian but for now enjoy Lobular Carcinoma In Situ done in watercolor. 😍 #pathart #pathartsky #breastpath #pathology
The discohesive metastatic menace 😈
#LobularCarcinoma
📸 1 Endometrial invasion
📸 2 Bone marrow invasion (paratrabecular)
#pathology
#breastpath
#blueskypath
#pathsky
#LobularCarcinoma
📸 1 Endometrial invasion
📸 2 Bone marrow invasion (paratrabecular)
#pathology
#breastpath
#blueskypath
#pathsky
April 5, 2025 at 7:06 PM
The discohesive metastatic menace 😈
#LobularCarcinoma
📸 1 Endometrial invasion
📸 2 Bone marrow invasion (paratrabecular)
#pathology
#breastpath
#blueskypath
#pathsky
#LobularCarcinoma
📸 1 Endometrial invasion
📸 2 Bone marrow invasion (paratrabecular)
#pathology
#breastpath
#blueskypath
#pathsky
February 3, 2025 at 6:07 PM
Not commonly seen without a clinical mass!
#PagetsDisease of nipple with associated invasion. Also #HGDCIS in subareolar ducts. Usually #ERNegative & #Her2Positive.
#pathsky
#Pathology
#BreastPath
😉
#PagetsDisease of nipple with associated invasion. Also #HGDCIS in subareolar ducts. Usually #ERNegative & #Her2Positive.
#pathsky
#Pathology
#BreastPath
😉
March 13, 2025 at 7:59 PM
Not commonly seen without a clinical mass!
#PagetsDisease of nipple with associated invasion. Also #HGDCIS in subareolar ducts. Usually #ERNegative & #Her2Positive.
#pathsky
#Pathology
#BreastPath
😉
#PagetsDisease of nipple with associated invasion. Also #HGDCIS in subareolar ducts. Usually #ERNegative & #Her2Positive.
#pathsky
#Pathology
#BreastPath
😉
Top tip!
Try to scan the sub capsular sinus of sentinel nodes with your 10x objective to spot single lobular carcinoma intruders.
🟣 = lobular carcinoma
🟢 = macrophage 🫛
Cytokeratin to confirm
#pathology
#BreastPath
#PathSky
😉
Try to scan the sub capsular sinus of sentinel nodes with your 10x objective to spot single lobular carcinoma intruders.
🟣 = lobular carcinoma
🟢 = macrophage 🫛
Cytokeratin to confirm
#pathology
#BreastPath
#PathSky
😉
March 11, 2025 at 7:43 PM
Top tip!
Try to scan the sub capsular sinus of sentinel nodes with your 10x objective to spot single lobular carcinoma intruders.
🟣 = lobular carcinoma
🟢 = macrophage 🫛
Cytokeratin to confirm
#pathology
#BreastPath
#PathSky
😉
Try to scan the sub capsular sinus of sentinel nodes with your 10x objective to spot single lobular carcinoma intruders.
🟣 = lobular carcinoma
🟢 = macrophage 🫛
Cytokeratin to confirm
#pathology
#BreastPath
#PathSky
😉
Breast core needle biopsy reveals haphazardly infiltrating tubules.
Do you know what it is or is it #TooCloseToDiagnose?
A) Tubular carcinoma
B) Microglandular adenosis
🔬 dpa-dapa.com/public/displ...
#PathSky #BreastPath #pathology
Do you know what it is or is it #TooCloseToDiagnose?
A) Tubular carcinoma
B) Microglandular adenosis
🔬 dpa-dapa.com/public/displ...
#PathSky #BreastPath #pathology
April 6, 2025 at 12:51 AM
Breast core needle biopsy reveals haphazardly infiltrating tubules.
Do you know what it is or is it #TooCloseToDiagnose?
A) Tubular carcinoma
B) Microglandular adenosis
🔬 dpa-dapa.com/public/displ...
#PathSky #BreastPath #pathology
Do you know what it is or is it #TooCloseToDiagnose?
A) Tubular carcinoma
B) Microglandular adenosis
🔬 dpa-dapa.com/public/displ...
