Second week is going... 😂
Anyway here's a spindle cell GIST that was found on an GI workup. Noted to be perigastric and stained very nicely for DOG1 and CD117. #PathSky
Anyway here's a spindle cell GIST that was found on an GI workup. Noted to be perigastric and stained very nicely for DOG1 and CD117. #PathSky
January 22, 2025 at 12:02 AM
Second week is going... 😂
Anyway here's a spindle cell GIST that was found on an GI workup. Noted to be perigastric and stained very nicely for DOG1 and CD117. #PathSky
Anyway here's a spindle cell GIST that was found on an GI workup. Noted to be perigastric and stained very nicely for DOG1 and CD117. #PathSky
Curing autoimmune diabetes in mice with islet and hematopoietic cell transplantation after CD117 antibody-based conditioning @jci.org
www.jci.org/articles/vie...
www.jci.org/articles/vie...
November 20, 2025 at 5:52 PM
Curing autoimmune diabetes in mice with islet and hematopoietic cell transplantation after CD117 antibody-based conditioning @jci.org
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Provisional results at @ash-hematology.bsky.social from the the NCI clinical trial using RIC #HCT with briquilimab (anti CD117) for patients with #GATA2. #BMFsm @sung-yun-pai.bsky.social Dani Arnold #ASH24
December 7, 2024 at 12:22 AM
Provisional results at @ash-hematology.bsky.social from the the NCI clinical trial using RIC #HCT with briquilimab (anti CD117) for patients with #GATA2. #BMFsm @sung-yun-pai.bsky.social Dani Arnold #ASH24
Targeting CD117 on hematopoietic stem and progenitor cells impairs CAR T cell activity @moltherapy.bsky.social
www.cell.com/molecular-th...
www.cell.com/molecular-th...
June 4, 2025 at 3:24 AM
Targeting CD117 on hematopoietic stem and progenitor cells impairs CAR T cell activity @moltherapy.bsky.social
www.cell.com/molecular-th...
www.cell.com/molecular-th...
charakteristisches Immunprofil mit erhöhter Mastzellaktivität und erhöhten Zonulinspiegeln - Zonulin ist ein körpereigenes Protein, das die Durchlässigkeit der Darmschleimhaut reguliert -, was auf eine beeinträchtigte Darmbarrierefunktion hindeutet – parallel zu einer erhöhten
March 9, 2026 at 12:35 PM
charakteristisches Immunprofil mit erhöhter Mastzellaktivität und erhöhten Zonulinspiegeln - Zonulin ist ein körpereigenes Protein, das die Durchlässigkeit der Darmschleimhaut reguliert -, was auf eine beeinträchtigte Darmbarrierefunktion hindeutet – parallel zu einer erhöhten
Spot on! This was CD45 dim and only expressed CD56 and CD117 and had an odd MPO positivity which was hinting at AML but this was Plasma cell leukemia!
November 18, 2024 at 5:25 PM
Spot on! This was CD45 dim and only expressed CD56 and CD117 and had an odd MPO positivity which was hinting at AML but this was Plasma cell leukemia!
#slidearchiveseries renal oncocytoma #gupath
🔬solid-nested growth, edematous stroma
🎨 CD117 positive, CK7 negative or scattered single/small clusters of positive cells, Hale collodial iron negative (apical luminal positivity may be seen)
🔬solid-nested growth, edematous stroma
🎨 CD117 positive, CK7 negative or scattered single/small clusters of positive cells, Hale collodial iron negative (apical luminal positivity may be seen)
December 11, 2024 at 3:30 AM
#slidearchiveseries renal oncocytoma #gupath
🔬solid-nested growth, edematous stroma
🎨 CD117 positive, CK7 negative or scattered single/small clusters of positive cells, Hale collodial iron negative (apical luminal positivity may be seen)
🔬solid-nested growth, edematous stroma
🎨 CD117 positive, CK7 negative or scattered single/small clusters of positive cells, Hale collodial iron negative (apical luminal positivity may be seen)
CD117 is a pitfall in flow cytometry also because it can make plasma cells look like blasts if they have an unusual pattern of other stains on flow. Most plasma cell flow does not include CD117 so it's not an issue, but if flow is not targeted to plasma cells it can cause difficulty.
