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arkanalabs.bsky.social
#DiagnoseThis! In the presence of a negative immunofluorescence panel, what is your diagnosis?

#renalpath #kidneypath #pathology #renal #DiagnoseThis
November 2, 2026 at 3:04 PM
jzrenalpath.bsky.social
Horrendous case of acute cellular rejection. Severe tubulointerstitial inflammation and vascular rejection. Plasma cell rich which is often recalcitrant and often seen w/treatment non-adherence (be sure to r/o BK and PTLD as well). #renalpath #pathsky #nephsky
November 3, 2026 at 1:01 PM
arkanalabs.bsky.social
Here is today's #eyeSCANdy. Shown is an acellular SEM findings in segmental membranous GN showing a capillary loop confluent zone (arrow) of GBM crater formations.

#renalpath #kidneypath #pathology #renal
November 4, 2026 at 3:48 PM
arkanalabs.bsky.social
Of note, endocarditis-associated glomerulonephritis can also present with a pauci-immune and crescentic morphologic pattern and may warrant exclusion in at-risk patients or if clinical concern exists.

#renalpath #kidneypath #pathology #renal #DiagnoseThis
November 3, 2026 at 4:01 PM
arkanalabs.bsky.social
However, it is important to understand that this finding is not entirely specific to infection and can rarely be seen in a range of kidney diseases (such as C3 glomerulonephritis).

#renalpath #kidneypath #pathology #renal #DiagnoseThis!
October 27, 2026 at 3:13 PM
arkanalabs.bsky.social
#DiagnoseThis! What is this finding and what is it classically associated with?

#renalpath #kidneypath #pathology #renal #DiagnoseThis!
October 26, 2026 at 3:05 PM
gracechoung.bsky.social
Microvascular inflammation in kidney transplants: finally an effective treatment? - Kidney International www.kidney-international.org/article/S008...

#renalpath #pathsky @jeanhoumd.bsky.social
Microvascular inflammation in kidney transplants: finally an effective treatment?
Microvascular inflammation—glomerulitis and peritubular capillaritis—is the hallmark histologic lesion of antibody-mediated allograft rejection and may also occur in the absence of donor-specific anti...
www.kidney-international.org
October 23, 2026 at 3:21 PM
gracechoung.bsky.social
Clinicopathologic and Outcome Characteristics of Glomerulopathy With Striated Deposits: A Case Series - American Journal of Kidney Diseases www.ajkd.org/article/S027...

#pathsky #nephsky #renalpath
Clinicopathologic and Outcome Characteristics of Glomerulopathy With Striated Deposits: A Case Series
Glomerulopathy with striated deposits (GSD) is a rare entity defined by ultrastructural deposits with striated substructure. Prior data were limited to case reports. This case series characterizes GSD...
www.ajkd.org
October 21, 2026 at 3:32 PM
arkanalabs.bsky.social
What is this immunoperoxidase stain? For bonus points, what was found on electron microscopy?

#renalpath #kidneypath #pathology #renal
October 19, 2026 at 3:03 PM
arkanalabs.bsky.social
However, this finding is encountered in fibrillary glomerulopathy in approximately 10% of cases. And, while it may necessitate a paraproteinemia workup, in those with no paraproteinemia it is likely clinically insignificant.

#renalpath #kidneypath #pathology #renal #DiagnoseThis!
October 20, 2026 at 3:10 PM
arkanalabs.bsky.social
Of note, myoglobin casts and hemoglobin casts cannot always be distinguished from each other on morphology alone. And, in most cases immunoperoxidase staining for hemoglobin and myoglobin can easily facilitate differentiation.

#DiagnoseThis #renalpath #kidneypath #pathology #rena
October 13, 2026 at 3:00 PM
arkanalabs.bsky.social
The images show lymphocytic tubulitis as well as an eosinophil-rich interstitial inflammatory infiltrate. These findings are consistent with acute interstitial nephritis... 

#renalpath #kidneypath #pathology #renal #pathtwitter
October 6, 2026 at 5:05 PM
kidneyint.bsky.social
From podocyte biology to #glomerular medicine: the 15th International #Podocyte Conference 2025

doi.org/10.1016/j.kint.2026.07.026

#NephSky #MedSky @isgd.bsky.social #Podocyte2025 #ISGD #GlomerularDisease #KidneyResearch #RenalPath #TranslationalNephrology #OpenAccess
October 2, 2026 at 4:28 PM
arkanalabs.bsky.social
Interestingly, the perihilar focal segmental glomerulosclerosis identified here was present in numerous glomeruli as well as marked glomerulomegaly.

