#PathSky #research #breastpath
#PathSky #research #breastpath
Macro: multiple nodular aggregates
Histology: Myxoid Fibroadenoma
#PathSky #PediPath #BreastPath
Macro: multiple nodular aggregates
Histology: Myxoid Fibroadenoma
#PathSky #PediPath #BreastPath
#Cytokeratin5 positive.
#ER variable.
Note that the apocrine cells next door are CK5 and ER negative.
#BreastPath
#pathology
#BlueskyPath
😉
#Cytokeratin5 positive.
#ER variable.
Note that the apocrine cells next door are CK5 and ER negative.
#BreastPath
#pathology
#BlueskyPath
😉
Apocrine metaplasia involves replacement of epithelium by apocrine cells (large, eosinophilic granular cytoplasm, round nuclei, prominent nucleoli, apical snouts)
In FCC, these cells line pre-existing/dilated ducts and cysts.
#BreastPath
Apocrine metaplasia involves replacement of epithelium by apocrine cells (large, eosinophilic granular cytoplasm, round nuclei, prominent nucleoli, apical snouts)
In FCC, these cells line pre-existing/dilated ducts and cysts.
#BreastPath
True papillary fronds having fibrovascular cores lined by both epithelial cells (showing apocrine metaplasia here) AND myoepithelial cells
Typically in a dilated duct
apocrine tufting without FVCs is not intraductal papilloma
#BreastPath #Pathology
True papillary fronds having fibrovascular cores lined by both epithelial cells (showing apocrine metaplasia here) AND myoepithelial cells
Typically in a dilated duct
apocrine tufting without FVCs is not intraductal papilloma
#BreastPath #Pathology
Represents adenosis (proliferation of glands/acini) where the lining cells show apocrine metaplasia
Key: lobulocentric proliferation of glands/acini lined by apocrine cells, often with surrounding sclerosis
#BreastPath #PathSky #Pathology #PathTwitter
Represents adenosis (proliferation of glands/acini) where the lining cells show apocrine metaplasia
Key: lobulocentric proliferation of glands/acini lined by apocrine cells, often with surrounding sclerosis
#BreastPath #PathSky #Pathology #PathTwitter
A) Apocrine cells lining cysts
B) Stromal fibrosis around ducts
C) True papillae
D) Lobulocentric proliferation
#BreastPath #PathSky #Pathology #PathTwitter
A) Apocrine cells lining cysts
B) Stromal fibrosis around ducts
C) True papillae
D) Lobulocentric proliferation
#BreastPath #PathSky #Pathology #PathTwitter
What is your interpretation?
A) Fibrocystic change
B) Intraductal papilloma
C) Apocrine adenosis
#BreastPath #PathSky #Pathology #PathTwitter
🔬 dpa-dapa.com/public/displ...
What is your interpretation?
A) Fibrocystic change
B) Intraductal papilloma
C) Apocrine adenosis
#BreastPath #PathSky #Pathology #PathTwitter
🔬 dpa-dapa.com/public/displ...
Infiltrative spindle cell proliferation
Minimal atypia
Locally aggressive, entraps normal breast mimicking carcinoma
Inactivated Wnt/β-catenin via APC/CTNNB1 mutation
✅Nuclear β-catenin+, actin+, desmin-
🔬 dpa-dapa.com/public/displ...
#BreastPath #Pathology
Infiltrative spindle cell proliferation
Minimal atypia
Locally aggressive, entraps normal breast mimicking carcinoma
Inactivated Wnt/β-catenin via APC/CTNNB1 mutation
✅Nuclear β-catenin+, actin+, desmin-
🔬 dpa-dapa.com/public/displ...
#BreastPath #Pathology
Well-circumscribed spindle cell tumor
Uniform bland spindled cells in fascicles
Interspersed hyalinized collagen
Entrapped epithelial elements is unusual
CD34+, desmin+, ER+, loss of nuclear RB1
🔬 dpa-dapa.com/public/displ...
#BreastPath #Pathology
Well-circumscribed spindle cell tumor
Uniform bland spindled cells in fascicles
Interspersed hyalinized collagen
Entrapped epithelial elements is unusual
CD34+, desmin+, ER+, loss of nuclear RB1
🔬 dpa-dapa.com/public/displ...
#BreastPath #Pathology
Dense keloid-like collagen replacing breast parenchyma
Perivascular and periductal lymphocytic infiltrates
More common in long-standing type 1 diabetes or autoimmune diseases
No epithelial proliferation or atypia
#BreastPath #Pathology
🔬 dpa-dapa.com/public/displ...
Dense keloid-like collagen replacing breast parenchyma
Perivascular and periductal lymphocytic infiltrates
More common in long-standing type 1 diabetes or autoimmune diseases
No epithelial proliferation or atypia
#BreastPath #Pathology
🔬 dpa-dapa.com/public/displ...
Well-circumscribed developmental malformation
Normal breast entrapped by smooth muscle bundles
🔬 dpa-dapa.com/public/displ...
#BreastPath #Pathology
Well-circumscribed developmental malformation
Normal breast entrapped by smooth muscle bundles
🔬 dpa-dapa.com/public/displ...
