#ArtistFave15
#MusicChallenge
Bon Iver
10. Perth
A starts off mellow, then switches gears in a fairly thunderous fashion. A really accomplished switcheroo from the understated and fabled For Emma.
m.youtube.com/watch?v=c3GN...
#MusicChallenge
Bon Iver
10. Perth
A starts off mellow, then switches gears in a fairly thunderous fashion. A really accomplished switcheroo from the understated and fabled For Emma.
m.youtube.com/watch?v=c3GN...
November 6, 2025 at 6:13 AM
#ArtistFave15
#MusicChallenge
Bon Iver
10. Perth
A starts off mellow, then switches gears in a fairly thunderous fashion. A really accomplished switcheroo from the understated and fabled For Emma.
m.youtube.com/watch?v=c3GN...
#MusicChallenge
Bon Iver
10. Perth
A starts off mellow, then switches gears in a fairly thunderous fashion. A really accomplished switcheroo from the understated and fabled For Emma.
m.youtube.com/watch?v=c3GN...
December 3, 2025 at 10:42 PM
Lenny Kravitz - Black Velveteen
YouTube video by LennyKravitzVEVO
www.youtube.com
June 14, 2025 at 10:01 PM
All six posters we are presenting at the #Kidneywk about associations between COVID19 infection or vaccination & various kidney related conditions: Acute Kidney Injury, egfr slope in the general population and kidney transplant recipients, IgA , C3GN and vascular access interventions were finished!
October 13, 2025 at 4:27 AM
All six posters we are presenting at the #Kidneywk about associations between COVID19 infection or vaccination & various kidney related conditions: Acute Kidney Injury, egfr slope in the general population and kidney transplant recipients, IgA , C3GN and vascular access interventions were finished!
Lenny Kravitz - Black Velveteen
It's not a sin
Titanium skin
Just take her for a spin
www.youtube.com/watch?v=c3GN...
It's not a sin
Titanium skin
Just take her for a spin
www.youtube.com/watch?v=c3GN...
Lenny Kravitz - Black Velveteen
YouTube video by LennyKravitzVEVO
www.youtube.com
February 1, 2026 at 12:24 AM
Lenny Kravitz - Black Velveteen
It's not a sin
Titanium skin
Just take her for a spin
www.youtube.com/watch?v=c3GN...
It's not a sin
Titanium skin
Just take her for a spin
www.youtube.com/watch?v=c3GN...
Our #Covid19 work in #KidneyWk :
> transplant fx over time
doi.org/10.1681/ASN....
> kidney fx over time
doi.org/10.1681/ASN....
> AKI
doi.org/10.1681/ASN....
> #C3GN
doi.org/10.1681/ASN....
> #IgAN
doi.org/10.1681/ASN....
> dialysis vasc access
doi.org/10.1681/ASN....
TLDR: don't get covid
> transplant fx over time
doi.org/10.1681/ASN....
> kidney fx over time
doi.org/10.1681/ASN....
> AKI
doi.org/10.1681/ASN....
> #C3GN
doi.org/10.1681/ASN....
> #IgAN
doi.org/10.1681/ASN....
> dialysis vasc access
doi.org/10.1681/ASN....
TLDR: don't get covid
doi.org
November 4, 2025 at 5:51 PM
Our #Covid19 work in #KidneyWk :
> transplant fx over time
doi.org/10.1681/ASN....
> kidney fx over time
doi.org/10.1681/ASN....
> AKI
doi.org/10.1681/ASN....
> #C3GN
doi.org/10.1681/ASN....
> #IgAN
doi.org/10.1681/ASN....
> dialysis vasc access
doi.org/10.1681/ASN....
TLDR: don't get covid
> transplant fx over time
doi.org/10.1681/ASN....
> kidney fx over time
doi.org/10.1681/ASN....
> AKI
doi.org/10.1681/ASN....
> #C3GN
doi.org/10.1681/ASN....
> #IgAN
doi.org/10.1681/ASN....
> dialysis vasc access
doi.org/10.1681/ASN....
TLDR: don't get covid
And it’s live
Iptacopan in C3GN makes it to @thelancet.com
www.thelancet.com/journals/lan...
#NephSky
Iptacopan in C3GN makes it to @thelancet.com
www.thelancet.com/journals/lan...
