AT2 cell–derived GM-CSF is essential for establishing a terminally differentiated CD301b+ lung cDC2 compartment and type 2 immunity @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
GM-CSF derived from alveolar type 2 cells promotes CD301b+ cDC2 generation and allergic airway inflammation
AT2 cell–derived GM-CSF is essential for establishing a terminally differentiated CD301b+ lung cDC2 compartment and type 2 immunity.
www.science.org
August 8, 2025 at 6:18 PM
AT2 cell–derived GM-CSF is essential for establishing a terminally differentiated CD301b+ lung cDC2 compartment and type 2 immunity @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Our paper made the cover of Nature Immunology’s September issue! 🎉
Aren’t dendritic cells beautiful? 😍
SEM shows pDCs as they switch identity into cDC2-like cells.
Congrats to the whole team! 👏
🔗 www.nature.com/ni/volumes/2...
Aren’t dendritic cells beautiful? 😍
SEM shows pDCs as they switch identity into cDC2-like cells.
Congrats to the whole team! 👏
🔗 www.nature.com/ni/volumes/2...
September 2, 2025 at 3:54 PM
Our paper made the cover of Nature Immunology’s September issue! 🎉
Aren’t dendritic cells beautiful? 😍
SEM shows pDCs as they switch identity into cDC2-like cells.
Congrats to the whole team! 👏
🔗 www.nature.com/ni/volumes/2...
Aren’t dendritic cells beautiful? 😍
SEM shows pDCs as they switch identity into cDC2-like cells.
Congrats to the whole team! 👏
🔗 www.nature.com/ni/volumes/2...
AT2 cell–derived GM-CSF is essential for establishing a terminally differentiated CD301b+ lung cDC2 compartment and type 2 immunity
@sciimmunology.bsky.social
@chschneider.bsky.social
www.science.org/doi/epdf/10....
@sciimmunology.bsky.social
@chschneider.bsky.social
www.science.org/doi/epdf/10....
August 9, 2025 at 3:15 AM
AT2 cell–derived GM-CSF is essential for establishing a terminally differentiated CD301b+ lung cDC2 compartment and type 2 immunity
@sciimmunology.bsky.social
@chschneider.bsky.social
www.science.org/doi/epdf/10....
@sciimmunology.bsky.social
@chschneider.bsky.social
www.science.org/doi/epdf/10....
How I managed to live my life and not see this absolutely epic piece of internet culture that illustrates audio of LBJ ordering pants is beyond me. There are still tears in my eyes from this.
www.youtube.com/watch?v=nR_m...
www.youtube.com/watch?v=nR_m...
LBJ Orders Pants
YouTube video by pthiso
www.youtube.com
July 3, 2025 at 4:37 AM
Plasmacytoid dendritic cells can transition to become cDC2s under to influence of TNF, while type-I interferon reduces TNFR expression and thereby inhibits transition. These transitioned cDC2 seem fully functional. 🧪 ⑂
Hornero et al 2025 in Nat Immunol
www.nature.com/articles/s41...
Hornero et al 2025 in Nat Immunol
www.nature.com/articles/s41...
September 11, 2025 at 2:51 AM
Plasmacytoid dendritic cells can transition to become cDC2s under to influence of TNF, while type-I interferon reduces TNFR expression and thereby inhibits transition. These transitioned cDC2 seem fully functional. 🧪 ⑂
Hornero et al 2025 in Nat Immunol
www.nature.com/articles/s41...
Hornero et al 2025 in Nat Immunol
www.nature.com/articles/s41...
