#BreastPath
🏅 Congratulations to Dr. Madhuri Wadehra & collaborators, Dr. Neda Moatamed & Dr. Wiriya Pipatsakulrojand, on receiving a Translational Research Fund Grant for their project "Tracking Subtype Switching in Triple-Negative Breast Cancer to Improve Treatment Response."

#PathSky #research #breastpath
November 18, 2025 at 6:02 PM
Teen single breast lesion without other signs or symptoms.
Macro: multiple nodular aggregates
Histology: Myxoid Fibroadenoma
#PathSky #PediPath #BreastPath
August 18, 2025 at 5:17 PM
Just published! Check out this latest article 👉🏻 HER2 amplification is rare (1.7%) in low-grade, tubule-forming breast cancers with 2+ HER2 IHC; findings suggest ISH may be unnecessary in this subset #breastpath #IHCpath #pathsky
May 29, 2025 at 12:44 AM
#UsualEpithelialHyperplasia doesn’t get more florid than this.
#Cytokeratin5 positive.
#ER variable.
Note that the apocrine cells next door are CK5 and ER negative.
#BreastPath
#pathology
#BlueskyPath
😉
May 24, 2025 at 8:30 PM
✅ Fibrocystic change (including apocrine metaplasia)
Apocrine metaplasia involves replacement of epithelium by apocrine cells (large, eosinophilic granular cytoplasm, round nuclei, prominent nucleoli, apical snouts)
In FCC, these cells line pre-existing/dilated ducts and cysts.
#BreastPath
May 10, 2025 at 12:46 PM
❌ Intraductal papilloma with apocrine metaplasia:
True papillary fronds having fibrovascular cores lined by both epithelial cells (showing apocrine metaplasia here) AND myoepithelial cells
Typically in a dilated duct
apocrine tufting without FVCs is not intraductal papilloma
#BreastPath #Pathology
May 10, 2025 at 12:46 PM
❌ Apocrine Adenosis: proliferative lesion
Represents adenosis (proliferation of glands/acini) where the lining cells show apocrine metaplasia
Key: lobulocentric proliferation of glands/acini lined by apocrine cells, often with surrounding sclerosis
#BreastPath #PathSky #Pathology #PathTwitter
May 10, 2025 at 12:46 PM
All these options can involve apocrine cells, but which feature favors fibrocystic change?
A) Apocrine cells lining cysts
B) Stromal fibrosis around ducts
C) True papillae
D) Lobulocentric proliferation
#BreastPath #PathSky #Pathology #PathTwitter
May 10, 2025 at 12:46 PM
MRI core needle biopsy for a non-mass enhancing lesion.
What is your interpretation?
A) Fibrocystic change
B) Intraductal papilloma
C) Apocrine adenosis
#BreastPath #PathSky #Pathology #PathTwitter
🔬 dpa-dapa.com/public/displ...
May 10, 2025 at 12:46 PM
✅Fibromatosis
Infiltrative spindle cell proliferation
Minimal atypia
Locally aggressive, entraps normal breast mimicking carcinoma
Inactivated Wnt/β-catenin via APC/CTNNB1 mutation
✅Nuclear β-catenin+, actin+, desmin-
🔬 dpa-dapa.com/public/displ...
#BreastPath #Pathology
May 2, 2025 at 10:08 AM
❌Myofibroblastoma
Well-circumscribed spindle cell tumor
Uniform bland spindled cells in fascicles
Interspersed hyalinized collagen
Entrapped epithelial elements is unusual
CD34+, desmin+, ER+, loss of nuclear RB1
🔬 dpa-dapa.com/public/displ...
#BreastPath #Pathology
May 2, 2025 at 10:08 AM
❌Fibrous mastopathy
Dense keloid-like collagen replacing breast parenchyma
Perivascular and periductal lymphocytic infiltrates
More common in long-standing type 1 diabetes or autoimmune diseases
No epithelial proliferation or atypia
#BreastPath #Pathology
🔬 dpa-dapa.com/public/displ...
May 2, 2025 at 10:08 AM
❌Myoid hamartoma
Well-circumscribed developmental malformation
Normal breast entrapped by smooth muscle bundles
🔬 dpa-dapa.com/public/displ...
#BreastPath #Pathology
May 2, 2025 at 10:08 AM
The IHC below confirms the diagnosis. What is it?
A) RB1
B) STAT6
C) β-catenin
D) Desmin
#BreastPath #Pathology #PathTwiter
May 2, 2025 at 10:08 AM
Breast core needle biopsy. Diagnosis?
A) Myofibroblastoma
B) Myoid hamartoma
C) Fibrous mastopathy
D) Fibromatosis
#BreastPath #Pathology #PathTwiter #PathSky
🔬 dpa-dapa.com/public/displ...
May 2, 2025 at 10:08 AM
✅Sclerosing adenosis
✅Benign, myoepithelial cells present
Glands distorted with compressed lumens
Stroma sclerotic / collagenous
Architecture lobulocentric (retained at low power)
#PathSky #BreastPath #PathTwitter #Pathology
🔬 dpa-dapa.com/public/displ...
April 28, 2025 at 12:49 PM
❌Radial Scar
Benign, myoepithelial cells present
Glands entrapped & distorted
Stroma sclerotic with elastotic core
Architecture with central scar and radiating structures
#PathSky #BreastPath #PathTwitter #Pathology
🔬 pathpresenter.net/public/displ...
April 28, 2025 at 12:49 PM
❌Microglandular adenosis
Benign, but lacks myoepithelial cells
Glands with open round lumens with colloid-like contents
Architecture haphazard & infiltrative
#PathSky #BreastPath #PathTwitter #Pathology
🔬 dpa-dapa.com/public/displ...
🔬 tumourclassification.iarc.who.int/Viewer/Index...
April 28, 2025 at 12:49 PM
❌Tubular Carcinoma
Malignant, lacks myoepithelial cells
Glands with open angulated lumens
Stroma desmoplastic
Architecture haphazard & infiltrative
#PathSky #BreastPath #PathTwitter #Pathology
🔬 dpa-dapa.com/public/displ...
April 28, 2025 at 12:49 PM
Breast core needle biopsy.

