#CD8Tcells
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gmj-georgia.bsky.social
🔬 Researchers have identified how immune cells trigger kidney damage in lupus. A new study in Science Translational Medicine reveals that CD8+ T ce…

#Autoimmunedisease #CD8Tcells #Immunotherapy #Kidneyinflammation #Lupusnephritis

#Autoimmunedisease #CD8Tcells #Immunotherapy #Kidneyinflammation …
How Immune Cells Trigger Lupus Kidney Damage
🔬 Researchers have identified how immune cells trigger kidney damage in lupus. A new study in Science Translational Medicine reveals that CD8+ T ce… #Autoimmunedisease #CD8Tcells #Immunotherapy #Kidneyinflammation #Lupusnephritis
news.gmj.ge
September 25, 2026 at 3:26 AM
lindavsinclair.bsky.social
New pre-print out from
Rusty Jones’ team:
Dietary restriction enhances CD8+T cell metabolic fitness via increased ketolysis ->boosts mitochondrial membrane potential ->fuels TCA cycle-dependent pathways —>more effective CD8 effectors in TME
#immunosky #immunometabolism #CD8Tcells
#cancermetabolism
November 16, 2024 at 7:58 AM
zania-stamataki.bsky.social
Cancer as a city with different neighbourhoods: #spatial profiling helps us identify the cells as apartments, and look inside for their activities -Great talk by @bottomleymatt.bsky.social from @uniofoxford.bsky.social
#BSIWinterSchool24
@britsocimm.bsky.social
#CD8Tcells #senescence #ImmunoSky
December 3, 2024 at 12:00 PM
pozniakjoanna.bsky.social
🆕 Our back-to-back papers reveal a surprising villain in ICB resistance: NK cells.

🧬 Targeting regulatory NK cells may boost T cell–driven immunotherapy.

#Immunotherapy #CancerResearch #ICB #NKcells #Melanoma #CD8Tcells
Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype
AbstractImmune checkpoint blockade (ICB) has revolutionized cancer treatment. Unfortunately, the inability of lymphocytes to infiltrate the tumor nest, a phenomenon known as immune exclusion, drastica...
aacrjournals.org
June 18, 2025 at 1:36 PM
imtadvances.bsky.social
Tracking CD8+ T cells in tumours is key for immunotherapy research. Our new study compares nuclear imaging methods to see which best reflects T cell infiltration.

🔗 Open access: https://bit.ly/4ncWCzv

#Immunotherapy #CD8TCells #CancerResearch
October 17, 2025 at 10:23 AM
imtadvances.bsky.social
🔬 First head-to-head comparison of nuclear imaging for tumour CD8⁺ T cells shows [⁸⁹Zr]Zr-anti-CD8-IgG2a(silent) & [⁸⁹Zr]Zr-OT-I track T-cell infiltration & migration, aiding immunotherapy strategies.

👉 https://bit.ly/4ncWCzv
##Immunotherapy #CD8Tcells #CancerResearch
November 6, 2025 at 10:40 AM
amjtransplant.bsky.social
In our July issue: "Identification of a Highly Functional Effector CD8+ T Cell Program after Transplantation in Mice and Humans," by Leathem et al
doi.org/10.1016/j.aj...
#Transplantation #TransplantResearch #CD8TCells #TCells #Immunology
Figure 1 CD43 1B11 agonism of CD8+ T cells can overcome subthreshold antigen and costimulation signals.
July 20, 2026 at 9:00 PM
castltrastondrs.medsky.network
People infected with #SarsCoV2 🦠 that cleared the virus more quickly if they had high levels of #cd8tcells and mucosal IgA. This suggests that #COVID19vaccines that optimally induce these responses may help reduce transmission.

www.science.org/doi/pdf/10.1...
Abstract Abstract
February 15, 2024 at 7:21 AM
alicefrolov.bsky.social
Sharing a new data visualization exploring the phenotypic reprogramming of exhausted CD8+ T cells following PD-1 axis blockade.

#TcellExhaustion #CheckpointBlockade #TumorImmunology #CD8Tcells #AntiPD1 #Tpex #ImmuneCheckpoint #CancerImmunotherapy
Sharing a new data visualization exploring the phenotypic reprogramming of exhausted CD8+ T cells following PD-1 axis blockade. Figure: "Reprogramming exhausted CD8+ T cells with anti-PD-1 therapy" Subtitle: "Marker-defined transitions from terminal exhaustion toward progenitor/effector states after checkpoint blockade" The visualization employs a faceted marginal-distribution slope arrow design, functioning as a state-transition flow map. Each facet corresponds to a defined exhaustion-associated marker axis (TCF1, TOX, TIM-3, PD-1, GZMB, and Ki-67), with paired marginal distributions rendered pre- and post-treatment. Slope arrows connect the density centroids across conditions, encoding both the directionality and relative magnitude of population-level marker shifts. This approach was chosen to make explicit the differential mobilization of progenitor-exhausted (Tpex) versus terminally exhausted (Tex_term) subsets rather than collapsing the transition into a single trajectory summary. The simulated data are calibrated to reproduce trends consistent with the current literature. Under anti-PD-1, the TCF1+ TOX-intermediate progenitor compartment shows expansion accompanied by upward slope vectors in Ki-67 and GZMB, consistent with proliferative burst and reacquisition of effector potential. Concurrently, the TIM-3-high, TCF1-negative terminally differentiated fraction contracts, and its centroid displays limited displacement along the TCF1 axis, reflecting the constrained plasticity of terminally exhausted cells. This asymmetry underscores that checkpoint blockade preferentially acts on the Tpex reservoir rather than fully reverting terminal exhaustion, a distinction with direct implications for durability of response.
September 12, 2026 at 5:18 PM
paulinastrzyz.bsky.social
New in Advanced Science: Apoptotic vesicles from mesenchymal stem cells selectively induce CD8⁺ T cell apoptosis via calcium overload—offering a novel strategy to treat type IV hypersensitivity
#Immunotherapy #ExtracellularVesicles #Nanomedicine #CD8Tcells #Hypersensitivity
🔗 doi.org/10.1002/advs...
Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction
The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED-ApoVs) in the treatment of CD8+ T cell-mediated hypersensitivity reactions is noteworthy. SHED-A...
doi.org
June 19, 2025 at 10:10 AM
alicefrolov.bsky.social
Sharing a visualization from a conceptual synthesis of the CD8+ T cell terminal exhaustion (Tex) program in tumor-infiltrating lymphocytes.