#NephSky
September 26, 2025 at 9:37 AM
And it’s live
Iptacopan in C3GN makes it to @thelancet.com
www.thelancet.com/journals/lan...
#NephSky
Iptacopan in C3GN makes it to @thelancet.com
www.thelancet.com/journals/lan...
#NephSky
T0b
The pathophysiology of C3GN & IC-MPGN is thought to be caused by:
Genetic mutations or
Acquired defect of complement proteins or
Auto-antibodies against complement factors and/or regulating proteins. #NephJC
The pathophysiology of C3GN & IC-MPGN is thought to be caused by:
Genetic mutations or
Acquired defect of complement proteins or
Auto-antibodies against complement factors and/or regulating proteins. #NephJC
January 14, 2026 at 2:08 AM
T0b
The pathophysiology of C3GN & IC-MPGN is thought to be caused by:
Genetic mutations or
Acquired defect of complement proteins or
Auto-antibodies against complement factors and/or regulating proteins. #NephJC
The pathophysiology of C3GN & IC-MPGN is thought to be caused by:
Genetic mutations or
Acquired defect of complement proteins or
Auto-antibodies against complement factors and/or regulating proteins. #NephJC
perfect timing for the video to go live
youtu.be/Fo6J__RgWA0
#NephGR #C3GN since #iptacopan just got FDA approval for C3GN www.novartis.com/news/media-r...
#NephSky
youtu.be/Fo6J__RgWA0
#NephGR #C3GN since #iptacopan just got FDA approval for C3GN www.novartis.com/news/media-r...
#NephSky
C3 Glomerulopathy: The Promise of a targeted therapy with Prof. Carla Nester
YouTube video by Ottawa Nephrology
youtu.be
March 24, 2025 at 3:31 PM
perfect timing for the video to go live
youtu.be/Fo6J__RgWA0
#NephGR #C3GN since #iptacopan just got FDA approval for C3GN www.novartis.com/news/media-r...
#NephSky
youtu.be/Fo6J__RgWA0
#NephGR #C3GN since #iptacopan just got FDA approval for C3GN www.novartis.com/news/media-r...
#NephSky
Case report: De novo C3 Glomerulonephritis in a Kidney Transplant Recipient Associated with an Unreported CFH Variant
#openaccess
#C3GN
#openaccess
#C3GN
De novo C3 Glomerulonephritis in a Kidney Transplant Recipient Associated with an Unreported CFH Variant
C3 glomerulopathy (C3G), encompassing dense deposit disease (DDD) and C3 glomerulonephritis (C3GN), is defined by predominant C3 deposition in glomeruli without significant immunoglobulin, reflecting…
buff.ly
September 11, 2025 at 10:01 PM
Case report: De novo C3 Glomerulonephritis in a Kidney Transplant Recipient Associated with an Unreported CFH Variant
#openaccess
#C3GN
#openaccess
#C3GN
I’m sorry #NephMadness, but having C3GN treatment in the final is…silly.
How many C3GN patients does the average nephrologist see in a year?!
#NephSky #BlueRibbonFail
How many C3GN patients does the average nephrologist see in a year?!
#NephSky #BlueRibbonFail
April 8, 2026 at 1:19 PM
I’m sorry #NephMadness, but having C3GN treatment in the final is…silly.
How many C3GN patients does the average nephrologist see in a year?!
#NephSky #BlueRibbonFail
How many C3GN patients does the average nephrologist see in a year?!
#NephSky #BlueRibbonFail
Challenges in the Diagnosis and Management of Immune Complex-Mediated Membranoproliferative Glomerulonephritis and Complement 3 Glomerulopathy
doi.org/10.1016/j.ek...
#KIRReview #C3GN #ICMPGN
doi.org/10.1016/j.ek...
#KIRReview #C3GN #ICMPGN
January 9, 2025 at 2:00 PM
Challenges in the Diagnosis and Management of Immune Complex-Mediated Membranoproliferative Glomerulonephritis and Complement 3 Glomerulopathy
doi.org/10.1016/j.ek...
#KIRReview #C3GN #ICMPGN
doi.org/10.1016/j.ek...