#BreastPath #Pathology
A) RB1
B) STAT6
C) β-catenin
D) Desmin
#BreastPath #Pathology #PathTwiter
A) RB1
B) STAT6
C) β-catenin
D) Desmin
#BreastPath #Pathology #PathTwiter
A) Myofibroblastoma
B) Myoid hamartoma
C) Fibrous mastopathy
D) Fibromatosis
#BreastPath #Pathology #PathTwiter #PathSky
🔬 dpa-dapa.com/public/displ...
A) Myofibroblastoma
B) Myoid hamartoma
C) Fibrous mastopathy
D) Fibromatosis
#BreastPath #Pathology #PathTwiter #PathSky
🔬 dpa-dapa.com/public/displ...
✅Benign, myoepithelial cells present
Glands distorted with compressed lumens
Stroma sclerotic / collagenous
Architecture lobulocentric (retained at low power)
#PathSky #BreastPath #PathTwitter #Pathology
🔬 dpa-dapa.com/public/displ...
✅Benign, myoepithelial cells present
Glands distorted with compressed lumens
Stroma sclerotic / collagenous
Architecture lobulocentric (retained at low power)
#PathSky #BreastPath #PathTwitter #Pathology
🔬 dpa-dapa.com/public/displ...
Benign, myoepithelial cells present
Glands entrapped & distorted
Stroma sclerotic with elastotic core
Architecture with central scar and radiating structures
#PathSky #BreastPath #PathTwitter #Pathology
🔬 pathpresenter.net/public/displ...
Benign, myoepithelial cells present
Glands entrapped & distorted
Stroma sclerotic with elastotic core
Architecture with central scar and radiating structures
#PathSky #BreastPath #PathTwitter #Pathology
🔬 pathpresenter.net/public/displ...
Benign, but lacks myoepithelial cells
Glands with open round lumens with colloid-like contents
Architecture haphazard & infiltrative
#PathSky #BreastPath #PathTwitter #Pathology
🔬 dpa-dapa.com/public/displ...
🔬 tumourclassification.iarc.who.int/Viewer/Index...
Benign, but lacks myoepithelial cells
Glands with open round lumens with colloid-like contents
Architecture haphazard & infiltrative
#PathSky #BreastPath #PathTwitter #Pathology
🔬 dpa-dapa.com/public/displ...
🔬 tumourclassification.iarc.who.int/Viewer/Index...
Malignant, lacks myoepithelial cells
Glands with open angulated lumens
Stroma desmoplastic
Architecture haphazard & infiltrative
#PathSky #BreastPath #PathTwitter #Pathology
🔬 dpa-dapa.com/public/displ...
Malignant, lacks myoepithelial cells
Glands with open angulated lumens
Stroma desmoplastic
Architecture haphazard & infiltrative
#PathSky #BreastPath #PathTwitter #Pathology
🔬 dpa-dapa.com/public/displ...
Is it #TooFarToDiagnosis?
A) Tubular carcinoma
B) Microglandular adenosis
C) Sclerosing adenosis
D) Radial scar
#PathSky #BreastPath #PathTwitter #Pathology
🔬 dpa-dapa.com/public/displ...
Is it #TooFarToDiagnosis?
A) Tubular carcinoma
B) Microglandular adenosis
C) Sclerosing adenosis
D) Radial scar
#PathSky #BreastPath #PathTwitter #Pathology
🔬 dpa-dapa.com/public/displ...
#pathology
#BreastPath
#BluePath
😉
#pathology
#BreastPath
#BluePath
😉
low-grade cytologic atypia: monotonous, mildly enlarged nuclei
"flat" = NO architectural disorder
Apical snouts & luminal secretions
TDLUs may be dilated/cystic
#BreastPath #PathSky #Pathology
🔬 pathpresenter.net/public/displ...
🔬 dpa-dapa.com/public/displ...
low-grade cytologic atypia: monotonous, mildly enlarged nuclei
"flat" = NO architectural disorder
Apical snouts & luminal secretions
TDLUs may be dilated/cystic
#BreastPath #PathSky #Pathology
🔬 pathpresenter.net/public/displ...
🔬 dpa-dapa.com/public/displ...
A) cellular stratification
B) clonal/monotonous cells
C) nuclear polarization
D) associated calcification
#BreastPath #PathSky #PathTwitter #Pathology
A) cellular stratification
B) clonal/monotonous cells
C) nuclear polarization
D) associated calcification
#BreastPath #PathSky #PathTwitter #Pathology
How would you interpret this core needle biopsy?
A) Flat epithelial atypia
B) Atypical ductal hyperplasia
C) Columnar cell change
🔬 pathpresenter.net/public/displ...
#BreastPath #PathSky #PathTwitter #Pathology
How would you interpret this core needle biopsy?
A) Flat epithelial atypia
B) Atypical ductal hyperplasia
C) Columnar cell change
🔬 pathpresenter.net/public/displ...
#BreastPath #PathSky #PathTwitter #Pathology
Top tip! Always look carefully at busy columnar lined ducts.
😉
#pathology
#BreastPath
#BluePath
Top tip! Always look carefully at busy columnar lined ducts.
😉
#pathology
#BreastPath
#BluePath