#renalpath #kidneypath #pathology #renal #pathtwitter
September 29, 2026 at 2:08 PM
arkanalabs.bsky.social
This photomicrograph of a Jones silver stain is interesting in that it shows two findings. First, at 10 o’clock an area of hyalinosis at the perihilar region is present and compatible with perihilar focal segmental glomerulosclerosis.

#renalpath #kidneypath #pathology #renal #pathtwitter
September 29, 2026 at 2:03 PM
arkanalabs.bsky.social
And, while myeloid bodies can be seen in patients on chloroquine or hydroxychloroquine therapy, they are typically sparse or focal in these settings.

#renalpath #kidneypath #pathology #renal #pathtwitter
September 29, 2026 at 2:07 PM
arkanalabs.bsky.social
As suspected, extensive accumulation of intra-podocyte myeloid bodies (a.k.a. zebra bodies, myelinosomes) are seen in all podocyte cell bodies examined (see image below). And, subsequent testing revealed Fabry disease in this patient.

#renalpath #kidneypath #pathology #renal #pathtwitter
September 29, 2026 at 2:07 PM
gracechoung.bsky.social
Podocyte and Tubular Vacuolization in Patients Receiving Pegcetacoplan - Kidney International www.kidney-international.org/article/S008...

#renalpath #pathsky #nephsky
September 27, 2026 at 5:34 PM
jzrenalpath.bsky.social
Pt with myelofibrosis, NR proteinuria, progressive CKD. Hypercellular glomeruli + intracapillary megakaryocytes, + mesangial sclerosis, +chronic microangiopathic changes c/w MPN-related glomerulopathy. Also renal extramedullary hematopeosis. IHC is CD61 #renalpath #pathsky #nephsky
September 24, 2026 at 10:39 PM
gracechoung.bsky.social
The ultrastructure of a cast: the art and science of renal tubular pathology: Ultrastructural Pathology: Vol 50 , No 3 - Get Access www.tandfonline.com/doi/full/10....

#EM #ultrastructure #renalpath #pathsky
The ultrastructure of a cast: the art and science of renal tubular pathology
Renal tubular casts are cylindrical structures formed primarily in the distal convoluted tubule or collecting tubule. They are composed of materials filling the tubular lumen and molding along its ...
www.tandfonline.com
September 15, 2026 at 10:29 PM
jzrenalpath.bsky.social
Well developed example of medullary angiitis (pubmed.ncbi.nlm.nih.gov/23079202/) in a case of MPO-ANCA associated GN. Neutrophils and hemorrhage in the medulla. Also plenty of active crescents in this case. #renalpath #pathsky #nephsky
September 9, 2026 at 6:33 PM
renalpathsociety.bsky.social
Yale Pathology is accepting applications for 1-year combined Renal & GU Pathology fellowship starting July 1, 2027 & 2028. See image below and link for more info.
Apply: path.education@mailman.yale.edu
medicine.yale.edu/pathology/tr...
#renalpath #GU #fellowship #pathysky
@yalepathology.bsky.social
September 4, 2026 at 7:34 PM
arkanalabs.bsky.social
- diagnosis of C3 glomerulopathy is rendered.

Reference Link: www.ncbi.nlm.nih.gov/pubmed/24429...

#renalpath #kidneypath #pathology #renal #pathtwitter
September 1, 2026 at 1:24 PM
kidneyint.bsky.social
Commentary
No staining needed: reading kidney injury by its own light.
Barbara Mara Klinkhammer and Christos Chatziantonious

doi.org/10.1016/j.kint.2026.06.017

Original article: doi.org/10.1016/j.kint.2026.05.016

#NephSky #MedSky @sorbonne-universite.fr @inserm.fr @rwth.bsky.social #RenalPath
September 1, 2026 at 3:51 PM
arkanalabs.bsky.social
These photomicrographs show a membranous pattern glomerulopathy with C3 staining by immunofluorescence. While it is tempting to diagnosis this as C3 glomerulopathy, that is not correct in this case.

Reference Link: www.ncbi.nlm.nih.gov/pubmed/24429...

#renalpath #kidneypath #pathology #pathtwitter
September 1, 2026 at 1:22 PM