Nature research paper: mRNA vaccines engage unconventional pathways in CD8+ T cell priming
go.nature.com/4cdaw2n
go.nature.com/4cdaw2n
mRNA vaccines engage unconventional pathways in CD8+ T cell priming - Nature
mRNA–lipid-nanoparticle vaccines do not require type 1 conventional dendritic (cDC1) cells or the WDFY4-dependent cross-presentation pathway for CD8+ T cell priming but, instead, engage both cDC1 and cDC2 cells redundantly.
go.nature.com
April 17, 2026 at 8:11 AM
Nature research paper: mRNA vaccines engage unconventional pathways in CD8+ T cell priming
go.nature.com/4cdaw2n
go.nature.com/4cdaw2n
It’s been a great week for the GommerLab. Today I am proud of Dr. Albert Nguyen who as a student then a postdoc saw this work to the finish line. Also grateful to Dr. Chrys Brown (MSKCC) - Working together we learned new things about cDC2 biology. Yay team science!
Sequential lymphotoxin-β receptor and retinoic acid receptor signals regulate cDC2 fate - Nature Immunology
Nguyen et al. show that the splenic environment provides sequential signals via lymphotoxin and retinoic acid that guide cDC2A development and retention.
www.nature.com
November 21, 2025 at 1:15 PM
It’s been a great week for the GommerLab. Today I am proud of Dr. Albert Nguyen who as a student then a postdoc saw this work to the finish line. Also grateful to Dr. Chrys Brown (MSKCC) - Working together we learned new things about cDC2 biology. Yay team science!
Suin Jo, Kenneth Murphy et al. @washumedicine.bsky.social utilize several genetic models to distinguish roles of cDC1 and cDC2 in presentation of different forms of antigens to CD4⁺ and CD8⁺ T cells in vivo. https://buff.ly/42LUFDr
February 7, 2025 at 5:16 PM
Suin Jo, Kenneth Murphy et al. @washumedicine.bsky.social utilize several genetic models to distinguish roles of cDC1 and cDC2 in presentation of different forms of antigens to CD4⁺ and CD8⁺ T cells in vivo. https://buff.ly/42LUFDr
WeekendRead! @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social &co show @science.org that cDC1s & Rorgt APCs drive peripheral Tregs to dietary antigens, & that helminth infections increase the ratio of inflammatory cDC2 preventing tolerance induction!
Identification of antigen-presenting cell–T cell interactions driving immune responses to food
The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal ant...
www.science.org
December 21, 2024 at 3:52 PM
WeekendRead! @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social &co show @science.org that cDC1s & Rorgt APCs drive peripheral Tregs to dietary antigens, & that helminth infections increase the ratio of inflammatory cDC2 preventing tolerance induction!
@biorxiv-immuno.bsky.social Identification of distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation
www.biorxiv.org/content/10.1...
@ucberkeleyofficial.bsky.social
www.biorxiv.org/content/10.1...
@ucberkeleyofficial.bsky.social
November 6, 2025 at 2:42 AM
@biorxiv-immuno.bsky.social Identification of distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation
www.biorxiv.org/content/10.1...
@ucberkeleyofficial.bsky.social
www.biorxiv.org/content/10.1...
@ucberkeleyofficial.bsky.social
Combining an innate immune agonist and immune checkpoint blockade effectively treats pancreatic tumors in mouse models via cDC2-primed IFNγ-expressing CD4+ T cells
@cp-cancercell.bsky.social @harvardmed.bsky.social
www.cell.com/cancer-cell/...
@cp-cancercell.bsky.social @harvardmed.bsky.social
www.cell.com/cancer-cell/...
May 7, 2026 at 11:12 PM
Combining an innate immune agonist and immune checkpoint blockade effectively treats pancreatic tumors in mouse models via cDC2-primed IFNγ-expressing CD4+ T cells
@cp-cancercell.bsky.social @harvardmed.bsky.social
www.cell.com/cancer-cell/...
@cp-cancercell.bsky.social @harvardmed.bsky.social
www.cell.com/cancer-cell/...
IL-13 signaling in cDC2 is required for systemic anaphylactic responses
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
July 15, 2026 at 7:50 PM
IL-13 signaling in cDC2 is required for systemic anaphylactic responses
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Check out what's coming in April, Live! at the Library!