Figure: "Transcriptional and Epigenetic Architecture of CD8+ T Cell Exhaustion"

#TcellExhaustion #TumorImmunology #CD8Tcells #Epigenetics
Sharing a visualization from a conceptual synthesis of the CD8+ T cell terminal exhaustion (Tex) program in tumor-infiltrating lymphocytes. Figure: "Transcriptional and Epigenetic Architecture of CD8+ T Cell Exhaustion" Subtitle: "Relative feature intensity across the terminal exhaustion (Tex) program in tumor-infiltrating lymphocytes" The figure employs a radar bar-style plot in which each radial axis corresponds to a defining molecular feature of the terminal exhaustion state, with bar length encoding relative feature intensity on a normalized scale. Axes span the canonical inhibitory receptor module (PDCD1, HAVCR2, LAG3, TIGIT, CTLA4), the exhaustion-defining transcription factor TOX and its cofactor NR4A family members, alongside the progenitor-associated factor TCF7, which is depicted at low relative intensity to reflect the loss of stem-like potential upon terminal differentiation. Additional axes capture chromatin-level features, including the acquisition of exhaustion-specific accessible regulatory elements, EZH2-associated repressive marks at effector loci, and diminished accessibility at TCF7-dependent enhancers. Effector cytokine capacity (IFNG, TNF, IL2) and proliferative indices are rendered as attenuated, consistent with the hypofunctional terminal phenotype. The intent is to juxtapose transcriptional and epigenetic determinants within a single coordinate system, emphasizing that TOX-driven epigenetic commitment enforces a stable, largely irreversible chromatin landscape that constrains the response to checkpoint blockade. I want to state explicitly that the data plotted are simulated. The values do not derive from a specific experimental dataset; rather, they are constructed to illustrate a literature-grounded qualitative trend consistent with published single-cell RNA-seq and ATAC-seq characterizations of Tex populations. The figure is intended as a didactic and conceptual scaffold, not as primary evidence.
August 1, 2026 at 5:00 PM
amjtransplant.bsky.social
In our July issue, "Inhibition of T cell polyamine metabolism promotes transplant acceptance by modulating cytotoxic CD8+ T cell differentiation," by Tang et al
www.amjtransplant.org/article/S160...
#TransplantImmunology #TransplantResearch #HeartTransplantation #CD8TCells #TransplantTolerance
Figure 2 Inhibition of T cell polyamine metabolism promotes transplant acceptance.
July 31, 2026 at 7:30 PM
msklibrary.bsky.social
Synapse: Your Connection to our MSK Authors
Meet: Anna Mary Varghese @AnnaVarghese4

Research Focus: Medicine; Associate Attending

synapse.mskcc.org/synapse/work...

#PancreaticCancer #Immunotherapy #CancerVaccine #Neoantigen #RNAVaccine #CD8TCells #CancerResearch #BreakthroughScience
July 8, 2025 at 7:06 PM
friclab.bsky.social
Celebrating great success of #AcademiaICRC student!! @klara_mensikova won🥈with talk on #CD8Tcells & #immunosenescence in the Theoretical and preclinical research section at 66th Student Scientific Conference @Science_MEDMUNI ! Project led by @LaznickovaPetra @FricLab @FNUSA_ICRC
February 4, 2025 at 8:35 PM
arxivlens.bsky.social
Metabolomic profiling reveals the potential of fatty acids as regulators of exhausted CD8 T cells during chronic viral infection.
Dorrestein, Pieter C et al.
Paper
Details
#Metabolomics #CD8TCells #ChronicInfection
January 6, 2026 at 9:00 AM
arxivlens.bsky.social
Modulating CD8⁺ T cell immunity through exercise: mechanistic insights and implications for precision immunotherapy.
Chen, Xu et al.
Paper
Details
#Immunotherapy #CD8Tcells #ExerciseScience
January 1, 2026 at 9:01 AM
mheming.bsky.social
5/16
Age primarily affected #Tcells in #CSF and blood, which became activated with age. Interestingly, #CD8Tcells increased in #CSF with age but decreased in blood, suggesting that age-related changes are partially compartment-specific.
December 12, 2024 at 9:33 PM
obalsiger.bsky.social
This is an interesting study looking at different nuclear imaging methods to determine which best reflects T cell infiltration

@imtadvances.bsky.social
#immunotherspy #CD8TCells
imtadvances.bsky.social Immunotherapy Advances @imtadvances.bsky.social · Oct 17
Tracking CD8+ T cells in tumours is key for immunotherapy research. Our new study compares nuclear imaging methods to see which best reflects T cell infiltration.

🔗 Open access: https://bit.ly/4ncWCzv

#Immunotherapy #CD8TCells #CancerResearch
October 17, 2025 at 1:00 PM