The remarkably long lifespan of bowhead whales could be due to an increased ability to repair DNA mutations, according to research in Nature. go.nature.com/4hzvDN7 🌏 🧪
November 4, 2025 at 2:10 AM
The remarkably long lifespan of bowhead whales could be due to an increased ability to repair DNA mutations, according to research in Nature. go.nature.com/4hzvDN7 🌏 🧪
The remarkably long lifespan of bowhead whales could be due to an increased ability to repair DNA mutations, according to research in Nature. go.nature.com/4hzvDN7 🌏 🧪
October 29, 2025 at 10:08 PM
The remarkably long lifespan of bowhead whales could be due to an increased ability to repair DNA mutations, according to research in Nature. go.nature.com/4hzvDN7 🌏 🧪
Bowhead whales live over 200 years and resist diseases. Studies highlight the protein CIRBP, which improves DNA repair and may influence research on human aging.
DOI: 10.1016/j.celrep.2014.12.008
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DOI: 10.1016/j.celrep.2014.12.008
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May 3, 2026 at 4:24 AM
Bowhead whales live over 200 years and resist diseases. Studies highlight the protein CIRBP, which improves DNA repair and may influence research on human aging.
DOI: 10.1016/j.celrep.2014.12.008
🐳🐳🐳
DOI: 10.1016/j.celrep.2014.12.008
🐳🐳🐳
Bowhead whales live over 200 years and resist diseases. Studies highlight the protein CIRBP, which improves DNA repair and may influence research on human aging.
DOI: 10.1016/j.celrep.2014.12.008
DOI: 10.1016/j.celrep.2014.12.008
April 28, 2026 at 1:00 AM
Bowhead whales live over 200 years and resist diseases. Studies highlight the protein CIRBP, which improves DNA repair and may influence research on human aging.
DOI: 10.1016/j.celrep.2014.12.008
DOI: 10.1016/j.celrep.2014.12.008
Longevity protein.
"New research traces the answer to a protein called CIRBP. It plays a key role in repairing one of the most dangerous kinds of genetic damage, a double-strand break . . .
'That sort of damage can spark disease and shorten lives across many species, humans included."
"New research traces the answer to a protein called CIRBP. It plays a key role in repairing one of the most dangerous kinds of genetic damage, a double-strand break . . .
'That sort of damage can spark disease and shorten lives across many species, humans included."
Scientists find a remarkable molecule that could help humans live up to 200 years cancer free
One answer for how bowhead whales live to be 200 years old with no signs of cancer was recently identified as a protein called CIRBP.
www.earth.com
May 16, 2026 at 10:44 PM
Longevity protein.
"New research traces the answer to a protein called CIRBP. It plays a key role in repairing one of the most dangerous kinds of genetic damage, a double-strand break . . .
'That sort of damage can spark disease and shorten lives across many species, humans included."
"New research traces the answer to a protein called CIRBP. It plays a key role in repairing one of the most dangerous kinds of genetic damage, a double-strand break . . .
'That sort of damage can spark disease and shorten lives across many species, humans included."
🐋🧬 Firsanov, Zacher & Gorbunova et al. reveal why bowhead whales live 200+ years: enhanced DNA repair via CIRBP, no extra tumor suppressors! Whale cells have fewer mutations and CIRBP overexpression extended lifespan in Drosophila. 🪰 @nature.com
doi.org/10.1038/s415... 🧪
doi.org/10.1038/s415... 🧪
Evidence for improved DNA repair in the long-lived bowhead whale
Nature - Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.
doi.org
December 31, 2025 at 7:48 AM
🐋🧬 Firsanov, Zacher & Gorbunova et al. reveal why bowhead whales live 200+ years: enhanced DNA repair via CIRBP, no extra tumor suppressors! Whale cells have fewer mutations and CIRBP overexpression extended lifespan in Drosophila. 🪰 @nature.com
doi.org/10.1038/s415... 🧪
doi.org/10.1038/s415... 🧪
The strategy in humans is more focused on getting cells to self-destruct when damaged, while whales put emphasis on 'fixing up' their old cells, which may extend longevity more effectively.
In particular, the bowhead has a strong "Cold-inducible RNA-binding protein" (CIRBP) response.
In particular, the bowhead has a strong "Cold-inducible RNA-binding protein" (CIRBP) response.
November 24, 2025 at 2:27 PM
The strategy in humans is more focused on getting cells to self-destruct when damaged, while whales put emphasis on 'fixing up' their old cells, which may extend longevity more effectively.
In particular, the bowhead has a strong "Cold-inducible RNA-binding protein" (CIRBP) response.
In particular, the bowhead has a strong "Cold-inducible RNA-binding protein" (CIRBP) response.