✅ Concerts
✅ Poetry
✅ Dance
✅ Fun
✅ Free!
https://newsroom.loc.gov/news/music-and-poetry-take-the-stage-during-live--at-the-library-this-april/s/c34a4d95-cdc2-4db5-b8cd-07eb5672324b?loclr=blsky
✅ Concerts
✅ Poetry
✅ Dance
✅ Fun
✅ Free!
https://newsroom.loc.gov/news/music-and-poetry-take-the-stage-during-live--at-the-library-this-april/s/c34a4d95-cdc2-4db5-b8cd-07eb5672324b?loclr=blsky
March 31, 2026 at 4:19 PM
Check out what's coming in April, Live! at the Library!
✅ Concerts
✅ Poetry
✅ Dance
✅ Fun
✅ Free!
https://newsroom.loc.gov/news/music-and-poetry-take-the-stage-during-live--at-the-library-this-april/s/c34a4d95-cdc2-4db5-b8cd-07eb5672324b?loclr=blsky
✅ Concerts
✅ Poetry
✅ Dance
✅ Fun
✅ Free!
https://newsroom.loc.gov/news/music-and-poetry-take-the-stage-during-live--at-the-library-this-april/s/c34a4d95-cdc2-4db5-b8cd-07eb5672324b?loclr=blsky
Thanks to @idoyagalab.bsky.social for supporting my postdoctoral work and making this paper possible. Super excited to show how pDCs regulate their antigen presentation function switching to cDC2!
🚨 Our latest paper is out in @natimmunol.nature.com ! 🧵
Plasmacytoid dendritic cells (pDCs) — the immune system’s IFN-I powerhouses — can change their identity!
Congrats to @rebecaarroyo.bsky.social, our team & collaborators 👏👏
🔗 www.nature.com/articles/s41...
Plasmacytoid dendritic cells (pDCs) — the immune system’s IFN-I powerhouses — can change their identity!
Congrats to @rebecaarroyo.bsky.social, our team & collaborators 👏👏
🔗 www.nature.com/articles/s41...
TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells - Nature Immunology
Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells. Here the authors show how...
www.nature.com
August 16, 2025 at 1:42 AM
Thanks to @idoyagalab.bsky.social for supporting my postdoctoral work and making this paper possible. Super excited to show how pDCs regulate their antigen presentation function switching to cDC2!
mRNA cancer vaccines have a hidden immune backup. In mice, they eliminated sarcoma tumors even without immune cells (cDC1) thought essential. Another type (cDC2) stepped in, triggering strong anti-tumor responses. This could lead to more effective cancer therapies.
A hidden immune backup system could supercharge mRNA cancer vaccines
Researchers have discovered an unexpected mechanism by which mRNA cancer vaccines activate the immune system. In studies with mice, they found that even when a traditionally essential immune cell (cDC
www.sciencedaily.com
July 11, 2026 at 8:04 AM
mRNA cancer vaccines have a hidden immune backup. In mice, they eliminated sarcoma tumors even without immune cells (cDC1) thought essential. Another type (cDC2) stepped in, triggering strong anti-tumor responses. This could lead to more effective cancer therapies.
WDFY4-dependent cross-presentation of immune complexes by cDC1 and cDC2 @jem.org
doi.org/10.1084/jem....
doi.org/10.1084/jem....
February 8, 2025 at 4:30 AM
WDFY4-dependent cross-presentation of immune complexes by cDC1 and cDC2 @jem.org
doi.org/10.1084/jem....
doi.org/10.1084/jem....