Is it #TooFarToDiagnosis?

A) Tubular carcinoma
B) Microglandular adenosis
C) Sclerosing adenosis
D) Radial scar
#PathSky #BreastPath #PathTwitter #Pathology
🔬 dpa-dapa.com/public/displ...
April 28, 2025 at 12:49 PM
Beware of mucin lobules associated with vessels in a breast biopsy 📸 1. A key feature of mucinous carcinoma 📸 2. Seen on FNA's but easily missed on biopsies if no epithelial islands seen.
#pathology
#BreastPath
#BluePath
😉
April 26, 2025 at 7:17 PM
❌Flat Epithelial Atypia (FEA)
low-grade cytologic atypia: monotonous, mildly enlarged nuclei
"flat" = NO architectural disorder
Apical snouts & luminal secretions
TDLUs may be dilated/cystic
#BreastPath #PathSky #Pathology
🔬 pathpresenter.net/public/displ...
🔬 dpa-dapa.com/public/displ...
April 26, 2025 at 3:38 PM
This (plus some others I included here) is columnar cell change, distinguished by its LACK of ___
A) cellular stratification
B) clonal/monotonous cells
C) nuclear polarization
D) associated calcification
#BreastPath #PathSky #PathTwitter #Pathology
April 26, 2025 at 3:38 PM
🧐🧐 Is it #TooCloseToDiagnose?

How would you interpret this core needle biopsy?

A) Flat epithelial atypia
B) Atypical ductal hyperplasia
C) Columnar cell change
🔬 pathpresenter.net/public/displ...
#BreastPath #PathSky #PathTwitter #Pathology
April 26, 2025 at 3:38 PM
The great deceptor at work again! #ColumnarCellChange colonised by #InsituLobularNeoplasia.
Top tip! Always look carefully at busy columnar lined ducts.
😉
#pathology
#BreastPath
#BluePath
April 22, 2025 at 6:13 PM