#CARD11
LightNews LightNews
jem.org
Bauman, Snow et al. show that impaired T cell receptor–induced CARD11-dependent JNK signaling upregulates GATA3 & NFAT2, two key proteins in TH2 cell development, identifying a new mechanism by which CARD11 variants spur atopic disease. rupress.org/jem/article/...
March 20, 2025 at 5:47 PM
labwaggoner.bsky.social
QRICH1 negatively regulates CD8+ T cell activation by fine-tuning CARD11 signaling to NF-κB
www.science.org/doi/10.1126/... @sciimmunology.bsky.social
March 15, 2025 at 2:58 AM
labwaggoner.bsky.social
Impaired TCR–induced CARD11-dependent JNK signaling results in ⬆️GATA3, NFAT2 that drive development of TH2 and atopic disease @jem.org
doi.org/10.1084/jem....
March 21, 2025 at 5:44 PM
rodrahimi.bsky.social
This is cool. Leveraging a rare gene fusion, CARD11–PIK3R3, found in a CD4+ cutaneous T cell lymphoma to make a more effective CAR T cell for immunotherapy. #ImmunoSky 🧪

www.nature.com/articles/s41...
www.nature.com
February 8, 2024 at 2:24 PM
thegoldenway33.bsky.social
The Artiste
Queen of Stones
(Muse of Stones)

#Card11

Chrysalis Tarot
Toney Brooks
Holly Sierra

#TarotSky
#WitchSky
#SpiritualPath
#SpiritualJourney

🎨🖌️🖼️📝📖📚🎹🎼🎶
November 12, 2024 at 1:26 AM
ke0opr.bsky.social
#PlaneAlert ICAO: #ADFF4F
Owner: #USAF
Flt: #CARD11 #668403 #T38
Time: 2026-09-30 09:19:12 CDT
Min Alt: 13000 ft

#adsb #planefence #planealert by kx1t sdr-e adsbexchange flightaware faa
September 30, 2026 at 2:19 PM
ke0opr.bsky.social
#PlaneAlert ICAO: #AE002B
Owner: #USAF
Flt: #CARD11 #6714949 #T38
Time: 2026-09-29 08:52:38 CDT
Min Alt: 11175 ft

#adsb #planefence #planealert by kx1t sdr-e adsbexchange flightaware faa
September 29, 2026 at 1:56 PM
lillemeier-lab.bsky.social
An inverse correlation between TCR signal strength and exhausted CD8+ #T-cell differentiation. Fine-tuning the CARD11-mediated #TCR signal strength reinvigorated antitumor function and indicates a strategy for improving cancer #immunotherapy.
rdcu.be/etHhG
CARD11 signaling regulates CD8+ T cell tumoricidal function
Nature Immunology - Here the authors use genetic mutations to alter TCR signal strength and clonal selection of exhausted CD8+ T cells. They implicate CARD11 signaling as a sensor of this TCR...
rdcu.be
June 27, 2025 at 7:19 AM
ke0opr.bsky.social
ICAO: #AE002B
Owner: #USAF
Flt: #CARD11 #6714949 #T38
Time: 2026-09-29 08:52:38 CDT
Min Alt: 11175 ft
Min Dist: 95.05 nm (-151deg SSW)

#adsb #planefence by kx1t sdr-e adsbexchange flightaware faa
September 29, 2026 at 2:01 PM
ke0opr.bsky.social
ICAO: #ADFF4F
Owner: #USAF
Flt: #CARD11 #668403 #T38
Time: 2026-09-30 09:19:12 CDT
Min Alt: 13000 ft
Min Dist: 94.8 nm (-149deg SSW)

#adsb #planefence by kx1t sdr-e adsbexchange flightaware faa
September 30, 2026 at 2:39 PM
ke0opr.bsky.social
#PlaneAlert ICAO: #AE002F
Owner: #USAF
Flt: #CARD11 #688110 #T38
Time: 2026-09-28 08:41:50 CDT
Min Alt: 11325 ft

#adsb #planefence #planealert by kx1t sdr-e adsbexchange flightaware faa
September 28, 2026 at 1:42 PM
ke0opr.bsky.social
ICAO: #AE002F
Owner: #USAF
Flt: #CARD11 #688110 #T38
Time: 2026-09-28 09:05:24 CDT
Min Alt: 16875 ft
Min Dist: 81.64 nm (-125deg SW)

#adsb #planefence by kx1t sdr-e adsbexchange flightaware faa
September 28, 2026 at 2:25 PM
ke0opr.bsky.social
#PlaneAlert ICAO: #ADFF4F
Owner: #USAF
Flt: #CARD11 #668403 #T38
Time: 2026-09-24 11:07:21 CDT
Min Alt: 13075 ft