Cold stresses & hypoxia actually induce this protein, which can repair damaged DNA & stabilize chromosomes.
There are other repair mechanisms that are advanced in these long-lived whales that simply weren't selected in humans during their evolution.
There are other repair mechanisms that are advanced in these long-lived whales that simply weren't selected in humans during their evolution.
Bowhead whales’ secret to long life may lie in a protein
University of Rochester scientists link the whales’ longevity to CIRBP, a DNA-repair protein that could one day help humans live longer.
www.rochester.edu
November 24, 2025 at 2:27 PM
Cold stresses & hypoxia actually induce this protein, which can repair damaged DNA & stabilize chromosomes.
There are other repair mechanisms that are advanced in these long-lived whales that simply weren't selected in humans during their evolution.
There are other repair mechanisms that are advanced in these long-lived whales that simply weren't selected in humans during their evolution.
Las ballenas boreales viven más de 200 años y resisten enfermedades. Estudios destacan la proteína CIRBP, que mejora la reparación del ADN y podría influir en investigaciones sobre envejecimiento humano.
DOI: 10.1016/j.celrep.2014.12.008
DOI: 10.1016/j.celrep.2014.12.008
April 28, 2026 at 1:00 AM
Las ballenas boreales viven más de 200 años y resisten enfermedades. Estudios destacan la proteína CIRBP, que mejora la reparación del ADN y podría influir en investigaciones sobre envejecimiento humano.
DOI: 10.1016/j.celrep.2014.12.008
DOI: 10.1016/j.celrep.2014.12.008
Upcoming seminar by Lea HUILIO : Regulations de CIRBP en reponse aux stress lies a l'infection bacterienne at IBENS, Tuesday 06 October 2026 at 14:00. More info
September 25, 2026 at 5:43 AM
Upcoming seminar by Lea HUILIO : Regulations de CIRBP en reponse aux stress lies a l'infection bacterienne at IBENS, Tuesday 06 October 2026 at 14:00. More info
Grönlanninvalas voi elää yli 200 vuotiaaksi. Tässä on tutkittu miten se sen tekee.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 4, 2025 at 10:18 AM
Grönlanninvalas voi elää yli 200 vuotiaaksi. Tässä on tutkittu miten se sen tekee.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bowhead whales produce high levels of the protein CIRBP, which enhances DNA repair and may contribute to their exceptional longevity and resistance to age-related diseases. doi.org/g98gxv
Bowhead whales' secret to long life may lie in a protein known as CIRBP
As humans age, we become more vulnerable to cancer and other diseases. Bowhead whales, however, can live for up to 200 years while staying remarkably disease resistant.
phys.org
October 29, 2025 at 5:05 PM
Bowhead whales produce high levels of the protein CIRBP, which enhances DNA repair and may contribute to their exceptional longevity and resistance to age-related diseases. doi.org/g98gxv
bowhead whales live for 200+ years! turns out they make 100x more of a dna repair protein (cirbp) than we do. when researchers put the whale version of cirbp into human cells, it doubled their dna repair efficiency. maybe they're onto something for longer, healthier lives for us!
March 16, 2026 at 2:05 PM
bowhead whales live for 200+ years! turns out they make 100x more of a dna repair protein (cirbp) than we do. when researchers put the whale version of cirbp into human cells, it doubled their dna repair efficiency. maybe they're onto something for longer, healthier lives for us!
Thrilled that our PAR-labeling tech supported new Nature findings from the Gorbunova–Seluanov team! Characterizing CIRBP in bowhead whales reveals how PARP regulation may shape longevity. Kudos to Hongrui Liu & Raymond Cai!
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...
Evidence for improved DNA repair in long-lived bowhead whale - Nature
Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein. &nbs...
www.nature.com
October 29, 2025 at 7:42 PM
Thrilled that our PAR-labeling tech supported new Nature findings from the Gorbunova–Seluanov team! Characterizing CIRBP in bowhead whales reveals how PARP regulation may shape longevity. Kudos to Hongrui Liu & Raymond Cai!
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...
Assessing Donor Kidney Function: The Role of CIRBP in Predicting Delayed Graft ... - Frontiers - goo.gl/alerts/cGtkyH #GoogleAlerts
Frontiers | Assessing Donor Kidney Function: The Role of CIRBP in Predicting Delayed Graft Function Post-Transplant
Introduction: Delayed graft function (DGF) shortens the survival time of transplanted kidneys and increases the risk of rejection. Current methods are inadeq...
goo.gl
December 31, 2024 at 2:51 AM
Assessing Donor Kidney Function: The Role of CIRBP in Predicting Delayed Graft ... - Frontiers - goo.gl/alerts/cGtkyH #GoogleAlerts
Ferroptosis and Glioblastoma Insights from CIRBP Research - Thailand Medical News
www.thailandmedical.news
December 29, 2024 at 10:28 AM
“…when Dr. Gorbunova and Dr. Seluanov inserted the bowhead CIRBP gene into human cells, the rate of DNA repair in those cells doubled.”