#PathSky #BreastPath #pathology
On the lymphatic highway en route to the axilla. #BadNews #BreastCarcinoma #TumourEmboli
Hope everyone has a good weekend 💚
#pathology
#BluePath
#BreastPath
😉
Hope everyone has a good weekend 💚
#pathology
#BluePath
#BreastPath
😉
March 14, 2025 at 6:24 PM
On the lymphatic highway en route to the axilla. #BadNews #BreastCarcinoma #TumourEmboli
Hope everyone has a good weekend 💚
#pathology
#BluePath
#BreastPath
😉
Hope everyone has a good weekend 💚
#pathology
#BluePath
#BreastPath
😉
Always keep 👀s open when scanning breast cores with columnar cell change for intruders 😉
📸1 Columnar lining with >2 layers
📸2 Vacuolated 3rd population
📸3 E-cadherin
#InsituLobularNeoplasia
#pathology
#breastpath
#pathsky
🤓
📸1 Columnar lining with >2 layers
📸2 Vacuolated 3rd population
📸3 E-cadherin
#InsituLobularNeoplasia
#pathology
#breastpath
#pathsky
🤓
December 13, 2024 at 8:34 PM
Always keep 👀s open when scanning breast cores with columnar cell change for intruders 😉
📸1 Columnar lining with >2 layers
📸2 Vacuolated 3rd population
📸3 E-cadherin
#InsituLobularNeoplasia
#pathology
#breastpath
#pathsky
🤓
📸1 Columnar lining with >2 layers
📸2 Vacuolated 3rd population
📸3 E-cadherin
#InsituLobularNeoplasia
#pathology
#breastpath
#pathsky
🤓
A good example of a #micrometastasis from #BreastCarcinoma in a #SentinelNode identified by Iron Oxide tracer. No ☢️ needed ✅.
📸 1 Subcapsular sinus containing Iron laden macrophages
📸 2 Micrometastasis
#pathology
#BreastPath
#PathSky
🤓
📸 1 Subcapsular sinus containing Iron laden macrophages
📸 2 Micrometastasis
#pathology
#BreastPath
#PathSky
🤓
November 24, 2024 at 7:49 PM
A good example of a #micrometastasis from #BreastCarcinoma in a #SentinelNode identified by Iron Oxide tracer. No ☢️ needed ✅.
📸 1 Subcapsular sinus containing Iron laden macrophages
📸 2 Micrometastasis
#pathology
#BreastPath
#PathSky
🤓
📸 1 Subcapsular sinus containing Iron laden macrophages
📸 2 Micrometastasis
#pathology
#BreastPath
#PathSky
🤓
February 29, 2024 at 10:51 AM
It made me stop for a second: Breast DCIS with some serious koilocytoid features! (HPV was not detected). #BreastPath #GynPath #PathSky #Pathtwitter #PathX #Patologia
January 22, 2025 at 3:56 PM
It made me stop for a second: Breast DCIS with some serious koilocytoid features! (HPV was not detected). #BreastPath #GynPath #PathSky #Pathtwitter #PathX #Patologia
Distinguishing #UsualEpithelialHyperplasia from #DCIS can be tricky. Hope this helps you 😉🔬
#pathology
#BreastPath
#pathology
#BreastPath
November 16, 2024 at 10:58 AM
Distinguishing #UsualEpithelialHyperplasia from #DCIS can be tricky. Hope this helps you 😉🔬
#pathology
#BreastPath
#pathology
#BreastPath
Just published! Check out this latest article 👉🏻 HER2 amplification is rare (1.7%) in low-grade, tubule-forming breast cancers with 2+ HER2 IHC; findings suggest ISH may be unnecessary in this subset #breastpath #IHCpath #pathsky
The Value of Routine Reflex In Situ Hybridization Testing in Low-grade Tubule-forming Invasive Breast Cancers With Equivocal HER2 Immunohistochemistry - A Reappraisal of the ASCO/CAP Guidelines journals.lww.com/appliedimmun...
The Value of Routine Reflex In Situ Hybridization Testing... : Applied Immunohistochemistry & Molecular Morphology
emistry (IHC). While this recommendation mainly addresses aggressive tumor types such as micropapillary carcinoma, it is applied to low-grade, tubule-forming IBCs unlikely to show HER2 amplification. ...