November 21, 2024 at 1:51 PM
CD117 is a pitfall in flow cytometry also because it can make plasma cells look like blasts if they have an unusual pattern of other stains on flow. Most plasma cell flow does not include CD117 so it's not an issue, but if flow is not targeted to plasma cells it can cause difficulty.
Most hospital pathology labs can do a CD117 immunostain, it’s an easy routine immunohistochemistry test
If a patient meets other DX criteria and has abnormally high mast cells per power field even on mast cell meds: DX confirmed pmc.ncbi.nlm.nih.gov/articles/PMC...
#MCAS #Mastocytosis #HaT
If a patient meets other DX criteria and has abnormally high mast cells per power field even on mast cell meds: DX confirmed pmc.ncbi.nlm.nih.gov/articles/PMC...
#MCAS #Mastocytosis #HaT
Mast Cells in Gastrointestinal Disease
The function of mast cells in allergic inflammatory reactions is well documented in the literature. Mast cells also play an important role in the regulation of gastrointestinal visceral sensitivity an...
pmc.ncbi.nlm.nih.gov
June 25, 2026 at 5:34 AM
Most hospital pathology labs can do a CD117 immunostain, it’s an easy routine immunohistochemistry test
If a patient meets other DX criteria and has abnormally high mast cells per power field even on mast cell meds: DX confirmed pmc.ncbi.nlm.nih.gov/articles/PMC...
#MCAS #Mastocytosis #HaT
If a patient meets other DX criteria and has abnormally high mast cells per power field even on mast cell meds: DX confirmed pmc.ncbi.nlm.nih.gov/articles/PMC...
#MCAS #Mastocytosis #HaT
#slidearchiveseries eosinophilic solid and cystic renal cell carcinoma #gupath #pathsky #pathoutpic
🔬 solid and cystic architecture, basophilic intracytoplasmic stippling, and eosinophilic inclusions
🎨 PAX8+, frequently CK20+, usually CK7-/CD117-, majority Cathepsin K+
🔬 solid and cystic architecture, basophilic intracytoplasmic stippling, and eosinophilic inclusions
🎨 PAX8+, frequently CK20+, usually CK7-/CD117-, majority Cathepsin K+
December 11, 2024 at 11:38 AM
#slidearchiveseries eosinophilic solid and cystic renal cell carcinoma #gupath #pathsky #pathoutpic
🔬 solid and cystic architecture, basophilic intracytoplasmic stippling, and eosinophilic inclusions
🎨 PAX8+, frequently CK20+, usually CK7-/CD117-, majority Cathepsin K+
🔬 solid and cystic architecture, basophilic intracytoplasmic stippling, and eosinophilic inclusions
🎨 PAX8+, frequently CK20+, usually CK7-/CD117-, majority Cathepsin K+
#slidearchiveseries chromophobe renal cell carcinoma #gupath #pathsky #pathoutpic
✅ solid sheet-like architecture
✅ plant-like cell borders (vegetable cells)
✅ irregular, wrinkled nuclei (raisinoid)
✅ binucleation and perinuclear halos
🎨 CK7, CD117, Hale colloidal iron
✅ solid sheet-like architecture
✅ plant-like cell borders (vegetable cells)
✅ irregular, wrinkled nuclei (raisinoid)
✅ binucleation and perinuclear halos
🎨 CK7, CD117, Hale colloidal iron
June 7, 2025 at 2:52 PM
#slidearchiveseries chromophobe renal cell carcinoma #gupath #pathsky #pathoutpic
✅ solid sheet-like architecture
✅ plant-like cell borders (vegetable cells)
✅ irregular, wrinkled nuclei (raisinoid)
✅ binucleation and perinuclear halos
🎨 CK7, CD117, Hale colloidal iron
✅ solid sheet-like architecture
✅ plant-like cell borders (vegetable cells)
✅ irregular, wrinkled nuclei (raisinoid)
✅ binucleation and perinuclear halos
🎨 CK7, CD117, Hale colloidal iron
My big fear about AI is the incorrect information. It's nearly impossible to tell in an AI chat whether it is hallucinating something or saying something factual. I had a chat with google awhile back, when I was curious what it knew about thymic SCC. g.co/gemini/share...