#adsb #planefence #planealert by kx1t sdr-e adsbexchange flightaware faa
September 24, 2026 at 4:07 PM
labwaggoner.bsky.social
CARD11 signaling regulates CD8+ T cell tumoricidal function @natimmunol.nature.com
www.nature.com/articles/s41...
June 18, 2025 at 7:19 PM
rridrobot.bsky.social
A paper using RRID:AB_465936 from @thermofishersci.bsky.social was just published. We value the author's support of reproducibility. #OpenScience #ReproducibleResearch #methodsmatter
Potentiation of noncanonical NF-κB signaling and marginal zone B cell expansion by CARD11-mediated regulation of p100 processing
doi.org
November 30, 2025 at 8:00 AM
ke0opr.bsky.social
ICAO: #ADFF4F
Owner: #USAF
Flt: #CARD11 #668403 #T38
Time: 2026-09-24 11:16:40 CDT
Min Alt: 14000 ft
Min Dist: 85.67 nm (-143deg SW)
Squawk: #0141
#adsb #planefence by kx1t sdr-e adsbexchange flightaware faa
September 24, 2026 at 4:23 PM
rridrobot.bsky.social
A paper using RRID:AB_2572515 from @thermofishersci.bsky.social was just published in Journal of Experimental Medicine. RRIDs improve reproducibility in scientific research. #accelerateopenscience #OpenResearch #RRID
Dominant interfering CARD11 variants disrupt JNK signaling to promote GATA3 expression in T cells
Read the full paper: Dominant interfering CARD11 variants disrupt JNK signaling to promote GATA3 expression in T cells
doi.org
March 22, 2026 at 7:01 AM
ke0opr.bsky.social
#PlaneAlert ICAO: #AE0031
Owner: #USAF
Flt: #CARD11 #688130 #T38
Time: 2026-09-23 11:34:12 CDT
Min Alt: 14025 ft

#adsb #planefence #planealert by kx1t sdr-e adsbexchange flightaware faa
September 23, 2026 at 4:34 PM
ke0opr.bsky.social
ICAO: #AE0031
Owner: #USAF
Flt: #CARD11 #688130 #T38
Time: 2026-09-23 11:56:37 CDT
Min Alt: 7400 ft
Min Dist: 80.7 nm (-141deg SW)

#adsb #planefence by kx1t sdr-e adsbexchange flightaware faa
September 23, 2026 at 5:02 PM
rridrobot.bsky.social
The authors included RRIDs in their None paper! We value the author's support of reproducibility. #RRID #RRID #OpenScience
QRICH1 mediates an intracellular checkpoint for CD8+ T cell activation via the CARD11 signalosome
doi.org
August 12, 2025 at 7:02 AM
jem.org
Bauman, Snow and colleagues show that dominant interfering CARD11 variants disrupt JNK signaling to promote GATA3 expression in T cells. rupress.org/jem/article/...

📘 In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
April 10, 2025 at 3:15 PM
ucldiscovery.bsky.social
Open Access UCL Research: Transcriptome Profiling Associated with CARD11 Overexpression in Colorectal Cancer Implicates a Potential Role for Tumor Immune Microenvironment and Cancer Pathways Modulation via NF-κB
discovery.ucl.ac.uk/id/eprint/10...
Transcriptome Profiling Associated with CARD11 Overexpression in Colorectal Cancer Implicates a Potential Role for Tumor Immune Microenvironment and Cancer Pathways Modulation via NF-κB ...
UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
discovery.ucl.ac.uk
March 3, 2025 at 8:18 AM
follicular.bsky.social
🧪 "Several “primary atopic disorders” have been linked to monogenic defects that attenuate TCR signaling, consistent with the paradigm that weaker TCR signal strength favors T helper type 2 (TH2) vs. TH1 cell differentiation..." #Immunosky
rupress.org/jem/article/...
Dominant interfering CARD11 variants disrupt JNK signaling to promote GATA3 expression in T cells | Journal of Experimental Medicine | Rockefeller University Press
This study demonstrates that impaired T cell receptor–induced CARD11-dependent JNK signaling results in upregulation of GATA3 and NFAT2, two key proteins i
rupress.org
June 3, 2025 at 7:47 PM
esidsociety.bsky.social
Join the first ESID Grand Round of 2026, taking place on Wednesday, 28 Jan at 16:30 CET.

🧬 Topic: Biology and Clinical Manifestations of CARD11-Driven Disorders🎙 Moderator: Prof. Fabian Hauck
🗣️ Speakers: Andrew Snow, Letizia Baldini, Maria Alejandra Mejia Gonzalez
💻 Register: bit.ly/3NZQZbL
January 23, 2026 at 1:03 PM
ke0opr.bsky.social
ICAO: #ADFF55

Flt: #CARD11 #6714950 #T38
Time: 2026-09-21 16:01:20 CDT
Min Alt: 10400 ft
Min Dist: 85.8 nm (-153deg SSW)

#adsb #planefence by kx1t sdr-e adsbexchange flightaware faa
September 21, 2026 at 9:11 PM