journals.lww.com
May 29, 2025 at 12:44 AM
Just published! Check out this latest article 👉🏻 HER2 amplification is rare (1.7%) in low-grade, tubule-forming breast cancers with 2+ HER2 IHC; findings suggest ISH may be unnecessary in this subset #breastpath #IHCpath #pathsky
🔬𝐓𝐫𝐢𝐩𝐥𝐞-𝐍𝐞𝐠𝐚𝐭𝐢𝐯𝐞 𝐁𝐫𝐞𝐚𝐬𝐭 𝐂𝐚𝐫𝐜𝐢𝐧𝐨𝐦𝐚 (𝐍𝐒𝐓) 🔬
⚠️ Pitfall alert
- TNBCs can have a range of morphologies
- DCIS is usually absent
- ❌ GATA3
- ✔️ SOX10 (mimic melanoma)
- Always do keratin + review patients history
#Breastpath #Dermpath #Pathtwitter #Pathresidents
⚠️ Pitfall alert
- TNBCs can have a range of morphologies
- DCIS is usually absent
- ❌ GATA3
- ✔️ SOX10 (mimic melanoma)
- Always do keratin + review patients history
#Breastpath #Dermpath #Pathtwitter #Pathresidents
January 2, 2025 at 11:58 PM
🔬𝐓𝐫𝐢𝐩𝐥𝐞-𝐍𝐞𝐠𝐚𝐭𝐢𝐯𝐞 𝐁𝐫𝐞𝐚𝐬𝐭 𝐂𝐚𝐫𝐜𝐢𝐧𝐨𝐦𝐚 (𝐍𝐒𝐓) 🔬
⚠️ Pitfall alert
- TNBCs can have a range of morphologies
- DCIS is usually absent
- ❌ GATA3
- ✔️ SOX10 (mimic melanoma)
- Always do keratin + review patients history
#Breastpath #Dermpath #Pathtwitter #Pathresidents
⚠️ Pitfall alert
- TNBCs can have a range of morphologies
- DCIS is usually absent
- ❌ GATA3
- ✔️ SOX10 (mimic melanoma)
- Always do keratin + review patients history
#Breastpath #Dermpath #Pathtwitter #Pathresidents
✅Radial Scar (all of the above)
Benign, myoepithelial cells present
Glands entrapped & distorted
Stroma sclerotic with elastotic core
Architecture with central scar and radiating structures
Hyperplasia of associated TDLUs
#PathSky #BreastPath
🔬https://pathpresenter.net/public/display?token=5e2d124b
Benign, myoepithelial cells present
Glands entrapped & distorted
Stroma sclerotic with elastotic core
Architecture with central scar and radiating structures
Hyperplasia of associated TDLUs
#PathSky #BreastPath
🔬https://pathpresenter.net/public/display?token=5e2d124b
April 5, 2025 at 11:13 AM
✅Radial Scar (all of the above)
Benign, myoepithelial cells present
Glands entrapped & distorted
Stroma sclerotic with elastotic core
Architecture with central scar and radiating structures
Hyperplasia of associated TDLUs
#PathSky #BreastPath
🔬https://pathpresenter.net/public/display?token=5e2d124b
Benign, myoepithelial cells present
Glands entrapped & distorted
Stroma sclerotic with elastotic core
Architecture with central scar and radiating structures
Hyperplasia of associated TDLUs
#PathSky #BreastPath
🔬https://pathpresenter.net/public/display?token=5e2d124b
March 7, 2025 at 7:38 PM
The great deceptor at work again! #ColumnarCellChange colonised by #InsituLobularNeoplasia.
Top tip! Always look carefully at busy columnar lined ducts.
😉
#pathology
#BreastPath
#BluePath
Top tip! Always look carefully at busy columnar lined ducts.
😉
#pathology
#BreastPath
#BluePath
April 22, 2025 at 6:13 PM
The great deceptor at work again! #ColumnarCellChange colonised by #InsituLobularNeoplasia.
Top tip! Always look carefully at busy columnar lined ducts.
😉
#pathology
#BreastPath
#BluePath
Top tip! Always look carefully at busy columnar lined ducts.
😉
#pathology
#BreastPath
#BluePath
✅Microglandular adenosis
Lacks myoepithelial layer but retains is basement membrane (see collagen IV stain)
Round glands
Bland stroma
Apical snouts absent
Colloid-like luminal contents
Unremarkable atypia
✅Diffuse S100+
ER/PR variable, HER2-
#PathSky #BreastPath #Pathology
Lacks myoepithelial layer but retains is basement membrane (see collagen IV stain)
Round glands
Bland stroma
Apical snouts absent
Colloid-like luminal contents
Unremarkable atypia
✅Diffuse S100+
ER/PR variable, HER2-
#PathSky #BreastPath #Pathology
April 6, 2025 at 12:51 AM
✅Microglandular adenosis
Lacks myoepithelial layer but retains is basement membrane (see collagen IV stain)
Round glands
Bland stroma
Apical snouts absent
Colloid-like luminal contents
Unremarkable atypia
✅Diffuse S100+
ER/PR variable, HER2-
#PathSky #BreastPath #Pathology
Lacks myoepithelial layer but retains is basement membrane (see collagen IV stain)
Round glands
Bland stroma
Apical snouts absent
Colloid-like luminal contents
Unremarkable atypia
✅Diffuse S100+
ER/PR variable, HER2-
#PathSky #BreastPath #Pathology
MRI core needle biopsy for a non-mass enhancing lesion.
