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#DiagnoseThis! What is this finding and what is it classically associated with?

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October 26, 2026 at 3:05 PM
However, it is important to understand that this finding is not entirely specific to infection and can rarely be seen in a range of kidney diseases (such as C3 glomerulonephritis).

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October 27, 2026 at 3:13 PM
However, this finding is encountered in fibrillary glomerulopathy in approximately 10% of cases. And, while it may necessitate a paraproteinemia workup, in those with no paraproteinemia it is likely clinically insignificant.

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October 20, 2026 at 3:10 PM
#DiagnoseThis! The patient is a 67 y/o Caucasian female with slowly progressive kidney disease and 2.3 gm/24 hr proteinuria. Aside from hypertension she has no significant past medical history. Congo red was negative, however immunofluorescence showed IgG and lambda staining within glomeruli.
October 19, 2026 at 3:02 PM
October 12, 2026 at 3:04 PM
Of note, myoglobin casts and hemoglobin casts cannot always be distinguished from each other on morphology alone. And, in most cases immunoperoxidase staining for hemoglobin and myoglobin can easily facilitate differentiation.

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October 13, 2026 at 3:00 PM
October 5, 2026 at 5:06 PM
Diagnosethis
October 4, 2026 at 7:47 PM
September 28, 2026 at 1:03 PM
The immunofluorescence study is negative. What is your diagnosis?

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September 21, 2026 at 12:55 PM
September 14, 2026 at 1:02 PM
What is the most likely diagnosis?

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September 7, 2026 at 1:03 PM
In the setting of weak C3 (1-2+) only staining by routine immunofluorescence, what is your diagnosis?

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August 31, 2026 at 1:03 PM
What is your diagnosis in this renal transplant biopsy?

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August 24, 2026 at 1:02 PM
What is the most likely diagnosis? For bonus points, what is the basic differential for this morphologic finding (non-immune and immune)?

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August 17, 2026 at 1:02 PM
What is your diagnosis in this renal transplant patient?

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August 10, 2026 at 1:02 PM
What is your diagnosis in this renal transplant patient?

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August 3, 2026 at 1:02 PM
July 27, 2026 at 2:04 PM
What is your diagnosis (IgG stain shown)?

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July 20, 2026 at 1:01 PM
July 13, 2026 at 1:02 PM
July 6, 2026 at 2:15 PM
June 29, 2026 at 12:45 PM
This IF image is from a 22 y/o Asian male with hematuria. What immunoreactant does it represent and what is the diagnosis?

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June 23, 2026 at 1:03 PM
June 16, 2026 at 2:31 PM
June 8, 2026 at 1:02 PM