Gemini - CD117 Expression in Squamous Cell Carcinoma
Created with Gemini
g.co
November 19, 2024 at 1:31 PM
My big fear about AI is the incorrect information. It's nearly impossible to tell in an AI chat whether it is hallucinating something or saying something factual. I had a chat with google awhile back, when I was curious what it knew about thymic SCC. g.co/gemini/share...
RRIDs were included in this in Cancer Research Communications paper. Thanks for making your methods matter! #BetterScience #methodsmatter #ReproducibleResearch
Enhancement of CD117-targeted bispecific T-cell engagement by CD33-targeted bispecific T-cell co-stimulation in acute myeloid leukemia
Read the full paper: Enhancement of CD117-targeted bispecific T-cell engagement by CD33-targeted bispecific T-cell co-stimulation in acute myeloid leukemia
doi.org
April 30, 2026 at 7:01 AM
RRIDs were included in this in Cancer Research Communications paper. Thanks for making your methods matter! #BetterScience #methodsmatter #ReproducibleResearch
RRIDs were included in this in Immuno-Oncology and Technology paper. RRIDs improve reproducibility in scientific research. #BetterScience #OpenScience #STMpublishing
Transient mRNA-Based CD117 CAR T cells effectively target acute myeloid leukemia in vitro for potential use as a preconditioning strategy
Read the full paper: Transient mRNA-Based CD117 CAR T cells effectively target acute myeloid leukemia in vitro for potential use as a preconditioning strategy
doi.org
February 11, 2026 at 8:01 AM
RRIDs were included in this in Immuno-Oncology and Technology paper. RRIDs improve reproducibility in scientific research. #BetterScience #OpenScience #STMpublishing
Reference 2:
Angirekula M et al. CD117, BAP1, MTAP, and TdT Is a Useful Immunohistochemical Panel to Distinguish Thymoma from Thymic Carcinoma. Cancers (Basel). 2022;14(9):2299.
Angirekula M et al. CD117, BAP1, MTAP, and TdT Is a Useful Immunohistochemical Panel to Distinguish Thymoma from Thymic Carcinoma. Cancers (Basel). 2022;14(9):2299.
September 4, 2025 at 10:20 PM
Reference 2:
Angirekula M et al. CD117, BAP1, MTAP, and TdT Is a Useful Immunohistochemical Panel to Distinguish Thymoma from Thymic Carcinoma. Cancers (Basel). 2022;14(9):2299.
Angirekula M et al. CD117, BAP1, MTAP, and TdT Is a Useful Immunohistochemical Panel to Distinguish Thymoma from Thymic Carcinoma. Cancers (Basel). 2022;14(9):2299.
Make sure you are testing for UBTF-TDs in paed MDS/AML (and adult MDS/AML!).
Morphological/immunophenotypic clues = dysplasia in paed AML, CD34/CD117 dim
Molecular clues = FLT3mut/WT1mut
Menin inhibition as potential therapeutic modality.
#hemesky #hemepath
journals.lww.com/ajsp/fulltex...
Morphological/immunophenotypic clues = dysplasia in paed AML, CD34/CD117 dim
Molecular clues = FLT3mut/WT1mut
Menin inhibition as potential therapeutic modality.
#hemesky #hemepath
journals.lww.com/ajsp/fulltex...
Pediatric Myeloid Neoplasms With UBTF Tandem Duplications:... : The American Journal of Surgical Pathology
e of AML. To further our understanding of myeloid neoplasms with UBTF-TD, we analyzed clinical, morphologic, and immunophenotypic characteristics of 27 pediatric patients with UBTF-TD-positive myeloid...
journals.lww.com
January 8, 2025 at 3:19 AM
Make sure you are testing for UBTF-TDs in paed MDS/AML (and adult MDS/AML!).
Morphological/immunophenotypic clues = dysplasia in paed AML, CD34/CD117 dim
Molecular clues = FLT3mut/WT1mut
Menin inhibition as potential therapeutic modality.
#hemesky #hemepath
journals.lww.com/ajsp/fulltex...