#KIRReview #C3GN #ICMPGN
Oblique illumination images of RBC cast (IgAN), WBC cast (AAV), lipid/RTEC cast (C3GN), WBC cast (cryoglobulinemic GN). 500x #UrinarySediment #UrineMicroscopy @OchsnerNephro Will present “liquid kidney biopsy in GN” soon at #NKFClinicals @nkf
December 10, 2024 at 5:03 AM
Oblique illumination images of RBC cast (IgAN), WBC cast (AAV), lipid/RTEC cast (C3GN), WBC cast (cryoglobulinemic GN). 500x #UrinarySediment #UrineMicroscopy @OchsnerNephro Will present “liquid kidney biopsy in GN” soon at #NKFClinicals @nkf
11/n in this large C3GN cohort from Columbia Univ, those features were not reported either www.kidney-international.org/action/showP...
www.kidney-international.org
December 22, 2025 at 7:23 PM
11/n in this large C3GN cohort from Columbia Univ, those features were not reported either www.kidney-international.org/action/showP...
💉Immune checkpoint inhibitors: 🦸♂️heroes in cancer🦀, 🦹♂️villains for kidneys 🫘?
#ICI-AKI can hit both
Glomeruli (C3GN, MCD, vasculitis)
&
Tubulointerstitium (ATIN, ATN, tubulitis)
📖 doi.org/10.34067/KID... 🆕
@asnpublications.bsky.social K360
#Onconephrology #Nephrology #AKI #NephSky #NephPearls
#ICI-AKI can hit both
Glomeruli (C3GN, MCD, vasculitis)
&
Tubulointerstitium (ATIN, ATN, tubulitis)
📖 doi.org/10.34067/KID... 🆕
@asnpublications.bsky.social K360
#Onconephrology #Nephrology #AKI #NephSky #NephPearls
April 26, 2025 at 9:24 AM
💉Immune checkpoint inhibitors: 🦸♂️heroes in cancer🦀, 🦹♂️villains for kidneys 🫘?
#ICI-AKI can hit both
Glomeruli (C3GN, MCD, vasculitis)
&
Tubulointerstitium (ATIN, ATN, tubulitis)
📖 doi.org/10.34067/KID... 🆕
@asnpublications.bsky.social K360
#Onconephrology #Nephrology #AKI #NephSky #NephPearls
#ICI-AKI can hit both
Glomeruli (C3GN, MCD, vasculitis)
&
Tubulointerstitium (ATIN, ATN, tubulitis)
📖 doi.org/10.34067/KID... 🆕
@asnpublications.bsky.social K360
#Onconephrology #Nephrology #AKI #NephSky #NephPearls
T3b
Because increased complement activation causes C3GN and IC-MPGN, complement inhibition is a logical target with an increasing list of efficacious meds.
However, previous complement inhibitors eculizumab/avacopan (C5/C5a inhibitors) showed limited effects due to ongoing C3 activation. #NephJC
Because increased complement activation causes C3GN and IC-MPGN, complement inhibition is a logical target with an increasing list of efficacious meds.
However, previous complement inhibitors eculizumab/avacopan (C5/C5a inhibitors) showed limited effects due to ongoing C3 activation. #NephJC
January 14, 2026 at 2:37 AM
T3b
Because increased complement activation causes C3GN and IC-MPGN, complement inhibition is a logical target with an increasing list of efficacious meds.
However, previous complement inhibitors eculizumab/avacopan (C5/C5a inhibitors) showed limited effects due to ongoing C3 activation. #NephJC
Because increased complement activation causes C3GN and IC-MPGN, complement inhibition is a logical target with an increasing list of efficacious meds.
However, previous complement inhibitors eculizumab/avacopan (C5/C5a inhibitors) showed limited effects due to ongoing C3 activation. #NephJC
Nice examples of subepithelial hump-like deposits seen in cases of recurrent C3GN and DDD. Found in 31% of recurrent C3G patient biopsies in our institutional series (indication biopsies). Exudative features also common (25% of cases). www.wjgnet.com/2220-3230/fu... #renalpath #pathsky #nephsky
June 9, 2025 at 10:33 PM
Nice examples of subepithelial hump-like deposits seen in cases of recurrent C3GN and DDD. Found in 31% of recurrent C3G patient biopsies in our institutional series (indication biopsies). Exudative features also common (25% of cases). www.wjgnet.com/2220-3230/fu... #renalpath #pathsky #nephsky
T0h
The efficacy and safety of pegcetacoplan (PEG) in C3GN & IC-MPGN were unknown.