If we had hunted them to extinction, we wouldn’t have learned this. I’m feeling grateful to all the 1970s “save the whales” activists.
If we had hunted them to extinction, we wouldn’t have learned this. I’m feeling grateful to all the 1970s “save the whales” activists.
Life Lessons from (Very Old) Bowhead Whales
www.nytimes.com
October 30, 2025 at 8:26 PM
“…when Dr. Gorbunova and Dr. Seluanov inserted the bowhead CIRBP gene into human cells, the rate of DNA repair in those cells doubled.”
If we had hunted them to extinction, we wouldn’t have learned this. I’m feeling grateful to all the 1970s “save the whales” activists.
If we had hunted them to extinction, we wouldn’t have learned this. I’m feeling grateful to all the 1970s “save the whales” activists.
Cold-inducible RNA-binding protein CIRBP: A whales secret to long life?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Evidence for improved DNA repair in long-lived bowhead whale - Nature
Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein. &nbs...
www.nature.com
November 3, 2025 at 7:42 AM
Cold-inducible RNA-binding protein CIRBP: A whales secret to long life?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CIRBP is a stress-responsive protein that can interact with histamine signaling pathways. Histamine is a pro-inflammatory agonist that can influence the expression of CIRBP, and CIRBP, in turn, can be involved in inflammatory responses.
November 24, 2025 at 2:42 PM
CIRBP is a stress-responsive protein that can interact with histamine signaling pathways. Histamine is a pro-inflammatory agonist that can influence the expression of CIRBP, and CIRBP, in turn, can be involved in inflammatory responses.
"There were some other proteins that were expressed in bowhead whales at slightly higher levels, but CIRBP stood out because it was present at 100-fold higher levels.” - Vera Gorbunova, Doris Johns Cherry Professor of Biology and of Medicine www.rochester.edu/newscenter/c...
Bowhead whales’ secret to long life may lie in a protein
University of Rochester scientists link the whales’ longevity to CIRBP, a DNA-repair protein that could one day help humans live longer.
www.rochester.edu
October 30, 2025 at 10:57 AM
"There were some other proteins that were expressed in bowhead whales at slightly higher levels, but CIRBP stood out because it was present at 100-fold higher levels.” - Vera Gorbunova, Doris Johns Cherry Professor of Biology and of Medicine www.rochester.edu/newscenter/c...
La ballena boreal puede vivir más de 200 años. Investigaciones científicas estudian su ADN y proteínas como CIRBP para entender su longevidad y resistencia a enfermedades, aunque todavía no existen aplicaciones médicas comprobadas en humanos.
DOI:10.1038/s41586-025-09694-5
DOI:10.1038/s41586-025-09694-5
March 17, 2026 at 8:30 AM
La ballena boreal puede vivir más de 200 años. Investigaciones científicas estudian su ADN y proteínas como CIRBP para entender su longevidad y resistencia a enfermedades, aunque todavía no existen aplicaciones médicas comprobadas en humanos.
DOI:10.1038/s41586-025-09694-5
DOI:10.1038/s41586-025-09694-5
Bowhead whales fix their DNA after double strand breaks in a way that is less likely to result in cancer-causing mutations.
Yet another reason to be guardians of the environment and other creatures, if for no other reason than pure self-interest.
#CIRBP
#Cancer
#Medicine
#Biology
Yet another reason to be guardians of the environment and other creatures, if for no other reason than pure self-interest.
#CIRBP
#Cancer
#Medicine
#Biology
I LOVE WHALES AAAA #science #biology #medicine #cancer #dna #genetics #whales
YouTube video by Dr. Cal your Science Pal
youtube.com
November 16, 2025 at 5:21 PM
The key is a protein called CIRBP. It repairs the most dangerous type of DNA damage: double-strand breaks. Bowhead whales produce it at unusually high levels.
When researchers introduced the bowhead version of CIRBP into human cells, genome stability improved.
When researchers introduced the bowhead version of CIRBP into human cells, genome stability improved.
April 3, 2026 at 12:02 PM
The key is a protein called CIRBP. It repairs the most dangerous type of DNA damage: double-strand breaks. Bowhead whales produce it at unusually high levels.
When researchers introduced the bowhead version of CIRBP into human cells, genome stability improved.
When researchers introduced the bowhead version of CIRBP into human cells, genome stability improved.