Morphological/immunophenotypic clues = dysplasia in paed AML, CD34/CD117 dim
Molecular clues = FLT3mut/WT1mut
Menin inhibition as potential therapeutic modality.
#hemesky #hemepath
journals.lww.com/ajsp/fulltex...
If you’re new to mast cell disorders: CD117 evaluates how many mast cells are clumped per power field, so clinicians evaluate for abnormally high number of mast cells
CD25 can evaluate phenotype expressions of abnormal mast cells www.nature.com/articles/mod...
#MCAS #Mastocytosis #HaT
CD25 can evaluate phenotype expressions of abnormal mast cells www.nature.com/articles/mod...
#MCAS #Mastocytosis #HaT
Immunophenotyping in systemic mastocytosis diagnosis: ‘CD25 positive’ alone is more informative than the ‘CD25 and/or CD2’ WHO criterion - Modern Pathology
Modern Pathology - Immunophenotyping in systemic mastocytosis diagnosis: ‘CD25 positive’ alone is more informative than the ‘CD25 and/or CD2’ WHO criterion
www.nature.com
June 25, 2026 at 5:51 AM
If you’re new to mast cell disorders: CD117 evaluates how many mast cells are clumped per power field, so clinicians evaluate for abnormally high number of mast cells
CD25 can evaluate phenotype expressions of abnormal mast cells www.nature.com/articles/mod...
#MCAS #Mastocytosis #HaT
CD25 can evaluate phenotype expressions of abnormal mast cells www.nature.com/articles/mod...
#MCAS #Mastocytosis #HaT
Good afternoon!
Today's article explains that noncanonical β-catenin interactions promote leukemia-initiating activity in early T-ALL our.
tinyurl.com/2hh7u2xt
Today's article explains that noncanonical β-catenin interactions promote leukemia-initiating activity in early T-ALL our.
tinyurl.com/2hh7u2xt
January 9, 2024 at 1:10 PM
Good afternoon!
Today's article explains that noncanonical β-catenin interactions promote leukemia-initiating activity in early T-ALL our.
tinyurl.com/2hh7u2xt
Today's article explains that noncanonical β-catenin interactions promote leukemia-initiating activity in early T-ALL our.
tinyurl.com/2hh7u2xt
...aggregates. Dystrophic and/or psammomatous calcifications are usually detected. The lesional cells can express CD34 and rarely SMA, whereas KIT (CD117), DOG1, desmin, STAT6, β-catenin, and ALK are negative.
August 4, 2025 at 9:45 PM
...aggregates. Dystrophic and/or psammomatous calcifications are usually detected. The lesional cells can express CD34 and rarely SMA, whereas KIT (CD117), DOG1, desmin, STAT6, β-catenin, and ALK are negative.
(2/4)
📌 Tests are helpful—but not reliable.
#MCAS is a clinical diagnosis.
🔬Labs often miss it due to mishandling or timing.
📉 Normal results ≠ no MCAS.
Blood or tissue markers (histamine, chromogranin A, CD117) can confirm but not exclude. 💡
📌 Tests are helpful—but not reliable.
#MCAS is a clinical diagnosis.
🔬Labs often miss it due to mishandling or timing.
📉 Normal results ≠ no MCAS.
Blood or tissue markers (histamine, chromogranin A, CD117) can confirm but not exclude. 💡
April 14, 2025 at 5:06 PM
(2/4)
📌 Tests are helpful—but not reliable.
#MCAS is a clinical diagnosis.
🔬Labs often miss it due to mishandling or timing.
📉 Normal results ≠ no MCAS.
Blood or tissue markers (histamine, chromogranin A, CD117) can confirm but not exclude. 💡
📌 Tests are helpful—but not reliable.
#MCAS is a clinical diagnosis.
🔬Labs often miss it due to mishandling or timing.
📉 Normal results ≠ no MCAS.