Thus the VALIANT study was done to study UPCR, eGFR and safety in these devastating GNs where complement dysregulation is central to the pathophysiology. #NephJC
The efficacy and safety of pegcetacoplan (PEG) in C3GN & IC-MPGN were unknown.
Thus the VALIANT study was done to study UPCR, eGFR and safety in these devastating GNs where complement dysregulation is central to the pathophysiology. #NephJC
January 14, 2026 at 2:14 AM
T0h
The efficacy and safety of pegcetacoplan (PEG) in C3GN & IC-MPGN were unknown.
Thus the VALIANT study was done to study UPCR, eGFR and safety in these devastating GNs where complement dysregulation is central to the pathophysiology. #NephJC
The efficacy and safety of pegcetacoplan (PEG) in C3GN & IC-MPGN were unknown.
Thus the VALIANT study was done to study UPCR, eGFR and safety in these devastating GNs where complement dysregulation is central to the pathophysiology. #NephJC
14/n just a reminder of the recently published VALIANT trial that demonstrated the benefit of pegcetacoplan in C3GN www.nejm.org/doi/full/10....
www.nejm.org
December 22, 2025 at 7:23 PM
14/n just a reminder of the recently published VALIANT trial that demonstrated the benefit of pegcetacoplan in C3GN www.nejm.org/doi/full/10....
While C3 by pronase IF on FFPE is less sensitive/reliable, it can still be helpful when positive. Left frozen C3, right FFPE C3 from a case of recurrent C3GN in a txp. Did IF par to rule out masked deposits just in case (there were non). So the stain can work. #renalpath #pathsky #nephsky
January 24, 2025 at 11:37 PM
While C3 by pronase IF on FFPE is less sensitive/reliable, it can still be helpful when positive. Left frozen C3, right FFPE C3 from a case of recurrent C3GN in a txp. Did IF par to rule out masked deposits just in case (there were non). So the stain can work. #renalpath #pathsky #nephsky
I would defer to @anujajava.bsky.social and other real experts for that one
I am just happy Dr Nester and colleagues could demonstrate that an RCT could be done in a rare disease like C3GN
I think the maker of expensivumab has funded zero true RCTs?
I am just happy Dr Nester and colleagues could demonstrate that an RCT could be done in a rare disease like C3GN
I think the maker of expensivumab has funded zero true RCTs?
January 8, 2025 at 11:04 PM
I would defer to @anujajava.bsky.social and other real experts for that one
I am just happy Dr Nester and colleagues could demonstrate that an RCT could be done in a rare disease like C3GN
I think the maker of expensivumab has funded zero true RCTs?
I am just happy Dr Nester and colleagues could demonstrate that an RCT could be done in a rare disease like C3GN
I think the maker of expensivumab has funded zero true RCTs?
10/n also present in this case: autoimmune hemolytic anemia (AHA) (DAT+). In this report, autoimmune conditions were described in association with C3GN, but neither AHA nor high PR3 were reported! link.springer.com/content/pdf/...
link.springer.com
December 22, 2025 at 7:23 PM
10/n also present in this case: autoimmune hemolytic anemia (AHA) (DAT+). In this report, autoimmune conditions were described in association with C3GN, but neither AHA nor high PR3 were reported! link.springer.com/content/pdf/...
T3n #NephJC
⚖️ Enough to change practice now or do we need the results from the follow up?
C3GN is very rare, will you have enough experience or will you refer to a GN specialist for treatment?
⚖️ Enough to change practice now or do we need the results from the follow up?
C3GN is very rare, will you have enough experience or will you refer to a GN specialist for treatment?
January 14, 2026 at 2:49 AM
T3n #NephJC
⚖️ Enough to change practice now or do we need the results from the follow up?
C3GN is very rare, will you have enough experience or will you refer to a GN specialist for treatment?
⚖️ Enough to change practice now or do we need the results from the follow up?
C3GN is very rare, will you have enough experience or will you refer to a GN specialist for treatment?