What is your interpretation?
A) Fibrocystic change
B) Intraductal papilloma
C) Apocrine adenosis
#BreastPath #PathSky #Pathology #PathTwitter
🔬 dpa-dapa.com/public/displ...
What is your interpretation?
A) Fibrocystic change
B) Intraductal papilloma
C) Apocrine adenosis
#BreastPath #PathSky #Pathology #PathTwitter
🔬 dpa-dapa.com/public/displ...
May 10, 2025 at 12:46 PM
MRI core needle biopsy for a non-mass enhancing lesion.
What is your interpretation?
A) Fibrocystic change
B) Intraductal papilloma
C) Apocrine adenosis
#BreastPath #PathSky #Pathology #PathTwitter
🔬 dpa-dapa.com/public/displ...
What is your interpretation?
A) Fibrocystic change
B) Intraductal papilloma
C) Apocrine adenosis
#BreastPath #PathSky #Pathology #PathTwitter
🔬 dpa-dapa.com/public/displ...
✅ Fibrocystic change (including apocrine metaplasia)
Apocrine metaplasia involves replacement of epithelium by apocrine cells (large, eosinophilic granular cytoplasm, round nuclei, prominent nucleoli, apical snouts)
In FCC, these cells line pre-existing/dilated ducts and cysts.
#BreastPath
Apocrine metaplasia involves replacement of epithelium by apocrine cells (large, eosinophilic granular cytoplasm, round nuclei, prominent nucleoli, apical snouts)
In FCC, these cells line pre-existing/dilated ducts and cysts.
#BreastPath
May 10, 2025 at 12:46 PM
✅ Fibrocystic change (including apocrine metaplasia)
Apocrine metaplasia involves replacement of epithelium by apocrine cells (large, eosinophilic granular cytoplasm, round nuclei, prominent nucleoli, apical snouts)
In FCC, these cells line pre-existing/dilated ducts and cysts.
#BreastPath
Apocrine metaplasia involves replacement of epithelium by apocrine cells (large, eosinophilic granular cytoplasm, round nuclei, prominent nucleoli, apical snouts)
In FCC, these cells line pre-existing/dilated ducts and cysts.
#BreastPath
Teen single breast lesion without other signs or symptoms.
Macro: multiple nodular aggregates
Histology: Myxoid Fibroadenoma
#PathSky #PediPath #BreastPath
Macro: multiple nodular aggregates
Histology: Myxoid Fibroadenoma
#PathSky #PediPath #BreastPath
August 18, 2025 at 5:17 PM
Teen single breast lesion without other signs or symptoms.
Macro: multiple nodular aggregates
Histology: Myxoid Fibroadenoma
#PathSky #PediPath #BreastPath
Macro: multiple nodular aggregates
Histology: Myxoid Fibroadenoma
#PathSky #PediPath #BreastPath
Breast core needle biopsy.🧐🧐
Know what it is?
Or is it #TooFarToDiagnose??
A) Tubular carcinoma
B) Microglandular adenosis
C) Sclerosing adenosis
D) Radial scar
#PathSky #BreastPath #Pathology
🔬https://pathpresenter.net/public/display?token=5e2d124b
Know what it is?
Or is it #TooFarToDiagnose??
A) Tubular carcinoma
B) Microglandular adenosis
C) Sclerosing adenosis
D) Radial scar
#PathSky #BreastPath #Pathology
🔬https://pathpresenter.net/public/display?token=5e2d124b
April 5, 2025 at 11:13 AM
Breast core needle biopsy.🧐🧐
Know what it is?
Or is it #TooFarToDiagnose??
A) Tubular carcinoma
B) Microglandular adenosis
C) Sclerosing adenosis
D) Radial scar
#PathSky #BreastPath #Pathology
🔬https://pathpresenter.net/public/display?token=5e2d124b
Know what it is?
Or is it #TooFarToDiagnose??
A) Tubular carcinoma
B) Microglandular adenosis
C) Sclerosing adenosis
D) Radial scar
#PathSky #BreastPath #Pathology
🔬https://pathpresenter.net/public/display?token=5e2d124b