Blood or tissue markers (histamine, chromogranin A, CD117) can confirm but not exclude. 💡
A preprint using: CD117 (RRID:AB_10563203) from #BD was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #STMpublishing
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #STMpublishing
Structural Identification of Major Molecular Determinants for Phosphotyrosine Recognition in Tyrosine Kinases Reveals Tumour Promoting and Suppressive Functions
www.biorxiv.org
June 13, 2025 at 12:00 PM
A preprint using: CD117 (RRID:AB_10563203) from #BD was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #STMpublishing
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #STMpublishing
A nicely concise paper on antibody-linked lipid nanoparticles which target hematopoietic stem and progenitor cells in vivo, important yet tricky cell types to transduce for hematological gene therapy.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid Nanoparticles
Ex vivo autologous hematopoietic stem cell (HSC) gene therapy has provided new therapies for the treatment of hematological disorders. However, these therapies have several limitations owing to the manufacturing complexities and toxicity resulting from required conditioning regimens. Here, we developed a c-kit (CD117) antibody-targeted lipid nanoparticle (LNP) that, following a single intravenous injection, can deliver RNA (both siRNA and mRNA) to HSCs in vivo in rodents. This targeted delivery system does not require stem cell harvest, culture, or mobilization of HSCs to facilitate delivery. We also show that delivery of Cre recombinase mRNA at a dose of 1 mg kg–1 can facilitate gene editing to almost all (∼90%) hematopoietic stem and progenitor cells (HSPCs) in vivo, and edited cells retain their stemness and functionality to generate high levels of edited mature immune cells.
pubs.acs.org
May 8, 2026 at 6:53 PM
A nicely concise paper on antibody-linked lipid nanoparticles which target hematopoietic stem and progenitor cells in vivo, important yet tricky cell types to transduce for hematological gene therapy.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
＜（ドクター用）GIST ❶＞
GISTは消化管の最も一般的な間葉系腫瘍であり､ カハール介在細胞に由来すると考えられている。
形態学的特徴: 紡錘形細胞型または類上皮細胞型を呈する。
免疫組織化学的検査:KIT (CD117) 陽性が特徴的であり､ GISTの95%で陽性となる。DOG1 (Ano1) も診断に有用なマーカーである。
遺伝子変異解析: KIT遺伝子またはPDGFRA遺伝子の活性化変異が約85〜90%のGISTで認められる。これらの変異は治療薬の選択にも重要である
GISTは消化管の最も一般的な間葉系腫瘍であり､ カハール介在細胞に由来すると考えられている。
形態学的特徴: 紡錘形細胞型または類上皮細胞型を呈する。
免疫組織化学的検査:KIT (CD117) 陽性が特徴的であり､ GISTの95%で陽性となる。DOG1 (Ano1) も診断に有用なマーカーである。
遺伝子変異解析: KIT遺伝子またはPDGFRA遺伝子の活性化変異が約85〜90%のGISTで認められる。これらの変異は治療薬の選択にも重要である
June 29, 2026 at 7:08 AM
＜（ドクター用）GIST ❶＞
GISTは消化管の最も一般的な間葉系腫瘍であり､ カハール介在細胞に由来すると考えられている。
形態学的特徴: 紡錘形細胞型または類上皮細胞型を呈する。
免疫組織化学的検査:KIT (CD117) 陽性が特徴的であり､ GISTの95%で陽性となる。DOG1 (Ano1) も診断に有用なマーカーである。
遺伝子変異解析: KIT遺伝子またはPDGFRA遺伝子の活性化変異が約85〜90%のGISTで認められる。これらの変異は治療薬の選択にも重要である
GISTは消化管の最も一般的な間葉系腫瘍であり､ カハール介在細胞に由来すると考えられている。
形態学的特徴: 紡錘形細胞型または類上皮細胞型を呈する。
免疫組織化学的検査:KIT (CD117) 陽性が特徴的であり､ GISTの95%で陽性となる。DOG1 (Ano1) も診断に有用なマーカーである。
遺伝子変異解析: KIT遺伝子またはPDGFRA遺伝子の活性化変異が約85〜90%のGISTで認められる。これらの変異は治療薬の選択にも重要である
A preprint using: CD117 (c-Kit) Monocl (RRID:AB_1582226) from @thermofishersci.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #STMpublishing
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #STMpublishing
www.biorxiv.org
September 3, 2026 at 12:00 PM
A preprint using: CD117 (c-Kit) Monocl (RRID:AB_1582226) from @thermofishersci.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #STMpublishing
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #STMpublishing