Delighted to see our study on #DendriticCell control of #fungal #allergic airway #inflammation finally out in the wild! Spearheaded by @drpetercook.bsky.social, with so many fantastic collaborators - thanks to all! #ImmunoSky 🧪
rdcu.be/d68MU @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social
rdcu.be/d68MU @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social
Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in mice
Nature Communications - Fungal spores can promote immune responses of both type 2 (IL-4 / IL-5 / IL-13) and type 17 (IL-17). Here the authors characterise the subsets of cDC2 associated with type 2...
rdcu.be
January 22, 2025 at 2:21 PM
Delighted to see our study on #DendriticCell control of #fungal #allergic airway #inflammation finally out in the wild! Spearheaded by @drpetercook.bsky.social, with so many fantastic collaborators - thanks to all! #ImmunoSky 🧪
rdcu.be/d68MU @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social
rdcu.be/d68MU @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social
From the archives: the original 1989 artwork for Figure 3 in PMID:2674650 pubmed.ncbi.nlm.nih.gov/2674650/ #pombe #fissionyeast #cellcycle #cdc2
November 22, 2024 at 2:44 PM
From the archives: the original 1989 artwork for Figure 3 in PMID:2674650 pubmed.ncbi.nlm.nih.gov/2674650/ #pombe #fissionyeast #cellcycle #cdc2
Excited to share our lab’s latest paper! Building on her earlier work on AM, Julia used genetic tools and cool 3D thick-section imaging to explore lung GM-CSF biology. She discovered a distinctly localized CD301b⁺(MGL2) cDC2 subset that depends on GM-CSF from AT2 www.science.org/doi/10.1126/...
GM-CSF derived from alveolar type 2 cells promotes CD301b+ cDC2 generation and allergic airway inflammation
AT2 cell–derived GM-CSF is essential for establishing a terminally differentiated CD301b+ lung cDC2 compartment and type 2 immunity.
www.science.org
August 19, 2025 at 8:07 AM
Excited to share our lab’s latest paper! Building on her earlier work on AM, Julia used genetic tools and cool 3D thick-section imaging to explore lung GM-CSF biology. She discovered a distinctly localized CD301b⁺(MGL2) cDC2 subset that depends on GM-CSF from AT2 www.science.org/doi/10.1126/...
Preprint: Sequential Lymphotoxin Beta Receptor and Retinoic Acid Receptor signals regulate cDC2 fates
www.researchsquare.com/article/rs-4... @uoftpress.bsky.social @jengommerman.bsky.social
www.researchsquare.com/article/rs-4... @uoftpress.bsky.social @jengommerman.bsky.social
October 17, 2025 at 1:23 AM
Preprint: Sequential Lymphotoxin Beta Receptor and Retinoic Acid Receptor signals regulate cDC2 fates
www.researchsquare.com/article/rs-4... @uoftpress.bsky.social @jengommerman.bsky.social
www.researchsquare.com/article/rs-4... @uoftpress.bsky.social @jengommerman.bsky.social
Jo et al. distinguish roles of cDC1 & cDC2 in presentation of different forms of antigens to CD4⁺ & CD8⁺ T cells in vivo & reveal a common WDFY4-dependent cross-presentation pathway shared by cDC subsets rupress.org/jem/article/...
📘 In JEM #Immunology Collection rupress.org/jem/collecti...
📘 In JEM #Immunology Collection rupress.org/jem/collecti...
May 4, 2025 at 10:15 PM
Jo et al. distinguish roles of cDC1 & cDC2 in presentation of different forms of antigens to CD4⁺ & CD8⁺ T cells in vivo & reveal a common WDFY4-dependent cross-presentation pathway shared by cDC subsets rupress.org/jem/article/...
📘 In JEM #Immunology Collection rupress.org/jem/collecti...
📘 In JEM #Immunology Collection rupress.org/jem/collecti...
Shared pathway of WDFY4-dependent cross-presentation of immune complexes by cDC1 and cDC2. New study from Suin Jo, Kenneth Murphy and colleagues @washumedicine.bsky.social: https://buff.ly/42LUFDr
#TumorImmunology #DendriticCells
#TumorImmunology #DendriticCells
February 14, 2025 at 3:47 PM
Shared pathway of WDFY4-dependent cross-presentation of immune complexes by cDC1 and cDC2. New study from Suin Jo, Kenneth Murphy and colleagues @washumedicine.bsky.social: https://buff.ly/42LUFDr
#TumorImmunology #DendriticCells
#TumorImmunology #DendriticCells